Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation

Gene

Volumn 318, Issue 1-2, 2003, Pages 1-23

  Kozak, Marilyn ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

5 Untranslated region; Hepatitis C virus; Internal ribosome entry site; Picornavirus; RNA binding protein; Translational control

Indexed keywords

INITIATION FACTOR; MESSENGER RNA; NUCLEAR PROTEIN; RIBONUCLEASE; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; VIRUS RNA; VIRUS VECTOR;

APOPTOSIS; ENZYMATIC DEGRADATION; FOOT AND MOUTH DISEASE VIRUS; GENE EXPRESSION; HEPATITIS A VIRUS; HEPATITIS C VIRUS; HUMAN; INTERNAL RIBOSOME ENTRY SITE; MITOSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PICORNAVIRUS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROKARYOTE; PROMOTER REGION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN RNA BINDING; REGULATORY MECHANISM; REVIEW; RHINOVIRUS; RIBOSOME; RNA ANALYSIS; RNA PROCESSING; RNA SEQUENCE; RNA SPLICING; RNA STABILITY; RNA STRUCTURE; RNA TRANSLATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

HEPATITIS C VIRUS; PICORNAVIRIDAE;

EID: 0242285647     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(03)00774-1     Document Type: Review

References (210)

1. Akiri G., Nahari D., Finkelstein Y., Le S.-Y., Elroy-Stein O., Levi B.-Z. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene. 17:1998;227-236.
2. Ali N., Pruijn G.J.M., Kenan D.J., Keene J.D., Siddiqui A. Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation. J. Biol. Chem. 275:2000;27531-27540.
3. Ali I.K., McKendrick L., Morley S.J., Jackson R.J. Truncated initiation factor eIF4G lacking and eIF4E binding site can support capped mRNA translation. EMBO J. 20:2001;4233-4242.
4. Aulak K.S., Mishra R., Zhou L., Hyatt S.L., de Jonge W., Lamers W., Snider M., Hatzoglou M. Post-transcriptional regulation of the arginine transporter Cat-1 by amino acid availability. J. Biol. Chem. 274:1999;30424-30432.
5. pro. J. Virol. 76:2002;2529-2542.
6. Ballut L., Petit F., Mouzeyar S., Le Gall O., Candresse T., Schmid P., Nicolas P., Badaoui S. Biochemical identification of proteasome-associated endonuclease activity in sunflower. Biochim. Biophys. Acta. 1645:2003;30-39.
7. Bandyopadhyay P.K., Wang C., Lipton H.L. Cap-independent translation by the 5′ untranslated region of Theiler's murine encephalomyelitis virus. J. Virol. 66:1992;6249-6256.
8. Barends S., Bink H.H.J., van den Worm S.H.E., Pleij C.W.A., Kraal B. Entrapping ribosomes for viral translation: tRNA mimicry as a molecular Trojan horse. Cell. 112:2003;123-129.
9. Belsham G.J., Jackson R.J. Translation initiation on picornavirus RNA. Sonenberg N., Hershey J., Mathews M. Translational Control of Gene Expression. 2000;869-900 Cold Spring Harbor Press, New York.
10. Belsham G.J., Sonenberg N. RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol. Rev. 60:1996;499-511.
11. Belsham G.J., Sonenberg N. Picornavirus RNA translation: roles for cellular proteins. Trends Microbiol. 8:2000;330-335.
12. Bernstein J., Sella O., Le S.-Y., Elroy-Stein O. PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES). J. Biol. Chem. 272:1997;9356-9362.
13. Blackshear P.J., Stumpo D.J., Carballo E., Lawrence J.C. Jr. Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. J. Biol. Chem. 272:1997;31510-31514.
14. Bonneau A.-M., Sonenberg N. Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J. Biol. Chem. 262:1987;11134-11139.
15. Borman A.M., Deliat F.G., Kean K.M. Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. EMBO J. 13:1994;3149-3157.
16. Borman A.M., Le Mercier P., Girard M., Kean K.M. Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Res. 25:1997;925-932.
17. Borman A.M., Michel Y.M., Kean K.M. Detailed analysis of the requirements of hepatitis A virus internal ribosome entry segment for the eukaryotic initiation factor complex eIF4F. J. Virol. 75:2001;7864-7871.
18. Boussadia O., Amiot F., Cases S., Triqueneaux G., Jacquemin-Sablon H., Dautry F. Transcription of unr (upstream of N-ras) down-modulates N-ras expression in vivo. FEBS Lett. 420:1997;20-24.
19. Boussadia O., Niepmann M., Créancier L., Prats A.-C., Dautry F., Jacquemin-Sablon H. Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus. J. Virol. 77:2003;3353-3359.
20. Brasey A., Lopez-Lastra M., Ohlmann T., Beerens N., Berkhout B., Darlix J.-L., Sonenberg N. The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle. J. Virol. 77:2003;3939-3949.
