Are stimulants effective in the treatment of executive function deficits? Results from a randomized double blind study of OROS-methylphenidate in adults with ADHD

European Neuropsychopharmacology

Volumn 21, Issue 7, 2011, Pages 508-515

  Biederman, Joseph ^a,b   Mick, Eric ^a   Fried, Ronna ^a   Wilner, Nicole ^a   Spencer, Thomas J ^a,b   Faraone, Stephen V ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

ADHD; Adults; Cognitive performance; OROS methylphenidate

Indexed keywords

METHYLPHENIDATE; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG WITHDRAWAL; EXECUTIVE FUNCTION; EXECUTIVE FUNCTION DEFICIT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; METHYLPHENIDATE; PLACEBOS; PSYCHOLOGICAL TESTS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79959255249     PISSN: 0924977X     EISSN: 0924977X     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.11.005     Document Type: Article

References (40)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders: DSM-IV 1994, American Psychiatric Association, Washington, DC.
2. Barkley R.A., Murphy K.R., Fischer M. ADHD in Adults: What the Science Says 2008, Guilford Press, New York, NY.
3. Biederman J., Monuteaux M., Seidman L., Doyle A.E., Mick E., Wilens T., Ferrero F., Morgan C., Faraone S.V. Impact of executive function deficits and ADHD on academic outcomes in children. J. Consult. Clin. Psychol. 2004, 72(5):757-766.
4. Biederman J., Faraone S.V., Spencer T., Mick E., Monuteaux M., Aleardi M. Functional impairments in adults with self-reports of diagnosed aDHD: a controlled study of 1001 adults in the community. J. Clin. Psychiatry 2006, 67(4):524-540.
5. Biederman J., Mick E., Surman C., Doyle R., Hammerness P., Harpold T., Dunkel S., Dougherty M., Aleardi M., Spencer T. A randomized, placebo-controlled trial of OROS-methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry 2006, 59(9):829-835.
6. Biederman J., Petty C., Fried R., Fontanella J., Doyle A.E., Seidman L.J., Faraone S.V. Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder. Am. J. Psychiatry 2006, 163(10):1730-1738.
7. Biederman J., Petty C., Fried R., Fontanella J., Doyle A.E., Seidman L.J., Faraone S.V. Can self-reported behavioral scales assess executive function deficits?: A controlled study of adults with ADHD. J. Nerv. Ment. Dis. 2007, 195(3):240-246.
8. Biederman J., Petty C.R., Fried R., Doyle A.E., Spencer T., Seidman L.J., Gross L., Poetzl K., Faraone S.V. Stability of executive function deficits into young adult years: a prospective longitudinal follow-up study of grown up males with ADHD. Acta Psychiatr. Scand. 2007, 116(2):129-136.
9. Biederman J., Petty C.R., Doyle A.E., Spencer T., Henderson C.S., Marion B., Fried R., Faraone S.V. Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence. Dev. Neuropsychol. 2008, 33(1):44-61.
10. Biederman J., Petty C.R., Fried R., Black S., Faneuil A., Doyle A.E., Seidman L.J., Faraone S.V. Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHD. J. Atten. Disord. 2008, 12(1):92-102.
11. Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Kotarski, M., Spencer, T., 2010. A randomized, 3-phase, 34-week, double-blind, long-term efficacy study of osmotic-release oral system-methylphenidate in adults with attention-deficit/hyperactivity disorder. J. Clin. Psychopharmacol. 30 (5), 549-553.
12. Delis D., Kaplan E., Kraemer J.H. Delis-Kaplan executive function system (D-KEFS) 2001, The Psychological Corporation.
13. Epstein J.N., Johnson D.E., Varia I.M., Conners C.K. Neuropsychological assessment of response inhibition in adults with ADHD. J. Clin. Exp. Neuropsychol. 2001, 23(3):362-371.
14. Faraone S.V. Genetics of adult attention-deficit/hyperactivity disorder. Psychiatr. Clin. North Am. 2004, 27(2):303-321.
15. Faraone S.V., Biederman J. Functional impairments in adult ADHD implications for diagnosis. 158th Annual meeting of the American Psychiatric Association 2005, American Psychiatric Association, Atlanta, GA.
