Cambogin is preferentially Cytotoxic to cells expressing PDGFR

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Tian, Ze ^a,d   Shen, Jie ^a   Wang, Fengfei ^b   Xiao, Peigen ^a   Yang, Junshan ^a   Lei, Hetian ^a,c   Kazlauskas, Andrius ^c   Kohane, Isaac S ^d   Wu, Erxi ^b  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

^c SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMBOGIN; CASPASE; CYCLIN A; CYCLIN E; NATURAL PRODUCT; PLATELET DERIVED GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG; GARCINOL; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TERPENE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SENSITIVITY; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYCLIN A; CYCLIN E; HUMANS; MEDULLOBLASTOMA; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; PLANT EXTRACTS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; S PHASE; SIGNAL TRANSDUCTION; TERPENES;

EID: 79959328549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021370     Document Type: Article

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