21. Carrasco L., Battaner E., Vazquez D. The elongation steps in protein synthesis by eukaryotic ribosomes: effects of antibiotics. Methods Enzymol. 30:1974;282-289.
22. Chang P.-J., Liu S.-T. Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the Zta protein of Epstein-Barr virus. J. Virol. 75:2001;1142-1151.
23. Chang K.H., Brown E.A., Lemon S.M. Cell type-specific proteins which interact with the 5′ nontranslated region of hepatitis A virus RNA. J. Virol. 67:1993;6716-6725.
24. Chappell S.A., LeQuesne J.P.C., Paulin F.E.M., deSchoolmeester M.L., Stoneley M., Soutar R.L., Ralston S.H., Helfrich M.H., Willis A.E. A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation. Oncogene. 19:2000;4437-4440.
25. Chappell S.A., Edelman G.M., Mauro V.P. A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity. Proc. Natl. Acad. Sci. U. S. A. 97:2000;1536-1541.
26. Chappell S.A., Owens G.C., Mauro V.P. A 5′ leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia. J. Biol. Chem. 276:2001;36917-36922.
27. Chiang P.-W., Carpenter L.E., Hagerman P.J. The 5′-untranslated region of the FMR1 message facilitates translation by internal ribosome entry. J. Biol. Chem. 276:2001;37916-37921.
28. Chung G.T.Y., Yamada Y., Pannell R., Forster A., Rabbitts T.H. The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis. Nucleic Acids Res. 31:2003;e46.
29. Clemens M.J., Bushell M., Jeffrey I.W., Pain V.M., Morley S.J. Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. Cell Death Differ. 7:2000;603-615.
30. Coldwell M.J., Mitchell S.A., Stoneley M., MacFarlane M., Willis A.E. Initiation of Apaf-1 translation by internal ribosome entry. Oncogene. 19:2000;899-905.
31. Coldwell M.J., deSchoolmeester M.L., Fraser G.A., Pickering B.M., Packham G., Willis A.E. The p35 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene. 20:2001;4095-4100.
32. Collier A.J., Gallego J., Klinck R., Cole P.T., Harris S.J., Harrison G.P., Aboul-ela F., Varani G., Walker S. A conserved RNA structure within the HCV IRES eIF3-binding site. Nat. Struct. Biol. 9:2002;375-380.
33. Cornelis S., Bruynooghe Y., Denecker G., Van Huffel S., Tinton S., Beyaert R. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. Mol. Cell. 5:2000;597-605.
34. Créancier L., Mercier P., Prats A.-C., Morello D. c-myc internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice. Mol. Cell. Biol. 21:2001;1833-1840.
35. pro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. J. Biol. Chem. 266:1991;14714-14720.
36. De Felipe P., Izquierdo M. Construction and characterization of pentacistronic retrovirus vectors. J. Gen. Virol. 84:2003;1281-1285.
37. Deffaud C., Darlix J.-L. Characterization of an internal ribosomal entry segment in the 5′ leader of murine leukemia virus env RNA. J. Virol. 74:2000;846-850.
38. De Gregorio E., Preiss T., Hentze M.W. Translation driven by an eIF4G core domain in vivo. EMBO J. 18:1999;4865-4874.
39. De Pietri Tonelli D., Mihailovich M., Schnurbus R., Pesole G., Grohovaz F., Zacchetti D. Translational control of Scamper expression via a cell-specific internal ribosome entry site. Nucleic Acids Res. 31:2003;2508-2513.
40. Dorokhov Y.L., Skulachev M.V., Ivanov P.A., Zvereva S.D., Tjulkina L.G., Merits A., Gleba Y.Y., Hohn T., Atabekov J.G. Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry. Proc. Natl. Acad. Sci. U. S. A. 99:2002;5301-5306.
41. Dumas E., Staedel C., Colombat M., Reigadas S., Chabas S., Astier-Gin T., Cahour A., Litvak S., Ventura M. A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5′ UTR. Nucleic Acids Res. 31:2003;1275-1281.
42. Elgadi M.M., Smiley J.R. Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. J. Virol. 73:1999;9222-9231.
43. Fernandez J., Yaman I., Mishra R., Merrick W.C., Snider M.D., Lamers W.H., Hatzoglou M. Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability. J. Biol. Chem. 276:2001;12285-12291.
44. Fernandez J., Yaman I., Sarnow P., Snider M.D., Hatzoglou M. Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2α J. Biol. Chem. 277:2002;19198-19205.
45. Fletcher S.P., Ali I.K., Kaminski A., Digard P., Jackson R.J. The influence of viral coding sequences on pestivirus IRES activity reveals further parallels with translation initiation in prokaryotes. RNA. 8:2002;1558-1571.
46. Follett E.A.C., Pringle C.R., Pennington T.H. Virus development in enucleate cells: echovirus, poliovirus, pseudorabies virus, reovirus, respiratory syncytial virus and Semliki forest virus. J. Gen. Virol. 26:1975;183-196.
