Strategies for the enzymatic enrichment of PUFA from fish oil

European Journal of Lipid Science and Technology

Volumn 113, Issue 6, 2011, Pages 717-723

  Mbatia, Betty ^a,b   Mattiasson, Bo ^a   Mulaa, Francis ^b   Adlercreutz, Patrick ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

DHA; EPA; Esterification; Hydrolysis; Lipase specificity

Indexed keywords

BURKHOLDERIA CEPACIA; LATES NILOTICUS; THERMOMYCES LANUGINOSUS;

EID: 79958847512     PISSN: 14387697     EISSN: 14389312     Source Type: Journal    
DOI: 10.1002/ejlt.201000560     Document Type: Article

References (34)

1. Gámez-Meza, N., Higuera-Ciapara, I., Calderon, A. M., de la Barca, L., et al. Seasonal variation in the fatty acid composition and quality of sardine oil from Sardinops sagax caeruleus of the Gulf of California. Lipids 1999, 34, 639-642.
2. Williams, C. M., Burdge, G., Long-chain n-3 PUFA: Plant v. marine sources. Proc. Nutr. Soc. 2006, 65, 42-50.
3. Ackman, R. G., Ratnayake, W. M. N., Olsson, B., The basic fatty-acid composition of atlantic fish oils-potential similarities useful for enrichment of polyunsatuarted fatty-acids by urea complexation. J. Am. Oil Chem. 1988, 65, 136-138.
4. Wanasundara, U. N., Shahidi, F., Concentration of omega 3-polyunsaturated fatty acids of seal blubber oil by urea complexation: Optimization of reaction conditions. Food Chem. 1999, 65, 41-49.
5. Mukherjee, K. D., Kiewitt, I., Hills, M. J., Substrate specificities of lipases in view of kinetic resolution of unsaturated fatty acids. Appl. Microbiol. Biotechnol. 1993, 40, 489-493.
6. Okada, T., Morrissey, M. T., Production of n-3 polyunsaturated fatty acid concentrate from sardine oil by immobilized Candida rugosa lipase. J. Am. Oil Chem. 2008, 73, C146-C150.
7. Lyberg, A. M., Adlercreutz, P., Lipase specificity towards eicosapentaenoic acid and docosahexaenoic acid depends on substrate structure. Biochim. Biophys. Acta 2008, 1784, 343-350.
8. Carvalho, P., Campos, P., Noffs, M., Fregolente, P., Fregolente, L., Enzymatic hydrolysis of salmon oil by native lipases: Optimization of process parameters. J. Br. Chem. Soc. 2009, 20, 117-124.
9. Lyberg, A. M., Adlercreutz, P., Lipase-catalysed enrichment of DHA and EPA in acylglycerols resulting from squid oil ethanolysis. Eur. J. Lipid Sci. Technol. 2008, 110, 317-324.
10. Haraldsson, G. G., Kristinsson, B., Sigurdardottir, R., Gudmundsson, G. G., Breivik, H., The preparation of concentrates of eicosapentaenoic acid and docosahexaenoic acid by lipase-catalyzed transesterification of fish oil with ethanol. J. Am. Oil Chem. 1997, 74, 1419-1424.
11. Tanaka, Y., Funada, T., Hirano, J., Hashizume, R., Triglyceride specificity of Candida cylindracea lipase-effect of docosahexaenoic acid on resistance of triglycerides to lipase. J. Am. Oil Chem. 1993, 70, 1031-1034.
12. Mbatia, B., Adlercreutz, P., Mulaa, F., Mattiasson, B., Enzymatic enrichment of n-3 polyunsaturated fatty acids in Nile perch (Lates niloticus) viscera oil. Eur. J. Lipid Sci. Technol. 2010, 112, 977-984.
13. Hoshino, T., Yamane, T., Shimizu, S., Bioreactor for enzymatic-reaction of fat and fatty-acid derivatives. 12. selective hydrolysis of fish oil by lipase to concentrate n-3 polyunsaturated fatty-acids. Agric. Biol. Chem. 1990, 54, 1459-1467.
