Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent

American Journal of Pathology

Volumn 178, Issue 5, 2011, Pages 2091-2099

  Kamsteeg, Marijke ^a   Bergers, Mieke ^a   De Boer, Roelie ^a   Zeeuwen, Patrick L J M ^a   Hato, Stanleyson V ^a   Schalkwijk, Joost ^a   Tjabringa, Geuranne S ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; ELAFIN; FAS ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4; STAT6 PROTEIN;

ADULT; APOPTOSIS; ARTICLE; ATOPIC DERMATITIS; CELL STIMULATION; CELL STRUCTURE; DNA FRAGMENTATION; ELECTRON MICROSCOPY; EPIDERMIS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MOLECULAR MECHANICS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TH2 CELL;

EID: 79959215052     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.01.037     Document Type: Article

References (44)

1. Bieber T: Atopic dermatitis. N Engl J Med 2008, 358:1483-1494
2. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002, 347:1151-1160
3. Zeeuwen PL, de Jongh GJ, Rodijk-Olthuis D, Kamsteeg M, Verhoosel RM, van Rossum MM, Hiemstra PS, Schalkwijk J: Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients. PLoS ONE 2008, 3:e2301
4. Elias PM, Schmuth M: Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2009, 9:437-446
5. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, Digiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006, 38:441-446
6. Brown SJ, McLean WH: Eczema genetics: current state of knowledge and future goals. J Invest Dermatol 2009, 129:543-552
7. Komatsu N, Saijoh K, Kuk C, Liu AC, Khan S, Shirasaki F, Takehara K, Diamandis EP: Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients. Exp Dermatol 2007, 16:513-519 (Pubitemid 46845395)
8. de Jongh GJ, Zeeuwen PL, Kucharekova M, Pfundt R, van der Valk PG, Blokx W, Dogan A, Hiemstra PS, van de Kerkhof PC, Schalkwijk J: High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 2005, 125:1163-1173
9. Werfel T: The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol 2009, 129:1878-1891
10. Nomura I, Gao B, Boguniewicz M, Darst MA, Travers JB, Leung DY: Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 2003, 112:1195-1202 (Pubitemid 37550015)
11. Kamsteeg M, Jansen PA, Vlijmen-Willems IM, van Erp PE, Rodijk- Olthuis D, van der Valk PG, Feuth T, Zeeuwen PL, Schalkwijk J: Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis. Br J Dermatol 2010, 162:568-578
12. Sly WS, Hu PY: Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem 1995, 64:375-401
13. Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E: Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. Genomics 1996, 38:273-276 (Pubitemid 27030114)
14. Aihara K, Kuroda S, Kanayama N, Matsuyama S, Tanizawa K, Horie M: A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Brain Res Mol Brain Res 2003, 116:86-93 (Pubitemid 36993700)
15. Kamsteeg M, Zeeuwen PL, de Jongh GJ, Rodijk-Olthuis D, Zeeuwen-Franssen ME, van Erp PE, Schalkwijk J: Increased expression of carbonic anhydrase II (CAII) in lesional skin of atopic dermatitis: regulation by Th2 cytokines. J Invest Dermatol 2007, 127:1786-1789 (Pubitemid 46933402)
16. Jin H, He R, Oyoshi M, Geha RS: Animal models of atopic dermatitis. J Invest Dermatol 2009, 129:31-40
17. Tjabringa G, Bergers M, van Rens D, de Boer R, Lamme E, Schalkwijk J: Development and validation of human psoriatic skin equivalents. Am J Pathol 2008, 173:815-823
18. Engelhart K, El Hindi T, Biesalski HK, Pfitzner I: In vitro reproduction of clinical hallmarks of eczematous dermatitis in organotypic skin models. Arch Dermatol Res 2005, 297:1-9
19. Zeeuwen PL, van Vlijmen-Willems IM, Jansen BJ, Sotiropoulou G, Curfs JH, Meis JF, Janssen JJ, van Ruissen F, Schalkwijk J: Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. J Invest Dermatol 2001, 116:693-701 (Pubitemid 32467647)
20. Minner F, Poumay Y: Candidate housekeeping genes require evaluation before their selection for studies of human epidermal keratinocytes. J Invest Dermatol 2009, 129:770-773
21. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408 (Pubitemid 34164012)
