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Volumn 2011, Issue , 2011, Pages

Toxicokinetics of kava

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOCHROME P450 2D6; DEBRISOQUINE; DESMETHOXYYANGONIN; DIHYDROKAWAIN; DIHYDROMETHYSTICIN; FLAVOKAVAIN B; GAMMA GLUTAMYLTRANSFERASE; KAVA; KAVA EXTRACT; KAVALACTONE; KAWAIN; LACTONE; METHYSTICIN; PIPERMETHYSTINE; PLACEBO; PYRAN DERIVATIVE; UNCLASSIFIED DRUG; YANGONIN;

EID: 79959274467     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2011/326724     Document Type: Review
Times cited : (24)

References (54)
  • 1
    • 0141839116 scopus 로고    scopus 로고
    • Kava lactones and the kava-kava controversy
    • DOI 10.1016/S0031-9422(03)00381-9
    • Whitton P. A., Lau A., Salisbury A., Whitehouse J., Evans C. S., Kava lactones and the kava-kava controversy Phytochemistry 2003 64 3 673 679 (Pubitemid 37176400)
    • (2003) Phytochemistry , vol.64 , Issue.3 , pp. 673-679
    • Whitton, P.A.1    Lau, A.2    Salisbury, A.3    Whitehouse, J.4    Evans, C.S.5
  • 3
    • 78651346028 scopus 로고    scopus 로고
    • Kava hepatotoxicity solution: A six-point plan for new kava standardization
    • Teschke R., Sarris J., Lebot V., Kava hepatotoxicity solution: a six-point plan for new kava standardization Phytomedicine 2011 18 2-3 96 103
    • (2011) Phytomedicine , vol.18 , Issue.23 , pp. 96-103
    • Teschke, R.1    Sarris, J.2    Lebot, V.3
  • 4
    • 0034949915 scopus 로고    scopus 로고
    • Interaction of various Piper methysticum cultivars with CNS receptors in vitro
    • DOI 10.1055/s-2001-14334
    • Dinh L. D., Simmen U., Bueter K. B., Bueter B., Lundstrom K., Schaffner W., Interaction of various Piper methysticum cultivars with CNS receptors in vitro Planta Medica 2001 67 4 306 311 (Pubitemid 32588563)
    • (2001) Planta Medica , vol.67 , Issue.4 , pp. 306-311
    • Dinh, L.D.1    Simmen, U.2    Bueter, K.B.3    Bueter, B.4    Lundstrom, K.5    Schaffner, W.6
  • 5
    • 33845346818 scopus 로고    scopus 로고
    • Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract
    • DOI 10.1016/j.etp.2006.08.002, PII S0940299306000947
    • Clayton N. P., Yoshizawa K., Kissling G. E., Burka L. T., Chan P. C., Nyska A., Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract Experimental and Toxicologic Pathology 2007 58 4 223 236 (Pubitemid 44873076)
    • (2007) Experimental and Toxicologic Pathology , vol.58 , Issue.4 , pp. 223-236
    • Clayton, N.P.1    Yoshizawa, K.2    Kissling, G.E.3    Burka, L.T.4    Chan, P.-C.5    Nyska, A.6
  • 6
    • 2442706282 scopus 로고    scopus 로고
    • Effects of Kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes
    • DOI 10.1078/0944711041495263
    • Zou L., Henderson G. L., Harkey M. R., Sakai Y., Li A., Effects of kava (kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes Phytomedicine 2004 11 4 285 294 (Pubitemid 38657457)
    • (2004) Phytomedicine , vol.11 , Issue.4 , pp. 285-294
    • Zou, L.1    Henderson, G.L.2    Harkey, M.R.3    Sakai, Y.4    Li, A.5
  • 7
    • 0037178665 scopus 로고    scopus 로고
    • Post-insult exposure to () kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus
    • DOI 10.1016/S0006-8993(02)02745-2, PII S0006899302027452
    • Mulholland P. J., Prendergast M. A., Post-insult exposure to () kavain potentiates N -methyl-D-aspartate toxicity in the developing hippocampus Brain Research 2002 945 1 106 113 (Pubitemid 34756582)
    • (2002) Brain Research , vol.945 , Issue.1 , pp. 106-113
    • Mulholland, P.J.1    Prendergast, M.A.2
  • 8
    • 79952214337 scopus 로고    scopus 로고
    • Kavalactones yangonin and methysticin induce apoptosis in human hepatocytes (HepG2) in vitro
    • Tang J., Dunlop R. A., Rowe A., Rodgers K. J., Ramzan I., Kavalactones yangonin and methysticin induce apoptosis in human hepatocytes (HepG2) in vitro Phytotherapy Research 2011 25 3 417 423
    • (2011) Phytotherapy Research , vol.25 , Issue.3 , pp. 417-423
