Continuing Education Course #3:Current Practices and Future Trends in Neuropathology Assessment for Developmental Neurotoxicity Testing

Toxicologic Pathology

Volumn 39, Issue 1, 2011, Pages 289-293

  Bolon, Brad ^a   Garman, Robert H ^b   Gundersen, Hans Jørgen G ^c   Allan Johnson, G ^d   Kaufmann, Wolfgang ^e,k   Krinke, Georg ^f   Little, Peter B ^g   Makris, Susan L ^h   Mellon, R Daniel ⁱ   Sulik, Kathleen K ^j   Jensen, Karl ^h  

^a GEMpath Inc   (United States)

^b Veterinary Pathology Inc   (United States)

^c AARHUS UNIVERSITY   (Denmark)

^d DUKE UNIVERSITY   (United States)

^e BASF SE   (Germany)

^f US Environmental Protection Agency ^*  (Switzerland)

^g CHARLES RIVER LABORATORIES   (United States)

^h U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

ⁱ CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^j UNIVERSITY OF NORTH CAROLINA   (United States)

^k MERCK KGAA   (Germany)

more..

Author keywords

developmental neurotoxicity; neuropathology; risk assessment

Indexed keywords

ANIMAL; ARTICLE; CEREBELLUM; CONTINUING EDUCATION; EDUCATION; HISTOLOGY; HUMAN; METHODOLOGY; NERVE CELL; NEUROLOGIC DISEASE; NEUROSCIENCE; PATHOLOGY; PRACTICE GUIDELINE; RISK ASSESSMENT; TOXICITY AND INTOXICATION; TOXICITY TESTING; TOXICOLOGY;

ANIMALS; CEREBELLUM; EDUCATION, CONTINUING; GUIDELINES AS TOPIC; HISTOLOGICAL TECHNIQUES; HUMANS; NERVOUS SYSTEM DISEASES; NEURONS; NEUROSCIENCES; NEUROTOXICITY SYNDROMES; PATHOLOGY; RISK ASSESSMENT; TOXICITY TESTS; TOXICOLOGY;

EID: 79959501921     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310386247     Document Type: Article

References (32)

