Copper amine oxidase: Cunning cofactor and controversial copper

Current Opinion in Structural Biology

Volumn 11, Issue 6, 2001, Pages 666-673

  Dawkes, Helen C ^a   Phillips, Simon E V ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4,5 TRIHYDROXYPHENYLALANINE QUINONE; ALDEHYDE; AMINE; AMINE OXIDASE (COPPER CONTAINING); AMMONIA; COPPER; HYDROGEN PEROXIDE; OXYGEN; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

BINDING SITE; BIOGENESIS; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CRYSTAL; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; FREEZING; IMAGE ANALYSIS; KINETICS; METAL BINDING; OXIDATION; PRIORITY JOURNAL; REDUCTION; REVIEW; SPECTROSCOPY; STRUCTURE ANALYSIS;

EID: 0035693326     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(01)00270-6     Document Type: Review

References (42)

1. Copper-containing amine oxidases
2. The reductive and oxidative half-reactions and the role of copper ions in plant and mammalian copper-amine oxidases
3. Copper-containing oxidases
4. Oxygen reactions of the copper oxidases
5. Generation of the topa quinone cofactor in bacterial in monoamine-oxidase by cupric ion-dependent autoxidation of a specific tyrosyl residue
6. Evidence for a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase
7. Structure and biogenesis of topaquinone and related cofactors
8. A new redox cofactor in eukaryotic enzymes - 6-hydoxydopa at the active-site of bovine serum amine oxidase
9. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase
10. Copper proteins in the transport and activation of dioxygen, and in the reduction of inorganic molecules
11. Crystal structure of a quinoenzyme-copper amine oxidase of Escherichia coli at 2Å resolution
12. The active site base controls cofactor reactivity in Escherichia coli amine oxidase: X-ray crystallographic studies with mutational variants
13. Crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2 Å resolution
14. Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: Implications for the biogenesis of topaquinone
15. Copper amine oxidase from Hansenula polymorpha: The crystal structure determined at 2.4 Å resolution reveals the active conformation
16. Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: Exploring the reductive half-reaction
17. Visualization of dioxygen bound to copper during enzyme catalysis
18. Probing the mechanism of proton coupled electron transfer to dioxygen: The oxidative half-reaction of bovine serum amine oxidase
19. The oxidation and reduction reactions of bovine serum amine oxidase - A kinetic study
20. Oxidation of benzylamine Br-derivatives by lentil seedling copper-amine oxidase
21. Novel cofactors via post-translational modifications of enzyme active sites
22. Chemically modified amino acids in copper proteins that bind or activate dioxygen
23. Physiological importance of quinoenzymes and the O-quinone family of cofactors
24. Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds
25. Stoichiometry of the topa quinone biogenesis reaction in copper amine oxidases
26. Mutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase
27. Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast
28. Crystal structure at 2.5 Å resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli
29. The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast
30. A study on the reactions of plant copper amine oxidase with C3 and C4 aliphatic diamines
31. Molecular mode of interaction of plant amine oxidase with the mechanism-based inhibitor 2-butyne-amine oxidase with the mechanism-based inhibitor 2-butyne-1,4-diamine
32. A Cu(I)semiquinone state in substrate-reduced amine oxidases
33. An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha
34. Quinoenzymes in biology
35. Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential
36. A theoretical study of the mechanism for the reductive half-reaction of pea seedling amine oxidase (PSAO)
37. A spectroscopic and kinetic study of Escherichia coli amine oxidase
38. Spectroscopic characterization of carbon monoxide complexes generated for copper/topa quinone-containing amine oxidases
39. + during dioxygen activation in a copper amine oxidase from yeast
40. The metal function in the reactions of bovine serum amine oxidase with substrates and hydrazine inhibitors
41. Effect of metal substitution in copper amine oxidase from lentil seedlings