Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors

Phytomedicine

Volumn 17, Issue 6, 2010, Pages 404-409

  Wang, L E ^a   Cui, X Y ^a   Cui, S Y ^a   Cao, J X ^a   Zhang, J ^a   Zhang, Y H ^a   Zhang, Q Y ^a   Bai, Y J ^a   Zhao, Y Y ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

5 HT1A receptor; 8 OH DPAT; p MPPI; Pentobarbital induced sleep; Semen Ziziphi spinosae; Spinosin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO N [2 [4 (METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N 2 PYRIDINYLBENZAMIDE; FLAVONOID; PENTOBARBITAL; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SPINOSIN; UNCLASSIFIED DRUG; 4-(2'-METHOXYPHENYL)-1-(2'-(N-(2''-PYRIDINYL)-4-IODOBENZAMIDO)ETHYL)PIPERAZINE; AMINOPYRIDINE DERIVATIVE; C-GLYCOSIDE; HERBACEOUS AGENT; MONOSACCHARIDE; PIPERAZINE DERIVATIVE; SEROTONIN; SEROTONIN 1 ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SEROTONINERGIC SYSTEM; SLEEP; SLEEP TIME; SLOW WAVE SLEEP; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG COMBINATION; DRUG EFFECTS; MALE; METABOLISM; PHYTOTHERAPY; PLANT SEED; SLEEP INITIATION AND MAINTENANCE DISORDERS; SPRAGUE DAWLEY RAT; TIME; WAKEFULNESS; ZIZIPHUS;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMINOPYRIDINES; ANIMALS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; FLAVONOIDS; MALE; MONOSACCHARIDES; PENTOBARBITAL; PHYTOTHERAPY; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEEDS; SEROTONIN; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP, REM; TIME FACTORS; WAKEFULNESS; ZIZIPHUS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS;

RATTUS;

EID: 77950020313     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.01.014     Document Type: Article

References (37)

1. 1A receptors. Pharmacol. Biochem. Behav. 57 (1997) 301-307
2. 1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats. Brain Res. 692 (1995) 251-258
3. 1A antagonist NAN-190 in rats. Brain Res. Bull. 39 (1996) 373-379
4. 1A autoreceptors and increases dorsal raphe unit activity in awake cats. Eur. J. Pharmacol. 356 (1998) 167-178
5. 1A ligands given systemically and locally in different brain regions. Rev. Neurosci. 9 (1998) 265-273
6. 1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain Res. 770 (1997) 81-88
7. 1-like receptor agonists enhance wakefulness. Neuropharmacology 31 (1992) 623-633
8. Fernández S.P., Wasowski C., Paladini A.C., and Marder M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur. J. Pharmacol. 512 (2005) 189-198
9. 1A agonist and antagonist drug administration in behaving cats. J. Pharmacol. Exp. Ther. 270 (1994) 1345-1358
10. Grundmann O., Nakajima J.I., Kamata K., Seo S., and Butterweck V. Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice. Phytomedicine 16 (2009) 295-302
11. Hjorth S., Carlsson A., Lindberg P., Wikström H., Arvidsson L.E., Hacksell U., and Nilsson J.L.G. 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplifies ergot congener with central 5-HT receptor stimulating activity. J. Neural Transm. 55 (1982) 169-188
12. 1A agonist, 8-OH-DPAT, preferentially activates cell 5-HT autoreceptors in rat brain in vivo. N-S Arch. Pharmacol. 338 (1988) 463-471
13. 1A receptors in the rat brain. J. Neurosci. Res. 46 (1996) 697-708
14. A receptor subtype and state specificity. Proc. Natl. Acad. Sci. USA 101 (2004) 3674-3679
15. Loscalzo L.M., Wasowski C., Paladini A.C., and Marder M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur. J. Pharmacol. 580 (2008) 306-313
16. Marder M., and Paladini A.C. GABAA-receptor ligands of flavonoid structure. Curr. Top. Med. Chem. 2 (2002) 853-867
17. Marder M., Viola H., Wasowski C., Fernández S., Medina J.H., and Paladini A.C. 6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacol. Biochem. Behav. 75 (2003) 737-745
18. Medina J.H., Viola H., Wolfman C., Marder M., Wasowski C., Calvo D., and Paladini A.C. Overview - flavonoids: a new family of benzodiazepine receptor ligands. Neurochem. Res. 22 (1997) 419-425
19. 1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat. J. Sleep Res. 1 (1992) 169-175
20. Monti J.M., and Jantos H. Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness. Neuropharmacology 33 (1994) 705-708
21. Monti J.M., Jantos H., and Monti D. Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OH-DPAT: prevention with WAY 100635. Eur. Neuropsychopharmacol. 12 (2002) 47-55
22. Portas C.M., Thakkar M., Rainnie D., and McCarley R.W. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. J. Neurosci. 16 (1996) 2820-2828
23. Qiu M.H., Qu W.M., Xu X.H., Yan M.M., Urade Y., and Huang Z.L. D1/D2 receptor-targeting l-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice. Pharmacol. Biochem. Behav. 94 (2009) 16-23
24. Radja F., Laporte A.M., Daval G., Verge D., Gozlan H., and Hamon M. Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochem. Int. 18 (1991) 1-15
25. 1B serotonin receptors in adult rat brain. J. Comp. Neurol. 417 (2000) 181-194
26. Shinomiya K., Shigemoto Y., Omichi J., Utsu Y., Mio M., and Kamei C. Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats. Psychopharmacology 173 (2004) 203-209
27. Sørensen E., Bjorvatn B., and Ursin R. p-MPPI antagonizes sleep as well as behavioral effects of 8-OH-DPAT in the freely moving rat. Soc. Neurosci. Abstr. 24 (1998) 695
28. 1A receptor antagonist p-MPPI in the freely moving rat. Behav. Brain Res. 114 (2000) 31-38
29. 1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat. Brain Res. 897 (2001) 122-130
30. 1A receptor antagonist p-MPPI antagonizes sleep-waking and behavioural effects of 8-OH-DPAT in rats. Behav. Brain Res. 121 (2001) 181-187
31. 1A autoreceptors on serotonergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci. 2 (1990) 1144-1154
32. 1A selective agonists. Eur. J. Pharmacol 128 (1986) 295-298
33. Uchida S., Okudaira N., Nishihara K., and Iguchi Y. Flunitrazepam effects on human sleep EEG spectra: differences in MREM, REM and individual responses. Life Sci. 58 (1996) 199-205
34. Ursin R. Serotonin and sleep. Sleep Med. Rev. 6 (2002) 55-69
35. Wang L.E., Bai Y.J., Shi X.R., Cui X.Y., Cui S.Y., Zhang F., Zhang Q.Y., Zhao Y.Y., and Zhang Y.H. Spinosin, a C-glycoside flavonoid from semen Ziziphi spinosae, potentiated pentobarbital induced sleep via the serotonergic system. Pharmacol. Biochem. Behav. 90 (2008) 399-403
36. Yoshimoto M., Higuchi H., Kamata M., Yoshida K., Shimizu T., and Hishikawa Y. The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats. Eur. Neuropsychopharmacol. 9 (1999) 29-35
37. Yuan C.L., Wang Z.B., Jiao Y., Cao A.M., Huo Y.L., and Cui C.X. Sedative and hypnotic constituents of flavonoids in the seeds of Ziziphus spinosae. Zhong Yao Tong Bao (China J. Chin. Mater. Med.) 12 (1987) 34-36