22. Trautmann A, Akdis M, Kleemann D, Altznauer F, Simon HU, Graeve T, Noll M, Brocker EB, Blaser K, Akdis CA: T cell-mediated Fasinduced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 2000, 106:25-35 (Pubitemid 30437237)
23. Muller KM, Jaunin F, Masouye I, Saurat JH, Hauser C: Th2 cells mediate IL-4-dependent local tissue inflammation. J Immunol 1993, 150:5576-5584 (Pubitemid 23180672)
24. Novak N, Bieber T: Allergic and nonallergic forms of atopic diseases. J Allergy Clin Immunol 2003, 112:252-262 (Pubitemid 36981361)
25. Grewe M, Walther S, Gyufko K, Czech W, Schopf E, Krutmann J: Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol 1995, 105:407-410
26. Leung DY, Bieber T: Atopic dermatitis. Lancet 2003, 361:151-160 (Pubitemid 36092023)
27. Junghans V, Jung T, Neumann C: Human keratinocytes constitutively express IL-4 receptor molecules and respond to IL-4 with an increase in B7/BB1 expression. Exp Dermatol 1996, 5:316-324 (Pubitemid 27060539)
28. Akaiwa M, Yu B, Umeshita-Suyama R, Terada N, Suto H, Koga T, Arima K, Matsushita S, Saito H, Ogawa H, Furue M, Hamasaki N, Ohshima K, Izuhara K: Localization of human interleukin 13 receptor in non-haematopoietic cells. Cytokine 2001, 13:75-84 (Pubitemid 32579312)
29. Ohtani T, Memezawa A, Okuyama R, Sayo T, Sugiyama Y, Inoue S, Aiba S: Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation. J Invest Dermatol 2009, 129:1412-1420
30. Kerstan A, Leverkus M, Trautmann A: Effector pathways during eczematous dermatitis: where inflammation meets cell death. Exp Dermatol 2009, 18:893-899
31. Trautmann A, Akdis M, Brocker EB, Blaser K, Akdis CA: New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis. Trends Immunol 2001, 22:530-532 (Pubitemid 33016388)
32. Trautmann A, Akdis M, Blaser K, Akdis CA: Role of dysregulated apoptosis in atopic dermatitis. Apoptosis 2000, 5:425-429 (Pubitemid 32162625)
33. Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch R, Brocker EB, Blaser K, Akdis CA: Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol 2001, 108:839-846 (Pubitemid 33096219)
34. McLaren JW: Measurement of aqueous humor flow. Exp Eye Res 2009, 88:641-647
35. Nelson BR, Claes K, Todd V, Chaverra M, Lefcort F: NELL2 promotes motor and sensory neuron differentiation and stimulates mitogenesis in DRG in vivo. Dev Biol 2004, 270:322-335 (Pubitemid 38748556)
36. Urashima R, Mihara M: Cutaneous nerves in atopic dermatitis: a histological, immunohistochemical and electron microscopic study. Virchows Arch 1998, 432:363-370 (Pubitemid 28171999)
37. Parsons WH, Sigal NH, Wyvratt MJ: FK-506: a novel immunosuppressant. Ann NY Acad Sci 1993, 685:22-36
38. Supuran CT: Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008, 7:168-181
39. Ballardini N, Johansson C, Lilja G, Lindh M, Linde Y, Scheynius A, Agerberth B: Enhanced expression of the antimicrobial peptide LL-37 in lesional skin of adults with atopic eczema. Br J Dermatol 2009, 161:40-47
40. Gambichler T, Skrygan M, Tomi NS, Othlinghaus N, Brockmeyer NH, Altmeyer P, Kreuter A: Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin. Int Arch Allergy Immunol 2008, 147:17-24
41. Harder J, Dressel S, Wittersheim M, Cordes J, Meyer-Hoffert U, Mrowietz U, Folster-Holst R, Proksch E, Schroder JM, Schwarz T, Glaser R: Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol 2010, 130:2138-2139
42. Boorsma DM, Flier J, Sampat S, Ottevanger C, de Haan P, Hooft L, Willemze R, Tensen CP, Stoof TJ: Chemokine IP-10 expression in cultured human keratinocytes. Arch Dermatol Res 1998, 290:335-341 (Pubitemid 28369391)
43. Mori T, Kabashima K, Yoshiki R, Sugita K, Shiraishi N, Onoue A, Kuroda E, Kobayashi M, Yamashita U, Tokura Y: Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated Langerhans cell Th2 chemokines. J Invest Dermatol 2008, 128:1719-1727 (Pubitemid 351847394)
44. Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, Bowman EP, Krueger JG: Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008, 128:1207-1211 (Pubitemid 351543220)