Virtual Neuropathology: ThreE-Dimensional Visualization of Lesions Due to Toxic Insult

Toxicologic Pathology

Volumn 28, Issue 1, 2000, Pages 100-104

  Lester, David S ^a   Pine, P Scott ^a   Delnomdedieu, Marielle ^b   Johannessen, Jan N ^a   Johnson, G Allan ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

drug effects; histology; Magnetic resonance imaging (MRI); microscopy; neurotoxicity; rat brain

Indexed keywords

DOMOIC ACID; GOLD CHLORIDE; MYELIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; DIAGNOSTIC VALUE; HISTOPATHOLOGY; MICROSCOPIC ANATOMY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STAINING; THREE DIMENSIONAL IMAGING; VIRTUAL REALITY;

ANIMALIA;

EID: 0033979674     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800112     Document Type: Article

References (14)

1. Ben-Horin N., Hazvi S., Bendel P., Schul R. (1996). The ontogeny of a neurotoxic lesion in rat brain revealed by combined MRI and histology. Brain Res 718: 97-104.
2. Benveniste H., Qui H., Hedlund LW, D'Ercole F., Johnson GA (1998). Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy. Reg Anesth Pain Med 23: 589-599.
3. Delnomdedieu M., Appel NM, Pine PS, Hayakawa T., Lester DS, Johnson GA (1999). MR microscopy of contrast-structure in a rat model of Parkinson's disease. Proc ISMRM 7: 450 (abstract).
4. Delnomdedieu M., Hedlund LW, Johnson GA, Maronpot RR (1996). Magnetic resonance microscopy—A new tool for the toxicologic pathologist. Toxicol Pathol 24: 36-44.
5. Delnomdedieu M., Hedlund LW, Maronpot RR, Johnson GA (1998). Magnetic resonance microscopy and histopathology: Comparative approach of bromobenzene-induced hepatotoxicity in the rat. Hepatology 27: 526-532.
6. Hayakawa T., Chang Mch, Bell JM, Seeman R., Rapoport SI, Appel NM (1998). Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease. Brain Res 807: 177-181.
7. John J., Govindaraju V., Raghunathan P., Kumar VM (1996). Magnetic resonance imaging of temporal changes of neurotoxic lesion in the rat. Brain Res Bull 40: 273-277.
8. Johnson GA, Benveniste H., Black RD, Hedlund LW, Maronpot RR, Smith BR (1993). Histology by magnetic resonance microscopy. Magn Reson Q 9: 1-30.
9. Johnson GA, Benveniste H., Engelhardt RT, Qui H., Hedlund LW (1997). Magnetic resonance microscopy in basic studies of brain structure and function. Ann NY Acad Sci 820: 139-148.
10. Lester DS, Johannessen JN, Pine PS, McGregor GN, Johnson GA (1999). Virtual neuropathology: A new approach to preclinical pathology using magnetic resonance imaging microscopy. Spectroscopy 14: 17-22.
11. Lester DS, Lyon RC, McGregor GN, Engelhardt RT, Schmued LC, Johnson GA, Johannessen JN (1999). Three-dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy. Neuroreport 10: 737-741.
12. Moller HE, Chen XJ, Chawla MS, Cofer GP, Driehuys B., Hedlund LW, Suddarth SA, Johnson GA (1999). Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases. Magn Reson Med 41: 800-808.
13. Schmued LC (1990). A rapid, sensitive histochemical stain for myelin in frozen brain sections. J Histochem Cytochem 38: 717-720.
14. Smith BR, Huff DS, Johnson GA (1999). Magnetic resonance imaging of embryos: An Internet resource for the study of embryonic development. Comput Med Imaging Graph 23: 33-40.