Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension

Journal of Heart and Lung Transplantation

Volumn 30, Issue 7, 2011, Pages 827-833

  Choudhary, Gaurav ^a,b   Troncales, Frederick ^a,b   Martin, Douglas ^a,b   Harrington, Elizabeth O ^a,b   Klinger, James R ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

chronic hypoxia; endothelin; endothelin receptor blocker; protein kinase C; pulmonary hypertension; right ventricle

Indexed keywords

BOSENTAN; COLLAGEN; ENDOTHELIN 1; ISOPROTEIN; PROCOLLAGEN; PROCOLLAGEN 1; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARDIOPULMONARY HEMODYNAMICS; COLORIMETRY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISEASE MODEL; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; HEART MUSCLE FIBROSIS; HEART OUTPUT; HEART RIGHT ATRIUM PRESSURE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE OUTFLOW TRACT; HEART RIGHT VENTRICLE PRESSURE; HEART RIGHT VENTRICLE SYSTOLIC PRESSURE; HEART STROKE VOLUME; HYPOXIA; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; THERAPY EFFECT;

ANIMALS; ANOXIA; ANTIHYPERTENSIVE AGENTS; COLLAGEN; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; FIBROSIS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; MYOCARDIUM; PROTEIN ISOFORMS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; SIGNAL TRANSDUCTION; SULFONAMIDES; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 79959194250     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2011.03.010     Document Type: Article

References (36)

1. A. Giaid, M. Yanagisawa, and D. Langleben Expression of endothelin-1 in the lungs of patients with pulmonary hypertension N Engl J Med 328 1993 1732 1739 (Pubitemid 23170122)
2. N. Galie, A. Manes, and A. Branzi The endothelin system in pulmonary arterial hypertension Cardiovasc Res 61 2004 227 237 (Pubitemid 38091763)
3. G.R. Lee, D. Bell, and E.J. Kelso Evidence for altered ETB receptor characteristics during development and progression of ventricular cardiomyocyte hypertrophy Am J Physiol Heart Circ Physiol 287 2004 H425 H432
4. D. Hayashi, S. Kudoh, and I. Shiojima Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1 Biochem Biophys Res Commun 322 2004 310 319 (Pubitemid 39093871)
5. Y. Xia, and M. Karmazyn Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation J Pharmacol Exp Ther 310 2004 43 51 (Pubitemid 38812693)
6. M.U. Braun, P. Szalai, and R.H. Strasser Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes Cardiovasc Res 59 2003 658 667 (Pubitemid 38368682)
7. S.J. Chen, Y.F. Chen, and Q.C. Meng Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats J Appl Physiol 79 1995 2122 2131
8. N.S. Hill, R.R. Warburton, and L. Pietras Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats J Appl Physiol 83 1997 1209 1215 (Pubitemid 27433089)
9. P.H. Sugden Signalling pathways in cardiac myocyte hypertrophy Ann Med 33 2001 611 622 (Pubitemid 34081499)
10. T.G. Parker Molecular biology of cardiac growth and hypertrophy Herz 18 1993 245 255 (Pubitemid 23256875)
11. I. Komuro, Y. Katoh, and T. Kaida Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes Possible role of protein kinase C activation J Biol Chem 266 1991 1265 1268 (Pubitemid 21907253)
12. K. Obara, S. Hata, and K. Sato Contractile potentiation by endothelin-1 involves protein kinase C-delta activity in the porcine coronary artery Jpn J Physiol 49 1999 175 183 (Pubitemid 29318588)
13. A. Clerk, M.A. Bogoyevitch, and M.B. Anderson Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts J Biol Chem 269 1994 32848 32857
14. T. Markou, C.S. Yong, and P.H. Sugden Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes J Biol Chem 281 2006 8321 8331 (Pubitemid 43847932)
15. M. Uenoyama, S. Ogata, and K. Nakanishi Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats Acta Physiol (Oxf) 198 2010 431 440
16. R.J. Phillips, M.D. Burdick, and K. Hong Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis J Clin Invest 114 2004 438 446 (Pubitemid 39071616)
17. E.C. Miner, and W.L. Miller A look between the cardiomyocytes: the extracellular matrix in heart failure Mayo Clin Proc 81 2006 71 76 (Pubitemid 43054320)
18. H. Ito, Y. Hirata, and S. Adachi Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes J Clin Invest 92 1993 398 403 (Pubitemid 23209021)
19. L. Piacentini, M. Gray, and N.Y. Honbo Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C J Mol Cell Cardiol 32 2000 565 576 (Pubitemid 30658926)
20. M. Clozel, V. Breu, and G.A. Gray Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist J Pharmacol Exp Ther 270 1994 228 235 (Pubitemid 24229632)
21. H.C. Thomas, M.W. Lame, and S.K. Dunston Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells Toxicol Appl Pharmacol 151 1998 236 244 (Pubitemid 128421787)
22. H.C. Rosenberg, and M. Rabinovitch Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension Am J Physiol 255 1988 H1484 H1491
23. T. Sugita, T.M. Hyers, and I.M. Dauber Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats J Appl Physiol 54 1983 371 374 (Pubitemid 13153511)
24. H. Kimura, Y. Kasahara, and K. Kurosu Alleviation of monocrotaline- induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 Lab Invest 78 1998 571 581 (Pubitemid 28246981)
25. A.E. Schultze, and R.A. Roth Fibrinolytic activity in blood and lungs of rats treated with monocrotaline pyrrole Toxicol Appl Pharmacol 121 1993 129 137 (Pubitemid 23221282)
26. K.R. Stenmark, B. Meyrick, and N. Galie Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure Am J Physiol Lung Cell Mol Physiol 297 2009 L1013 L1032
27. D.J. Prockop, K.I. Kivirikko, and L. Tuderman The biosynthesis of collagen and its disorders (first of two parts) N Engl J Med 301 1979 13 23 (Pubitemid 9226521)
28. K. Riches, M.E. Morley, and N.A. Turner Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts J Mol Cell Cardiol 47 2009 391 399
29. M.E. Morley, K. Riches, and C. Peers Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling Biochem Soc Trans 35 2007 905 907 (Pubitemid 350206392)
30. S. Hafizi, J. Wharton, and A.H. Chester Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts Cell Physiol Biochem 14 2004 285 292 (Pubitemid 39179197)
31. S.F. Steinberg Structural basis of protein kinase C isoform function Physiol Rev 88 2008 1341 1378
32. J. Jiang, V. Yuen, and H. Xiang Improvement in cardiac function of diabetic rats by bosentan is not associated with changes in the activation of PKC isoforms Mol Cell Biochem 282 2006 177 185 (Pubitemid 43019476)
33. T. Inoguchi, R. Battan, and E. Handler Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation Proc Natl Acad Sci USA 89 1992 11059 11063
34. T. Jiang, E. Pak, and H.L. Zhang Endothelin-dependent actions in cultured AT-1 cardiac myocytes The role of the epsilon isoform of protein kinase C Circ Res 78 1996 724 736 (Pubitemid 26106885)
35. M.A. Bogoyevitch, P.J. Parker, and P.H. Sugden Characterization of protein kinase C isotype expression in adult rat heart Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin Circ Res 72 1993 757 767 (Pubitemid 23077766)
36. Y. Takeishi, P. Ping, and R. Bolli Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy Circ Res 86 2000 1218 1223 (Pubitemid 30436661)