Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice

Journal of Lipid Research

Volumn 52, Issue 7, 2011, Pages 1373-1382

  Thabuis, Clémentine ^a,b   Destaillats, Frédéric ^c   Lambert, Didier M ^d   Muccioli, Giulio G ^c,d   Maillot, Matthieu ^a,b   Harach, Touafiq ^c   Tissot Favre, Delphine ^c   Martin, Jean Charles ^a,b  

^a INSERM   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Endocannabinoid; Indirect calorimetry; Nutrigenomics; PLS

Indexed keywords

ENDOCANNABINOID; HYDROLASE; KDS 5104; N OLEOYLETHANOLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIC INTAKE; CD36 GENE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE COMPARISON; ENERGY EXPENDITURE; FAT GENE; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; HYDROLYSIS; LIPID DIET; LIPID STORAGE; LIPID TRANSPORT; LIPOGENESIS; LONG TERM CARE; MALE; MARKER GENE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ADIPOSE TISSUE; ADIPOSITY; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; BODY WEIGHT; DIETARY FATS; DIETARY SUPPLEMENTS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; OLEIC ACIDS;

EID: 79959214149     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M013391     Document Type: Article

References (30)

1. Bisogno, T., I. Delton-Vandenbroucke, A. Milone, M. Lagarde, and V. Di Marzo. 1999. Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. Arch. Biochem. Biophys. 370: 300-307.
2. Yang, Y., M. Chen, K. E. Georgeson, and C. M. Harmon. 2007. Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292: R235-R241.
3. Sun, Y. X., K. Tsuboi, L. Y. Zhao, Y. Okamoto, D. M. Lambert, and N. Ueda. 2005. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochim. Biophys. Acta. 1736: 211-220.
4. Fegley, D., S. Gaetani, A. Duranti, A. Tontini, M. Mor, G. Tarzia, and D. Piomelli. 2005. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J. Pharmacol. Exp. Ther. 313: 352-358.
5. Thabuis, C., D. Tissot-Favre, J. B. Bezelgues, J. C. Martin, C. Cruz-Hernandez, F. Dionisi, and F. Destaillats. 2008. Biological functions and metabolism of oleoylethanolamide. Lipids. 43: 887-894.
6. Lo Verme, J., S. Gaetani, J. Fu, F. Oveisi, K. Burton, and D. Piomelli. 2005. Regulation of food intake by oleoylethanolamide. Cell. Mol. Life Sci. 62: 708-716.
7. Rodriguez de Fonseca, F., M. Navarro, R. Gomez, L. Escuredo, F. Nava, J. Fu, E. Murillo-Rodriguez, A. Giuffrida, J. LoVerme, S. Gaetani, et al. 2001. An anorexic lipid mediator regulated by feeding. Nature. 414: 209-212. (Pubitemid 33051235)
8. Fu, J., S. Gaetani, F. Oveisi, J. Lo Verme, A. Serrano, F. Rodriguez de Fonseca, A. Rosengarth, H. Luecke, B. Di Giacomo, G. Tarzia, et al. 2003. Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-. Nature. 425: 90-93. (Pubitemid 37101723)
9. Fu, J., F. Oveisi, S. Gaetani, E. Lin, and D. Piomelli. 2005. Oleoylethanolamide, an endogenous PPAR-[alpha] agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 48: 1147-1153. (Pubitemid 40725987)
10. Desvergne, B., and W. Wahli. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20: 649-688.
11. Guzman, M., J. Lo Verme, J. Fu, F. Oveisi, C. Blazquez, and D. Piomelli. 2004. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J. Biol. Chem. 279: 27849-27854. (Pubitemid 38900052)
12. Diep, T. A., A. N. Madsen, B. Holst, M. M. Kristiansen, N. Wellner, S. H. Hansen, and H. S. Hansen. 2011. Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor. FASEB J. 25: 765-774.
13. Thabuis, C., F. Destaillats, J. F. Landrier, D. Tissot-Favre, and J. C. Martin. 2010. Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice. J. Nutr. Biochem. 21: 922-928.
14. Navarro, V., M. P. Portillo, A. Margotat, J. F. Landrier, M. T. Macarulla, D. Lairon, and J. C. Martin. 2009. A multi-gene analysis strategy identifies metabolic pathways targeted by trans-10, cis-12-conjugated linoleic acid in the liver of hamsters. Br. J. Nutr. 102: 537-545.
15. Oltvai, Z. N., and A. L. Barabasi. 2002. Systems biology. Life's complexity pyramid. Science. 298: 763-764.
16. Kleemann, R., M. van Erk, L. Verschuren, A. M. van den Hoek, M. Koek, P. Y. Wielinga, A. Jie, L. Pellis, I. Bobeldijk-Pastorova, T. Kelder, et al. 2010. Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance. PLoS ONE. 5: e8817.
17. Wold, S., N. Kettaneh, and K. Tjessem. 1996. Hierarchical multiblock PLS and PC models for easier model interpretation and as an alternative to variable selection. J. Chemom. 10: 463-482. (Pubitemid 126465332)
18. Shannon, P., A. Markiel, O. Ozier, N. S. Baliga, J. T. Wang, D. Ramage, N. Amin, B. Schwikowski, and T. Ideker. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13: 2498-2504.
19. Astarita, G., B. Di Giacomo, S. Gaetani, F. Oveisi, T. R. Compton, S. Rivara, G. Tarzia, M. Mor, and D. Piomelli. 2006. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J. Pharmacol. Exp. Ther. 318: 563-570.
20. Terpstra, A. H. M. 2001. Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J. Nutr. 131: 2067-2068. (Pubitemid 32661081)
21. McGarry, J. D., and D. W. Foster. 1980. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49: 395-420.
22. Kotz, C. M., J. A. Teske, and C. J. Billington. 2008. Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R699-R710.
23. Cani, P. D., M. L. Montoya, A. M. Neyrinck, N. M. Delzenne, and D. M. Lambert. 2004. Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br. J. Nutr. 92: 757-761. (Pubitemid 39562153)
24. Nielsen, M. J., G. Petersen, A. Astrup, and H. S. Hansen. 2004. Food intake is inhibited by oral oleoylethanolamide. J. Lipid Res. 45: 1027-1029.
25. Popeijus, H. E., W. H. Saris, and R. P. Mensink. 2008. Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome. Int. J. Obes. (Lond). 32: 1076-1082.
26. Ntambi, J. M., M. Miyazaki, J. P. Stoehr, H. Lan, C. M. Kendziorski, B. S. Yandell, Y. Song, P. Cohen, J. M. Friedman, and A. D. Attie. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. U S A. 99: 11482-11486.
27. Terrazzino, S., F. Berto, M. Dalle Carbonare, M. Fabris, A. Guiotto, D. Bernardini, and A. Leon. 2004. Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression. FASEB J. 18: 1580-1582. (Pubitemid 39561639)
28. Serrano, A., I. Del Arco, F. Javier Pavon, M. Macias, V. Perez-Valero, and F. Rodriguez de Fonseca. 2008. The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats. Neuropharmacology. 54: 226-234.
29. Miyazaki, M., Y. C. Kim, and J. M. Ntambi. 2001. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 42: 1018-1024.
30. Van Wymelbeke, V., J. Louis-Sylvestre, and M. Fantino. 2001. Substrate oxidation and control of food intake in men after a fat-substitute meal compared with meals supplemented with an isoenergetic load of carbohydrate, long-chain triacylglycerols, or medium-chain triacylglycerols. Am. J. Clin. Nutr. 74: 620-630.