Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ

Blood

Volumn 117, Issue 24, 2011, Pages 6520-6531

  Janda, Elzbieta ^a   Palmieri, Camillo ^a   Pisano, Antonio ^a   Pontoriero, Marilena ^a   Iaccino, Enrico ^a,b   Falcone, Cristina ^a   Fiume, Giuseppe ^a   Gaspari, Marco ^a   Nevolo, Maria ^a   Di Salle, Emanuela ^a   Rossi, Annalisa ^a   De Laurentiis, Annamaria ^a,b   Greco, Adelaide ^c,d,e   Di Napoli, Daniele ^f   Verheij, Elwin ^g   Britti, Domenico ^a   Lavecchia, Luca ^a   Quinto, Ileana ^a,h   Scala, Giuseppe ^a,h  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b Italsistemi Biotechnology Institute   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^e CNR   (Italy)

^f CARDARELLI HOSPITAL   (Italy)

^g TNO   (Netherlands)

^h UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; BRUTON TYROSINE KINASE INHIBITOR GAMMA; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C; SERINE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL MEMBRANE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPLEEN; TANDEM MASS SPECTROMETRY;

EID: 79959257186     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-09-308080     Document Type: Article

References (45)

1. Lindvall JM, Blomberg KE, Valiaho J, et al. Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Immunol Rev. 2005;203:200-215. (Pubitemid 40185385)
2. Maas A, Hendriks RW. Role of Bruton's tyrosine kinase in B cell development. Dev Immunol. 2001;8(3-4):171-181. (Pubitemid 34019530)
3. Blomberg KE, Smith CI, Lindvall JM. Gene expression signatures in primary immunodeficiencies: the experience from human disease and mouse models. Curr Mol Med. 2007;7(6):555-566. (Pubitemid 47618052)
4. Tsukada S, Rawlings DJ, Witte ON. Role of Bruton's tyrosine kinase in immunodeficiency. Curr Opin Immunol. 1994;6(4):623-630. (Pubitemid 24249522)
5. Uckun FM, Waddick KG, Mahajan S, et al. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science. 1996; 273(5278):1096-1100. (Pubitemid 26278163)
6. Scharenberg AM, Kinet JP. PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell. 1998;94(1):5-8. (Pubitemid 28347462)
7. Petro JB, Rahman SM, Ballard DW, Khan WN. Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med. 2000;191(10):1745-1754.
8. Shinners NP, Carlesso G, Castro I, et al. Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family. J Immunol. 2007; 179(6):3872-3880.
9. Takata M, Kurosaki T. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. J Exp Med. 1996;184(1):31-40. (Pubitemid 26247212)
10. Ellmeier W, Jung S, Sunshine MJ, et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J Exp Med. 2000; 192(11):1611-1624.
11. Kerner JD, Appleby MW, Mohr RN, et al. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity. 1995;3(3):301-312.
12. Brazin KN, Fulton DB, Andreotti AH. A specific intermolecular association between the regulatory domains of a Tec family kinase. J Mol Biol. 2000;302(3):607-623.
13. Várnai P, Rother KI, Balla T. Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem. 1999;274(16):10983-10989.
14. Rawlings DJ, Scharenberg AM, Park H, et al. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 1996; 271(5250):822-825. (Pubitemid 26058937)
15. Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ. Phosphorylation of 2 regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc Natl Acad Sci U S A. 1997;94(21):11526-11533. (Pubitemid 27451032)
16. Kang SW, Wahl MI, Chu J, et al. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J. 2001;20(20): 5692-5702. (Pubitemid 33010046)
17. Xu S, Lee KG, Huo J, Kurosaki T, Lam KP. Combined deficiencies in Bruton tyrosine kinase and phospholipase Cgamma2 arrest B-cell development at a pre-BCR+ stage. Blood. 2007;109(8): 3377-3384. (Pubitemid 46572526)
18. Turner M, Mee PJ, Costello PS, et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995; 378(6554):298-302.
19. Pappu R, Cheng AM, Li B, et al. Requirement for B cell linker protein (BLNK) in B cell development. Science. 1999;286(5446):1949-1954. (Pubitemid 129515902)
20. Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, Nielsen PJ. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 1999; 11(5):547-554.
21. Fruman DA, Satterthwaite AB, Witte ON. Xid-like phenotypes: a B cell signalosome takes shape. Immunity. 2000;13(1):1-3.
22. Kurosaki T, Tsukada S. BLNK: connecting Syk and Btk to calcium signals. Immunity. 2000;12(1): 1-5. (Pubitemid 30069209)
23. Ishiai M, Kurosaki M, Pappu R, et al. BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity. 1999;10(1):117-125. (Pubitemid 29077389)
24. Baba Y, Hashimoto S, Matsushita M, et al. BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci U S A. 2001;98(5):2582-2586. (Pubitemid 32209525)
25. Law CL, Chandran KA, Sidorenko SP, Clark EA. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol. 1996;16(4):1305-1315.
26. Saito K, Tolias KF, Saci A, et al. BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity. 2003;19(5): 669-678.
27. Schwartzberg PL. Amplifying Btk's signal. Immunity. 2003;19(5):634-636. (Pubitemid 37490787)
28. Liu W, Quinto I, Chen X, et al. Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat Immunol. 2001;2(10):939-946. (Pubitemid 32976166)
29. Spatuzza C, Schiavone M, Di Salle E, et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic Acids Res. 2008;36(13):4402-4416.
30. Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2008;2(1):90-102.
31. Puca A, Fiume G, Palmieri C, et al. IkappaB-alpha represses the transcriptional activity of the HIV-1 Tat transactivator by promoting its nuclear export. J Biol Chem. 2007;282(51):37146-37157.
32. Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006;1(6):2856-2860.
33. Palmieri C, Falcone C, Iaccino E, et al. In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder. Blood. 2010;116(2):226-238.
34. Giordano V, De Falco G, Chiari R, et al. Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 1997;158(9):4097-4103. (Pubitemid 127483907)
35. Leitges M, Schmedt C, Guinamard R, et al. Immunodeficiency in protein kinase cbeta-deficient mice. Science. 1996;273(5276):788-791. (Pubitemid 26271522)
36. Soh JW, Weinstein IB. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem. 2003; 278(36):34709-34716. (Pubitemid 37553321)
37. Fluckiger AC, Li Z, Kato RM, et al. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J. 1998;17(7):1973-1985. (Pubitemid 28154527)
38. Bajpai UD, Zhang K, Teutsch M, Sen R, Wortis HH. Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med. 2000;191(10):1735-1744. (Pubitemid 30331570)
39. Scharenberg AM, Humphries LA, Rawlings DJ. Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol. 2007;7(10):778-789. (Pubitemid 47480308)
40. Saito K, Scharenberg AM, Kinet JP. Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk. J Biol Chem. 2001;276(19):16201-16206.
41. Duronio V, Scheid MP, Ettinger S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal. 1998;10(4):233-239. (Pubitemid 28205901)
42. Suzuki H, Matsuda S, Terauchi Y, et al. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003; 4(3):280-286. (Pubitemid 36322139)
43. Kurosaki T. Regulation of BCR signaling. Mol. Immunol. In press.
44. Hashimoto S, Iwamatsu A, Ishiai M, et al. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood. 1999; 94(7):2357-2364. (Pubitemid 29467683)
45. Koyasu S. Beating a kinase? Nat Immunol. 2001; 2(10):897-898. (Pubitemid 32976157)