Retinal arteriolar wall signs and early age-related macular degeneration: The Singapore Malay eye study

American Journal of Ophthalmology

Volumn 152, Issue 1, 2011, Pages 108-113.e1

  Cheung, Chui Ming Gemmy ^a,b   Cheung, Carol Yim Lui ^b   Yang, Erica Liu ^b   Mitchell, Paul ^c   Wang, Jie Jin ^d   Wong, Tien Yin ^a,b,d,e  

^a SINGAPORE NATIONAL EYE CENTRE   (Singapore)

^b SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTERIOVENOUS NICKING; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CLINICAL PROTOCOL; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DRUSEN; EYE PHOTOGRAPHY; FAMILY HISTORY; FEMALE; FOCAL ARTERIOLAR NARROWING; GENDER; GLAUCOMA; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; ONSET AGE; POPULATION RESEARCH; PRIORITY JOURNAL; RETINA DISEASE; RETINA MACULA DEGENERATION; RETINAL ARTERIOLAR WALL DISEASE; RETINAL ARTERIOLAR WALL OPACITY; RETINAL HYPERPIGMENTATION; RETINAL HYPOPIGMENTATION; SINGAPORE; SMOKING; SYSTOLIC BLOOD PRESSURE;

EID: 79959611209     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2011.01.012     Document Type: Article

References (39)

