Modulation of N-type Ca2+ currents by moxonidine via imidazoline I1 receptor activation in rat superior cervical ganglion neurons

Biochemical and Biophysical Research Communications

Volumn 409, Issue 4, 2011, Pages 645-650

  Kim, Young Hwan ^a   Nam, Taick Sang ^a   Ahn, Duck Sun ^a   Chung, Seungsoo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Ca2+ channels; Hypertension; Imidazoline receptor; Moxonidine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL N TYPE; EFAROXAN; IMIDAZOLINE I1 RECEPTOR; MOXONIDINE; PERTUSSIS TOXIN; RAUWOLSCINE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CERVICAL GANGLION; CONTROLLED STUDY; DRUG INHIBITION; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; OUTCOME ASSESSMENT; PATCH CLAMP; PRIORITY JOURNAL; RAT; WHOLE CELL;

ANIMALS; CALCIUM CHANNELS, N-TYPE; IMIDAZOLES; IMIDAZOLINE RECEPTORS; NEURONS; NOREPINEPHRINE; RATS; SUPERIOR CERVICAL GANGLION; VASODILATOR AGENTS;

RATTUS;

EID: 79959312160     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.058     Document Type: Article

References (42)

1. Bousquet P., Feldman J., Schwartz J. Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp.Ther. 1984, 230:232-236.
2. Szabo B. Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacol. Ther. 2002, 93:1-35.
3. Urban R., Szabo B., Starke K. Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304. Eur. J. Pharmacol. 1995, 282:29-37.
4. Szabo B., Bock C., Nordheim U., Niederhoffer N. Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine. Ann. N. Y. Acad. Sci. 1999, 881:253-264.
5. Raasch W., Jungbluth B., Schafer U., Häuser W., Dominiak P. Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors. J. Pharmacol. Exp. Ther. 2003, 304:1063-1071.
6. Raasch W., Jungbluth B., Schäfer U., Häuser W., Dominiak P. Norepinephrine release is reduced by I1-receptors in addition to a2-adrenoceptors. Ann. N. Y. Acad. Sci. 2003, 1009:270-273.
7. Monroy-Ordoñez E.B., Villalón C.M., Cobos-Puc L.E., Marquez-Conde J.A., Sánchez-López A., Centurión D. Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats. Auton. Neurosci. 2008, 143:40-45.
8. Cobos-Puc L.E., Villalón C.M., Ramírez-Rosas M.B., Sánchez-López A., Lozano-Cuenca J., Gómez-Díaz B., MaassenVanDenBrink A., Centurion D. Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats. Eur. J. Pharmacol. 2009, 616:175-182.
9. el-Din M.M., Malik K.U. Differential effect of ω-Conotoxin on release of the adrenergic transmitter and the vasoconstrictor response to noradrenaline in the rat isolated kidney. Br. J. Pharmacol. 1988, 94:355-362.
10. Hirning L.D., Fox A.P., McCleskey E.W., Olivera B.M., Thayer S.A., Miller R.J., Tsien R.W. Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 1988, 239:57-61.
11. Clasbrummel B., Osswald H., Illes P. Inhibition of noradrenaline release by ω-conotoxin GVIA in the rat tail artery. Br. J. Pharmacol. 1989, 96:101-110.
12. Lipscombe D., Kongsamut S., Tsien R.W. α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature 1989, 340:639-642.
13. Pruneau D., Angus J.A. ω-conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries. Br. J. Pharmacol. 1990, 100:180-184.
14. Göthert M., Molderings G.J. Mibefradil- and ω-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart. Naunyn Schmiedebergs Arch. Pharmacol. 1997, 356:860-863.
15. Molderings G.J., Likungu J., Göthert M. N-type calcium channels control sympathetic neurotransmission in human heart atrium. Circulation 2000, 101:403-407.
16. Hille B. Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci. 1994, 17:531-536.
17. Toth P.T., Bindokas V.P., Bleakman D., Colmers W.F., Miller R.J. Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals. Nature 1993, 364:635-639.
18. Koh D.S., Hille B. Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc. Natl. Acad. Sci. USA 1997, 94:1506-1511.
19. Chung S., Ahn D.S., Kim Y.H., Kim Y.S., Joeng J.H., Nam T.S. Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons. Exp. Physiol. 2010, 95:982-993.
20. Ernsberger P., Meeley M.P., Mann J.J., Reis D.J. Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 1987, 134:1-13.
21. Piletz J.E., Zhu H., Chikkala D.N. Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J. Pharmacol. Exp. Ther. 1996, 279:694-702.
22. Plummer M.R., Logothetis D.E., Hess P. Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron 1989, 2:1453-1463.
23. Regan L.J., Sah D.W., Bean B.P. Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and ω-conotoxin. Neuron 1991, 6:269-280.
24. Mintz I.M., Venema V.J., Swiderek K.M., Lee T.D., Bean B.P., Adams M.E. P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 1992, 355:827-829.
25. Holz G.G.T., Rane S.G., Dunlap K. GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. Nature 1986, 319:670-672.
26. Jeong S.W., Wurster R.D. Muscarinic receptor activation modulates Ca2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway. J. Neurophysiol. 1997, 78:1476-1490.
27. Schofield G.G. Norepinephrine inhibits a Ca2+ current in rat sympathetic neurons via a G-protein. Eur. J. Pharmacol. 1991, 207:195-207.
28. Shapiro M.S., Wollmuth L.P., Hille B. Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neurons. J. Neurosci. 1994, 14:7109-7116.
29. Elmslie K.S., Zhou W., Jones S.W. LHRH and GTP-γ-S modify calcium current activation in bullfrog sympathetic neurons. Neuron 1990, 5:75-80.
30. Schäfer U., Burgdorf C., Engelhardt A., Kurz T., Richardt G. Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and α2-adrenoceptors. J. Pharmacol. Exp. Ther. 2002, 303:1163-1170.
31. Schafer U., Burgdorf C., Engelhardt A., Raasch W., Kurz T., Richardt G. Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors. Ann. N. Y. Acad. Sci. 2003, 1009:265-269.
32. Separovic D., Kester M., Ernsberger P. Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Mol. Pharmacol. 1996, 49:668-675.
33. Separovic D., Kester M., Haxhiu M.A., Ernsberger P. Activation of phosphatidylcholine-selective phospholipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla. Brain Res. 1997, 749:335-339.
34. Shimosawa T., Takano K., Ando K., Fujita T. Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings. Hypertension 2004, 44:897-902.
35. Shapiro M.S., Hille B. Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. Neuron 1993, 10:11-20.
36. Schofield G.G. Norepinephrine blocks a calcium current of adult rat sympathetic neurons via an α2-adrenoceptor. Eur. J. Pharmacol. 1990, 180:37-47.
37. Elmslie K.S. Neurotransmitter modulation of neuronal calcium channels. J. Bioenerg. Biomembr. 2003, 35:477-489.
38. Beech D.J., Bernheim L., Hille B. Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons. Neuron 1992, 8:97-106.
39. Beech D.J., Bernheim L., Mathie A., Hille B. Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons. Proc. Natl. Acad. Sci. USA 1991, 88:652-656.
40. Bernheim L., Mathie A., Hille B. Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons. Proc. Natl. Acad. Sci. USA 1992, 89:9544-9548.
41. Shapiro M.S., Wollmuth L.P., Hille B. Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron 1994, 12:1319-1329.
42. Chu T.C., Socci R.R., Ogidigben M.J., Potter D.E. Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine. J. Ocul. Pharmacol. Ther. 1997, 13:489-496.