16. Faraone S.V., Biederman J., Doyle A., Murray K., Petty C., Adamson J.J., Seidman L. Neuropsychological studies of late onset and subthreshold diagnoses of adult attention-deficit/hyperactivity disorder. Biol. Psychiatry 2006, 60(10):1081-1087.
17. Faraone S.V., Biederman J., Spencer T.J., Mick E., Murray K., Petty C., Adamson J.J., Monuteaux M.C. Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?. Am. J. Psychiatry 2006, 163(10):1720-1729.
18. Faraone S.V., Glatt S.J. A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J. Clin. Psychiatry 2010, 71(6):754-763.
19. Faraone S.V., Mick E. Molecular genetics of attention deficit hyperactivity disorder. Psychiatr. Clin. North Am. 2010, 33(1):159-180.
20. Faraone S.V., Spencer T., Aleardi M., Pagano C., Biederman J. Meta-analysis of the efficacy of methylphenidate for treating adult attention deficit hyperactivity disorder. J. Clin. Psychopharmacol. 2004, 54(1):24-29.
21. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV) 1997, American Psychiatric Press, Washington, DC.
22. Goldberg E., Podell K. Adaptive decision making, ecological validity, and the frontal lobes. J. Clin. Exp. Neuropsychol. 2000, 22(1):56-68.
23. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 1959, 32:50-55.
24. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 1960, 23:56-62.
25. Kessler R., Adler L., Barkley R., Biederman J., Conners C.K., Faraone S.V., Greenhill L.G., Jaeger S., Secnik K., Spencer T., Ustun B., Zaslavsky A.M. Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication. Biol. Psychiatry 2005, 57(11):1442-1451.
26. Kessler R.C., Adler L., Ames M., Barkley R.A., Birnbaum H., Greenberg P., Johnston J.A., Spencer T., Ustun T.B. The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J. Occup. Environ. Med. 2005, 47(6):565-572.
27. Kessler R.C., Adler L., Barkley R., Biederman J., Conners C.K., Demler O., Faraone S.V., Greenhill L.L., Howes M.J., Secnik K., Spencer T., Ustun T.B., Walters E.E., Zaslavsky A.M. The prevalence and correlates of adult ADHD in the United States: results from the national comorbidity survey replication. Am. J. Psychiatry 2006, 163(4):716-723.
28. Medori R., Ramos-Quiroga J.A., Casas M., Kooij J.J., Niemela A., Trott G.E., Lee E., Buitelaar J.K. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry 2008, 63(10):981-989.
29. Mick E., Faraone S.V. Genetics of attention deficit hyperactivity disorder. Child Adolesc. Psychiatr. Clin. N. Am. 2008, 17(2):261-284. vii-viii.
30. National Institute of Mental Health CGI (Clinical Global Impression) Scale - NIMH. Psychopharmacol. Bull. 1985, 21:839-844.
31. Orvaschel H. Schedule for Affective Disorder and Schizophrenia for School-Age Children Epidemiologic Version 1994, Nova Southeastern University, Center for Psychological Studies, Ft. Lauderdale.
32. Seidman L.J. Neuropsychological functioning in people with ADHD across the lifespan. Clin. Psychol. Rev. 2006, 26(4):466-485.
33. Shallice T., Burgess P.W. Deficits in strategy application following frontal lobe damage in man. Brain 1991, 114(Pt 2):727-741.
34. Spencer T., Biederman J., Wilens T., Faraone S.V., Doyle R.D., Surman C., Prince J., Mick E., Aleardi M., Herzig K. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry 2005, 57(5):456-463.
35. Spencer T.J., Adler L.A., McGough J.J., Muniz R., Jiang H., Pestreich L. Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry 2007, 61(12):1380-1387.
36. Spencer, T.J., Adler, L.A., Meihua, Q., Saylor, K.E., Brown, T.E., Holdnack, J.A., Schuh, K.J., Trzepacz, P.T., Kelsey, D.K., 2010. Validation of the adult ADHD investigator symptom rating scale (AISRS). J. Atten. Disord. 14 (1), 57-68.
37. Stata Statistical Software Release 10 [program] 2007, StataCorp LP, College Station, TX.
38. Valera E., Faraone S.V., Murray K., Seidman L.J. Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol. Psychiatry 2007, 61(12):1361-1369.
39. Wechsler D. Wechsler Adult Intelligence Scale III [manual] 1997, The Psychological Corporation, San Antonio, TX.
40. Wilkinson G.S. WRAT3 Wide Range Achievement Test: Administration Manual 1993, Wide Range, Inc., Wilmington, Delaware.