Delineating an epigenetic continuum for initiation, transformation and progression to breast cancer

Cancers

Volumn 3, Issue 2, 2011, Pages 1580-1592

  Chen, Kang Mei ^a   Stephen, Josena K ^a   Raju, Usha ^a   Worsham, Maria J ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Benign; Continuum; DNA methylation; Premalignant; Progression; Transformation

Indexed keywords

DNA;

APC GENE; ARTICLE; ATYPICAL DUCTAL HYPERPLASIA; ATYPICAL LOBULAR HYPERPLASIA; BENIGN TUMOR; BREAST APOCRINE METAPLASIA; BREAST CANCER; BREAST CARCINOMA; BREAST EPITHELIUM; BREAST FIBROADENOMA; BREAST HYPERPLASIA; BREAST LESION; BREAST PAPILLOMA; BREAST SCLEROSING ADENOSIS; CASP8 GENE; CDH13 GENE; CDKN2A GENE; CDKN2B GENE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; EPIGENETICS; ESR1 GENE; GSTP1 GENE; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; POLYMERASE CHAIN REACTION; PRECANCER; PROMOTER REGION; RARB GENE; RASSF1 GENE; TIMP3 GENE; TP73 GENE; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE;

EID: 79959689003     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3021580     Document Type: Article

References (37)

