Targeted cleavage of HIV RRE RNA by rev-coupled transition metal chelates

Journal of the American Chemical Society

Volumn 133, Issue 25, 2011, Pages 9912-9922

  Joyner, Jeff C ^a   Cowan, J A ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b MetalloPharm LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COORDINATION COMPLEX; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; DISSOCIATION CONSTANT; ETHYLENEDIAMINETETRAACETIC ACID; FLUORESCENCE TITRATIONS; ISOTHIOCYANATES; LYSINE SIDE CHAINS; METAL CENTERS; METAL CHELATE; MRNA BINDING; N-TERMINALS; NITRILOTRIACETIC ACID; OPTIMAL ACTIVITY; OXIDATIVE ACTIVITY; REACTIVE METALS; REACTIVE OXYGEN SPECIES; REDOX THERMODYNAMICS; REDUCTION POTENTIAL; REV RESPONSE ELEMENTS; RNA BINDING; SELECTIVE ERADICATION; SIMILAR SOLUTION; STEM-LOOP;

AMINO ACIDS; COBALT COMPOUNDS; COORDINATION REACTIONS; DISSOCIATION; METAL COMPLEXES; OPTIMIZATION; PEPTIDES; RNA; THERMODYNAMICS; TRANSITION METALS;

CHELATION;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; COBALT; COORDINATION COMPOUND; COPPER ION; EDETIC ACID; FERROUS ION; METAL CHELATE; METAL COMPLEX; NICKEL; NITRILOTRIACETIC ACID; PENTETIC ACID; REV PROTEIN; VIRUS RNA;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CHEMICAL REACTION; CROSS COUPLING REACTION; DISSOCIATION CONSTANT; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; OXIDATION REDUCTION POTENTIAL; RNA CLEAVAGE; THERMODYNAMICS;

ANTI-HIV AGENTS; CHELATING AGENTS; GENE PRODUCTS, REV; HIV; HYDROLYSIS; METALS, HEAVY; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; RNA, VIRAL;

EID: 79959491159     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203057z     Document Type: Article

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