Assessment of micronuclei in lymphocytes from workers exposed to vapours and aerosols of bitumen

Archives of Toxicology

Volumn 85, Issue SUPPL. 1, 2011, Pages

  Welge, Peter ^a   Marczynski, Boleslaw ^a   Raulf Heimsoth, Monika ^a   Spickenheuer, Anne ^a   Kendzia, Benjamin ^a   Heinze, Evelyn ^a   Angerer, Jürgen ^a,b   Käfferlein, Heiko U ^a   Pesch, Beate ^a   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Bitumen; Cross shift design; Genotoxic effects; Lymphocytes; Micronucleus

Indexed keywords

ASPHALT; CYTOCHALASIN B;

ADOLESCENT; ADULT; AEROSOL; ARTICLE; CONCENTRATION (PARAMETERS); CONSTRUCTION WORK; CONTROLLED STUDY; DEPENDENT VARIABLE; GERMANY; GROUPS BY AGE; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS TEST; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; REFERENCE VALUE; SHIFT WORKER; VAPOR;

ADOLESCENT; ADULT; AEROSOLS; AIR POLLUTANTS, OCCUPATIONAL; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL MONITORING; HUMANS; HYDROCARBONS; INHALATION EXPOSURE; LEUKOCYTES, MONONUCLEAR; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYCYCLIC HYDROCARBONS, AROMATIC; RISK ASSESSMENT; VOLATILIZATION; YOUNG ADULT;

EID: 79959611226     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0683-4     Document Type: Article

References (23)

1. Bolognesi C, Abbondandolo A, Barale R, Casalone R, Dalpra L, De Ferrari M, Degrassi F, Forni A, Lamberti L, Lando C, Migliore L, Padovani P, Pasquini R, Puntoni R, Sbrana I, Stella M, Bonassi S (1997) Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol Biomarkers Prev 6:249-256 (Pubitemid 27172890)
2. Bonassi S, Fenech M, Lando C, Lin YP, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Jia C, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hrelia P, Krishnaja AP, Lee TK, Migliore L, Mikhalevich L, Mirkova E, Mosesso P, Müller WU, Odagiri Y, Scarffi MR, Szabova E, Vorobtsova I, Vral A, Zijno A (2001) HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen 37:31-45
3. Bonassi S, Neri M, Lando C, Ceppi M, Lin YP, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Fenech M (2003) Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the human micronucleus project. Mutat Res 543:155-166 (Pubitemid 36324355)
4. Breuer D (2008a) Bitumen (Dämpfe und Aerosole, Bitumen- Kondensatstandard) 6305/2. BGIA-Arbeitsmappe Messung von Gefahrstoffen. Expositionsermittlung bei chemischen und biologischen Einwirkungen. 40. Lieferung. Erich Schmidt, Berlin
5. Breuer D (2008b) Bitumen (Dämpfe und Aerosole, Mineralö lstandard) 6305/1. BGIA-Arbeitsmappe Messung von Gefahrstoffen. Expositionsermittlung bei chemischen und biologischen Einwirkungen. 40. Lieferung. Erich Schmidt, Berlin
6. Breuer D, Hahn J-U, Höber D, Emmel C, Musanke U, Rühl R, Spickenheuer A, Raulf-Heimsoth M, Bramer R, Seidel A, Schilling B, Heinze E, Kendzia B, Marczynski B, Welge P, Angerer J, Brüning T, Pesch B (2011) Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in the Human Bitumen Study. Arch Toxicol. doi:10.1007/s00204-011-0678-1
7. Burgaz S, Erdem O, Karahalil B, Karakaya AE (1998) Cytogenetic biomonitoring of workers exposed to bitumen fumes. Mutat Res 419:123-130 (Pubitemid 28512977)
8. Fenech M (2000) The in vitro micronucleus technique. Mutat Res 455:81-95
9. Fenech M (2007) Cytokinesis-block micronucleus cytome assay. Nat Protoc 2:1084-1104
10. Fuhst R, Creutzenberg O, Ernst H, Hansen T, Pohlmann G, Preiss A, Rittinghausen S (2007) Twenty-four months inhalation carcinogenicity study of bitumen fumes in wistar (WU) rats. J Occup Environ Hyg 4(suppl 1):20-43 (Pubitemid 46766549)
11. IARC (2010) Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. IARC monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon
12. Järvholm B, Nordström G, Högstedt B, Levin JO, Wahlström J, Ostman C, Bergendahl C (1999) Exposure to polycyclic aromatic hydrocarbons and genotoxic effects on nonsmoking Swedish road pavement workers. Scand J Work Environ Health 25:131-136 (Pubitemid 29216914)
13. Karaman A, Pirim I (2009) Exposure to bitumen fumes and genotoxic effects on Turkish asphalt workers. Clin Toxicol (Phila) 47:321-326
14. Murray EB, Edwards JW (2005) Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4′-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes. Rev Environ Health 20:163-176 (Pubitemid 41659336)
15. NIOSH (2000) Hazard review: health effects of occupational exposure to asphalt. DHHS (NIOSH) publication no. 2001-110
16. Raulf-Heimsoth M, Pesch B, Rühl R, Brüning T (2011) The human bitumen study: executive summary. Arch Toxicol. doi:10.1007/s00204-011-0679-0
17. Rothman KJ (1998) Writing for epidemiology. Epidemiology 9:333-337
18. Rühl R, Musanke U, Kolmsee K, Prieß R, Zoubek G, Breuer D (2006) Vapours and aerosols of bitumen: exposure data obtained by the German bitumen forum. Ann Occup Hyg 50:459-468 (Pubitemid 44306029)
19. Schreiner CA (2010) Review of mechanistic studies relevant to the potential carcinogenicity of asphalts. Regul Toxicol Pharmacol. doi:10.1016/j.yrtph.2010.10.010
20. Schulte PA (2007) Gaps in scientific knowledge about the carcinogenic potential of asphalt/bitumen fumes. J Occup Environ Hyg 4(Suppl 1):3-5
21. Sivak A, Niemeier R, Lynch D, Beltis K, Simon S, Salomon R, Latta R, Belinky B, Menzies K, Lunsford A, Cooper C, Ross A, Bruner R (1997) Skin carcinogenicity of condensed asphalt roofing fumes and their fractions following dermal application to mice. Cancer Lett 117:113-123 (Pubitemid 27322923)
22. van Gooswilligen G (2000) Bitumen. In: Lucas AG (ed) Modern petroleum technology, vol 2. Wiley, Chichester, pp 407-430
23. WHO (2004) Asphalt (Bitumen). Concise international chemical assessment document 59. World Health Organization, Geneva