CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1

Journal of Neurochemistry

Volumn 118, Issue 1, 2011, Pages 93-104

  Fields, Jerel ^a   Gardner Mercer, Jessica ^b   Borgmann, Kathleen ^a   Clark, Ian ^c   Ghorpade, Anuja ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

astrocyte and neuroinflammation; CCAAT enhancer binding protein ; human immunodeficiency virus 1 associated dementia; tissue inhibitor of metalloproteinase 1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 1BETA; ISOPROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RNA ISOLATION; VIRUS ENCEPHALITIS;

ANALYSIS OF VARIANCE; ASTROCYTES; BRAIN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FETUS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV INFECTIONS; HIV-1; HUMANS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; TETRAZOLIUM SALTS; THIAZOLES; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS 1; RODENTIA;

EID: 79958825362     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07203.x     Document Type: Article

References (55)

1. Abraham J., Jang S., Godbout J. P., Chen J., Kelley K. W., Dantzer R., and, Johnson R. W., (2006) Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120. Neurobiol. Aging 29, 614-621. (Pubitemid 351312817)
2. Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., Nakajima T., Hirano T., and, Kishimoto T., (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9, 1897-1906.
3. Alberini C. M., Ghirardi M., Metz R., and, Kandel E. R., (1994) C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell 76, 1099-1114.
4. Albertini J. J., Sujka S. K., Helal M. A., Seigne J. D., and, Lockhart J. L., (1998) Adenocarcinoma in a continent colonic urinary reservoir. Urology 51, 499-500. (Pubitemid 28136696)
5. Borjabad A., Brooks A. I., and, Volsky D. J., (2009) Gene expression profiles of HIV-1-infected glia and brain: toward better understanding of the role of astrocytes in HIV-1-associated neurocognitive disorders. J. Neuroimmune Pharmacol. 5, 44-62.
6. Brambilla R., Bracchi-Ricard V., Hu W. H., Frydel B., Bramwell A., Karmally S., Green E. J., and, Bethea J. R., (2005) Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J. Exp. Med. 202, 145-156. (Pubitemid 41002917)
7. Brambilla R., Persaud T., and, Hu X., et al. (2009) Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J. Immunol. 182, 2628-2640.
8. Bugno M., Witek B., Bereta J., Bereta M., Edwards D. R., and, Kordula T., (1999) Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines. FEBS Lett. 448, 9-14. (Pubitemid 29151620)
9. Cardinaux J. R., Allaman I., and, Magistretti P. J., (2000) Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytes. Glia 29, 91-97. (Pubitemid 30031137)
10. Chaillan F. A., Rivera S., Marchetti E., Jourquin J., Werb Z., Soloway P. D., Khrestchatisky M., and, Roman F. S., (2006) Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behav. Brain Res. 173, 191-198. (Pubitemid 44308496)
11. Chen C., Chai H., and, Wang X., et al. (2008) Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood 112, 3205-3216.
12. Clark I. M., Rowan A. D., Edwards D. R., Bech-Hansen T., Mann D. A., Bahr M. J., and, Cawston T. E., (1997) Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochem. J. 324 (Pt 2), 611-617. (Pubitemid 27268009)
13. Cortes-Canteli M., Wagner M., Ansorge W., and, Perez-Castillo A., (2004) Microarray analysis supports a role for ccaat/enhancer-binding protein-beta in brain injury. J. Biol. Chem. 279, 14409-14417. (Pubitemid 38468983)
14. Crocker S., Whitmire J., Frausto R., Chertboonmuang P., Soloway P., Whitton J., and, Campbell I., (2006) Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am. J. Pathol. 169, 2104-2116. (Pubitemid 351181970)
15. Dean G., and, Clark I. M., (1999) Transcriptional regulation of the human tissue inhibitor of metalloproteinases-1: mapping transcriptional control in intron-1. Ann. NY Acad. Sci. 878, 510-511. (Pubitemid 29353597)
16. Dean G., Young D. A., Edwards D. R., and, Clark I. M., (2000) The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1. J. Biol. Chem. 275, 32664-32671.
17. Dhar A., Gardner J., Borgmann K., Wu L., and, Ghorpade A., (2006) Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation. J. Neurosci. Res. 83, 1271-1280. (Pubitemid 43668010)
18. Ejarque-Ortiz A., Medina M. G., Tusell J. M., Perez-Gonzalez A. P., Serratosa J., and, Saura J., (2007) Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microglia. Glia 55, 178-188. (Pubitemid 46036464)