1. L. Hyman, A.P. Schchat, and Q. He Hypertension, cardiovascular disease, and age-related macular degeneration Arch Ophthalmol 118 3 2000 351 358 (Pubitemid 30152375)
2. S.C. Tomany, J.J. Wang, and R. van Leeuwen Risk factors for incident age-related macular degeneration Pooled findings from 3 continents Ophthalmology 111 7 2004 1280 1287 (Pubitemid 38844822)
3. J.M. Seddon, G. Gensler, and R.C. Milton Association between C-reactive protein and age-related macular degeneration JAMA 291 6 2004 704 710 (Pubitemid 38543790)
4. R. Klein, B.E.K. Klein, and S.C. Jenson The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy The Beaver Dam Eye Study Ophthalmology 104 11 1997 1804 1812 (Pubitemid 28100335)
5. R. Klein, L. Clegg, and L.S. Cooper Prevalence of age-related maculopathy in the atherosclerosis risk in communities study Arch Ophthalmol 117 9 1999 1203 1210 (Pubitemid 29428829)
6. T.Y. Wong, G. Tikellis, C. Sun, R. Klein, D.J. Couper, and A.R. Sharrett Age-related macular degeneration and risk of coronary heart disease : the Atherosclerosis Risk in Communities Study Ophthalmology 114 1 2007 86 91 (Pubitemid 46014277)
7. R. Klein, B.E. Klein, and S.C. Tomany The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study Ophthalmology 110 4 2003 636 643 (Pubitemid 36520056)
8. P. Cackett, T.Y. Wong, and T. Aung Smoking, cardiovascular risk factors and age-related macular degeneration in Asians: The Singapore Malay Eye Study Am J Ophthalmol 146 6 2008 960 967
9. M. Miyazaki, H. Nakamura, and M. Kubo Risk factors for age related maculopathy in a Japanese population: the Hisayama study Br J Ophthalmol 87 4 2003 469 472 (Pubitemid 36399038)
10. R. Van Leeuwen, C.C. Klaver, and J.R. Vingerling Cholesterol and age-related macular degeneration: is there a link? Am J Ophthalmol 137 4 2004 750 752 (Pubitemid 38446692)
11. B.M. Neale, J. Fagerness, R. Reynolds, and L. Sobrin Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC) PNAS 107 16 2010 7395 7400
12. R. Reynolds, B. Rosner, and J.M. Seddon Serum lipid biomarkers and hepatic lipase gene assocations with age-related macular degeneration Ophthalmology 117 10 2010 1989 1995
13. H.L. Wilson, D.M. Schwartz, and H.R.F. Bhatt Statin and aspirin are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration Am J Ophthalmol 137 4 2004 615 624 (Pubitemid 38446673)
14. G. McGwin Jr, A. Xie, and C. Owsley The use of cholesterol-lowering medications and age-related macular degeneration Ophthalmology 112 3 2005 488 494 (Pubitemid 40312506)
15. R.H. Guymer, A.W.-I. Chiu, L. Lim, and P.N. Baird HMG CoA reductase inhibitors (statins): do they have a role in age-related macular degeneration? Surv Ophthalmol 50 2 2005 194 206 (Pubitemid 40340950)
16. N.F. Hall, C.R. Gale, H. Syddall, D.I. Phillips, and C.N. Martyn Risk of macular degeneration in users of statins: a cross-sectional study BMJ 323 7309 2001 375 376 (Pubitemid 32762463)
17. C.A. McCarty, B.N. Mukesh, R.H. Guymer, R.N. Baird, and H.R. Taylor Cholesterol-lowering medications reduce the risk of age-related maculopathy progression Med J Aust 175 6 2001 340 (Pubitemid 32888333)
18. J.S.L. Tan, P. Mitchell, E. Rochtchina, and J.J. Wang Statins and the long-term risk of incidence of age-related macular degeneration: the Blue Mountains Eye Study Am J Ophthalmol 143 4 2007 685 687 (Pubitemid 46452504)
19. R. Klein, M.D. Knutson, and B.E.K. Klein Statin use and the five-year incidence and progression of age-related macular degeneration Am J Ophthalmol 144 1 2007 1 6
20. T.Y. Wong, and S.L. Rogers Statins and age-related macular degeneration: Time for a randomized controlled trial? Am J Ophthalmol 144 1 2007 117 119 (Pubitemid 46963213)
21. R. Klein, A.R. Sharrett, and B.E. Klein Are retinal arteriolar abnormalities related to atherosclerosis? The Atherosclerosis Risk in Communities Study Arterioscler Thromb Vasc Biol 20 6 2000 1644 1650 (Pubitemid 30353900)
22. A.D. Hughes, T.Y. Wong, and N. Witt Determinants of retinal microvascular architecture in normal subjects Microcirculation 16 2 2009 159 166
23. N. Patton, A. Pattie, and T. MacGillivray The association between retinal vascular network geometry and cognitive ability in an elderly population Invest Ophthalmol Vis Sci 48 5 2007 1995 2000 (Pubitemid 351261266)
24. J.J. Wang, P. Mitchell, and H. Leung Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study Hypertension 42 4 2003 534 541 (Pubitemid 37237350)
25. G. Liew, S. Kaushik, E. Rochtchina, A.G. Tan, P. Mitchell, and J.J. Wang Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study Ophthalmology 113 9 2006 1481 1487 (Pubitemid 44292308)
26. R. Klein, B.E.K. Klein, S.C. Tomany, and T.Y. Wong The relation of retinal microvascular characteristics to age-related eye disease: The Beaver Dam Eye Study Am J Ophthalmol 137 3 2004 435 444 (Pubitemid 38328633)
27. V.S.E. Jeganathan, R. Kawasaki, and J.J. Wang Retinal vascular caliber and age-related macular degeneration: The Singapore Malay Eye Study Am J Ophthalmol 146 6 2008 954 959
28. H. Kramer, C. Han, and W. Post Racial/ethnic differences in hypertension and hypertension treatment and control in the multi-ethnic study of atherosclerosis (MESA) Am J Hypertens 17 10 2004 963 970 (Pubitemid 39361670)
29. R. Klein, M.D. Davis, and Y.L. Magli The Wisconsin age-related maculopathy grading system Ophthalmology 98 7 1991 1128 1134
30. S. Kaushik, A.G. Tan, P. Mitchell, and J.J. Wang Prevalence and associations of enhanced retinal arteriolar light reflex Ophthalmology 114 1 2007 113 120 (Pubitemid 46014297)
31. R. Kawasaki, J.M. Tielsch, J.J. Wang, and T.Y. Wong The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata Study Br J Ophthalmol 92 2 2008 161 166 (Pubitemid 351224086)
32. E.L. Michelson, J. Morganroth, C.W. Nichols, and H. MacVaugh III Retinal arteriolar changes as an indicator of coronary artery disease Arch Intern Med 139 10 1979 1139 1141 (Pubitemid 10143823)
33. E. Tedeschi-Reiner, M. Strozzi, B. Skoric, and Z. Reiner Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery disease Am J Cardiol 96 8 2005 1107 1109 (Pubitemid 41416603)
34. P. Libby Inflammation in atherosclerosis Nature 420 19 2002 868 874 (Pubitemid 36019640)
35. T.G. Farkas, V. Sylvester, and D. Archer The histochemistry of drusen Am J Ophthalmol 71 6 1971 1206 1215
36. R. Haimovici, D.L. Gantz, and S. Rumelt The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing microscopy Invest Ophthalmol Vis Sci 42 7 2001 1592 1599 (Pubitemid 32520753)
37. G. Malek, C.-M. Li, and C. Cuidry Apolipoprotein B in cholesterol-containing drusen and basal deposits in eyes with age-related maculopathy Am J Pathol 162 2 2003 413 425 (Pubitemid 36267849)
38. C.A. Curcio, J.B. Presley, and N.E. Medeiros Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy Exp Eye Res 81 6 2005 731 741 (Pubitemid 41790421)
39. N. Dashti, G. McGwin, C. Owsley, and C.A. Curcio Plasma apolipoproteins and risk for age related maculopathy Br J Ophthalmol 90 8 2006 1028 1033 (Pubitemid 44140187)