Peptide mimics of peptidoglycan are vaccine candidates and protect mice from infection with Staphylococcus aureus

Journal of Medical Microbiology

Volumn 60, Issue 7, 2011, Pages 995-1002

  Chen, Yiguo ^a   Liu, Beiyi ^a   Yang, Daqing ^a   Li, Xueli ^a   Wen, Liyan ^a   Zhu, Ping ^a   Fu, Ning ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN G; MAP P31; PEPTIDE LIBRARY; PEPTIDOGLYCAN; SP 31; STAPHYLOCOCCUS VACCINE; THYMUS DEPENDENT ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; BACTERIOPHAGE; BACTERIOSTASIS; BACTERIUM ISOLATION; CONTROLLED STUDY; ESCHERICHIA COLI; IMMUNOGENICITY; IN VITRO STUDY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; ULTRASOUND;

ANIMALS; ANTIBODY AFFINITY; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; IMMUNE SERA; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; PEPTIDES; PEPTIDOGLYCAN; RANDOM ALLOCATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS PHAGES; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, SYNTHETIC;

EID: 79959504148     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.028647-0     Document Type: Article

References (30)

1. Baker, M. (2006). Anti-infective antibodies: finding the path forward. Nat Biotechnol 24, 1491-1493.
2. Beninati, C., Arseni, S., Mancuso, G., Magliani, W., Conti, S., Midiri, A., Biondo, C., Polonelli, L. & Teti, G. (2004). Protective immunization against group B meningococci using anti-idiotypic mimics of the capsular polysaccharide. J Immunol 172, 2461-2468.
3. Buzzola, F. R., Barbagelata, M. S., Caccuri, R. L. & Sordelli, D. O. (2006). Attenuation and persistence of and ability to induce protective immunity to a Staphylococcus aureus aroA mutant in mice. Infect Immun 74, 3498-3506.
4. Datta, K., Lees, A. & Pirofski, L. A. (2008). Therapeutic efficacy of a conjugate vaccine containing a peptide mimotope of cryptococcal capsular polysaccharide glucuronoxylomannan. Clin Vaccine Immunol 15, 1176-1187.
5. Falklind-Jerkérus, S., Felici, F., Cavalieri, C., Lo Passo, C., Garufi, G., Pernice, I., Islam, M. M., Qadri, F. & Weintraub, A. (2005). Peptides mimicking Vibrio cholerae O139 capsular polysaccharide elicit protective antibody response. Microbes Infect 7, 1453-1460.
6. Jacob, E., Durham, L. C., Falk, M. C., Williams, T. J. & Wheat, L. J. (1987). Antibody response to teichoic acid and peptidoglycan in Staphylococcus aureus osteomyelitis. J Clin Microbiol 25, 122-127.
7. Jiang, X.-T., Liu, B.-Y., Zhu, P. & Fu, N. (2009). Production and characterization of a cross-reactive monoclonal antibody to lipopolysaccharide. Hybridoma (Larchmt) 28, 93-99.
8. Lin, H.-Y., Tang, C.-H., Chen, Y.-H., Wei, I.-H., Chen, J.-H., Lai, C.-H. & Lu, D.-Y. (2010). Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, phosphatidylinositol 3-kinase/AKT and NF-kB pathways in BV-2 microglia. Int Immunopharmacol 10, 883-891.
9. Luo, H.-B., Zheng, J., Zhu, P., Huang, L.-Q. & Fu, N. (2008). Protective immunity induced by peptide mimics to LPS in mice with endotoxic shock. Prog Inorg Biochem Biophys 35, 1312-1319.
10. MacKenzie, S. A., Roher, N., Boltaña, S. & Goetz, F. W. (2010). Peptidoglycan, not endotoxin, is the key mediator of cytokine gene expression induced in rainbow trout macrophages by crude LPS. Mol Immunol 47, 1450-1457.
11. Melzer, H., Baier, K., Felici, F., von Specht, B. U., Wiedermann, G., Kollaritsch, H., Wiedermann, U. & Duchêne, M. (2003). Humoral immune response against proteophosphoglycan surface antigens of Entamoeba histolytica elicited by immunization with synthetic mimotope peptides. FEMS Immunol Med Microbiol 37, 179-183.
12. Merkel, G. J. & Scofield, B. A. (2001). Characterization of a monoclonal antibody that binds to an epitope on soluble bacterial peptidoglycan fragments. Clin Diagn Lab Immunol 8, 647-651.
