Identification of two imidazole binding sites and key residues for substrate specificity in human primary amine oxidase AOC3

Biochemistry

Volumn 50, Issue 24, 2011, Pages 5507-5520

  Elovaara, Heli ^a,b   Kidron, Heidi ^c,f   Parkash, Vimal ^c   Nymalm, Yvonne ^c,g   Bligt, Eva ^c   Ollikka, Pauli ^d   Smith, David J ^d   Pihlavisto, Marjo ^d   Salmi, Marko ^b,e   Jalkanen, Sirpa ^a,b   Salminen, Tiina A ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d Biotie Therapies Corp   (Finland)

^e UNIVERSITY OF TURKU   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

^g PerkinElmer   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLAMINES; BINDING MODES; COFACTORS; COVALENTLY BOUND; DIFFERENT SUBSTRATES; ENZYMATIC ACTIVITIES; HIGH CONCENTRATION; HUMAN PLASMAS; MONOAMINE OXIDASE; NATIVE STRUCTURES; PRIMARY AMINES; SINGLE MUTATION; SPECIFIC INHIBITORS; SUBSTRATE SPECIFICITY; TOPAQUINONE; TRIPLE MUTANTS;

BINDING ENERGY; BINDING SITES; CONFORMATIONS; COPPER; ENZYME ACTIVITY; ORGANIC COMPOUNDS; TISSUE;

SUBSTRATES;

AMINE OXIDASE (FLAVIN CONTAINING); BENZYLAMINE; COPPER; IMIDAZOLE; LEUCINE; METHIONINE; METHYLAMINE; MUTANT PROTEIN; PHENETHYLAMINE; QUINONE DERIVATIVE; THREONINE; TYRAMINE; TYROSINE; VALINE; VASCULAR ADHESION PROTEIN 1;

ARTICLE; COVALENT BOND; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; INFLAMMATION; LEUKOCYTE; MOLECULAR DOCKING; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINE OXIDASE (COPPER-CONTAINING); AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL ADHESION MOLECULES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DIHYDROXYPHENYLALANINE; DISULFIDES; HUMANS; HYDROGEN BONDING; IMIDAZOLES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY;

EID: 79959235704     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200117z     Document Type: Article

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