A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis

American Journal of Neuroradiology

Volumn 32, Issue 6, 2011, Pages 1138-1142

  Klein, J P ^a   Arora, A ^a   Neema, M ^a   Healy, B C ^a   Tauhid, S ^a   Goldberg Zimring, D ^a   Chavarro Nieto, C ^a   Stankiewicz, J M ^a   Cohen, A B ^a   Buckle, G J ^a   Houtchens, M K ^a   Ceccarelli, A ^a   Dell'Oglio, E ^a   Guttmann, C R G ^a,b   Alsop, D C ^c   Hackney, D B ^c   Bakshi, Rohit ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CERVICAL SPINE; CONTROLLED STUDY; DISEASE CLASSIFICATION; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; SPINAL CORD ATROPHY; THORACIC SPINE; VERTEBRA; VOLUMETRY;

ADOLESCENT; ADULT; ATROPHY; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD; YOUNG ADULT;

EID: 79959325938     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A2459     Document Type: Article

References (32)

1. Bermel RA, Bakshi R. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol 2006;5:158-70 (Pubitemid 43107851)
2. Lin X, Tench CR, Evangelou N, et al. Measurement of spinal cord atrophy in multiple sclerosis. J Neuroimaging 2004;14:20S-26S
3. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey - National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-11
4. Evangelou N, DeLuca GC, Owens T, et al. Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions. Brain 2005;128:29-34 (Pubitemid 40070517)
5. Gilmore CP, DeLuca GC, Bö L, et al. Spinal cord neuronal pathology in multiple sclerosis. Brain Pathol 2009;19:642-49
6. Tallantyre EC, Bo L, Al-Rawashdeh O, et al. Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease. Brain 2009;132:1190-99
7. Gilmore CP, Bo L, Owens T, et al. Spinal cord gray matter demyelination in multiple sclerosis: a novel pattern of residual plaque morphology. Brain Pathol 2006;16:202-08 (Pubitemid 44175234)
8. Lycklama à Nijeholt GJ, Barkhof F, et al. MR of the spinal cord in multiple sclerosis: relation to clinical subtype and disability. AJNR Am J Neuroradiol 1997;18:1041-48
9. Lin X, Blumhardt LD, Constantinescu CS. The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurol Scand 2003;108:401-06 (Pubitemid 37464119)
10. Horsfield MA, Sala S, Neema M, et al. Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosis. Neuroimage 2010;50:446-55
11. Filippi M, Bozzali M, Horsfield MA, et al. A conventional and magnetization transfer MRI study of the cervical cord in patients with MS. Neurology 2000;54:207-13 (Pubitemid 30038761)
12. Liu C, Playford ED, Thompson AJ. Does neurorehabilitation have a role in relapsing-remitting multiple sclerosis? J Neurol 2003;250:1214-18 (Pubitemid 37289655)
13. Bieniek M, Altmann DR, Davies GR, et al. Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2006;77:1036-39 (Pubitemid 44338524)
14. Zivadinov R, Banas AC, Yella V, et al. Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol 2008;29:319-25 (Pubitemid 351287890)
15. Rashid W, Davies GR, Chard DT, et al. Increasing cord atrophy in early relapsing- remitting multiple sclerosis: a 3 year study. J Neurol Neurosurg Psychiatry 2006;77:51-55 (Pubitemid 43022690)
16. Mann RS, Constantinescu CS, Tench CR. Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: application of a new technique for measuring cross-sectional area on magnetic resonance images. J Magn Reson Imaging 2007;26:61-65 (Pubitemid 47235231)
17. Gilmore CP, DeLuca GC, Bo L, et al. Spinal cord atrophy in multiple sclerosis caused by white matter volume loss. Arch Neurol 2005;62:1859-62 (Pubitemid 41785079)
18. Stankiewicz JM, Neema M, Alsop DC, et al. Spinal cord lesions and clinical status in multiple sclerosis: a 1.5 T and 3 T MRI study. J Neurol Sci 2009;279:99-105
19. Arora A, Neema M, Stankiewicz J, et al. Regional and whole spinal cord atrophy in multiple sclerosis. Annual Meeting of the American Academy of Neurology, Chicago, Illinois. Neurology 2008;70(Suppl 1):A464
20. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52 (Pubitemid 14237132)
21. Cohen AB, Neema M, Arora A, et al. The relationship between spinal cord atrophy, brain atrophy, and disability in multiple sclerosis. Annual Meeting of the American Academy of Neurology, Toronto, Ontario, Canada. Neurology 2010;74(Suppl 2):A236
22. Deichmann R, Schwarzbauer C, Turner R. Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage 2004;21:757-67 (Pubitemid 38229939)
23. Tardif CL, Collins DL, Pike GB. Sensitivity of voxel-based morphometry analysis to choice of imaging protocol at 3 T. Neuroimage 2009;44:827-38
24. Arora A, Neema M, Tauhid S, et al. Global vs. regional spinal cord atrophy in multiple sclerosis. Annual Meeting of the American Academy of Neurology, Toronto, Ontario, Canada. Neurology 2010;74(Suppl 2):A118
25. Holm S. A simple sequentially rejective multiple test procedure. Scand J Statistics 1979;6:65-70
26. Rashid W, Davies GR, Chard DT, et al. Upper cervical cord area in early relapsing- remitting multiple sclerosis: cross-sectional study of factors influencing cord size. J Magn Reson Imaging 2006;23:473-76
27. Dalton CM, Chard DT, Davies GR, et al. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain 2004;127:1101-07 (Pubitemid 38623045)
28. Zivadinov R, Reder AT, Filippi M, et al. Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis. Neurology 2008;71:136-44
29. Miller DH. Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis. NeuroRx 2004;1:284-94 (Pubitemid 46591886)
30. Zivadinov R, Bakshi R. Role of MRI in multiple sclerosis I: inflammation and lesions. Front Biosci 2004;9:665-83 (Pubitemid 39043742)
31. Zivadinov R, Leist TP. Clinical-magnetic resonance imaging correlations in multiple sclerosis. J Neuroimaging 2005;15:10S-21S
32. Marliani AF, Clementi V, Albini Riccioli L, et al. Quantitative cervical spinal cord 3T proton MR spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol 2010;31:180-84