Optimization of labeling and metabolite analysis of copper-64-labeled azamacrocyclic chelators by radio-LC-MS

Nuclear Medicine and Biology

Volumn 32, Issue 1, 2005, Pages 29-38

  Boswell, C Andrew ^a   McQuade, Paul ^a   Weisman, Gary R ^b   Wong, Edward H ^b   Anderson, Carolyn J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Univ of New Hampshire   (United States)

Author keywords

Azamacrocycle; Copper 64; HPLC; Impurity identification; Metabolite analysis; Radio LC MS

Indexed keywords

1,4,8,11 TETRAAZACYCLOTETRADECANE 1,4,8,11 TETRAACETIC ACID; 4,11 BIS(CARBOXYMETHYL) 1,4,8,11 TETRAAZABICYCLO[6.6.2]HEXADECANE; ACETIC ACID DERIVATIVE; ALKANE DERIVATIVE; CHELATING AGENT; COPPER 64; COPPER COMPLEX; HEXADECANE; MACROCYCLIC COMPOUND; TRACER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL LABELING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLITE; METHODOLOGY; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHELATING AGENTS; COPPER RADIOISOTOPES; LIVER; MACROCYCLIC COMPOUNDS; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 13244289989     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2004.09.004     Document Type: Article

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