Measurement of aqueous humor flow

Experimental Eye Research

Volumn 88, Issue 4, 2009, Pages 641-647

  McLaren, Jay W ^a  

^a MAYO CLINIC   (United States)

Author keywords

aqueous dynamics; aqueous humor flow; fluorescein; glaucoma; intraocular pressure

Indexed keywords

ACETAZOLAMIDE; ADRENALIN; APRACLONIDINE; BETAXOLOL; BIMATOPROST; BRINZOLAMIDE; CLONIDINE; DORZOLAMIDE; IBOPAMINE; ISOPRENALINE; LATANOPROST; LEVOBUNOLOL; MELATONIN; PILOCARPINE; PROSTAGLANDIN F2 ALPHA ISOPROPYL ESTER; SALBUTAMOL; SCOPOLAMINE; TERBUTALINE; TIMOLOL; TRAVOPROST; VASOPRESSIN;

AQUEOUS HUMOR FLOW; AQUEOUS HUMOR FORMATION; EYE; FLOW RATE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; PRIORITY JOURNAL; REVIEW; WAKEFULNESS;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; AQUEOUS HUMOR; CARBONIC ANHYDRASE INHIBITORS; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE;

EID: 64249164638     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.10.018     Document Type: Review

References (103)

1. Alm A., and Villumsen J. PhXA34, a new potent ocular hypotensive drug. A study on dose-response relationship and on aqueous humor dynamics in healthy volunteers. Arch. Ophthalmol. 109 (1991) 1564-1568
2. Araie M., and Takase M. Effects of pilocarpine and carteolol, a new beta-adrenergic blocking agent on human aqueous humor dynamics. (author's transl). Nippon Ganka Gakkai Zasshi 84 (1980) 2085-2091
3. Becker B. Diamox and the therapy of glaucoma. Am. J. Ophthalmol. 38 (1954) 109-111
4. Becker B. The measurement of rate of aqueous flow with iodide. Invest. Ophthalmol. 1 (1962) 52-58
5. Breinin G.M., and Gortz H. Carbonic anhydrase inhibitor acetazoleamide (diamox); a new approach to the therapy of glaucoma. Arch. Ophthalmol. 52 (1954) 333-348
6. Brimijoin M.R., Larsson L.I., Arnce R., and Brubaker R.F. The scopolamine dermal patch and its effect on intraocular pressure and aqueous humor flow. J. Glaucoma 2 (1993) 203-205
7. Brown J.D., and Brubaker R.F. A study of the relation between intraocular pressure and aqueous humor flow in the pigment dispersion syndrome. Ophthalmology 96 (1989) 1468-1470
8. Brubaker R.F. Clinical measuerments of aqueous dynamics: implications for addressing glaucoma. In: Civan M.M. (Ed). The Eye's Aqueous Humor. From Secretion to Glaucoma (1998), Academic Press, San Diego
9. Brubaker R.F., Carlson K.H., Kullerstrand L.J., and McLaren J.W. Topical forskolin (colforsin) and aqueous flow in humans. Arch. Ophthalmol. 105 (1987) 637-641
10. Brubaker R.F., Nagataki S., Townsend D.J., Burns R.R., Higgins R.G., and Wentworth W. The effect of age on aqueous humor formation in man. Ophthalmology 88 (1981) 283-288
11. Brubaker R.F., Schoff E.O., Nau C.B., Carpenter S.P., Chen K., and Vandenburgh A.M. Effects of AGN 192024, a new ocular hypotensive agent, on aqueous dynamics. Am. J. Ophthalmol. 131 (2001) 19-24
12. Camras C.B., Podos S.M., Rosenthal J.S., Lee P.Y., and Severin C.H. Multiple dosing of prostaglandin F2 alpha or epinephrine on cynomolgus monkey eyes. I. Aqueous humor dynamics. Invest. Ophthalmol. Vis. Sci. 28 (1987) 463-469
13. Carlson K.H., Bourne W.M., and Brubaker R.F. Effect of long-term contact lens wear on corneal endothelial cell morphology and function. Invest. Ophthalmol. Vis. Sci. 29 (1988) 185-193
14. Carlson K.H., McLaren J.W., Topper J.E., and Brubaker R.F. Effect of body position on intraocular pressure and aqueous flow. Invest. Ophthalmol. Vis. Sci. 28 (1987) 1346-1352
15. Coakes R.L., and Brubaker R.F. The mechanism of timolol in lowering intraocular pressure. In the normal eye. Arch. Ophthalmol. 96 (1978) 2045-2048
