Arginine vasopressin controls p27Kip1 protein expression by PKC activation and irreversibly inhibits the proliferation of K-Ras-dependent mouse Y1 adrenocortical malignant cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1813, Issue 8, 2011, Pages 1438-1445

  Forti, Fabio L ^a   Armelin, Hugo A ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Arginine vasopressin; K Ras; Mouse Y1 adrenocortical cells; P27Kip1; Protein kinase C

Indexed keywords

ARGIPRESSIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FIBROBLAST GROWTH FACTOR 2; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C;

ADRENAL CORTEX CARCINOMA; ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADRENAL CORTEX NEOPLASMS; ANIMALS; ARGININE VASOPRESSIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTOR 2; GENES, RAS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TUMOR STEM CELL ASSAY;

EID: 79959341906     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.04.007     Document Type: Article

References (35)

1. Brownstein M.J., Russell J.T., Gainer H. Synthesis, transport, and release of posterior pituitary hormones. Science 1980, 207:373-378.
2. Young W.S., Gainer H. Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors. Neuroendocrinology 2003, 78:185-203.
3. Antoni F.A. Novel ligand specificity of pituitary vasopressin receptors in the rat. Neuroendocrinology 1984, 39:186-188.
4. Lolait S.J., O'Carroll A.M., Mahan L.C., Felder C.C., Button D.C. Extrapituitary expression of the rat V1b vasopressin receptor gene. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:6783-6787.
5. Bankir L. Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects. Cardiovasc. Res. 2001, 51:372-390.
6. Carter D.A., Fai C.K., Murphy D. Neurohypophyseal peptides as regulators of growth and development. A review. J. Mol. Neurosci. 1993, 4:11-19.
7. Caldwell H.K., Lee H.J., Macbeth A.H., Young W.S. Vasopressin: behavioral roles of an "original" neuropeptide. Prog. Neurobiol. 2008, 84:1-24.
8. Jard S., Barberis C., Audigier S., Tribollet E. Neurohypophyseal hormone receptor systems in brain and periphery. Prog. Brain Res. 1987, 72:173-187.
9. Alonso G., Galibert E., Boulay V., Guillou A., Jean A., Compan V., Guillon G. Sustained elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors. Endocrinology 2009, 150:239-250.
10. Rinschen M.M., Yu M.J., Wang G., Boja E.S., Hoffert J.D., Pisitkun T., Knepper M.A. Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:3882-3887.
11. North W.G. Gene regulation of vasopressin and vasopressin receptors in cancer. Exp. Physiol. 2000, 85:27S-40S.
12. Pequeux C., Keegan B.P., Hagelstein M.T., Geenen V., Legros J.J., North W.G. Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway. Endocr. Relat. Cancer 2004, 11:871-885.
13. Keegan B.P., Akerman B.L., Péqueux C., North W.G. Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies. Breast Cancer Res. Treat. 2006, 95:265-277.
14. Forti F.L., Armelin H.A. Vasopressin triggers senescence in K-ras transformed cells via RhoA-dependent downregulation of cyclin D1. Endocr. Relat. Cancer 2007, 14:1117-1725.
15. He Y.P., Zhao L.Y., Zheng Q.S., Liu S.W., Zhao X.Y., Lu X.L., Niu X.L. Arginine vasopressin stimulates proliferation of adult rat cardiac fibroblasts via protein kinase C-extracellular signal-regulated kinase 1/2 pathway. Acta Physiol. Sin. 2008, 60:333-340.
16. Schwindt T.T., Forti F.L., Juliano M.A., Juliano L., Armelin H.A. Arginine vasopressin inhibition of cyclin D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line. Biochemistry 2003, 42:2116-2121.
17. Yasumura Y., Buonassissi Y., Sato G. Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype. Cancer Res. 1966, 26:529-535.
18. Forti F.L., Schwindt T.T., Moraes M.S., Eichler C.B., Armelin H.A. ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. Biochemistry 2002, 41:10133-10140.
19. Schwab M., Alitalo K., Varmus H., Bishop J., George D. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature 1983, 303:497-501.
20. Forti F.L., Armelin H.A. ACTH inhibits A Ras-dependent anti-apoptotic and mitogenic pathway in mouse Y1 adrenocortical cells. Endocr. Res. 2000, 26:911-914.
21. Kelly-Spratt K.S., Philipp-Staheli J., Gurley K.E., Hoon-Kim K., Knoblaugh S., Kemp C.J. Inhibition of PI3K restores nuclear p27Kip1 expression in a mouse model of K-ras driven lung cancer. Oncogene 2009, 28:3652-3662.
22. Imoto M., Doki Y., Jiang W., Han E.K., Weinstein I.B. Effects of cyclin D1 overexpression on G1 progression-related events. Exp. Cell Res. 1997, 236:173-180.
23. James M., Ray A., Leznova D., Blain S.W. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol. Cell. Biol. 2008, 28:498-510.
24. Kim J.K., Diehl J.A. Nuclear cyclin D1: an oncogenic driver in human cancer. J. Cell. Physiol. 2009, 220:292-296.
25. Sicinski P., Zacharek S., Kim C. Duality of p27Kip1 function in tumorigenesis. Genes Dev. 2007, 21:1703-1706.
26. Borriello A., Cucciolla V., Oliva A., Zappia V., Della Ragione F. p27Kip1 metabolism: a fascinating labyrinth. Cell Cycle 2007, 6:1053-1061.
27. Besson A., Gurian-West M., Chen X., Kelly-Spratt K.S., Kemp C.J., James M., Roberts J.M. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 2006, 20:47-64.
28. Nakayama K., Ishida N., Shirane M., Inomata A., Inoue T., Shishido N., Horii I., Loh D.Y., Nakayama K. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996, 85:707-720.
29. Fero M.L., Rivkin M., Tasch M., Porter P., Carow C.E., Firpo E., Polyak K., Tsai L.H., Broudy V., Perlmutter R.M., Kaushansky K., Roberts J.M. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. Cell 1996, 85:733-744.
30. Kiyokawa H., Kineman R.D., Manova-Todorova K.O., Soares V.C., Hoffman E.S., Ono M., Khanam D., Hayday A.C., Frohman L.A., Koff A. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 1996, 85:721-732.
31. Fero M.L., Randel E., Gurley K.E., Roberts J.M., Kemp C.J. The murine gene p27Kip1 is haploinsufficient for tumour suppression. Nature 1998, 396:177-180.
32. Kawamata N., Morosetti R., Miller C.W., Park D., Spirin K.S., Nakamaki T., Takeuchi S., Hatta Y., Simpson J., Wilcyznski S. Molecular analysis of the cyclin-dependent kinase inhibitor gene p27Kip1 in human malignancies. Cancer Res. 1995, 55:2266-2269.
33. Ponce-Castaneda M.V., Lee M.H., Latres E., Polyak K., Lacombe L., Montgomery K., Mathew S., Krauter K., Sheinfeld J., Massague J. p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res. 1995, 55:1211-1214.
34. Chu I.M., Hengst L., Slingerland J.M. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer 2008, 8:253-267.
35. Blain S.W., Massagué J. 'Breast cancer banishes p27 from nucleus. Nat. Med. 2002, 8:1076-1078.