47. Gallie D.R., Ling J., Niepel M., Morley S.J., Pain V.M. The role of 5′ leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes. Nucleic Acids Res. 28:2000;2943-2953.
48. Gamarnik A.V., Andino R. Switch from translation to RNA replication in a positive-stranded RNA virus. Genes Dev. 12:1998;2293-2304.
49. Gan W., La Celle M., Rhoads R.E. Functional characterization of the internal ribosome entry site of eIF4G mRNA. J. Biol. Chem. 273:1998;5006-5012.
50. Gerlitz G., Jagus R., Elroy-Stein O. Phosphorylation of initiation factor-2α is required for activation of internal translation initiation during cell differentiation. Eur. J. Biochem. 269:2002;2810-2819.
51. Ghilardi N., Wiestner A., Skoda R.C. Thrombopoietin production is inhibited by a translational mechanism. Blood. 92:1998;4023-4030.
52. Giraud S., Greco A., Brink M., Diaz J.-J., Delafontaine P. Translation initiation of the insulin-like growth factor I receptor mRNA is mediated by an internal ribosome entry site. J. Biol. Chem. 276:2001;5668-5675.
53. Glass M.J., Summers D.F. Identification of a trans-acting activity from liver that stimulates hepatitis A virus translation in vitro. Virology. 193:1993;1047-1050.
54. Gosert R., Chang K.H., Rijnbrand R., Yi M., Sangar D.V., Lemon S.M. Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites in vivo. Mol. Cell. Biol. 20:2000;1583-1595.
55. Goss K.H., Trzepacz C., Tuohy T.M.F., Groden J. Attenuated APC alleles produce functional protein from internal translation initiation. Proc. Natl. Acad. Sci. U. S. A. 99:2002;8161-8166.
56. Graff J., Ehrenfeld E. Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro. J. Virol. 72:1998;3571-3577.
57. Graff J., Cha J., Blyn L.B., Ehrenfeld E. Interaction of poly(rC) binding protein 2 with the 5′ noncoding region of hepatitis A virus RNA and its effects on translation. J. Virol. 72:1998;9668-9675.
58. Green N.K., McNeish I.A., Doshi R., Searle P.F., Kerr D.J., Young L.S. Immune enhancement of nitroreductase-induced cytotoxicity: studies using a bicistronic adenovirus vector. Int. J. Cancer. 104:2003;104-112.
59. Grobe K., Esko J.D. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes by structured 5′-untranslated regions and internal ribosome entry sites. J. Biol. Chem. 277:2002;30699-30706.
60. Grundhoff A., Ganem D. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J. Virol. 75:2001;1857-1863.
61. Han B., Zhang J.-T. Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol. Cell. Biol. 22:2002;7372-7384.
62. Hecht K., Bailey J.E., Minas W. Polycistronic gene expression in yeast versus cryptic promoter elements. FEMS Yeast Res. 2:2002;215-224.
63. Hellen C.U.T., Sarnow P. Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev. 15:2001;1593-1612.
64. Hellen C.U.T., Wimmer E. Translation of encephalomyocarditis virus RNA by internal ribosomal entry. Curr. Topics Microbiol. Immunol. 203:1995;31-63.
65. Henis-Korenblit S., Shani G., Sines T., Marash L., Shohat G., Kimchi A. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc. Natl. Acad. Sci. U. S. A. 99:2002;5400-5405.
66. Hennecke M., Kwissa M., Metzger K., Oumard A., Kröger A., Schirmbeck R., Reimann J., Hauser H. Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Nucleic Acids Res. 29:2001;3327-3334.
67. Holcik M., Korneluk R.G. Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation. Mol. Cell. Biol. 20:2000;4648-4657.
68. Holcik M., Lefebvre C., Yeh C., Chow T., Korneluk R.G. A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat. Cell Biol. 1:1999;190-192.
69. Holcik M., Gordon B.W., Korneluk R.G. The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2. Mol. Cell. Biol. 23:2003;280-288.
70. Honda M., Kaneko S., Matsushita E., Kobayashi K., Abell G.A., Lemon S.M. Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation. Gastroenterology. 118:2000;152-162.
71. Horsburgh B.C., Kollmus H., Hauser H., Coen D.M. Translational recoding induced by G-rich mRNA sequences that form unusual structures. Cell. 86:1996;949-959.
72. Hunt T. The control of globin synthesis in rabbit reticulocytes. Ann. N. Y. Acad. Sci. 241:1974;223-231.
73. Hunt S.L., Jackson R.J. Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. RNA. 5:1999;344-359.
74. Hunt S.L., Hsuan J.J., Totty N., Jackson R.J. Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. Genes Dev. 13:1999;437-448.
75. Iizuka N., Najita L., Franzusoff A., Sarnow P. Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae. Mol. Cell. Biol. 14:1994;7322-7330.
