DNA adducts and strand breaks in workers exposed to vapours and aerosols of bitumen: Associations between exposure and effect

Archives of Toxicology

Volumn 85, Issue SUPPL. 1, 2011, Pages

  Marczynski, Boleslaw ^a   Raulf Heimsoth, Monika ^a   Spickenheuer, Anne ^a   Pesch, Beate ^a   Kendzia, Benjamin ^a   Mensing, Thomas ^a   Engelhardt, Beate ^a   Lee, Eun Hyun ^a   Schindler, Birgit K ^a   Heinze, Evelyn ^a   Welge, Peter ^a   Bramer, Rainer ^a   Angerer, Jürgen ^a,b   Breuer, Dietmar ^c   Käfferlein, Heiko U ^a   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c INSTITUT FÜR ARBEITSSCHUTZ DER DEUTSCHEN GESETZLICHEN UNFALLVERSICHERUNG IFA   (Germany)

Author keywords

Biomarkers; Bitumen; Genotoxicity; Human biomonitoring

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; 8 HYDROXYDEOXYGUANOSINE; ASPHALT; BIOLOGICAL MARKER; COTININE; CREATININE; DNA; NAPHTHALENE; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON;

ADOLESCENT; ADULT; AEROSOL; AIR MONITORING; AMBIENT AIR; ARTICLE; BLOOD SAMPLING; CONSTRUCTION WORK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; HYDROXYLATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLITE; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PRIORITY JOURNAL; URINALYSIS; VAPOR;

AEROSOLS; AIR POLLUTANTS, OCCUPATIONAL; BIOLOGICAL MARKERS; COMET ASSAY; CROSS-SECTIONAL STUDIES; DNA; DNA ADDUCTS; DNA BREAKS; ENVIRONMENTAL MONITORING; HUMANS; HYDROCARBONS; INHALATION EXPOSURE; MALE; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; POLYCYCLIC HYDROCARBONS, AROMATIC; RISK ASSESSMENT;

EID: 79959638753     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0682-5     Document Type: Article

References (60)

