Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells

Biochemical and Biophysical Research Communications

Volumn 410, Issue 2, 2011, Pages 235-241

  Lin, Jing ^a   Xu, Kai ^a   Gitanjali, Jayachandran ^a   Roth, Jack A ^a   Ji, Lin ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

FUS1 TUSC2; Lung cancer; Protein expression regulation; Tumor suppressor gene; Untranslated region (UTR); Upstream open reading frame (uORF)

Indexed keywords

FUS1 PROTEIN; MESSENGER RNA; RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CANCER CELL; CONTROLLED STUDY; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG CANCER; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; RNA SEQUENCE; RNA STRUCTURE;

BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; TUMOR SUPPRESSOR PROTEINS; UNTRANSLATED REGIONS;

EID: 79959709802     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.122     Document Type: Article

References (18)

1. Ji L., Minna J.D., Roth J.A. 3p21.3 tumor suppressor cluster: prospects for translational applications. Future Oncol. 2005, 1:79-92.
2. Lerman M.I., Minna J.D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p213: identification evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res. 2000, 60:6116-6133.
3. Zabarovsky E.R., Lerman M.I., Minna J.D. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 2002, 21:6915-6935.
4. Ji L., Roth J.A. Tumor suppressor FUS1 signaling pathway. J. Thor. Oncol. 2008, 3:327-330.
5. Uno F., Sasaki J., Nishizaki M., et al. Myristoylation of the FUS1 protein is required for tumor suppression in human lung cancer cells. Cancer Res. 2004, 64:2969-2976.
6. Ito I., Ji L., Tanaka F., et al. Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo. Cancer Gene Ther. 2004, 11:733-739.
7. Prudkin L., Behrens C., Liu D.D., et al. Loss and reduction of Fus1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. Clin. Cancer Res. 2008, 14:41-47.
8. Wistuba I.I., Tang M., Maitra A., et al. Genome-wide allelotyping analysis reveals multiple sites of allelic loss in gallbladder carcinoma. Cancer Res. 2001, 61:3795-3800.
9. Hughes T.A. Regulation of gene expression by alternative untranslated regions. Trends Genet. 2006, 22:119-122.
10. Hughes T.A., Brady H.J. Regulation of axin2 expression at the levels of transcription translation and protein stability in lung and colon cancer. Cancer Lett. 2006, 233:338-347.
11. Kozak M. Pushing the limits of the scanning mechanism for initiation of translation. Gene 2002, 299:1-34.
12. Kozak M. Regulation of translation via mRNA structure in prokaryotes and eukaryotes. Gene 2005, 361:13-37.
13. Kozak M. Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature 1984, 308:241-246.
14. Kozak M. Emerging links between initiation of translation and human diseases. Mamm. Genome 2002, 13:401-410.
15. Kozak M. Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation. Gene 2003, 318:1-23.
16. Lee D.Y., Deng Z., Wang C.H., Yang B.B., survival MicroRNA-378 promotes cell, growth tumor and angiogenesis by targeting SuFu and Fus-1 expression. Proc. Natl. Acad. Sci. USA 2007, 104:20350-20355.
17. Du L., Schageman J.J., Subauste M.C., et al. miR-93, miR-98 and miR-197 regulate expression of tumor suppressor gene FUS1. Mol. Cancer Res. 2009, 7:1234-1243.
18. Conne B., Stutz A., Vassalli J.D. The 3′untranslated region of messenger RNA: a molecular 'hotspot' for pathology. Nat. Med. 2000, 6:637-641.