76. Isoyama T., Kamoshita N., Yasui K., Iwai A., Shiroki K., Toyoda H., Yamada A., Takasaki Y., Nomoto A. Lower concentration of La protein required for internal ribosome entry on hepatitis C virus RNA than on poliovirus RNA. J. Gen. Virol. 80:1999;2319-2327.
77. Izumi R.E., Valdez B., Banerjee R., Srivastava M., Dasgupta A. Nucleolin stimulates viral internal ribosome entry site-mediated translation. Virus Res. 76:2001;17-29.
78. Jacob W.F., Santer M., Dahlberg A.E. A single base change in the Shine-Dalgarno region of 16S rRNA of Escherichia coli affects translation of many proteins. Proc. Natl. Acad. Sci. U. S. A. 84:1987;4757-4761.
79. Jan E., Sarnow P. Factorless ribosome assembly on the internal ribosome entry site of cricket paralysis virus. J. Mol. Biol. 324:2002;889-902.
80. Jankowsky J.L., Slunt H.H., Ratovitski T., Jenkins N.A., Copeland N.G., Borchelt D.R. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol. Eng. 17:2001;157-165.
81. Jespersen T., Duch M., Carrasco M.L., Warming S., Pedersen F.S. Expression of heterologous genes from an IRES translational cassette in replication competent murine leukemia virus vectors. Gene. 239:1999;227-235.
82. Johannes G., Carter M.S., Eisen M.B., Brown P.O., Sarnow P. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Proc. Natl. Acad. Sci. U. S. A. 96:1999;13118-13123.
83. Jopling C.L., Willis A.E. N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells. Oncogene. 20:2001;2664-2670.
84. Kaminski A., Jackson R.J. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA. 4:1998;626-638.
85. Kaminski A., Belsham G.J., Jackson R.J. Translation of encephalomyocarditis virus RNA: parameters influencing the selection of the internal initiation site. EMBO J. 13:1994;1673-1681.
86. Kaminski A., Hunt S.L., Patton J.G., Jackson R.J. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA. 1:1995;924-938.
87. Kamoshita N., Tsukiyama-Kohara K., Kohara M., Nomoto A. Genetic analysis of internal ribosomal entry site on hepatitis C virus RNA: implication for involvement of the highly ordered structure and cell type-specific transacting factors. Virology. 233:1997;9-18.
88. Kaufman R.J., Davies M.V., Wasley L.C., Michnick D. Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucleic Acids Res. 19:1991;4485-4490.
89. Kieft J.S., Zhou K., Jubin R., Doudna J.A. Mechanism of ribosome recruitment by hepatitis C IRES RNA. RNA. 7:2001;194-206.
90. Kieft J.S., Zhou K., Grech A., Jubin R., Doudna J.A. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat. Struct. Biol. 9:2002;370-374.
91. Kim Y.K., Jang S.K. Continuous heat shock enhances translational initiation directed by internal ribosomal entry site. Biochem. Biophys. Res. Commun. 297:2002;224-231.
92. Kim J.G., Armstrong R.C., Berndt J.A., Kim N.W., Hudson L.D. A secreted DNA-binding protein that is translated through an internal ribosome entry site (IRES) and distributed in a discrete pattern in the central nervous system. Mol. Cell. Neurosci. 12:1998;119-140.
93. Kim Y.K., Hahm B., Jang S.K. Polypyrimidine tract-binding protein inhibits translation of BiP mRNA. J. Mol. Biol. 304:2000;119-133.
94. Kim Y.K., Back S.H., Rho J., Leek S.H., Jang S.K. La autoantigen enhances translation of BiP mRNA. Nucleic Acids Res. 29:2001;5009-5016.
95. Kim J.H., Paek K.Y., Choi K., Kim T.-D., Hahm B., Kim K.-T., Jang S.K. Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. Mol. Cell. Biol. 23:2003;708-720.
96. Knauf U., Tschopp C., Gram H. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell. Biol. 21:2001;5500-5511.
97. Kolupaeva V.G., Hellen C.U.T., Shatsky I.N. Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus mRNAs. RNA. 2:1996;1199-1212.
98. Kolupaeva V.G., Lomakin I.B., Pestova T.V., Hellen C.U.T. Eukaryotic initiation factors 4G and 4A mediate conformational changes downstream of the initiation codon of the encephalomyocarditis virus internal ribosomal entry site. Mol. Cell. Biol. 23:2003;687-698.
99. Komar A.A., Lesnik T., Cullin C., Merrick W.C., Trachsel H., Altmann M. Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells. EMBO J. 22:2003;1199-1209.
100. Kong L.K., Sarnow P. Cytoplasmic expression of mRNAs containing the internal ribosome entry site and 3′ noncoding region of hepatitis C virus: effects of the 3′ leader on mRNA translation and mRNA stability. J. Virol. 76:2002;12457-12462.
101. Kozak M. Nucleotide sequences of 5′-terminal ribosome-protected initiation regions from two reovirus messages. Nature. 269:1977;390-394.