14. Wanasundara, U. N., Shahidi, F., Lipase-assisted concentration of n-3 polyunsaturated fatty acids in acylglycerols from marine oils. J. Am. Oil Chem. Soc. 1998, 75, 945-951.
15. Tanaka, Y., Hirano, J., Funada, T., Concentration of docosahexaenoic acid in glyceride by hydrolysis of fish oil with Candida cylindricae lipase. J. Am. Oil Chem. Soc. 1992, 69, 1210-1214.
16. Halldorsson, A., Kristinsson, B., Glynm, C., Haraldsson, G. G., Separation of EPA and DHA in fish oil by lipase-catalyzed esterification with glycerol. J. Am. Oil Chem. Soc. 2003, 80, 915-921.
17. Shimada, Y., Maruyama, K., Sugihara, A., Moriyama, S., Tominaga, Y., Purification of docosahexaenoic acid from tuna oil by a two-step enzymatic method: Hydrolysis and selective esterification. J. Am. Oil Chem. Soc. 1997, 74, 1441-1446.
18. Rakshit, S. K., Vasuhi, R., Kosugi, Y., Enrichment of polyunsaturated fatty acids from tuna oil using immobilized Pseudomonas fluorescens lipase. Bioprocess Eng. 2000, 23, 251-255.
19. Shimada, Y., Sugihara, A., Yodono, S., Nagao, T., et al. Enrichment of ethyl docosahexaenoate by selective alcoholysis with immobilized Rhizopus delemar lipase. J. Ferment. Bioeng. 1997, 84, 138-143.
20. Lee, C. H., Parkin, K. L., Comparative fatty acid selectivity of lipases in esterification reactions with glycerol and diol analogues in organic media. Biotechnol Prog. 2000, 16, 372-377.
21. Halldorsson, A., Kristinsson, B., Haraldsson, G. G., Lipase selectivity toward fatty acids commonly found in fish oil. Eur. J. Lipid Sci. Technol. 2004, 106, 79-87.
22. Mbatia, B., Adlercreutz, D., Adlercreutz, P., Mahadhy, A., et al. Enzymatic oil extraction and positional analysis of omega-3 fatty acids in Nile perch and salmon heads. Process Biochem. 2010, 45, 815-819.
23. Haraldsson, G. G., Kristinson, B., Separation of eicosapentaenoic acid and docosahexaenoic acid in fish oil by kinetic resolution using lipase. J. Am. Oil Chem. Soc. 1998, 75, 1551-1556.
24. Ahmed, S., Reddy, K., Swathy, S., Singh, S., et al. Enrichment of gamma-linolenic acid in the lipid extracted from Mucor zychae MTCC 5420. Food Res. Int. 2009, 42, 449-453.
25. Persson, M., Mladenoska, I., Wehtje, E., Adlercreutz, P., Preparation of lipases for use in organic solvents. Enzyme Microb. Technol. 2002, 31, 833-841.
26. Gitlesen, T., Bauer, M., Adlercreutz, P., Adsorption of lipase on polypropylene powder. Biochim. Biophys. Acta 1997, 1345, 188-196.
27. Bradford, M., A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
28. Christie, W. W., Han, X., Lipid Analysis: Isolation, Separation, Identification and Lipidomic Analysis, 4th Edn. The Oily Press, England 2010, 189-192.
29. Ahuja, S., Derivatisation in GC. J. Pharm. Sci. 1976, 65, 163-165.
30. Alltech ELSD. 2000, Evaporative Light Scattering Detector Operating Manual. 2002.
31. Svensson, J., Adlercreutz, P., Identification of triacylglycerols in the enzymatic transesterification of rapeseed and butter oil. Eur. J. Lipid Sci. Technol. 2008, 110, 1007-1014.
32. Fajardo, A., Cerdán, L., Medina, A., Martínez, M., et al. Concentration of eicosapentaenoic acid by selective esterification using lipases. J. Am. Oil Chem. Soc. 2006, 73, 215-221.
33. Christie, W. W., in: Hamilton, R. J., Rossell, J. B. (Eds.), Analysis of Oils and Fats, Elsevier, London 1986, pp. 313-339.
34. Sonnet, P., Gazzillo, J., Evaluation of lipase selectivity for hydrolysis. J. Am. Oil Chem. Soc. 1991, 68, 11-15.