GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration

Molecular Biology of the Cell

Volumn 22, Issue 12, 2011, Pages 2119-2130

  Zhang, Jin San ^a   Koenig, Alexander ^a   Young, Charles ^b   Billadeau, Daniel D ^a  

^a Information Technology   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANOSINE TRIPHOSPHATE; PROTEIN SH3; RHO FACTOR; RHOU PROTEIN; RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONTROLLED STUDY; ENDOSOME; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROLINE RICH PROTEIN DOMAIN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; ENDOSOMES; EPIDERMAL GROWTH FACTOR; GRB2 ADAPTOR PROTEIN; HUMANS; MAP KINASE KINASE 4; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSCRIPTION FACTOR AP-1;

EID: 79959234101     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-12-0969     Document Type: Article

References (33)

1. Alan JK, Berzat AC, Dewar BJ, Graves LM, Cox AD (2010). Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src. Mol Cell Biol 30, 4324-4338.
2. Aspenström P, Fransson A, Saras J (2004). Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J 377, 327-337. (Pubitemid 38142188)
3. Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD (2005). Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxylterminal palmitoylation motif. J Biol Chem 280, 33055-33065. (Pubitemid 41368355)
4. Brady DC, Alan JK, Madigan JP, Fanning AS, Cox AD (2009). The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol 29, 1035-1049.
5. Brazier H, Pawlak G, Vives V, Blangy A (2009). The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. Int J Biochem Cell Biol 41, 1391-1401.
6. Brazier H, Stephens S, Ory S, Fort P, Morrison N, Blangy A (2006). Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. J Bone Miner Res 21, 1387-1398. (Pubitemid 44300045)
7. Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M (2007). The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. J Cell Sci 120, 1927-1934. (Pubitemid 46979784)
8. Fritz G, Kaina B (2006). Rho GTPases: promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 6, 1-14.
9. Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P (2000). Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19, 2930-2942. (Pubitemid 30389083)
10. Gomez TS et al. (2006). HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 24, 741-752. (Pubitemid 43867363)
11. Hamann MJ, Lubking CM, Luchini DN, Billadeau DD (2007). Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol 27, 380-393.
12. Jaffe AB, Hall A (2002). Rho GTPases in transformation and metastasis. Adv Cancer Res 84, 57-80. (Pubitemid 34188194)
13. Jaffe AB, Hall A (2005). Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21, 247-269. (Pubitemid 41740635)
14. Jiang X, Huang F, Marusyk A, Sorkin A (2003). Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell 14, 858-870. (Pubitemid 36337438)
15. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (1992). The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70, 431-442.
16. Nicholson RI, Gee JM, Harper ME (2001). EGFR and cancer prognosis. Eur J Cancer 37 (Suppl), S9-S15. (Pubitemid 32938124)
17. Nolz JC, Nacusi LP, Segovis CM, Medeiros RB, Mitchell JS, Shimizu Y, Billadeau DD (2008). The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell Biol 182, 1231-1244.
18. Ory S, Brazier H, Blangy A (2007). Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration. Biol Cell 99, 701-716. (Pubitemid 350201920)
19. Rossman KL, Der CJ, Sondek J (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6, 167-180. (Pubitemid 40215811)
20. Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D (1993). The SH2 and SH3 domains of mammalian GRB2 couple the EGF receptor to the Ras activator mSos1. Nature 363, 83-85. (Pubitemid 23144967)
21. Ruusala A, Aspenström P (2008). The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. Mol Cell Biol 28, 1802-1814.
22. Saras J, Wollberg P, Aspenström P (2004). Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects. Exp Cell Res 299, 356-369. (Pubitemid 39179803)
23. Schiavone D, Dewilde S, Vallania F, Turkson J, Di Cunto F, Poli V (2009). The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways. Biochem J 421, 283-292.
24. Shutes A, Berzat AC, Cox AD, Der CJ (2004). Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Curr Biol 14, 2052-2056. (Pubitemid 39547961)
25. Singh G, Singh SK, König A, Reutlinger K, Nye MD, Adhikary T, Eilers M, Gress TM, Fernandez-Zapico ME, Ellenrieder V (2010). Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J Biol Chem 285, 27241-27250.
26. Sorkin A, Goh LK (2009). Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res 315, 683-696.
27. Stähle M, Veit C, Bachfischer U, Schierling K, Skripczynski B, Hall A, Gierschik P, Giehl K (2003). J Cell Sci 116 (Pt 18), 3835-3846.
28. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001). Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15, 1796-1807. (Pubitemid 32905637)
29. Tcherkezian J, Lamarche-Vane N (2007). Current knowledge of the large RhoGAP family of proteins. Biol Cell 99, 67-86. (Pubitemid 46242033)
30. Yamazaki T, Zaal K, Hailey D, Presley J, Lippincot-Schwartz J, Samelson LE (2002). Role of Grb2 in EGF-stimulated EGFR internalization. J Cell Sci 115, 1791-1802. (Pubitemid 34567241)
31. Zhang JS, Gong A, Cheville JC, Smith DI, Young CY (2005). AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer 43, 249-259. (Pubitemid 40726870)
32. Zhang JS, Gong A, Young CY (2007). ZNF185, an actin-cytoskeleton- associated growth inhibitory LIM protein in prostate cancer. Oncogene 26, 111-122. (Pubitemid 46067336)
33. Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (2001). A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Mol Cell Biol 21, 5041-5049. (Pubitemid 32656401)