1. Alexandrov K, Rojas M, Geneste O, Castegnaro M, Camus AM, Petruzzelli S, Giuntini C, Bartsch H (1992) An improved fluorometric assay for dosimetry of benzo[a]pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity. Cancer Res 52:6248-6253
2. Boffetta P (2010) Biomarkers in cancer epidemiology: an integrative approach. Carcinogenesis 31:121-126
3. Boffetta P, Burstyn I, Partanen T, Kromhout H, Svane O, Langård S, Järvholm B, Frentzel-Beyme R, Kauppinen T, Stücker I, Shaham J, Heederik D, Ahrens W, Bergdahl IA, Cenée S, Ferro G, Heikkilä P, Hooiveld M, Johansen C, Randem BG, Schill W (2003a) Cancer mortality among European asphalt workers: an international epidemiological study. I. Results of the analysis based on job titles. Am J Ind Med 43:18-27 (Pubitemid 36074874)
4. Boffetta P, Burstyn I, Partanen T, Kromhout H, Svane O, Langård S, Järvholm B, Frentzel-Beyme R, Kauppinen T, Stücker I, Shaham J, Heederik D, Ahrens W, Bergdahl IA, Cenée S, Ferro G, Heikkilä P, Hooiveld M, Johansen C, Randem BG, Schill W (2003b) Cancer mortality among European asphalt workers: an international epidemiological study. II. Exposure to bitumen fume and other agents. Am J Ind Med 43:28-39 (Pubitemid 36068833)
5. Boysen G, Hecht SS (2003) Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutat Res 543:17-30 (Pubitemid 36050911)
6. Breuer D, Hahn J-U, Höber D, Emmel C, Musanke U, Rühl R, Spickenheuer A, Raulf-Heimsoth M, Bramer R, Seidel A, Schilling B, Heinze E, Kendzia B, Marczynski B, Welge P, Angerer J, Brüning T, Pesch B (2011) Air sampling, analytical methodology and measurement strategy for bitumen and polycyclic aromatic hydrocarbons vapours and aerosols. Arch Toxicol (in press)
7. Burczynski ME, Lin HK, Penning TM (1999) Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAH), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res 59:607-614 (Pubitemid 29076058)
8. Cavallo D, Ursini CL, Bavazzano P, Cassinelli C, Frattini A, Perniconi B, Di Francesco A, Ciervo A, Rondinone B, Iavicoli S (2006) Sister chromatid exchange and oxidative DNA damage in paving workers exposed to PAHs. Ann Occup Hyg 50:211-218
9. Chu H, Nie L, Zhu M (2008) On estimation of bivariate biomarkers with known detection limits. Environmetrics 19:301-317 (Pubitemid 351580171)
10. Collins AR, Dusinská M, Gedik CM, Stětina R (1996) Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect 104(Suppl 3):465-469
11. Dipple A, Khan QA, Page JE, Pontén I, Szeliga J (1999) DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review). Int J Oncol 14:103-111
12. Dizdaroglu M (2005) Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat Res 591:45-59
13. European Asphalt and Pavement Association (EAPA) (2005) Asphalt in figures, EAPA, Brussels. Belgium
14. Fuchs J, Hengstler JG, Boettler G, Oesch F (1996) Primary DNA damage in peripheral mononuclear blood cells of workers exposed to bitumen-based products. Int Arch Occup Environ Health 68:141-146 (Pubitemid 26079731)
15. Gedik CM, Collins A, ESCODD (European Standards Committee on Oxidative DNA Damage) (2005) Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J 19:82-84 (Pubitemid 40069925)
16. Goetz ME, Luch A (2008) Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266:73-83
17. Hartlerode AJ, Scully R (2009) Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 423:157-168
18. IARC (1983) Polynuclear aromatic compounds, part 1: chemical, environmental and experimental data. IARC Monogr Eval Carcinog Risks Hum, vol 32. IARC, Lyon
19. IARC (1985) Bitumen. IARC Monogr Eval Carcinog Risks Chem Hum Overall evaluations of the carcinogenicity: an updating of IARC monographs, vol 1-42
20. IARC (2001) IARC epidemiological study of cancer mortality among European asphalt workers. IARC internal report no. 01/003
21. IARC (2002) IARC monograph on 'Some traditional herbal medicines, some mycotoxins, naphthalene and styrene', vol 82. International Agency for Research on Cancer, Lyon
