Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression

Brain Research

Volumn 1087, Issue 1, 2006, Pages 83-86

  Choi, SuJean ^a   Blake, Valarie ^a   Cole, Sara ^a   Fernstrom, John D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Appetite; Fenfluramine; Hypothalamus; mRNA; Neuropeptide; Rat

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; FENFLURAMINE; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; INJECTION; MALE; MEASUREMENT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT DURATION;

ANIMALS; ARCUATE NUCLEUS; BEHAVIOR, ANIMAL; BODY WEIGHT; CORTICOTROPIN-RELEASING HORMONE; EATING; FENFLURAMINE; GENE EXPRESSION; IN SITU HYBRIDIZATION; MALE; NEUROPEPTIDE Y; NEUROPEPTIDES; PRO-OPIOMELANOCORTIN; RATS; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

ANIMALIA;

EID: 33646896967     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.02.129     Document Type: Article

References (19)

1. Blundell J.E., Campbell D.B., Lesham M., and Tozer R. Comparison of the time course of the anorectic effect of fenfluramine and amphetamine with drug levels in blood. J. Pharm. Pharmacol. 27 (1975) 187-192
2. Choi S., Jonak E.M., Simpson L., Patil V., and Fernstrom J.D. Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions. Brain Res. 928 (2002) 30-39
3. Collin M., Backberg M., Onnestam K., and Meister B. 5-HT1A receptor immunoreactivity in hypothalamic neurons involved in body weight control. NeuroReport 13 (2002) 945-951
4. Dryden S., Frankish H.M., Wang Q., Pickavance L., and Williams G. The serotonergic agent fluoxetine reduces neuropeptide Y levels and neuropeptide Y secretion in the hypothalamus of lean and obese rats. Neuroscience 72 (1996) 557-566
5. Garattini S. Biological actions of drugs affecting serotonin and eating. Obes. Res. 3 Suppl. 4 (1995) 463s-470s
6. Garattini S., Caccia S., Mennini T., Samanin R., Consolo S., and Ladinsky H. Biochemical pharmacology of the anorectic drug fenfluramine: a review. Curr. Med. Res. Opin. 6 (1979) 15-27
7. Guy J., Pelletier G., and Bosler O. Serotonin innervation of neuropeptide Y-containing neurons in the rat arcuate nucleus. Neurosci. Lett. 85 (1988) 9-13
8. Heisler L.K., Cowley M.A., Tecott L.H., Fan W., Low M.J., Smart J.L., Rubinstein M., Tatro J.B., Marcus J.N., Holstege H., Lee C.E., Cone R.D., and Elmquist J.K. Activation of central melanocortin pathways by fenfluramine. Science 297 (2002) 609-611
9. Javed A., Kamradt M.C., Van de Kar L.D., and Gray T.S. D-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala. Neuroscience 90 (1999) 851-858
10. Laflamme N., Bovetto S., Richard D., and Rivest S. Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus. Br. J. Pharmacol. 117 (1996) 1021-1034
11. Liposits Z., Phelix C., and Paull W.K. Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study. Histochemistry 86 (1987) 541-549
12. Rowland N.E., and Carlton J. Neurobiology of an anorectic drug: Fenfluramine. Prog. Neurobiol. 27 (1986) 13-62
13. Rowland N.E., and Carlton J. Dexfenfluramine: effects on food intake in various animal models. Clin. Neuropharmacol. 11 Suppl. 1 (1988) S33-S50
14. Stanley B.G., Kyrkouli S.E., Lampert S., and Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7 (1986) 1189-1192
15. Sugrue M.F. Neuropharmacology of drugs affecting food intake. Pharmacol. Ther. 32 (1987) 145-182
16. Vickers S.P., Benwell K.R., Porter R.H., Bickerdike M.J., Kennett G.A., and Dourish C.T. Comparative effects of continuous infusion of mCPP, RO 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. Br. J. Pharmacol. 130 (2000) 1305-1314
17. Weintraub M. Long-term weight control: the National Heart, Lung, and Blood Institute funded multimodal intervention study. Clin. Pharmacol. Ther. 51 (1992) 581-646
18. Whitnall M.H. Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog. Neurobiol. 40 (1993) 573-629
19. Zaczek R., Battaglia G., Culp S., Appel N.M., Contrera J.F., and De Souza E.B. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. J. Pharmacol. Exp. Ther. 253 (1990) 104-112