16. Coakes R.L., and Siah P.B. Effects of adrenergic drugs on aqueous humour dynamics in the normal human eye. I. Salbutamol. Br. J. Ophthalmol. 68 (1984) 393-397
17. Coulangeon L.M., Sole M., Menerath J.M., and Sole P. Aqueous humor flow measured by fluorophotometry. A comparative study of the effect of various beta-blocker eyedrops in patients with ocular hypertension. Ophtalmologie 4 (1990) 156-161
18. Crawford K., Kaufman P.L., and Gabelt B.T. Effects of topical PGF2 alpha on aqueous humor dynamics in cynomolgus monkeys. Curr. Eye Res. 6 (1987) 1035-1044
19. Dailey R.A., Brubaker R.F., and Bourne W.M. The effects of timolol maleate and acetazolamide on the rate of aqueous formation in normal human subjects. Am. J. Ophthalmol. 93 (1982) 232-237
20. Erickson-Lamy K. The perfused human ocular anterior segment as a model for aqueous outflow physiology. J. Glaucoma 1 (1992) 44-53
21. Gabelt B.T., and Kaufman P.L. Prostaglandin F2 alpha increases uveoscleral outflow in the cynomolgus monkey. Exp. Eye Res. 49 (1989) 389-402
22. Gaul G.R., Will N.J., and Brubaker R.F. Comparison of a noncardioselective beta-adrenoceptor blocker and a cardioselective blocker in reducing aqueous flow in humans. Arch. Ophthalmol. 107 (1989) 1308-1311
23. Gharagozloo N.Z., Baker R.H., and Brubaker R.F. Aqueous dynamics in exfoliation syndrome. Am. J. Ophthalmol. 114 (1992) 473-478
24. Gharagozloo N.Z., Larson R.S., Kullerstrand L.J., and Brubaker R.F. Terbutaline stimulates aqueous humor flow in humans during sleep. Arch. Ophthalmol. 106 (1988) 1218-1220
25. Gharagozloo N.Z., Relf S.J., and Brubaker R.F. Aqueous flow is reduced by the alpha-adrenergic agonist, apraclonidine hydrochloride (ALO 2145). Ophthalmology 95 (1988) 1217-1220
26. Goldmann H. Abflussdruch, minutenvolumen und Widerstand der Kammerwasser Stromung des Menschen. Doc. Ophthalmol. 5 (1951) 278-356
27. Hayashi M., Yablonski M.E., and Bito L.Z. Eicosanoids as a new class of ocular hypotensive agents. 2. Comparison of the apparent mechanism of the ocular hypotensive effects of A and F type prostaglandins. Invest. Ophthalmol. Vis. Sci. 28 (1987) 1639-1643
28. Hayashi M., Yablonski M.E., Boxrud C., Fong N., Berger C., and Jovanovic L.J. Decreased formation of aqueous humour in insulin-dependent diabetic patients. Br. J. Ophthalmol. 73 (1989) 621-623
29. Holm O. A photogrammetric method for estimation of the pupillary aqueous flow in the living human eye, I. Acta Ophthalmol. 46 (1968) 254-277
30. Holm O., and Krakau C.E. A method of measuring pupillary aqueous flow. Acta Ophthalmol. 46 (1968) 558-563
31. Holm O., and Wiebert O. A photogrammetric method for estimation of the pupillary aqueous flow in the living human eye. II. Statistical evaluation of pupillary flow measurements. Acta Ophthalmol. 46 (1968) 1230-1242
32. Jacob E., FitzSimon J.S., and Brubaker R.F. Combined corticosteroid and catecholamine stimulation of aqueous humor flow. Ophthalmology 103 (1996) 1303-1308
33. Johnson D., Liesegang T.J., and Brubaker R.F. Aqueous humor dynamics in Fuchs' uveitis syndrome. Am. J. Ophthalmol. 95 (1983) 783-787
34. Johnson D.H. Trabecular meshwork and uveoscleral outflow models. J. Glaucoma 14 (2005) 308-310
35. Johnson D.H., and Brubaker R.F. Dynamics of aqueous humor in the syndrome of exfoliation with glaucoma. Am. J. Ophthalmol. 93 (1982) 629-634
36. Johnson D.H., and Tschumper R.C. Human trabecular meshwork organ culture. A new method. Invest. Ophthalmol. Vis. Sci. 28 (1987) 945-953
37. Johnson T.V., Fan S., Camras C.B., and Toris C.B. Aqueous humor dynamics in exfoliation syndrome. Arch. Ophthalmol. 126 (2008) 914-920
38. Jones R.F., and Maurice D.M. New methods of measuring the rate of aqueous flow in man with fluorescein. Exp. Eye Res. 5 (1966) 208-220
