2D and 3D assessment of neuropathology in rat brain after prenatal exposure to methylazoxymethanol, a model for developmental neurotoxicty

Reproductive Toxicology

Volumn 20, Issue 3, 2005, Pages 417-432

  De Groot, Didima M G ^a   Hartgring, Sarita ^a   Van De Horst, Linda ^a   Moerkens, Marja ^a   Otto, Marlies ^a   Bos Kuijpers, Marga H M ^a   Kaufmann, Wolfgang S H ^b   Lammers, Jan H C M ^a   O'Callaghan, James P ^c   Waalkens Berendsen, Ine D H ^a   Pakkenberg, Bente ^d   Gundersen, Hansjørgen G ^e  

^a TNO   (Netherlands)

^b BASF SE   (Germany)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^d Res Lab Stereology and Neurosci   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

Cerebellum; Developmental neurotoxicity; Hippocampus; Linear morphometry; Methylazoxymethanol; Neuron numbers; Rat; Stereology

Indexed keywords

METHYLAZOXYMETHANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN SIZE; BRAIN WEIGHT; CELL COUNT; CELL PROLIFERATION; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EVALUATION; FEMALE; HIPPOCAMPUS; LINEAR SYSTEM; MALE; MORPHOMETRICS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PROGENY; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; RAT; STEREOLOGY; STRENGTH; THREE DIMENSIONAL IMAGING;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANIMALS, OUTBRED STRAINS; BRAIN; CELL COUNT; FEMALE; IMAGING, THREE-DIMENSIONAL; INJECTIONS, INTRAPERITONEAL; MALE; MATERNAL EXPOSURE; METHYLAZOXYMETHANOL ACETATE; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SPECIFIC PATHOGEN-FREE ORGANISMS; TERATOGENS; TOXICITY TESTS;

EID: 21744450993     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.04.006     Document Type: Article

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