102. Kozak M. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:1991;887-903.
103. Kozak M. Interpreting cDNA sequences: some insights from studies on translation. Mamm. Genome. 7:1996;563-574.
104. Kozak M. Primer extension analysis of eukaryotic ribosome-mRNA complexes. Nucleic Acids Res. 26:1998;4853-4859.
105. Kozak M. Initiation of translation in prokaryotes and eukaryotes. Gene. 234:1999;187-208.
106. Kozak M. Do the 5′ untranslated domains of human cDNAs challenge the rules for initiation of translation (or is it vice versa)? Genomics. 70:2000;396-406.
107. Kozak M. New ways of initiating translation in eukaryotes? Mol. Cell. Biol. 21:2001;1899-1907.
108. Kozak M. Constraints on reinitiation of translation in mammals. Nucleic Acids Res. 29:2001;5226-5232.
109. Kozak M. Pushing the limits of the scanning mechanism for initiation of translation. Gene. 299:2002;1-34.
110. Kozak M. Emerging links between initiation of translation and human diseases. Mamm. Genome. 13:2002;401-410.
111. Krüger M., Beger C., Welch P.J., Barber J.R., Manns M.P., Wong-Staal F. Involvement of proteasome α-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Mol. Cell. Biol. 21:2001;8357-8364.
112. Kullmann M., Göpfert U., Siewe B., Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′ UTR. Genes Dev. 16:2002;3087-3099.
113. Lachance P.E.D., Miron M., Raught B., Sonenberg N., Lasko P. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol. Cell. Biol. 22:2002;1656-1663.
114. Laporte J., Bain C., Maurel P., Inchauspe G., Agut H., Cahour A. Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells. Blood. 101:2003;52-57.
115. Larsen L.K., Amri E.-Z., Mandrup S., Pacot C., Kristiansen K. Genomic organization of the mouse peroxisome proliferator-activated receptor β/γ gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency. Biochem. J. 366:2002;767-775.
116. Le S.-Y., Sonenberg N., Maizel J.V. Jr. Unusual folding regions and ribosome landing pad within hepatitis C virus and pestivirus RNAs. Gene. 154:1995;137-143.
117. Le Quesne J.P.C., Stoneley M., Fraser G.A., Willis A.E. Derivation of a structural model for the c-myc IRES. J. Mol. Biol. 310:2001;111-126.
118. Leskov K.S., Klokov D.Y., Li J., Kinsella T.J., Boothman D.A. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J. Biol. Chem. 278:2003;11590-11600.
119. Li S., Sonenberg N., Gingras A.-C., Peterson M., Avdulov S., Polunovsky V.A., Bitterman P.B. Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Mol. Cell. Biol. 22:2002;2853-2861.
120. Liu X., Constantinescu S.N., Sun Y., Bogan J.S., Hirsch D., Weinberg R.A., Lodish H.F. Generation of mammalian cells stably expressing multiple genes at predetermined levels. Anal. Biochem. 280:2000;20-28.
121. Lomakin I.B., Hellen C.U.T., Pestova T.V. Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosome entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol. Cell. Biol. 20:2000;6019-6029.
122. López de Quinto S., Lafuente E., Martínez-Salas E. IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA. 7:2001;1213-1226.
123. López de Quinto S., Sáiz M., de la Morena D., Sobrino F., Martínez-Salas E. IRES-driven translation is stimulated separately by the FMDV 3′-NCR and poly(A) sequences. Nucleic Acids Res. 30:2002;4398-4405.
124. Lyons A.J., Robertson H.D. Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet. J. Biol. Chem. 278:2003;26844-26850.
125. Maier D., Nagel A.C., Preiss A. Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation. Proc. Natl. Acad. Sci. U. S. A. 99:2002;15480-15485.
126. Malnou C.E., Pöyry T.A.A., Jackson R.J., Kean K.M. Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis. J. Virol. 76:2002;10617-10626.
127. Marcotrigiano J., Lomakin I.B., Sonenberg N., Pestova T.V., Hellen C.U.T., Burley S.K. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol. Cell. 7:2001;193-203.
128. Martínez-Salas E., Ramos R., Lafuente E., López de Quinto S. Functional interactions in internal translation initiation directed by viral and cellular IRES elements. J. Gen. Virol. 82:2001;973-984.
129. Martínez-Salas E., López de Quinto S., Ramos R., Fernández-Miragall O. IRES elements: features of the RNA structure contributing to their activity. Biochimie. 84:2002;755-763.
130. Maser R.S., Zinkel R., Petrini J.H.J. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nat. Genet. 27:2001;417-421.
131. Mathews M.B. Lost in translation. Trends Biochem. Sci. 27:2002;267-268.
132. McKendrick L., Morley S.J., Pain V.M., Jagus R., Joshi B. Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo. Eur. J. Biochem. 268:2001;5375-5385.