39. Kacere R.D., Dolan J.W., and Brubaker R.F. Intravenous epinephrine stimulates aqueous formation in the human eye. Invest. Ophthalmol. Vis. Sci. 33 (1992) 2861-2865
40. Kaplan B.H., Kalina P.H., Larsson L.I., Pach J.M., and Brubaker R.F. Aqueous humor flow in unilateral carotid stenosis. J. Glaucoma 5 (1996) 237-240
41. Katz I.M., Hubbard W.A., Getson A.J., and Gould A.L. Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Invest. Ophthalmol. 15 (1976) 489-492
42. Kerstetter J.R., Brubaker R.F., Wilson S.E., and Kullerstrand L.J. Prostaglandin F2 alpha-1-isopropylester lowers intraocular pressure without decreasing aqueous humor flow. Am. J. Ophthalmol. 105 (1988) 30-34
43. Khan A.R., and Brubaker R.F. Aqueous humor flow and flare in patients with myotonic dystrophy. Invest. Ophthalmol. Vis. Sci. 34 (1993) 3131-3139
44. Koskela T., and Brubaker R.F. Apraclonidine and timolol. Combined effects in previously untreated normal subjects. Arch. Ophthalmol 109 (1991) 804-806
45. Koskela T., and Brubaker R.F. The nocturnal suppression of aqueous humor flow in humans is not blocked by bright light. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2504-2506
46. Lane J.T., Toris C.B., Nakhle S.N., Chacko D.M., Wang Y.L., and Yablonski M.E. Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes. Am. J. Ophthalmol. 132 (2001) 321-327
47. Langham M., and Wybar K.C. Fluorophotometric apparatus for the objective determination of fluorescence in the anterior chamber of the living eye. Br. J. Ophthalmol. 38 (1954) 52-57
48. Langham M.E., and Wybar K.C. A fluorophotometer for the study of intra-ocular dynamics in the living animal. J. Physiol. (Lond) 120 (1953) 5-6
49. Langley D., and MacDonald R.K. Clinical method of observing changes in the rate of flow of aqueous humor in the human eye: I. Normal eyes. Br. J. Ophthalmol. 36 (1952) 432-437
50. Larson R.S., and Brubaker R.F. Isoproterenol stimulates aqueous flow in humans with Horner's syndrome. Invest. Ophthalmol. Vis. Sci. 29 (1988) 621-625
51. Larsson L.I., Pach J.M., and Brubaker R.F. Aqueous humor dynamics in patients with diabetes mellitus. Am. J. Ophthalmol. 120 (1995) 362-367
52. Larsson L.I., Rettig E.S., and Brubaker R.F. Aqueous flow in open-angle glaucoma. Arch. Ophthalmol. 113 (1995) 283-286
53. Larsson L.I., Rettig E.S., Sheridan P.T., and Brubaker R.F. Aqueous humor dynamics in low-tension glaucoma. Am. J. Ophthalmol. 116 (1993) 590-593
54. Lee D.A., Brubaker R.F., and Nagataki S. Acute effect of thymoxamine on aqueous humor formation in the epinephrine-treated normal eye as measured by fluorophotometry. Invest. Ophthalmol. Vis. Sci. 24 (1983) 165-168
55. Lee D.A., Topper J.E., and Brubaker R.F. Effect of clonidine on aqueous humor flow in normal human eyes. Exp. Eye Res. 38 (1984) 239-246
56. Lim K.S., Nau C.B., O'Byrne M.M., Hodge D.O., Toris C.B., McLaren J.W., and Johnson D.H. Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology 115 (2008) 790-795
57. Linden C., and Alm A. Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes. Acta Ophthalmol. Scand. 75 (1997) 412-415
58. Makabe R. Ophthalmological studies with dichlorophenylaminoimidazoline with special regard to its effect on intraocular pressure. Dtsch. Med. Wochenschr. 91 (1966) 1686-1688
59. Maurice D.M. A new objective fluorophotometer. Exp. Eye Res. 2 (1963) 33-38
60. Maus T.L., and Brubaker R.F. Measurement of aqueous humor flow by fluorophotometry in the presence of a dilated pupil. Invest. Ophthalmol. Vis. Sci. 40 (1999) 542-546
61. Maus T.L., Larsson L.I., McLaren J.W., and Brubaker R.F. Comparison of dorzolamide and acetazolamide as suppressors of aqueous humor flow in humans. Arch. Ophthalmol. 115 (1997) 45-49
