Primary DNA damage in peripheral mononuclear blood cells of workers exposed to bitumen-based products

International Archives of Occupational and Environmental Health

Volumn 68, Issue 3, 1996, Pages 141-146

  Fuchs, Juergen ^a   Hengstler, Jan Georg ^a   Boettler, Gerd ^a   Oesch, Franz ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Biomonitoring; Bitumen painters; DNA adducts; DNA strand breaks; Road paving workers; Roofers

Indexed keywords

ASPHALT; PHOSPHORUS 32;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CONSTRUCTION WORK; CONTROLLED STUDY; DNA ADDUCT; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; OCCUPATIONAL EXPOSURE;

EID: 0029877266     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00381622     Document Type: Article

References (24)

1. Bender MA, Awa AA, Brooks AL, Evans HJ, Groer PG, Little-field LG, Pereira C, Preston RJ, Wachholz BW (1988) Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutat Res 196: 103-159
2. Bender AP, Parker DL, Johnson RA, Scharber WK, Williams AN, Marbury MC, Mandel JS (1989) Minnesota highway maintenance worker study: cancer mortality. Am J Ind Med 15:545-556
3. Boyum A (1964) Separation of white blood cells. Nature 204:793
4. Chiazze L, Watkins DK, Amsel J (1991) Asphalt and risk of cancer in man. Br J Ind Med 48:538-542
5. Fuchs J, Wullenweber U, Hengstler JG, Bienfait HG, Hiltl G, Oesch F (1994) Genotoxic risk for humans due to work place exposure to ethylene oxide: remarkable individual differences in susceptibility. Arch Toxicol 68:343-348
6. Hansen E (1989) Cancer incidence in an occupational cohort exposed to bitumen fumes. Scand J Work Environ Health 15: 101-105
7. Hengstler JG, Fuchs J, Oesch F (1992) DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin. Cancer Res 52:5622-5626
8. 32P-postlabeling. Scand J Work Environ Health 16:135-143
9. Holmes GE, Bernstein C, Bernstein H (1992) Oxidative and other DNA damages as the basis of aging: a review. Mutat Res 275: 305-315
10. IARC (1985) Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 35. IARC, Lyon, France, pp 39-81
11. Jongeneelen FJ, Scheepers PLJ, Groenendijk A. van Aerts LAGJM, Anzion RBM, Bos RP, Veenstra SJ (1988) Airborne concentrations, skin contamination, and urinary metabolite excretion of polycyclic aromatic hydrocarbons among paving workers exposed to coal tar derived road tars. Am Ing Hyg Assoc J 49:600-607
12. Knecht U, Woitowitz HJ (1989) Risk of cancer from the use of tar bitumen in road workers. Br J Ind Med 46:24-30
13. Leadon SA, Cerutti PA (1982) A rapid and mild procedure for the isolation of DNA from mammalian cells. Anal Biochem 120: 282-288
14. Machado ML, Beatty PW; Fetzer JC, Glickman AH, McGinnis EL (1993) Evaluation of the relationship between PAH content and mutagenic activity of fumes from roofing and paving asphalts and coal tar pitch. Fundam Appl Toxicol 21:492-499
15. Monarca S, Pasquini R, Scassellati-Sforzolini G, Savino A. Bauleo FA, Angeli G (1987) Environmental monitoring of mutagenic/carcinogenic hazards during road paving operations with bitumens. Int Arch Occup Environ Health 59:393-402
16. Oesch F, Hengstler JG, Fuchs J (1994) Cigarette smoking protects mononuclear blood cells of carcinogen exposed workers from additional work-exposure-induced DNA single strand breaks. Mutat Res 321:175-185
17. Ovrebo S, Haugen A, Phillips DA, Hewer A (1992) Detection of polycyclic hydrocarbon-DNA adducts in white blood cells from coke oven workers: correlation with job categories. Cancer Res 52:1510-1514
18. Partanen T, Boffetta P (1994) Cancer risk in asphalt workers and roofers: review and meta-analysis of epidemiological studies. Am J Ind Med 26:721-740
19. 32P-posilabelling of aromatic DNA adducts in white blood cells of iron foundry workers. Mutat Res 204: 531-541
20. Popp W, Vahrenholz C, Yaman S, Müller C, Müller G, Schmieding W, Norpoth K, Fahnen R (1992) Investigation of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchange frequency in lymphocytes of female workers exposed to benzene and toluene. Carcinogenesis 13:57-61
21. 32P-Postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene. Carcinogenesis 6:1117-1126
22. Randerath K, Putman KL, Osterburg HH, Johnson SA, Morgan DG, Finch CE (1993) Age-dependent increases of DNA adducts (I-compounds) in human and rat brain. Mutat Res 295: 11-18
23. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551
24. Walles SA, Edling C, Amundi H, Johanson G (1993) Exposure dependent increase in DNA single strand breaks in leucocytes from workers exposed to low concentrations of styrene. Br J Ind Med 50:570-574