1. Bearer C. F. (2001). Developmental neurotoxicity: illustration of principles. Pediatr Clin N Am: Children’s Environ Health 48, 1199–1213.
2. Bolon B. Bradley A. Butt M. Jensen K. Krinke G. Mellon R.D. (2011). Compilation of International Regulatory Guidance Documents for Neuropathology Assessment During Nonclinical General Toxicity and Specialized Neurotoxicity Studies. Toxicol Pathol 39, 92–96.
3. Bolon B. Garman R. Jensen K. Krinke G. Stuart B. (2006). A “best practices” approach to neuropathologic assessment in developmental neurotoxicity testing—for today. Toxicol Pathol 34, 296–313.
4. Castoldi A. F. Johansson C. Onishchenko N. Coccini T. Roda E. Vahter M. Ceccatelli S. Manzo L. (2008). Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers. Regul Toxicol Pharmacol 51, 201–14.
5. Claudio L. Kwa W. C. Russell A. L. Wallinga D. (2000). Testing methods for developmental neurotoxicity of environmental chemicals. Toxicol Appl Pharmacol 164, 1–14.
6. D.D.G., de Groot, S., Hartgring, L., van de Horst, M., Moerkens, M., Otto, M.M.M., Bos-Kuijpers, W.W.H., Kaufmann, J.J.C.M., Lammers, J.P., O’Callaghan, I.I.H., Waalkens-Berendsen, B., Pakkenberg, H.H.G., Gundersen, 2D and 3D assessment of neuropathology in rat brain after prenatal exposure to methylazoxymethanol, a model for developmental neurotoxicity, Reprod Toxicol, (2005), 20, 417-432
7. Derauf C. Kekatpure M. Neyzi N. Lester B. Kosofsky B. (2009). Neuroimaging of children following prenatal drug exposure. Semin Cell Dev Biol 20, 441–54.
8. Dorph-Petersen K. A. Nyengaard J. R. Gundersen H. J. (2001). Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 204, 232–46.
9. Garman R. H. Fix A. S. Jortner B. S. Jensen K. F. Hardisty J. F. Claudio L. Ferenc S. (2001). Methods to identify and characterize developmental neurotoxicity for human health risk assessment. II: neuropathology. Environ Health Perspec 109 (Suppl. 1), 93–100.
10. Godin E. A. O’Leary-Moore S. K. Khan A. A. Parnell S. E. Ament J. J. Dehart D. B. Johnson B. W. Johnson G. A. Styner M. A. Sulik K. K. (2010). Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7. Alcohol Clin Exp Res 34, 98–111.
11. Hass U. (2003). Current status of developmental neurotoxicity: regulatory view. Toxicol Lett 140-141, 155–59.
12. Huang H. Yamamoto A. Hossain M. A. Younes L. Mori S. (2008). Quantitative cortical mapping of fractional anisotropy in developing rat brains. J Neurosci 28, 1427–33.
13. Jevtovic-Todorovic V. Hartman R. E. Izumi Y. Benshoff N. D. Dikranian K. Zorumski C. F. Olney J. W. Wozniak D. F. (2003). Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23, 876–82.
14. Johnson K. Ryan L. Davis J. Elmore A. Guenther B. Marcus J. Maronpot R. R. (2006). Application of magnetic resonance imaging in developmental neurotoxicity testing: a pilot study. Neurotoxicology 27, 846–51.
15. Jurewicz J. Hanke W. (2008). Prenatal and childhood exposure to pesticides and neurobehavioral development: review of epidemiological studies. Int J Occup Med Environ Health 21, 121–32.
16. Kaufmann W. (2003). Current status of developmental neurotoxicity: an industry perspective. Toxicol Lett 140-141, 161–69.
17. Kaufmann W. Gröters S. (2006). Developmental neuropathology in DNT-studies—a sensitive tool for the detection and characterization of developmental neurotoxicants. Reprod Toxicol 22, 196–213.
18. Korbo L. Pakkenberg B. Ladefoged O. Gundersen H. J. Arlien-Søborg P. Pakkenberg H. (1990). An efficient method for estimating the total number of neurons in rat brain cortex. J Neurosci Meth 31, 93–100.
19. Lester D. S. Pine P. S. Delnomdedieu M. Johannessen J. N. Johnson G. A. (2000). Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult. Toxicol Pathol 28, 100–104.
20. Lodygensky G. A. West T. Stump M. Holtzman D. M. Inder T. E. Neil J. J. (2010). In vivo MRI analysis of an inflammatory injury in the developing brain. Brain Behav Immun 24, 759–67.
21. Madeira M. D. Sousa N. Santer R. M. Paula-Barbosa M. M. Gundersen H. J. (1995). Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study. J Comp Neurol 361, 585–601.
22. National Research Council (NRC) (1993). Pesticides in the Diets of Infants and Children. National Academies Press, Washington, DC.
23. Organisation for Economic Cooperation and Development (OECD) (2007). OECD Guideline for the Testing of Chemicals: Guideline 426, Developmental Neurotoxicity Study. http://titania.sourceoecd.org/vl=28956674/cl=26/nw=1/rpsv/ij/oecdjournals/1607310x/v1n4/s26/p1.
24. Parnell S. E. O’Leary-Moore S. K. Godin E. A. Dehart D. B. Johnson B. W. Johnson G. A. Styner M. A. Sulik K. K. (2009). Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8. Alcohol Clin Exp Res 33, 1001–11.
25. Petiet A. Hedlund L. Johnson G. A. (2007). Staining methods for magnetic resonance microscopy of the rat fetus. J Magn Reson Imaging 25, 1192–98.
26. Petiet A. E. Kaufman M. H. Goddeeris M. M. Brandenburg J. Elmore S. A. Johnson G. A. (2008). High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. Proc Natl Acad Sci USA 105, 12331–36.
27. Raffaele K. C. Rowland J. May B. Makris S. L. Schumacher K. Scarano L. J. (2010). The use of developmental neurotoxicity data in pesticide risk assessments. Neurotoxicol Teratol 32, 563–72.
28. Rodier P. M. (1994). Comparative postnatal neurologic development. In Prenatal Exposure to Toxicants: Developmental Consequences (Needleman H. L. Bellinger D. eds.), pp. 3–23. Johns Hopkins University Press, Baltimore, MD.
29. Schwenk M. Gundert-Remy U. Heinemeyer G. Olejniczak K. Stahlmann R. Kaufmann W. Bolt H. M. Greim H. von Keutz E. Gelbke H. P. and the Deutsche Gesellschaft für experimentelle und klinische Pharmakologie (DGPT) (2003). Children as a sensitive subgroup and their role in regulatory toxicology: DGPT workshop report. Arch Toxicol 77, 2–6.
30. Senn C. Sommer E. W. Gerspach R. Krinke G. (2010). Developmental neurotoxicity: Practical experience from the conduct of a validation study. Proceedings, XII International Congress of Toxicology (IUTOX), Barcelona, Spain, July 19–23. [Poster P106-028].
31. U.S. Environmental Protection Agency (EPA) (1998). Health Effects Test Guidelines: OPPTS 870.6300, Developmental Neurotoxicity Study. http://www.epa.gov/oppts/pubs/frs/publications/Test_Guidelines/series870.htm.
32. Winneke G. (1996). Inorganic lead as a developmental neurotoxicant: some basic issues and the Düsseldorf experience. Neurotoxicology 17, 565–80.