62. Maus T.L., McLaren J.W., Shepard Jr. J.W., and Brubaker R.F. The effects of sleep on circulating catecholamines and aqueous flow in human subjects. Exp. Eye Res. 62 (1996) 351-358
63. Maus T.L., Nau C., and Brubaker R.F. Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents. Arch. Ophthalmol. 117 (1999) 586-591
64. Maus T.L., Young Jr. W.F., and Brubaker R.F. Aqueous flow in humans after adrenalectomy. Invest. Ophthalmol. Vis. Sci. 35 (1994) 3325-3331
65. McCannel C.A., Heinrich S.R., and Brubaker R.F. Acetazolamide but not timolol lowers aqueous humor flow in sleeping humans. Graefes Arch. Clin. Exp. Ophthalmol. 230 (1992) 518-520
66. McLaren J.W., and Brubaker R.F. A two-dimensional scanning ocular fluorophotometer. Invest. Ophthalmol. Vis. Sci. 26 (1985) 144-152
67. McLaren J.W., and Brubaker R.F. Measurement of fluorescein and fluorescein monoglucuronide in the living human eye. Invest. Ophthalmol. Vis. Sci. 27 (1986) 966-974
68. McLaren J.W., Herman D.C., Brubaker R.F., Nau C.B., Wayman L.L., Ciarniello M.G., Rosignoli M.T., and Dionisio P. Effect of ibopamine on aqueous humor production in normotensive humans. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4853-4858
69. Mishima H.K., Kiuchi Y., Takamatsu M., Racz P., and Bito L.Z. Circadian intraocular pressure management with latanoprost: diurnal and nocturnal intraocular pressure reduction and increased uveoscleral outflow. Surv. Ophthalmol. 41 Suppl. 2 (1997) S139-144
70. Mori M., Sakurai M., and Araie M. Effect of topical epinephrine on permeability of blood-aqueous barrier in human eyes. Jpn. J. Ophthalmol. 36 (1992) 342-347
71. Nagataki S. Aqueous humor dynamics of human eyes as studied using fluorescein. Jpn. J. Ophthalmol. 19 (1975) 235-249
72. Nagataki S., and Brubaker R.F. Early effect of epinephrine on aqueous formation in the normal human eye. Ophthalmology 88 (1981) 278-282
73. Nagataki S., and Brubaker R.F. Effect of pilocarpine on aqueous humor formation in human beings. Arch. Ophthalmol. 100 (1982) 818-821
74. Nilsson S.F., Samuelsson M., Bill A., and Stjernschantz J. Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-1-isopropylester in the cynomolgus monkey. Exp. Eye Res. 48 (1989) 707-716
75. O'Rourke J., and Macri F.J. Studies in uveal physiology. II. Clinical studies of the anterior chamber clearance of isotopic tracers. Arch. Ophthalmol. 84 (1970) 415-420
76. Pang I.H., McCartney M.D., Steely H.T., and Clark A.F. Human ocular perfusion organ culture: a versatile ex vivo model for glaucoma research. J. Glaucoma 9 (2000) 468-479
77. Phillips C.I., Howitt G., and Rowlands D.J. Propranolol as ocular hypotensive agent. Br. J. Ophthalmol. 51 (1967) 222-226
78. Reiss G.R., and Brubaker R.F. The mechanism of betaxolol, a new ocular hypotensive agent. Ophthalmology 90 (1983) 1369-1372
79. Reiss G.R., Lee D.A., Topper J.E., and Brubaker R.F. Aqueous humor flow during sleep. Invest. Ophthalmol. Vis. Sci. 25 (1984) 776-778
80. Rettig E.S., Larsson L.I., and Brubaker R.F. The effect of topical timolol on epinephrine-stimulated aqueous humor flow in sleeping humans. Invest. Ophthalmol. Vis. Sci. 35 (1994) 554-559
81. Sakurai M., Araie M., Oshika T., Mori M., Shoji N., and Masuda K. Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit. Jpn. J. Ophthalmol. 37 (1993) 252-258
82. Schadlu R., Maus T.L., Nau C.B., and Brubaker R.F. Comparison of the efficacy of apraclonidine and brimonidine as aqueous suppressants in humans. Arch. Ophthalmol. 116 (1998) 1441-1444
83. Schenker H.I., Yablonski M.E., Podos S.M., and Linder L. Fluorophotometric study of epinephrine and timolol in human subjects. Arch. Ophthalmol. 99 (1981) 1212-1216
