Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity

Drug Metabolism and Disposition

Volumn 39, Issue 7, 2011, Pages 1263-1269

  Nozawa, Takaaki ^a   Imai, Teruko ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CARBOXYLESTERASE; HYDROLASE; PRODRUG; SERINE PROTEINASE; TEMOCAPRIL; TEMOCAPRILAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE SECRETION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG TRANSPORT; ENZYME ACTIVITY; EPITHELIUM CELL; FOOD INTAKE; HYDROLYSIS; INTESTINE BRUSH BORDER; INTESTINE CELL; INTESTINE PERFUSION; INTESTINE PH; MALE; MESENTERIC VEIN; NONHUMAN; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; SMALL INTESTINE ABSORPTION; SMALL INTESTINE MUCOSA; STOMACH EMPTYING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INTESTINAL ABSORPTION; JEJUNUM; MALE; PRODRUGS; RATS; RATS, WISTAR; THIAZEPINES;

RATTUS;

EID: 79959486527     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.037937     Document Type: Article

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