Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT 1A and 5-HT 2A/2C receptors: Role for dorsal raphe nucleus

Pharmacology Biochemistry and Behavior

Volumn 99, Issue 4, 2011, Pages 566-572

  Cui, Su Ying ^a   Cui, Xiang Yu ^a   Zhang, Juan ^a   Wang, Zi Jun ^a   Yu, Bin ^a   Sheng, Zhao Fu ^a   Zhang, Xue Qiong ^a   Shi, Xiao Lei ^a   Zhang, Yong He ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

5 HT 1A receptor; 5 HT 2A 2C receptor; Diltiazem; Dorsal raphe nucleus; Hypnosis; Pentobarbital

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (2' METHOXY PHENYL) 1 [2' (N 2' PYRIDINYL)PARA IODOBENZAMINO]ETHYLPIPERAZINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; DILTIAZEM; PENTOBARBITAL; PROTEIN C FOS; RITANSERIN; SEROTONIN 2A AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; HYPNOSIS; IN VIVO STUDY; MALE; NONHUMAN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPHE MAGNUS NUCLEUS; RAT; SLEEP WAKING CYCLE; TUBEROMAMMILLARY NUCLEUS;

ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; CELL COUNT; DILTIAZEM; DRUG SYNERGISM; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GENE EXPRESSION; GENES, FOS; HYPNOTICS AND SEDATIVES; IMMUNOHISTOCHEMISTRY; MALE; PENTOBARBITAL; POLYSOMNOGRAPHY; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONERGIC NEURONS; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS;

RATTUS;

EID: 79959617001     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.06.001     Document Type: Article

References (35)