    • Tang, J.1    Dunlop, R.A.2    Rowe, A.3    Rodgers, K.J.4    Ramzan, I.5
  • 10
    • 0037989908 scopus 로고    scopus 로고
    • Piperidine alkaloids from piper methysticum
    • DOI 10.1016/S0031-9422(03)00111-0
    • Dragull K., Yoshida W. Y., Tang C. S., Piperidine alkaloids from Piper methysticum Phytochemistry 2003 63 2 193 198 (Pubitemid 36560138)
    • (2003) Phytochemistry , vol.63 , Issue.2 , pp. 193-198
    • Dragull, K.1    Yoshida, W.Y.2    Tang, C.-S.3
  • 11
    • 2442710270 scopus 로고    scopus 로고
    • Vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones
    • DOI 10.1093/toxsci/kfh067
    • Nerurkar P. V., Dragull K., Tang C. S., In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones Toxicological Sciences 2004 79 1 106 111 (Pubitemid 38660254)
    • (2004) Toxicological Sciences , vol.79 , Issue.1 , pp. 106-111
    • Nerurkar, P.V.1    Dragull, K.2    Tang, C.-S.3
  • 12
    • 34347232391 scopus 로고    scopus 로고
    • Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats
    • DOI 10.1093/toxsci/kfm035
    • Lim S. T. S., Dragull K., Tang C. S., Bittenbender H. C., Efird J. T., Nerurkar P. V., Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats Toxicological Sciences 2007 97 1 214 221 (Pubitemid 47072170)
    • (2007) Toxicological Sciences , vol.97 , Issue.1 , pp. 214-221
    • Lim, S.T.S.1    Dragull, K.2    Tang, C.-S.3    Bittenbender, H.C.4    Efird, J.T.5    Nerurkar, P.V.6
  • 13
    • 38849086101 scopus 로고    scopus 로고
    • Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?
    • DOI 10.1691/ph.2008.7638
    • Lechtenberg M., Quandt B., Schmidt M., Nahrstedt A., Is the alkaloid pipermethystine connected with the claimed liver toxicity of kava products? Pharmazie 2008 63 1 71 74 (Pubitemid 351187597)
    • (2008) Pharmazie , vol.63 , Issue.1 , pp. 71-74
    • Lechtenberg, M.1    Quandt, B.2    Schmidt, M.3    Nahrstedt, A.4
  • 15
    • 40549094283 scopus 로고    scopus 로고
    • Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots
    • DOI 10.1007/s11418-007-0203-2
    • Xuan T. D., Fukuta M., Wei A. C., Elzaawely A. A., Khanh T. D., Tawata S., Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots Journal of Natural Medicines 2008 62 2 188 194 (Pubitemid 351365814)
    • (2008) Journal of Natural Medicines , vol.62 , Issue.2 , pp. 188-194
    • Xuan, T.D.1    Fukuta, M.2    Wei, A.C.3    Elzaawely, A.A.4    Khanh, T.D.5    Tawata, S.6
  • 16
    • 78349302551 scopus 로고    scopus 로고
    • Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF- B and MAPK signaling pathways
    • Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S. X., Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF- B and MAPK signaling pathways FASEB Journal 2010 24 12 4722 4732
    • (2010) FASEB Journal , vol.24 , Issue.12 , pp. 4722-4732
    • Zhou, P.1    Gross, S.2    Liu, J.-H.3    Yu, B.-Y.4    Feng, L.-L.5    Nolta, J.6    Sharma, V.7    Piwnica-Worms, D.8    Qiu, S.X.9
  • 19
    • 67349168679 scopus 로고    scopus 로고
    • Kava hepatotoxicity: Comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures
    • Teschke R., Genthner A., Wolff A., Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures Journal of Ethnopharmacology 2009 123 3 378 384
    • (2009) Journal of Ethnopharmacology , vol.123 , Issue.3 , pp. 378-384
    • Teschke, R.1    Genthner, A.2    Wolff, A.3
  • 21
    • 20444458671 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders
    • DOI 10.1002/ptr.1609
    • Witte S., Loew D., Gaus W., Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders Phytotherapy Research 2005 19 3 183 188 (Pubitemid 40827638)
    • (2005) Phytotherapy Research , vol.19 , Issue.3 , pp. 183-188
    • Witte, S.1    Loew, D.2    Gaus, W.3
  • 22
    • 0035659284 scopus 로고    scopus 로고
    • Adverse-effect profile of kava
