Photodegradation illuminates the role of polyanions in prion infectivity

Prion

Volumn 5, Issue 2, 2011, Pages 49-51

  Piro, Justin R ^a   Supattapone, Surachai ^a  

^a Department of Biochemistry ^*  (United States)

Author keywords

Incorporation; Photodegradation; Polyanion; Prion; PrP

Indexed keywords

POLYANION; PRION PROTEIN;

NOTE; PHOTODEGRADATION; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN FOLDING;

ANIMALS; HUMANS; PHOTOLYSIS; POLYMERS; PRIONS;

CRICETINAE;

EID: 79959388976     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.5.2.16155     Document Type: Note

References (21)

1. Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, et al. Synthetic mammalian prions. Science 2004; 305:673-6.
2. Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, et al. Protease-sensitive synthetic prions. PLoS Pathog 6:1000736.
3. Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R, et al. Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. J Biol Chem 2010; 285:14083-7.
4. Makarava N, Kovacs GG, Bocharova O, Savtchenko R, Alexeeva I, Budka H, et al. Recombinant prion protein induces a new transmissible prion disease in wild-type animals. Acta Neuropathol 2010; 119: 177-87.
5. Deleault NR, Lucassen RW, Supattapone S. RNA molecules stimulate prion protein conversion. Nature 2003; 425:717-20. (Pubitemid 37314314)
6. Deleault NR, Geoghegan JC, Nishina K, Kascsak R, Williamson RA, Supattapone S. Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions. J Biol Chem 2005; 280:26873-9. (Pubitemid 41040721)
7. Deleault NR, Harris BT, Rees JR, Supattapone S. Formation of native prions from minimal componenets in vitro. Proc Natl Acad Sci USA 2007; 104:9741-6. (Pubitemid 47175337)
8. Geoghegan JC, Valdes PA, Orem NR, Deleault NR, Williamson RA, Harris BT, et al. Selective incorporation of polyanionic molecules into hamster prions. J Biol Chem 2007; 282:36341-53.
9. Wang F, Wang X, Yuan CG, Ma J. Generating a Prion with Bacterially Expressed Recombinant Prion Protein. Science 2010; 327:1132-5.
10. Wong C, Xiong LW, Horiuchi M, Raymond L, Wehrly K, Chesebro B, et al. Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein. EMBO J 2001; 20:377-86. (Pubitemid 32126974)
11. Shaked GM, Meiner Z, Avraham I, Taraboulos A, Gabizon R. Reconstitution of prion infectivity from solubilized protease-resistant PrP and nonprotein components of prion rods. J Biol Chem 2001; 276:14324-8.
12. Ben-Zaken O, Tzaban S, Tal Y, Horonchik L, Esko JD, Vlodavsky I, et al. Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem 2003; 278:40041-9. (Pubitemid 37248570)
13. Warner RG, Hundt C, Weiss S, Turnbull JE. Identification of the heparan sulfate binding sites in the cellular prion protein. J Biol Chem 2002; 277:18421-30. (Pubitemid 34952388)
14. Caughey B, Brown K, Raymond GJ, Katzenstein GE, Thresher W Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol 1994; 68:2135-41. (Pubitemid 24091890)
15. Kocisko DA, Come JH, Priola SA, Chesebro B, Raymond GJ, Lansbury PT, et al. Cell-free formation of protease-resistant prion protein. Nature 1994; 370:471-4. (Pubitemid 24263553)
16. Lucassen R, Nishina K, Supattapone S. In Vitro Amplification of Protease-Resistant Prion Protein Requires Free Sulfhydryl Groups. Biochemistry 2003; 42:4127-35.
17. Castilla J, Saa P, Hetz C, Soto C. In vitro generation of infectious scrapie prions. Cell 2005; 121:195-206.
18. Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001; 411:810-3. (Pubitemid 32588105)
19. Jeong BH, Kim NH, Jin JK, Choi JK, Lee YJ, Kim JI, et al. Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. J Neuropathol Exp Neurol 2009; 68:870-9.
20. Piro JR, Harris BT, Supattapone S. In situ photodegradation of incorporated polyanion does not alter prion infectivity. PLoS Pathog 2011; 7:1002001.
21. Deleault NR, Kascsak R, Geoghegan JC, Supattapone S. Species-dependent differences in cofactor utilization for formation of the protease-resistant prion protein in vitro. Biochemistry 2010; 49:3928-34.