13. Minors, S., Horton, J. K., Weeks, I., Davies, M. & Coles, G. A. (1988). A sensitive chemiluminescence based immunoassay for antibody to staphylococcal peptidoglycan. J Immunol Methods 115, 119-125.
14. Monzavi-Karbassi, B., Cunto-Amesty, G., Luo, P., Lees, A. & Kieber-Emmons, T. (2001). Immunological characterization of peptide mimetics of carbohydrate antigens in vaccine design strategies. Biologicals 29, 249-257.
15. Murphey, E. D., Fang, G. & Sherwood, E. R. (2008). Pretreatment with the Gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Staphylococcus aureus. Crit Care Med 36, 3067-3073.
16. Nozawa, T. (1985). [Studies on the measurement of antibody to streptococcal cell wall peptidoglycan in rat and human serum using the enzyme-linked immunosorbent assay (ELISA)]. Nippon Ika Daigaku Zasshi 52, 521-529 (in Japanese).
17. Pashov, A., Monzavi-Karbassi, B. & Kieber-Emmons, T. (2009). Immune surveillance and immunotherapy: lessons from carbohydrate mimotopes. Vaccine 27, 3405-3415.
18. Schaffer, A. C. & Lee, J. C. (2008). Vaccination and passive immunisation against Staphylococcus aureus. Int J Antimicrob Agents 32 (Suppl. 1), S71-S78.
19. Schaffer, A. C. & Lee, J. C. (2009). Staphylococcal vaccines and immunotherapies. Infect Dis Clin North Am 23, 153-171.
20. Schmaler, M., Jann, N. J., Ferracin, F. & Landmann, R. (2011). T and B cells are not required for clearing Staphylococcus aureus in systemic infection despite a strong TLR2-MyD88-dependent T cell activation. J Immunol 186, 443-452.
21. Schuman, R. F., Kokai-Kun, J. F., Foster, S. J., Stinson, J. R. & Fischer, G. W. (2007). Multifunctional Monoclonal Antibodies Directed to Peptidoglycan of Gram-Positive Bacteria. Alexandria, VA: Official Gazette of the United States Patent and Trademark Office Patents.
22. Spellberg, B. & Daum, R. S. (2010). A new view on development of a Staphylococcus aureus vaccine: insights from mice and men. Hum Vaccin 6, 857-859.
23. Styers, D., Sheehan, D. J., Hogan, P. & Sahm, D. F. (2006). Laboratory-based surveillance of current antimicrobial resistance patterns and trends among Staphylococcus aureus: 2005 status in the United States. Ann Clin Microbiol Antimicrob 5, 2.
24. Verbrugh, H. A., Van Dijk, W. C., Peters, R., Van Erne, M. E., Daha, M. R., Peterson, P. K. & Verhoef, J. (1980). Opsonic recognition of staphylococci mediated by cell wall peptidoglycan: antibodyindependent activation of human complement and opsonic activity of peptidoglycan antibodies. J Immunol 124, 1167-1173.
25. Verbrugh, H. A., Peters, R., Rozenberg-Arska, M., Peterson, P. K. & Verhoef, J. (1981). Antibodies to cell wall peptidoglycan of Staphylococcus aureus in patients with serious staphylococcal infections. J Infect Dis 144, 1-9.
26. Verbrugh, H. A., Verhoef, J., Wilkinson, B. J. & Peterson, P. K. (1983). Biology and clinical significance of peptidoglycan antibody response in staphylococcal infections. Scand J Infect Dis Suppl 41, 117-125.
27. Visser, L., De Heer, H. J., Boven, L. A., Van Riel, D., Van Meurs, M., Melief, M.-J., Zä hringer, U., Van Strijp, J., Lambrecht, B. N. & other authors (2005). Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease. J Immunol 174, 808-816.
28. Wergeland, H. I., Haaheim, L. R., Natås, O. B., Wesenberg, F. & Oeding, P. (1989). Antibodies to staphylococcal peptidoglycan and its peptide epitopes, teichoic acid, and lipoteichoic acid in sera from blood donors and patients with staphylococcal infections. J Clin Microbiol 27, 1286-1291.
29. Wheat, L. J., Wilkinson, B. J., Kohler, R. B. & White, A. C. (1983). Antibody response to peptidoglycan during staphylococcal infections. J Infect Dis 147, 16-22.
30. Xie, W., Huang, Y., Xie, W., Guo, A. & Wu, W. (2010). Bacteria peptidoglycan promoted breast cancer cell invasiveness and adhesiveness by targeting Toll-like receptor 2 in the cancer cells. PLoS ONE 5, e10850.