A label-free approach to identify inhibitors of α4β7-mediated cell adhesion to MadCAM

Journal of Biomolecular Screening

Volumn 16, Issue 5, 2011, Pages 536-544

  Bova, Michael P ^a   Nguyen, Lan ^a   Wallace, William ^a   Garrido, Caroline ^a   Xu, Ying Zi ^a   Semko, Chris ^a   Cockcroft, Kelly ^b   Sandberg, Eric ^b   Bard, Frederique ^a  

^a ELAN PHARMACEUTICALS   (United States)

^b SRU Biosystems   (United States)

Author keywords

cell adhesion; cell based assay; inflammatory diseases; label free; MadCAM

Indexed keywords

ALPHA4 INTEGRIN; ALPHA4BETA7 INTEGRIN; ALPHA4BETA7 INTEGRIN INHIBITOR; CALCIUM ION; CELL ADHESION MOLECULE; FC RECEPTOR; MAGNESIUM ION; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE; PROTEIN ANTIBODY; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BIOSENSOR; CELL ADHESION; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; MOLECULAR IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

CELL ADHESION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOGLOBULINS; INTEGRINS; JURKAT CELLS; KINETICS; METALS; MUCOPROTEINS; SMALL MOLECULE LIBRARIES;

EID: 79959487607     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111399337     Document Type: Article

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