22. IARC (2011) IARC Monograph on 'Bitumen and bitumen fumes, and some heterocyclic polycyclic aromatic hydrocarbons', vol 103. International Agency for Research on Cancer, Lyon
23. Jongeneelen FJ (1997) Methods for routine biological monitoring of carcinogenic PAH-mixtures. Sci Total Environ 199:141-149
24. Kennedy LJ, Moore K Jr, Caulfield JL, Tannenbaum SR, Dedon PC (1997) Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents. Chem Res Toxicol 10:386-392 (Pubitemid 27176299)
25. Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg EF Jr (1998) The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect 106(Suppl 1):289-295 (Pubitemid 28196053)
26. Lindberg HK, Väänänen V, Järventaus H, Suhonen S, Nygren J, Hämeilä M, Valtonen J, Heikkilä P, Norppa H (2008) Genotoxic effects of fumes from asphalt modified with waste plastic and tall oil pitch. Mutat Res 653:82-90
27. Lintelmann J, Angerer J (1999) PAH metabolites. In: Angerer J, Schaller KH (eds) Analyses of hazardous substances in biological materials, vol 6. Wiley, Weinheim, pp 163-187
28. Luch A (2005) Nature and nurture-lessons from chemical carcinogenesis. Nat Rev Cancer 5:113-125
29. Machado ML, Beatty PW, Fetzer JC, Glickman AH, McGinnis EL (1993) Evaluation of the relationship between PAH content and mutagenic activity of fumes from roofing and paving asphalts and coal tar pitch. Fundam Appl Toxicol 21:492-499 (Pubitemid 23338564)
30. Marczynski B, Rozynek P, Elliehausen HJ, Korn M, Baur X (1997) Detection of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, in white blood cells of workers occupationally exposed to styrene. Arch Toxicol 71:496-500 (Pubitemid 27285938)
31. Marczynski B, Rihs HP, Rossbach B, Hölzer J, Angerer J, Scherenberg M, Hoffmann G, Brüning T, Wilhelm M (2002) Analysis of 8-oxo-7,8-dihydro- 2′-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis 23:273-281 (Pubitemid 34224002)
32. Marczynski B, Raulf-Heimsoth M, Preuss R, Kappler M, Schott K, Pesch B, Zoubek G, Hahn JU, Mensing T, Angerer J, Käfferlein HU, Brüning T (2006) Assessment of DNA damage in WBCs of workers occupationally exposed to fumes and aerosols of bitumen. Cancer Epidemiol Biomark Prev 15:645-651
33. Marczynski B, Raulf-Heimsoth M, Spickenheuer A, Mensing T, Welge P, Förster K, Angerer J, Pesch B, Bramer R, Käfferlein HU, Breuer D, Hahn JU, Brüning T (2007) Ambient and biological monitoring of exposure and genotoxic effects in mastic asphalt workers exposed to fumes of bitumen. J Occup Environ Hygiene 4(Suppl 1):127-136 (Pubitemid 46763648)
34. McClean MD, Rinehart RD, Ngo L (2004) Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers. Ann Occup Hyg 48:565-578 (Pubitemid 39145482)
35. Møller P (2006) Assessment of reference values for DNA damage detected by the comet assay in human blood cell DNA. Mutat Res 612:84-104
36. National Toxicology Program (NTP) (2000) Toxicology and carcinogenesis studies of naphthalene (CAS 91-20-3) in F344/N rats (inhalation studies). Natl Toxicol Program Tech Rep Ser 500:1-173
37. NIOSH (2001) Health effects of occupational exposure to asphalt. DHHS (NIOSH) Publication No. 2001-110, Cincinnati, USA
38. Östling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commu 123:291-298 (Pubitemid 14030137)
39. Partanen T, Boffetta P (1994) Cancer risk in asphalt workers and roofers: review and meta-analysis of epidemiologic studies. Am J Ind Med 26:721-740 (Pubitemid 24377287)
40. Pesch B, Kappler M, Straif K, Marczynski B, Preuss R, Rossbach B, Rihs HP, Weiss T, Rabstein S, Pierl C, Scherenberg M, Adams A, Käfferlein HU, Angerer J, Wilhelm M, Seidel A, Brüning T (2007) Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect. Cancer Epidemiol Biomark Prev 16:1863-1873 (Pubitemid 47450519)
41. Pesch B, Spickenheuer A, Kendzia B, Schindler BK, Welge P, Marczynski B, Rihs H-P, Raulf-Heimsoth M, Angerer J, Brüning T (2011) Urinary metabolites of polycyclic aromatic hydrocarbons in workers exposed to vapours and aerosols of bitumen. Arch Toxicol (in press)
