Neuroprotective effects of 17β-estradiol after hypovolemic cardiac arrest in immature piglets: The role of nitric oxide and peroxidation

Shock

Volumn 36, Issue 1, 2011, Pages 30-37

  Semenas, Egidijus ^a   Sharma, Hari Shanker ^a   Nozari, Ala ^b   Basu, Samar ^a   Wiklund, Lars ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cardiopulmonary resuscitation; hemorrhage; immaturity; nitric oxide; sex

Indexed keywords

AMIODARONE; DEXTRAN; ESTRADIOL; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; SODIUM CHLORIDE; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HEART ARREST; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; HISTOLOGY; HYPOVOLEMIA; IMMATURITY; MALE; NEUROPROTECTION; NONHUMAN; PEROXIDATION; PROTEIN EXPRESSION; RESUSCITATION; SURVIVAL;

ANIMALS; BRAIN; CARDIOPULMONARY RESUSCITATION; ESTRADIOL; FEMALE; HEART ARREST; HEMODYNAMICS; HYPOVOLEMIA; LIPID PEROXIDATION; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; SWINE; VENTRICULAR FIBRILLATION;

EID: 79959689812     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182150f43     Document Type: Article

References (35)

1. Rea TD, Eisenberg MS, Becker LJ, Lima AR, Fahrenbruch CE, Copass MK, Cobb LA: Emergency medical services and mortality from heart disease: a community study. Ann Emerg Med 41:494-499, 2003. (Pubitemid 36373517)
2. Wenzel V, Krismer AC, Arntz HR, Sitter H, Stadlbauer KH, Lindner KH: A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med 350:105-113, 2004. (Pubitemid 38056221)
3. Choudhry MA, Schwacha MG, Hubbard WJ, Kerby JD, Rue LW, Bland KI, Chaudry IH: Gender differences in acute response to trauma-hemorrhage. Shock 24(suppl 1):101-106, 2005.
4. Yu, HP, Chaudry IH: The role of estrogen and receptor antagonists in maintaining organ function after trauma-hemorrhage. Shock 31:227-237, 2009.
5. Semenas E, Nozari A, Wiklund L: Sex differences in cardiac injury after severe haemorrhage and ventricular fibrillation in pigs. Resuscitation 81:1718-1722, 2010.
6. Semenas E, Nozari A, Sharma HS, Basu S, Rubertsson S, Wiklund L: Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs. Acta Anaesthesiol Scand 54:343-353, 2010.
7. Hurn PD, Vannucci SJ, Hagberg H: Adult or perinatal brain injury: does sex matter? Stroke 36:193-195, 2005. (Pubitemid 40170780)
8. Lang JT, McCullough LD: Pathways to ischemic neuronal cell death: are sex differences relevant? J Transl Med 6:33, 2008.
9. Hurn PD, Brass LM: Estrogen and stroke: a balanced analysis. Stroke 34:338-341, 2003. (Pubitemid 36206316)
10. Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM: Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 74:555-561, 2009.
11. Noppens RR, Kofler J, Hurn PD, Traystman RJ: Dose-dependent neuroprotection by 17beta-estradiol after cardiac arrest and cardiopulmonary resuscitation. Crit Care Med 33:1595-1602, 2005. (Pubitemid 40980618)
12. Wise PM, Dubal DB, Wilson ME, Rau SW, Bottner M: Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology 142:969-973, 2001. (Pubitemid 32202802)
13. Park EM, Cho S, Frys KA, Glickstein SB, Zhou P, Anrather J, Ross ME, Iadecola C: Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. J Cereb Blood Flow Metab 26:392-401, 2006.
14. Brown CM, Dela Cruz CD, Yang E, Wise PM: Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury. Exp Neurol 210:782-787, 2008.
15. Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M, Poitras MF, Dawson TM, Dawson VL, Northington F, et al.: PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. J Neurochem 90:1068-1075, 2004. (Pubitemid 39167340)
16. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD: Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab 25:502-512, 2005.
17. Basu S: Radioimmunoassay of 8-iso-prostaglandin F2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids 58:319-325, 1998. (Pubitemid 28275903)
18. Basu S: Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids 58:347-352, 1998. (Pubitemid 28329082)
19. Hannon JP, Bossone CA, Wade CE: Normal physiological values for conscious pigs used in biomedical research. Lab Anim Sci 40:293-298, 1990. (Pubitemid 20198131)
20. Sharma HS, Cervos-Navarro J: Brain oedema and cellular changes induced by acute heat stress in young rats. Acta Neurochir Suppl (Wien) 51:383-386, 1990.
21. Wiklund L, Sharma HS, Basu S: Circulatory arrest as a model for studies of global ischemic injury and neuroprotection. Ann N Y Acad Sci 1053:205-219, 2005. (Pubitemid 43031099)
22. Sharma HS: Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11:1353-1389, 2005. (Pubitemid 40598002)
23. Sharma HS, Westman J, Alm P, Sjoquist PO, Cervos-Navarro J, Nyberg F: Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51. Ann N Y Acad Sci 813:581-590, 1997. (Pubitemid 27189944)
24. Sharma HS, Miclescu A, Wiklund L: Cardiac arrest-induced regional bloodbrain barrier breakdown, edema formation and brain pathology: a light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain. J Neural Transm 118:87-114, 2011.
25. Noppens RR, Kofler J, Grafe MR, Hurn PD, Traystman RJ: Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-beta. J Cereb Blood Flow Metab 29:277-286, 2009.
26. Simoncini T, Genazzani AR: Non-genomic actions of sex steroid hormones. Eur J Endocrinol 148:281-292, 2003. (Pubitemid 36410713)
27. Landers JP, Spelsberg TC: New concepts in steroid hormone action: transcription factors, proto-oncogenes, and the cascade model for steroid regulation of gene expression. Crit Rev Eukaryot Gene Expr 2:19-63, 1992.
28. Green PS, Simpkins JW: Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci 18:347-358, 2000. (Pubitemid 30243066)
29. Vedder H, Anthes N, Stumm G, Wurz C, Behl C, Krieg JC: Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system. J Neurochem 72:2531-2538, 1999. (Pubitemid 29242205)
30. Hurn PD, Macrae IM: Estrogen as a neuroprotectant in stroke. J Cereb Blood Flow Metab 20:631-652, 2000. (Pubitemid 30217502)
31. Hurn PD, Littleton-Kearney MT, Kirsch JR, Dharmarajan AM, Traystman RJ: Postischemic cerebral blood flow recovery in the female: effect of 17betaestradiol. J Cereb Blood Flow Metab 15:666-672, 1995.
32. Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P, et al.: Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci USA 100: 9614-9619, 2003. (Pubitemid 37033976)
33. Chambliss KL, Shaul PW: Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev 23:665-686, 2002. (Pubitemid 35191628)
34. Grohe C, Kann S, Fink L, Djoufack PC, Paehr M, van Eickels M, Vetter H, Meyer R, Fink KB: 17beta-Estradiol regulates nNOS and eNOS activity in the hippocampus. Neuroreport 15:89-93, 2004. (Pubitemid 41614978)
35. Pelligrino DA, Gay RL 3rd, Baughman VL, Wang Q: NO synthase inhibition modulates NMDA-induced changes in cerebral blood flow and EEG activity. Am J Physiol 271:H990YH995, 1996.