Synthesis of new pyrimidine derivatives with evaluation of their anti-inflammatory and analgesic activities

Acta Poloniae Pharmaceutica - Drug Research

Volumn 68, Issue 4, 2011, Pages 507-517

  Nofal, Zienab M ^a   Fahmy, Hoda H ^a   Zarea, Eman S ^a   El Eraky, Wafaa ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Analgesic activities; Anti inflammatory; Condensation reaction; Cyclization; Diazo coupling reaction; Pyrimidine derivatives

Indexed keywords

3 (6 AMINO 2,4 DIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 5 OXO 4,5 DIHYDRO 1H PYRAZOLE 4 CARBOXAMIDE; 5 (4 ACETYL 5 OXO 4,5 DIHYDRO 1H PYRAZOL 3 YL) 6 AMINOPYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(1H 3,5 DIOXOPYRAZOLIDIN 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(3 AMINO 5 OXO 1 PHENYL 4,5 DIHYDRO 1H PYRAZOL 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(3 METHYL 5 OXO 1 PHENYL 4,5 DIHYDRO 1H PYRAZOL 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(3,5 DIAMINO 1H PYRAZOL 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(3,5 DIMETHYL 1 PHENYLPYRAZOL 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [[1 (3 CHLOROPHENYL) 3 METHYL 5 OXO 4,5 DIHYDRO 1H PYRAZOL 4 YL]DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [[1 (3 CHLOROPHENYL) 3,5 DIMETHYLPYRAZOL 4 YL]DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; 6 [[1 (3 CHLOROPHENYL) 3,5 DIOXOPYRAZOLIDIN 4 YL]DIAZENYL]PYRIMIDINE 2,4 (1H,3H) DIONE; ACETIC ACID; ACETOACETIC ACID DERIVATIVE; ACETOPHENONE DERIVATIVE; ACETYLACETONE; AMIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; DIAZONIUM COMPOUND; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; INDOMETACIN; MALONIC ACID DERIVATIVE; MALONONITRILE; PYRIMIDINE DERIVATIVE; SEMICARBAZIDE; THIOSEMICARBAZIDE; THIOUREA; TRAMADOL; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; CYCLOCONDENSATION; DRUG EFFICACY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PAW EDEMA; POLYMERIZATION; RAT; SUBSTITUTION REACTION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; DISEASE MODELS, ANIMAL; HOT TEMPERATURE; INFLAMMATION; MALE; MICE; MOLECULAR STRUCTURE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959586773     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Dannhandt G., Kiefer W.: Eur. J. Med. Chem. 36, 109 (2001).
2. Pratico D., Dogne J.M.: Circulation 112, 1073 (2005).
3. Zhou J.P., Ding Y.W., Zhang H.B., Xu L., Dai Y.: Chinese Chem. Lett. 19, 669 (2008).
4. Laneri S., Sacchi A., Rossi F.: Eur. J. Med. Chem. 33, 163 (1998).
5. Sacchi A., Ablignente E., Rossi F.: J. Med. Chem.. 32, 6 (1997).
6. Holla B.S., Mahalinga M., Karthikeyan M.S.: Bioorg. Med. Chem. 14, 2040 (2006).
7. Davarani S.S.H., Fumani N.S., Moradi H.A.N.F.: Tetrahedron Lett. 49, 710 (2008).
8. Mikhaylichenko S.N., Patel S.M., Dalili S., Chesnyuk A.A., Zaplishny W.N.: Tetrahedron Lett. 50, 2505 (2009).
9. Nofal Z.M., Fahmy H.H., Madkour H.M., Zareaa E.S., Hassan S.A.: Egypt. Pharm. J. 5, 45 (2006).
10. Venu T.D., Khanum S.A., Firdouse A., Manuprasad B.K., Shashikanth S., Mohamed R., Vishwanth B.S.: Bioorg. Med. Chem. Lett. 18, 4409 (2008).
11. Rashad A.E., Hegab M.I., Abdel-Megeid R.E., Micky J.A., Abdel-Megeid F.M.E.: Bioorg. Med. Chem. 16, 7102 (2008).
12. Tietze L.F., Steinmetz A., Baltkenhohl F.: Bioorg. Med. Chem. Lett., 7, 1303 (1997).
13. Cherdantseva N.M., Nesterov V.M., Safonova T.S.: Chem. Heterocycl. Comp. 6, 674 (1983).
14. Abdel-Latif N.A., El-Shihi T.H., Eslam I.E., El-Sawy E.R.: Egypt. Pharm. J. 4, 313 (2005).
15. Dabiri M., Azimi S. C., Khavasi H.R., Bazgir A.: Tetrahedron 64, 7307 (2008).
16. Karci F., Demirçali A.: Dyes Pigm. 74, 288 (2007).