42. Pouget JP, Ravanat JL, Douki T, Richard MJ, Cadet J (1999) Measurement of DNA base damage in cells exposed to low doses of γ-radiation: comparison between the HPLC-EC and comet assays. Int J Radiat Biol 75:51-58 (Pubitemid 29057044)
43. Raulf-Heimsoth M, Pesch B, Rühl R, Brüning T (2011) The human bitumen study: executive summary. Arch Toxicol (in press)
44. Rojas M, Alexandrov K, Auburtin G, Wastiaux-Denamur A, Mayer L, Mahieu B, Sebastien P, Bartsch H (1995) anti-benzo[a]pyrene diolepoxide-DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking. Carcinogenesis 16:1373-1376
45. Rojas M, Alexandrov K, Cascorbi I, Brockmöller J, Likhachev A, Pozharisski K, Bouvier G, Auburtin G, Mayer L, Kopp-Schneider A, Roots I, Bartsch H (1998) High benzo[a]pyrene diol epoxide DNA adduct levels in lung and blood cells from subjects with combined CYP1A1 MspI/Msp/I-GSTM1*0/*0 genotypes. Pharmacogenetics 8:109-118 (Pubitemid 28227318)
46. Royston P, Sauerbrei W (2008) Multivariable model-building: a pragmatic approach to regression analysis based on fractional polynomials for continuous variables. Wiley, Chichester
47. Scherer G, Meger-Kossien I, Angerer J, Knecht U (2001) Cotinine. In: Angerer J, Schaller KH (eds) Analyses of hazardous substances in biological materials, vol 7. Wiley, Weinheim, pp 171-189
48. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
49. Sivak A, Niemeier R, Lynch D, Beltis K, Simon S, Salomon R, Latta R, Belinky B, Menzies K, Lunsford A, Cooper C, Ross A, Bruner R (1997) Skin carcinogenicity of condensed asphalt roofing fumes and their fractions following dermal application to mice. Cancer Lett 117:113-123 (Pubitemid 27322923)
50. Sobus JR, McClean MD, Herrick RF, Waidyanatha S, Nylander-French LA, Kupper LL, Rappaport SM (2009a) Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workers. Ann Occup Hyg 53:561-571
51. Sobus JR, Waidyanatha S, McClean MD, Herrick RF, Smith TJ, Garshick E, Laden F, Hart JE, Zheng Y, Rappaport SM (2009b) Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 66:99-104
52. Spencer JP, Jenner A, Aruoma OI, Cross CE, Wu R, Halliwell B (1996) Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage. Biochem Biophys Res Commun 224:17-22
53. Spickenheuer A, Rühl R, Höber D, Raulf-Heimsoth M, Marczynski B, Welge P, Breuer D, Gabriel S, Musanke U, Rode P, Heinze E, Kendzia B, Bramer R, Knecht U, Hahn J-U, Brüning T, Pesch B (2011) Levels and determinants of exposure to vapours and aerosols of bitumen. Arch Toxicol (in press)
54. Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Cogliano V, WHO International Agency for Research on Cancer Monograph Working Group (2005) Carcinogenicity of polycyclic aromatic hydrocarbons. Lancet Oncol 6:931-932 (Pubitemid 41685225)
55. Taussky HH (1954) A micro-colorimetric determination of creatinine in urine by the Jaffey's reaction. J Biol Chem 208:853-861
56. Toraason M, Hayden C, Marlow D, Rinehart R, Mathias P, Werren D, Olsen LD, Neumeister CE, Mathews ES, Cheever KL, Marlow KL, DeBord DG, Reid TM (2001) DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure. Int Arch Occup Environ Health 74:396-404 (Pubitemid 32780718)
57. Watters JL, Satia JA, da Costa KA, Boysen G, Collins LB, Morrow JD, Milne GL, Swenberg JA (2009) Comparison of three oxidative stress biomarkers in a sample of healthy adults. Biomarkers 14:587-595
58. Welge P, Marczynski B, Raulf-Heimsoth M, Spickenheuer A, Kendzia B, Heinze E, Angerer J, Käfferlein HU, Pesch B, Brüning T (2011) Assessment of micronuclei in lymphocytes from workers exposed to vapours and aerosols of bitumen. Arch Toxicol (in press)
59. Wild CP (2005) Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomark Prev 14:1847-1850
60. World Health Organisation (WHO), Asphalt (Bitumen) (2004) Concise International Chemical Assessment Document 59, WHO, Geneva