84. Schneider T.L., and Brubaker R.F. Effect of chronic epinephrine on aqueous humor flow during the day and during sleep in normal healthy subjects. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2507-2510
85. Tetsuka H., Tsuchisaka H., Kin K., Takahashi Y., and Takase M. A mechanism for reducing intraocular pressure in normal volunteers using UF-021, a prostaglandin-related compound. Nippon Ganka Gakkai Zasshi 96 (1992) 496-500
86. Topper J.E., and Brubaker R.F. Effects of timolol, epinephrine, and acetazolamide on aqueous flow during sleep. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1315-1319
87. Toris C.B., Camras C.B., and Yablonski M.E. Effects of PhXA41, a new prostaglandin F2 alpha analog, on aqueous humor dynamics in human eyes. Ophthalmology 100 (1993) 1297-1304
88. Toris C.B., Koepsell S.A., Yablonski M.E., and Camras C.B. Aqueous humor dynamics in ocular hypertensive patients. J. Glaucoma 11 (2002) 253-258
89. Toris C.B., Zhan G., Fan S., Dickerson J.E., Landry T.A., Bergamini M.V.W., and Camras C.B. Effects of travoprost on aqueous humor dynamics in patients with elevated intraocular pressure. J. Glaucoma 16 (2007) 189-195
90. Townsend D.J., and Brubaker R.F. Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry. Invest. Ophthalmol. Vis. Sci. 19 (1980) 256-266
91. Vale J., Gibbs A.C., and Phillips C.I. Topical propranolol and ocular tension in the human. Br. J. Ophthalmol. 56 (1972) 770-775
92. Vanlandingham B.D., FitzSimon J.S., and Brubaker R.F. Aqueous humor flow in sleeping humans is unaffected by norepinephrine infusion. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1759-1762
93. Vanlandingham B.D., Maus T.L., and Brubaker R.F. The effect of dorzolamide on aqueous humor dynamics in normal human subjects during sleep. Ophthalmology 105 (1998) 1537-1540
94. Viggiano S.R., Abboud C.F., and Brubaker R.F. Effect of desmopressin on aqueous humor flow in humans. Am. J. Ophthalmol. 115 (1993) 511-516
95. Viggiano S.R., Koskela T.K., Klee G.G., Samples J.R., Arnce R., and Brubaker R.F. The effect of melatonin on aqueous humor flow in humans during the day. Ophthalmology 101 (1994) 326-331
96. Villumsen J., and Alm A. Prostaglandin F2 alpha-isopropylester eye drops: effects in normal human eyes. Br. J. Ophthalmol. 73 (1989) 419-426
97. Walker S.D., Brubaker R.F., and Nagataki S. Hypotony and aqueous humor dynamics in myotonic dystrophy. Invest. Ophthalmol. Vis. Sci. 22 (1982) 744-751
98. Wang Y.-L., Hayashi M., Yablonski M.E., and Toris C.B. Effects of multiple dosing of epinephrine on aqueous humor dynamics in human eyes. J. Ocul. Pharmacol. Ther. 18 (2002) 53-63
99. Wentworth W.O., and Brubaker R.F. Aqueous humor dynamics in a series of patients with third neuron Horner's syndrome. Am. J. Ophthalmol. 92 (1981) 407-415
100. Wilson S.E., Bourne W.M., O'Brien P.C., and Brubaker R.F. Endothelial function and aqueous humor flow rate in patients with Fuchs' dystrophy. Am. J. Ophthalmol. 106 (1988) 270-278
101. Yablonski M.E., Zimmerman T.J., Waltman S.R., and Becker B. A fluorophotometric study of the effect of topical timolol on aqueous humor dynamics. Exp. Eye Res. 27 (1978) 135-142
102. Ziai N., Dolan J.W., Kacere R.D., and Brubaker R.F. The effects on aqueous dynamics of PhXA41, a new prostaglandin F2 alpha analogue, after topical application in normal and ocular hypertensive human eyes. Arch. Ophthalmol. 111 (1993) 1351-1358
103. Ziai N., Ory S.J., Khan A.R., and Brubaker R.F. Beta-human chorionic gonadotropin, progesterone, and aqueous dynamics during pregnancy. Arch. Ophthalmol. 112 (1994) 801-806