    • Connor K. M., Davidson J. R. T., Churchill L. E., Witte S., Loew D., Gaus W., Adverse-effect profile of kava CNS Spectrums 2001 6 10 848 853 (Pubitemid 34027308)
    • (2001) CNS Spectrums , vol.6 , Issue.10 , pp. 848-853
    • Connor, K.M.1    Davidson, J.R.T.2    Churchill, L.E.3
  • 23
    • 1842479653 scopus 로고    scopus 로고
    • Kava kava: Examining new reports of toxicity
    • DOI 10.1016/j.toxlet.2003.07.005, PII S0378427404000402
    • Clouatre D. L., Kava kava: examining new reports of toxicity Toxicology Letters 2004 150 1 85 96 (Pubitemid 38447238)
    • (2004) Toxicology Letters , vol.150 , Issue.1 , pp. 85-96
    • Clouatre, D.L.1
  • 30
    • 0024396491 scopus 로고
    • Identification of some human urinary metabolites of the intoxicating beverage kava
    • DOI 10.1016/S0021-9673(01)89682-5
    • Duffield A. M., Jamieson D. D., Lidgard R. O., Duffield P. H., Bourne D. J., Identification of some human urinary metabolites of the intoxicating beverage kava Journal of Chromatography A 1989 475 273 281 (Pubitemid 19193596)
    • (1989) Journal of Chromatography , vol.475 , pp. 273-281
    • Duffield, A.M.1    Jamieson, D.D.2    Lidgard, R.O.3    Duffield, P.H.4    Bourne, D.J.5
  • 31
    • 0026085914 scopus 로고
    • Mass spectral characterization of urinary metabolites of D,L-kawan
    • Kppel C., Tenczer J., Mass spectral characterization of urinary metabolites of D,L-kawan Journal of Chromatography B 1991 562 1-2 207 211
    • (1991) Journal of Chromatography B , vol.562 , Issue.12 , pp. 207-211
    • Kppel, C.1    Tenczer, J.2
  • 32
    • 0018409023 scopus 로고
    • Metabolism of some kava pyrones in the rat
    • Rasmussen A. K., Scheline R. R., Solheim E., Hansel R., Metabolism of some kava pyrones in the rat Xenobiotica 1979 9 1 1 16 (Pubitemid 9093507)
    • (1979) Xenobiotica , vol.9 , Issue.1 , pp. 1-16
    • Rasmussen, A.K.1    Scheline, R.R.2    Solheim, E.3
  • 34
    • 14944372185 scopus 로고    scopus 로고
    • Synthesis, in vitro reactivity, and identification of 6-phenyl-3-hexen-2- one in human urine after kava-kava (Piper methysticum) ingestion
    • DOI 10.1055/s-2005-837781
    • Zou L., Harkey M. R., Henderson G. L., Synthesis, in vitro reactivity, and identification of 6-phenyl-3-hexen-2-one in human urine after kava-kava (Piper methysticum) ingestion Planta Medica 2005 71 2 142 146 (Pubitemid 40363557)
    • (2005) Planta Medica , vol.71 , Issue.2 , pp. 142-146
    • Zou, L.1    Harkey, M.R.2    Henderson, G.L.3
  • 36
    • 24944587145 scopus 로고    scopus 로고
    • Pharmacokinetics and disposition of the kavalactone kawain: Interaction with kava extract and kavalactones in vivo and in vitro
    • DOI 10.1124/dmd.105.004317
    • Mathews J. M., Etheridge A. S., Valentine J. L., Black S. R., Coleman D. P., Patel P., So J., Burka L. T., Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro Drug Metabolism and Disposition 2005 33 10 1555 1563 (Pubitemid 41324005)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.10 , pp. 1555-1563
    • Mathews, J.M.1    Etheridge, A.S.2    Valentine, J.L.3    Black, S.R.4    Coleman, D.P.5    Patel, P.6    So, J.7    Burka, L.T.8
  • 39
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • DOI 10.1038/sj.tpj.6500285
    • Ingelman-Sundberg M., Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity Pharmacogenomics Journal 2005 5 1 6 13 (Pubitemid 40220611)
    • (2005) Pharmacogenomics Journal , vol.5 , Issue.1 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 40
    • 0035915733 scopus 로고    scopus 로고
    • Hepatitis associated with kava, a herbal remedy for anxiety
    • Escher M., Desmeules J., Giostra E., Mentha G., Hepatitis associated with kava, a herbal remedy for anxiety British Medical Journal 2001 322 7279 139 (Pubitemid 32116192)
    • (2001) British Medical Journal , vol.322 , Issue.7279 , pp. 139
    • Escher, M.1    Desmeules, J.2    Giostra, E.3
  • 43
    • 0345564969 scopus 로고    scopus 로고