133. Meerovitch K., Svitkin Y.V., Lee H.S., Lejbkowicz F., Kenan D.J., Chan E.K.L., Agol V.I., Keene J.D., Sonenberg N. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J. Virol. 67:1993;3798-3807.
134. Miskimins W.K., Wang G., Hawkinson M., Miskimins R. Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation. Mol. Cell. Biol. 21:2001;4960-4967.
135. Mitchell S.A., Brown E.C., Coldwell M.J., Jackson R.J., Willis A.E. Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of pyrimidine tract binding protein and upstream of N-ras. Mol. Cell. Biol. 21:2001;3364-3374.
136. Mitchell S.A., Spriggs K.A., Coldwell M.J., Jackson R.J., Willis A.E. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol. Cell. 11:2003;757-771.
137. Moll I., Huber M., Grill S., Sairafi P., Mueller F., Brimacombe R., Londei P., Bläsi U. Evidence against an interaction between the mRNA downstream box and 16S rRNA in translation initiation. J. Bacteriol. 183:2001;3499-3505.
138. Morley S.J., Naegele S. Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells. J. Biol. Chem. 277:2002;32855-32859.
139. Morrish B.C., Rumsby M.G. The 5′ untranslated region of protein kinase Cδ directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis. Mol. Cell. Biol. 22:2002;6089-6099.
140. Murray K.E., Roberts A.W., Barton D.J. Poly(rC) binding proteins mediate poliovirus mRNA stability. RNA. 7:2001;1126-1141.
141. Negulescu D., Leong L.E.-C., Chandy K.G., Semler B.L., Gutman G.A. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J. Biol. Chem. 273:1998;20109-20113.
142. Nevins T.A., Harder Z.M., Korneluk R.G., Holcik M. Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1. J. Biol. Chem. 278:2003;3572-3579.
143. Nicholson R., Pelletier J., Le S.-Y., Sonenberg N. Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J. Virol. 65:1991;5886-5894.
144. Niepmann M., Petersen A., Meyer K., Beck E. Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus. J. Virol. 71:1997;8330-8339.
145. Obrig T., Irvin J., Culp W., Hardesty B. Inhibition of peptide initiation on reticulocyte ribosomes by edeine. Eur. J. Biochem. 21:1971;31-41.
146. Ochs K., Zeller A., Saleh L., Bassili G., Song Y., Sonntag A., Niepmann M. Impaired binding of standard initiation factors mediates poliovirus translation attenuation. J. Virol. 77:2003;115-122.
147. O'Connor M., Asai T., Squires C.L., Dahlberg A.E. Enhancement of translation by the downstream box does not involve base pairing of mRNA with the penultimate stem sequence of 16S rRNA. Proc. Natl. Acad. Sci. U. S. A. 96:1999;8973-8978.
148. Odreman-Macchioli F.E., Tisminetzky S.G., Zotti M., Baralle F.E., Buratti E. Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES. Nucleic Acids Res. 28:2000;875-885.
149. Odreman-Macchioli F., Baralle F.E., Buratti E. Mutational analysis of the different bulge regions of hepatitis C virus domain II and their influence on internal ribosome entry site translational ability. J. Biol. Chem. 276:2001;41648-41655.
150. Ostareck D.H., Ostareck-Lederer A., Shatsky I.N., Hentze M.W. Lipoxygenase mRNA silencing in erythroid differentiation: the 3′ UTR regulatory complex controls 60S ribosomal subunit joining. Cell. 104:2001;281-290.
151. Otto G.A., Lukavsky P.J., Lancaster A.M., Sarnow P., Puglisi J.D. Ribosomal proteins mediate the hepatitis C virus IRES-HeLa 40S interaction. RNA. 8:2002;913-923.
152. Owens G.C., Chappell S.A., Mauro V.P., Edelman G.M. Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1471-1476.
153. Paulous S., Malnou C.E., Michel Y.M., Kean K.M., Borman A.M. Comparison of the capacity of different viral internal ribosome entry segments to direct translation initiation in poly(A)-dependent reticulocyte lysates. Nucleic Acids Res. 31:2003;722-733.
154. Paz I., Abramovitz L., Choder M. Starved Saccharomyces cerevisiae cells have the capacity to support internal initiation of translation. J. Biol. Chem. 274:1999;21741-21745.
155. Peek R., Pruijn G.J.M., Van Venrooij W.J. Interaction of the La (SS-B) autoantigen with small ribosomal subunits. Eur. J. Biochem. 236:1996;649-655.
156. Pestova T.V., Hellen C.U.T. Translation elongation after assembly of ribosomes on the Cricket paralysis virus internal ribosomal entry site without initiation factors or initiator tRNA. Genes Dev. 17:2003;181-186.
157. Pestova T.V., Hellen C.U.T., Wimmer E. Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5′ nontranslated region and involvement of a cellular 57-kilodalton protein. J. Virol. 65:1991;6194-6204.
158. Pestova T.V., Borukhov S.I., Hellen C.U.T. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature. 394:1998;854-859.