1. Worsham, M.J.; Pals, G.; Raju, U.; Wolman, S.R. Establishing a molecular continuum in breast cancer DNA microarrays and benign breast disease. Cytometry 2002, 47, 56-59.
2. Worsham, M.J.; Chen, K.M.; Meduri, V.; Nygren, A.O.; Errami, A.; Schouten, J.P.; Benninger, M.S. Epigenetic events of disease progression in head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg. 2006, 132, 668-677.
3. Worsham, M.J.; Pals, G.; Schouten, J.P.; Van Spaendonk, R.M.; Concus, A.; Carey, T.E.; Benninger, M.S. Delineating genetic pathways of disease progression in head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg. 2003, 129, 702-708.
4. Arpino, G.; Laucirica, R.; Elledge, R.M. Premalignant and in situ breast disease: Biology and clinical implications. Ann. Intern. Med. 2005, 143, 446-457.
5. Worsham, M.J.; Raju, U.; Lu, M.; Kapke, A.; Cheng, J.; Wolman, S.R. Multiplicity of benign breast lesions is a risk factor for progression to breast cancer. Clin. Cancer Res. 2007, 13, 5474-5479.
6. Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
7. Warnecke, P.M.; Bestor, T.H. Cytosine methylation and human cancer. Curr. Opin. Oncol. 2000, 12, 68-73.
8. Yang, X.; Yan, L.; Davidson, N.E. DNA methylation in breast cancer. Endocr. Relat. Cancer 2001, 8, 115-127.
9. Widschwendter, M.; Jones, P.A. DNA methylation and breast carcinogenesis. Oncogene 2002, 21, 5462-5482.
10. Wajed, S.A.; Laird, P.W.; DeMeester, T.R. DNA methylation: An alternative pathway to cancer. Ann. Surg. 2001, 234, 10-20.
11. Jones, P.A.; Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 2002, 3, 415-428.
12. Gasco, M.; Sullivan, A.; Repellin, C.; Brooks, L.; Farrell, P.J.; Tidy, J.A.; Dunne, B.; Gusterson, B.; Evans, D.J.; Crook, T. Coincident inactivation of 14-3-3sigma and p16ink4a is an early event in vulval squamous neoplasia. Oncogene 2002, 21, 1876-1881.
13. Nuovo, G.J.; Plaia, T.W.; Belinsky, S.A.; Baylin, S.B.; Herman, J.G. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc. Natl. Acad. Sci. USA 1999, 96, 12754-12759.
14. Stephen, J.K.; Vaught, L.E.; Chen, K.M.; Shah, V.; Schweitzer, V.G.; Gardner, G.; Benninger, M.S.; Worsham, M.J. An epigenetically derived monoclonal origin for recurrent respiratory papillomatosis. Arch. Otolaryngol. Head Neck Surg. 2007, 133, 684-692.
15. Stephen, J.K.; Vaught, L.E.; Chen, K.M.; Sethi, S.; Shah, V.; Benninger, M.S.; Gardner, G.M.; Schweitzer, V.G.; Khan, M.; Worsham, M.J. Epigenetic events underlie the pathogenesis of sinonasal papillomas. Mod. Pathol. 2007, 20, 1019-1027.
16. Lewis, C.M.; Cler, L.R.; Bu, D.W.; Zochbauer-Muller, S.; Milchgrub, S.; Naftalis, E.Z.; Leitch, A.M.; Minna, J.D.; Euhus, D.M. Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. Clin. Cancer Res. 2005, 11, 166-172.
17. Euhus, D.M.; Bu, D.; Milchgrub, S.; Xie, X.J.; Bian, A.; Leitch, A.M.; Lewis, C.M. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 2008, 17, 1051-1059.
18. Shivakumar, L.; Minna, J.; Sakamaki, T.; Pestell, R.; White, M.A. The rassf1a tumor suppressor blocks cell cycle progression and inhibits cyclin d1 accumulation. Mol. Cell Biol. 2002, 22, 4309-4318.
19. Lehmann, U.; Langer, F.; Feist, H.; Glockner, S.; Hasemeier, B.; Kreipe, H. Quantitative assessment of promoter hypermethylation during breast cancer development. Am. J. Pathol. 2002, 160, 605-612.
20. Pasquali, L.; Bedeir, A.; Ringquist, S.; Styche, A.; Bhargava, R.; Trucco, G. Quantification of cpg island methylation in progressive breast lesions from normal to invasive carcinoma. Cancer Lett. 2007, 257, 136-144.
21. Liu, Z.; Yang, L.; Cui, D.X.; Liu, B.L.; Zhang, X.B.; Ma, W.F.; Zhang, Q. Methylation status and protein expression of adenomatous polyposis coli (APC) gene in breast cancer. Ai Zheng 2007, 26, 586-590.
22. Lee, A.; Kim, Y.; Han, K.; Kang, C.S.; Jeon, H.M.; Shim, S.I. Detection of tumor markers including carcinoembryonic antigen, apc, and cyclin d2 in fine-needle aspiration fluid of breast. Arch. Pathol. Lab. Med. 2004, 128, 1251-1256.
23. Moscow, J.A.; Townsend, A.J.; Goldsmith, M.E.; Whang-Peng, J.; Vickers, P.J.; Poisson, R.; Legault-Poisson, S.; Myers, C.E.; Cowan, K.H. Isolation of the human anionic glutathione s-transferase cdna and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proc. Natl. Acad. Sci. USA 1988, 85, 6518-6522.
24. Esteller, M.; Corn, P.G.; Urena, J.M.; Gabrielson, E.; Baylin, S.B.; Herman, J.G. Inactivation of glutathione s-transferase p1 gene by promoter hypermethylation in human neoplasia. Cancer Res. 1998, 58, 4515-4518.
25. Lee, W.H.; Morton, R.A.; Epstein, J.I.; Brooks, J.D.; Campbell, P.A.; Bova, G.S.; Hsieh, W.S.; Isaacs, W.B.; Nelson, W.G. Cytidine methylation of regulatory sequences near the pi-class glutathione s-transferase gene accompanies human prostatic carcinogenesis. Proc. Natl. Acad. Sci. USA 1994, 91, 11733-11737.
26. Gomez, D.E.; Alonso, D.F.; Yoshiji, H.; Thorgeirsson, U.P. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions. Eur. J. Cell Biol. 1997, 74, 111-122.
27. Gomez, D.E.; De Lorenzo, M.S.; Alonso, D.F.; Andrade, Z.A. Expression of metalloproteinases (mmp-1, mmp-2, and mmp-9) and their inhibitors (timp-1 and timp-2) in schistosomal portal fibrosis. Am. J. Trop. Med. Hyg. 1999, 61, 9-13.
28. Bachman, K.E.; Herman, J.G.; Corn, P.G.; Merlo, A.; Costello, J.F.; Cavenee, W.K.; Baylin, S.B.; Graff, J.R. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999, 59, 798-802.
29. Chen, K.; Sawhney, R.; Khan, M.; Benninger, M.S.; Hou, Z.; Sethi, S.; Stephen, J.K.; Worsham, M.J. Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg. 2007, 133, 1131-1138.
30. Stearns, V.; Yamauchi, H.; Hayes, D.F. Circulating tumor markers in breast cancer: Accepted utilities and novel prospects. Breast Cancer Res. Treat. 1998, 52, 239-259.
31. Pathak, K.A.; Khanna, R.; Khanna, H.D.; Khanna, S.; Gupta, S.; Khanna, N.N. Carcinoembryonic antigen: An invaluable marker for advanced breast cancer. J. Postgrad. Med. 1996, 42, 68-71.
32. Das, P.M.; Singal, R. DNA methylation and cancer. J. Clin. Oncol. 2004, 22, 4632-4642.
33. Raju UL.M., Sethi S, Qureshi H, Wolman SR, Worsham, MJ. Molecular classification of breast carcinoma in situ. Curr. Genomics 2006, 7, 523-532.
34. Schouten, J.P.; McElgunn, C.J.; Waaijer, R.; Zwijnenburg, D.; Diepvens, F.; Pals, G. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res. 2002, 30, e57.
35. Kunjoonju, J.P.; Raitanen, M.; Grenman, S.; Tiwari, N.; Worsham, M.J. Identification of individual genes altered in squamous cell carcinoma of the vulva. Genes Chromosomes Cancer 2005, 44, 185-193.
36. Worsham, M.J.; Pals, G.; Schouten, J.P.; Miller, F.; Tiwari, N.; van Spaendonk, R.; Wolman, S.R. High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the mcf10 model. Breast Cancer Res. Treat. 2006, 96, 177-186.
37. Nygren, A.O.; Ameziane, N.; Duarte, H.M.; Vijzelaar, R.N.; Waisfisz, Q.; Hess, C.J.; Schouten, J.P.; Errami, A. Methylation-specific mlpa (ms-mlpa): Simultaneous detection of cpg methylation and copy number changes of up to 40 sequences. Nucleic Acids Res. 2005, 33, e128.