    • Liver Function Test Abnormalities in Users of Aqueous Kava Extracts
    • DOI 10.1081/CLT-120025347
    • Clough A. R., Bailie R. S., Currie B., Liver function test abnormalities in users of aqueous kava extracts Journal of Toxicology. Clinical Toxicology 2003 41 6 821 829 (Pubitemid 37499010)
    • (2003) Journal of Toxicology - Clinical Toxicology , vol.41 , Issue.6 , pp. 821-829
    • Clough, A.R.1    Bailie, R.S.2    Currie, B.3
  • 44
    • 34248545938 scopus 로고    scopus 로고
    • Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii
    • DOI 10.1080/15563650701365875, PII 778639110
    • Brown A. C., Onopa J., Holck P., Kaufusi P., Kabasawa D., Craig W. J., Dragull K., Levine A. M., Baker J. D., Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii Clinical Toxicology 2007 45 5 549 556 (Pubitemid 46763668)
    • (2007) Clinical Toxicology , vol.45 , Issue.5 , pp. 549-556
    • Brown, A.C.1    Onopa, J.2    Holck, P.3    Kaufusi, P.4    Kabasawa, D.5    Craig, W.J.6    Dragull, K.7    Levine, A.M.8    Baker, J.D.9
  • 45
    • 38549109650 scopus 로고    scopus 로고
    • Mechanisms of Cholestasis
    • DOI 10.1016/j.cld.2007.11.010, PII S1089326107001195
    • Zollner G., Trauner M., Mechanisms of cholestasis Clinics in Liver Disease 2008 12 1 1 26 (Pubitemid 351163143)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.1 , pp. 1-26
    • Zollner, G.1    Trauner, M.2
  • 46
    • 33847262105 scopus 로고    scopus 로고
    • Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    • DOI 10.1093/toxsci/kfl173
    • Roberts R. A., Ganey P. E., Ju C., Kamendulis L. M., Rusyn I., Klaunig J. E., Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis Toxicological Sciences 2007 96 1 2 15 (Pubitemid 46323203)
    • (2007) Toxicological Sciences , vol.96 , Issue.1 , pp. 2-15
    • Roberts, R.A.1    Ganey, P.E.2    Ju, C.3    Kamendulis, L.M.4    Rusyn, I.5    Klaunig, J.E.6
  • 47
    • 33845899370 scopus 로고    scopus 로고
    • Role of Kupffer cells in the pathogenesis of liver disease
    • Kolios G., Valatas V., Kouroumalis E., Role of Kupffer cells in the pathogenesis of liver disease World Journal of Gastroenterology 2006 12 46 7413 7420 (Pubitemid 46017736)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.46 , pp. 7413-7420
    • Kolios, G.1    Valatas, V.2    Kouroumalis, E.3
  • 50
    • 46449120427 scopus 로고    scopus 로고
    • 3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock
    • DOI 10.1080/10739680701675213, PII 792840054
    • Henrich D., Lehnert M., Herzog C., Niederlaender S., Relja B., Conzelmann L., Marzi I., Differential effects of GdCl 3 or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock Microcirculation 2008 15 5 427 439 (Pubitemid 351927731)
    • (2008) Microcirculation , vol.15 , Issue.5 , pp. 427-439
    • Henrich, D.1    Lehnert, M.2    Herzog, C.3    Niederlaender, S.4    Relja, B.5    Conzelmann, L.6    Marzi, I.7
  • 51
    • 11144268153 scopus 로고    scopus 로고
    • Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats
    • DOI 10.1016/j.jhep.2004.09.019, PII S016882780400426X
    • Sturm E., Havinga R., Baller J. F. W., Wolters H., Van Rooijen N., Kamps J. A. A. M., Verkade H. J., Karpen S. J., Kuipers F., Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats Journal of Hepatology 2005 42 1 102 109 (Pubitemid 40038907)
    • (2005) Journal of Hepatology , vol.42 , Issue.1 , pp. 102-109
    • Sturm, E.1    Havinga, R.2    Baller, J.F.W.3    Wolters, H.4    Van Rooijen, N.5    Kamps, J.A.A.M.6    Verkade, H.J.7    Karpen, S.J.8    Kuipers, F.9
  • 53
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W., Metlakunta A., Dedousis N., Zhang P., Sipula I., Dube J. J., Scott D. K., O'Doherty R. M., Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance Diabetes 2010 59 2 347 357
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6    Scott, D.K.7    O'Doherty, R.M.8


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