159. Pestova T.V., Shatsky I.N., Fletcher S.P., Jackson R.J., Hellen C.U.T. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev. 12:1998;67-83.
160. Pickering B.M., Mitchell S.A., Evans J.R., Willis A.E. Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Nucleic Acids Res. 31:2003;639-646.
161. Pilipenko E.V., Gmyl A.P., Maslova S.V., Svitkin Y.V., Sinyakov A.N., Agol V.I. Prokaryotic-like cis elements in the cap-independent internal initiation of translation on picornavirus RNA. Cell. 68:1992;119-131.
162. Pilipenko E.V., Gmyl A.P., Maslova S.V., Belov G.A., Sinyakov A.N., Huang M., Brown T.D.K., Agol V.I. Starting window, a distinct element in the cap-independent internal initiation of translation on picornavirus RNA. J. Mol. Biol. 241:1994;398-414.
163. Pilipenko E.V., Pestova T.V., Kolupaeva V.G., Khitrina E.V., Poperechnaya A.N., Agol V.I., Hellen C.U.T. A cell cycle-dependent protein serves as a template-specific translation initiation factor. Genes Dev. 14:2000;2028-2045.
164. Pilipenko E.V., Viktorova E.G., Guest S.T., Agol V.I., Roos R.P. Cell-specific proteins regulate viral RNA translation and virus-induced disease. EMBO J. 20:2001;6899-6908.
165. Pyronnet S., Pradayrol L., Sonenberg N. A cell cycle-dependent internal ribosome entry site. Mol. Cell. 5:2000;607-616.
166. Qiao J., Roy V., Girard M.H., Caruso M. High translation efficiency is mediated by the encephalomyocarditis virus internal ribosomal entry sites if the natural sequence surrounding the eleventh AUG is retained. Human Gene Ther. 13:2002;881-887.
167. Rijnbrand R.C.A., Lemon S.M. Internal ribosome entry site-mediated translation in hepatitis C virus replication. Curr. Topics Microbiol. Immunol. 242:2000;85-116.
168. Romero J.R., Rotbart H.A. Sequence analysis of the downstream 5′ nontranslated region of seven echoviruses with different neurovirulence phenotypes. J. Virol. 69:1995;1370-1375.
169. Saleh L., Rust R.C., Füllkrug R., Beck E., Bassili G., Ochs K., Niepmann M. Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site. J. Gen. Virol. 82:2001;757-763.
170. Sarnow P. Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J. Virol. 77:2003;2801-2806.
171. Sasahara M., Amano S., Sato H., Yang J.G., Hayase Y., Kaneko M., Sato I., Suzaki M., Hazama F. Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end. Oncogene. 16:1998;1571-1578.
172. Scheper G.C., Voorma H.O., Thomas A.A. Basepairing with 18S ribosomal RNA in internal initiation of translation. FEBS Lett. 352:1994;271-275.
173. Scheper G.C., van Kollenburg B., Hu J., Luo Y., Goss D.J., Proud C.G. Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. J. Biol. Chem. 277:2002;3303-3309.
174. Schlatter S., Fussenegger M. Novel CNBP- and La-based translation control systems for mammalian cells. Biotech. Bioeng. 81:2003;1-12.
175. Sella O., Gerlitz G., Le S.-Y., Elroy-Stein O. Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein. Mol. Cell. Biol. 19:1999;5429-5440.
176. Shaffer D.R., Lemon S.M. Temperature-sensitive hepatitis A virus mutants with deletions downstream of the first pyrimidine-rich tract of the 5′ nontranslated RNA are impaired in RNA synthesis. J. Virol. 69:1995;6498-6506.
177. Shaffer D.R., Emerson S.U., Murphy P.C., Govindarajan S., Lemon S.M. A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5′ nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection. J. Virol. 69:1995;6600-6604.
178. Shiroki K., Ohsawa C., Sugi N., Wakiyama M., Miura K., Watanabe M., Suzuki Y., Sugano S. Internal ribosome entry site-mediated translation of Smad5 in vivo: requirement for a nuclear event. Nucleic Acids Res. 30:2002;2851-2861.
179. Siegel V., Walter P. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J. 7:1988;1769-1775.
180. Somogyi P., Jenner A.J., Brierley I., Inglis S.C. Ribosomal pausing during translation of an RNA pseudoknot. Mol. Cell. Biol. 13:1993;6931-6940.
181. Spahn C.M.T., Kieft J.S., Grassucci R.A., Penczek P.A., Zhou K., Doudna J.A., Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science. 291:2001;1959-1962.
182. Steitz J.A., Jakes K. How ribosomes select initiator regions in mRNA: base pair formation between the 3′ terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 72:1975;4734-4738.
183. Stoneley M., Subkhankulova T., Le Quesne J.P.C., Coldwell M.J., Jopling C.L., Belsham G.J., Willis A.E. Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment. Nucleic Acids Res. 28:2000;687-694.