1. N. Akaike, N. Tokutomi, and Y. Ikemoto Augmentation of GABA-induced current in frog sensory neurons by pentobarbital Am J Physiol 258 1990 C452 C460
2. B. Bjorvatn, S. Fagerland, T. Eid, and R. Ursin Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats Brain Res 770 1997 81 88 (Pubitemid 27468054)
3. C. Cirelli, and G. Tononi On the functional significance of c-fos induction during the sleep-waking cycle Sleep 23 2000 453 469 (Pubitemid 30409232)
4. G.L. Collingridge, P.W. Gage, and B. Robertson Inhibitory post-synaptic currents in rat hippocampal CA1 neurones J Physiol 356 1984 551 564 (Pubitemid 14011565)
5. C. Dugovic Functional activity of 5-HT2 receptors in the modulation of the sleep/wakefulness states J Sleep Res 1 1992 163 168
6. C. Dugovic, and A. Wauquier 5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat Eur J Pharmacol 137 1987 145 146 (Pubitemid 17084723)
7. C. Dugovic, A. Wauquier, J.E. Leysen, R. Marrannes, and P.A. Janssen Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat Psychopharmacology (Berl) 97 1989 436 442 (Pubitemid 19102542)
8. M.R. Dzoljic, O.E. Ukponmwan, and P.R. Saxena 5-HT1-like receptor agonists enhance wakefulness Neuropharmacology 31 1992 623 633
9. S. Hjorth, and T. Magnusson The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo Naunyn Schmiedebergs Arch Pharmacol 338 1988 463 471 (Pubitemid 19014451)
10. G.E. Hoffman, M.S. Smith, and J.G. Verbalis C-Fos and related immediate early gene products as markers of activity in neuroendocrine system Front Neuroendocrinol 14 1993 173 213 (Pubitemid 23195792)
11. M. Jouvet Sleep and serotonin: an unfinished story Neuropsychopharmacology 21 1999 24S 27S (Pubitemid 29396467)
12. L.H. Lin, P. Whiting, and R.A. Harris Molecular determinants of general anesthetic action: role of GABAA receptor structure J Neurochem 60 1993 1548 1553 (Pubitemid 23088334)
13. C.A. Lowry, A.K. Evans, P.J. Gasser, M.W. Hale, D.R. Staub, and A. Shekhar Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus J.M. Monti, S.R. Pandi-Perumal, B.L. Jacobs, D.J. Nutt, Serotonin and sleep: molecular, functional and clinical aspects 2008 Birkhauser Verlag Basel 25 67
14. J. Lu, L.E. Nelson, N. Franks, M. Maze, N.L. Chamberlin, and C.B. Saper Role of endogenous sleep-wake and analgesic systems in anesthesia J Comp Neurol 508 2008 648 662 (Pubitemid 351656390)
15. J.M. Monti The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep Sleep Med Rev 14 2010 319 327
16. J.M. Monti, and H. Jantos Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat J Sleep Res 1 1992 169 175
17. J.M. Monti, and H. Jantos Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness Neuropharmacology 33 1994 705 708 (Pubitemid 24178787)
18. L.E. Nelson, T.Z. Guo, J. Lu, C.B. Saper, N.P. Franks, and M. Maze The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway Nat Neurosci 5 2002 979 984
19. J. Ochi, and K. Shimizu Occurrence of dopamine-containing neurons in the midbrain raphe nuclei of the rat Neurosci Lett 8 1978 317 320 (Pubitemid 8391378)
20. G.A. Paxinos, and C. Watson The rat brain in stereotaxic coordinates 4th ed. 1998 Academic Press San Diego
21. C.M. Portas, M. Thakkar, D. Rainnie, and R.W. McCarley Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving rat J Neurosci 16 1996 2820 2828 (Pubitemid 26124354)
22. C.B. Saper, T.C. Chou, and T.E. Scammell The sleep switch: hypothalamic control of sleep and wakefulness Trends Neurosci 24 2001 726 731 (Pubitemid 33097540)
23. K. Shinomiya, Y. Shigemoto, J. Omichi, Y. Utsu, M. Mio, and C. Kamei Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats Psychopharmacology (Berl) 173 2004 203 209 (Pubitemid 38591166)
24. S. Silhol, L. Glin, and C. Gottesmann Study of the 5-HT2 antagonist ritanserin on sleep-walking cycle in the rat Pharmacol Biochem Behav 41 1992 241 243
25. E. Sorensen, J. Gronli, B. Bjorvatn, A. Bjorkum, and R. Ursin Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat Brain Res 897 2001 122 130 (Pubitemid 32244359)
26. H.W. Steinbusch Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals Neuroscience 6 1981 557 618 (Pubitemid 11102583)
27. H. Takahashi, M. Yoshimoto, H. Higuchi, T. Shimizu, and Y. Hishikawa Different effects of L-type and T-type calcium channel blockers on the hypnotic potency of triazolam and zolpidem in rats Eur Neuropsychopharmacol 9 1999 317 321 (Pubitemid 29253783)
28. D.L. Tanelian, P. Kosek, I. Mody, and M.B. MacIver The role of the GABAA receptor/chloride channel complex in anesthesia Anesthesiology 78 1993 757 776 (Pubitemid 23110051)
29. A. Tung, and W.B. Mendelson Anesthesia and sleep Sleep Med Rev 8 2004 213 225 (Pubitemid 38715679)
30. R. Ursin Serotonin and sleep Sleep Med Rev 6 2002 55 69
31. Q.P. Wang, J.L. Guan, and S. Shioda Immunoelectron microscopic study of beta-endorphinergic synaptic innervation of GABAergic neurons in the dorsal raphe nucleus Synapse 42 2001 234 241 (Pubitemid 33027296)
32. L.E. Wang, X.Y. Cui, S.Y. Cui, J.X. Cao, J. Zhang, and Y.H. Zhang Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors Phytomedicine 17 2010 404 409
33. X. Zhao, X.Y. Cui, B.Q. Chen, Q.P. Chu, H.Y. Yao, and B.S. Ku Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system Eur J Pharmacol 506 2004 101 105 (Pubitemid 39592906)
34. X. Zhao, X.Y. Cui, Q.P. Chu, B.Q. Chen, X.M. Wang, and Z.B. Lin Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system J Neural Transm 113 2006 1395-02
35. X. Zhao, X.Y. Cui, L.E. Wang, and Y.H. Zhang Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: the TMN and VLPO as key elements in the pathway Neuropharmacology 56 2009 937 943