184. Stoneley M., Chappell S.A., Jopling C.L., Dickens M., MacFarlane M., Willis A.E. c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol. Cell. Biol. 20:2000;1162-1169.
185. Szer W., Kurylo-Borowska Z. Effect of edeine on aminoacyl-tRNA binding to ribosomes and its relationship to ribosomal binding sites. Biochim. Biophys. Acta. 224:1970;477-486.
186. Topisirovic I., Capili A.D., Borden K.L.B. Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner. Mol. Cell. Biol. 22:2002;6183-6198.
187. Toth R.L., Chapman S., Carr F., Cruz S.S. A novel strategy for the expression of foreign genes from plant virus vectors. FEBS Lett. 489:2001;215-219.
188. Trotta R., Vignudelli T., Candini O., Intine R.V., Pecorari L., Guerzoni C., Santilli G., Byrom M.W., Goldoni S., Ford L.P., Caligiuri M.A., Maraia R.J., Perrotti D., Calabretta B. BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer Cell. 3:2003;145-160.
189. Tsukiyama-Kohara K., Poulin F., Kohara M., DeMaria C.T., Cheng A., Wu Z., Gingras A.-C., Katsume A., Elchebly M., Spiegelman B.M., Harper M.-E., Tremblay M.L., Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 7:2001;1128-1132.
190. Vagner S., Galy B., Pyronnet S. Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites. EMBO Rep. 21:2001;893-898.
191. van Daalen Wetters T., Macrae M., Brabant M., Sittler A., Coffino P. Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational. Mol. Cell. Biol. 9:1989;5484-5490.
192. van der Velden A.W., van Nierop K., Voorma H.O., Thomas A.A.M. Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1. Int. J. Biochem. Cell Biol. 34:2002;286-297.
193. van Eyll O., Michiels T. Non-AUG-initiated internal translation of the L* protein of Theiler's virus and importance of this protein for viral persistence. J. Virol. 76:2002;10665-10673.
194. Venkatesan A., Dasgupta A. Novel fluorescence-based screen to identify small synthetic internal ribosome entry site elements. Mol. Cell. Biol. 21:2001;2826-2837.
195. Walter B.L., Nguyen J.H.C., Ehrenfeld E., Semler B.L. Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements. RNA. 5:1999;1570-1585.
196. Walter B.L., Parsley T.B., Ehrenfeld E., Semler B.L. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J. Virol. 76:2002;12008-12022.
197. Wang C., Sarnow P., Siddiqui A. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J. Virol. 67:1993;3338-3344.
198. Wang C., Sarnow P., Siddiqui A. A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA. J. Virol. 68:1994;7301-7307.
199. Watada H., Mirmira R.G., Leung J., German M.S. Transcriptional and translational regulation of β-cell differentiation factor Nkx6.1. J. Biol. Chem. 275:2000;34224-34230.
200. Wilson J.E., Pestova T.V., Hellen C.U.T., Sarnow P. Initiation of protein synthesis from the A site of the ribosome. Cell. 102:2000;511-520.
201. Wood J., Frederickson R.M., Fields S., Patel A.H. Hepatitis C virus 3′ X region interacts with human ribosomal proteins. J. Virol. 75:2001;1348-1358.
202. Wu X.-Q., Iyengar P., RajBhandary U.L. Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes. EMBO J. 15:1996;4734-4739.
203. Xiao Q., Sharp T.V., Jeffrey I.W., James M.C., Pruijn G.J., van Venrooij W.J., Clemens M.J. The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA. Nucleic Acids Res. 22:1994;2512-2518.
204. Xiao Z.-S., Simpson L.G., Quarles L.D. IRES-dependent translational control of Cbfa1/Runx2 expression. J. Cell. Biochem. 88:2003;493-505.
205. Yaman I., Fernandez J., Liu H., Caprara M., Komar A.A., Koromilas A.E., Zhou L., Snider M.D., Scheuner D., Kaufman R.J., Hatzoglou M. The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell. 113:2003;519-531.
206. Yamanaka S., Zhang X.-Y., Maeda M., Miura K., Wang S., Farese R.V. Jr., Iwao H., Innerarity T.L. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 19:2000;5533-5541.
207. Yang D., Cheung P., Sun Y., Yuan J., Zhang H., Carthy C.M., Anderson D.R., Bohunek L., Wilson J.E., McManus B.M. A Shine-Dalgarno-like sequence mediates in vitro ribosomal internal entry and subsequent scanning for translation initiation of coxsackievirus B3 RNA. Virology. 305:2003;31-43.
208. Zhang X., Richie C., Legerski R.J. Translation of hSNM1 is mediated by an internal ribosome entry site that upregulates expression during mitosis. DNA Repair. 1:2002;379-390.
209. Zhou W., Edelman G.M., Mauro V.P. Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1531-1536.
210. Zhou W., Edelman G.M., Mauro V.P. Isolation and identification of short nucleotide sequences that affect translation initiation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 100:2003;4457-4462.