19. Fassina G., Ferrari N., Brigati C., Benelli R., Santi L., Noonan D. M., and, Albini A., (2000) Tissue inhibitors of metalloproteases: regulation and biological activities. Clin. Exp. Metastasis 18, 111-120. (Pubitemid 32165244)
20. Faulkner J. R., Herrmann J. E., Woo M. J., Tansey K. E., Doan N. B., and, Sofroniew M. V., (2004) Reactive astrocytes protect tissue and preserve function after spinal cord injury. J. Neurosci. 24, 2143-2155. (Pubitemid 38314546)
21. Ferrari C. C., Depino A. M., Prada F., Muraro N., Campbell S., Podhajcer O., Perry V. H., Anthony D. C., and, Pitossi F. J., (2004) Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. Am. J. Pathol. 165, 1827-1837. (Pubitemid 39435180)
22. Ferrari C. C., Pott Godoy M. C., Tarelli R., Chertoff M., Depino A. M., and, Pitossi F. J., (2006) Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol. Dis. 24, 183-193. (Pubitemid 44437611)
23. Gardner J., and, Ghorpade A., (2003) Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. J. Neurosci. Res. 74, 801-806. (Pubitemid 37490412)
24. Gardner J., Borgmann K., Deshpande M. S., Dhar A., Wu L., Persidsky R., and, Ghorpade A., (2006) Potential mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases. J. Neurosci. Res. 83, 1281-1292. (Pubitemid 43668011)
25. Gris P., Tighe A., Levin D., Sharma R., and, Brown A., (2007) Transcriptional regulation of scar gene expression in primary astrocytes. Glia 55, 1145-1155. (Pubitemid 47204206)
26. Heales S. J., Lam A. A., Duncan A. J., and, Land J. M., (2004) Neurodegeneration or neuroprotection: the pivotal role of astrocytes. Neurochem. Res. 29, 513-519. (Pubitemid 38295002)
27. Herrmann J. E., Imura T., and, Song B., et al. (2008) STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 28, 7231-7243.
28. Hornebeck W., (2003) Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol. Biol. (Paris) 51, 569-573. (Pubitemid 37466375)
29. Jaworski D. M., (2000) Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Glia 30, 199-208. (Pubitemid 30199433)
30. Jourquin J., Tremblay E., and, Bernard A., et al. (2005) Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. Eur. J. Neurosci. 22, 2569-2578. (Pubitemid 41758999)
31. La Fleur M., Underwood J. L., Rappolee D. A., and, Werb Z., (1996) Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. J. Exp. Med. 184, 2311-2326. (Pubitemid 27023731)
32. Laird M. D., Vender J. R., and, Dhandapani K. M., (2008) Opposing roles for reactive astrocytes following traumatic brain injury. Neurosignals 16, 154-164. (Pubitemid 351263222)
33. Lindl K. A., Marks D. R., Kolson D. L., and, Jordan-Sciutto K. L., (2010) HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities. J. Neuroimmune Pharmacol. 5, 294-309.
34. Liu J., Zhao M.-L., Brosnan C. F., and, Lee S. C., (1996) Expression of type II nitric oxide synthase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist. J. Immunol., 157, 3569-3576. (Pubitemid 126449171)
35. Lorenzl S., Albers D. S., Narr S., Chirichigno J., and, Beal M. F., (2002) Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease. Exp. Neurol. 178, 13-20. (Pubitemid 35425605)
36. Lorenzl S., Albers D. S., LeWitt P. A., Chirichigno J. W., Hilgenberg S. L., Cudkowicz M. E., and, Beal M. F., (2003) Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. J. Neurol. Sci. 207, 71-76. (Pubitemid 36292132)
37. Lorenzl S., Buerger K., Hampel H., and, Beal M. F., (2008) Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia. Int. Psychogeriatr. 20, 67-76. (Pubitemid 350256061)
38. Manthrope M., Fagnani R., Skaper S. D., and, Varon S., (1986) An automated colorimetric microassay for neurotrophic factors. Dev. Brain Res. 25, 191-198. (Pubitemid 16188172)
39. Menard C., Hein P., and, Paquin A., et al. (2002) An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron 36, 597-610. (Pubitemid 35346754)
40. Nadeau S., Hein P., Fernandes K. J., Peterson A. C., and, Miller F. D., (2005) A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Mol. Cell. Neurosci. 29, 525-535. (Pubitemid 40984694)
41. Oberheim N. A., Takano T., and, Han X., et al. (2009) Uniquely hominid features of adult human astrocytes. J. Neurosci. 29, 3276-3287.
42. Ould-yahoui A., Tremblay E., and, Sbai O., et al. (2009) A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons. PLoS ONE 4, e8289.
43. Pagenstecher A., Stalder A. K., Kincaid C. L., Shapiro S. D., and, Campbell I. L., (1998) Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. Am. J. Pathol. 152, 729-741. (Pubitemid 28110720)
44. Panenka W., Jijon H., Herx L. M., Armstrong J. N., Feighan D., Wei T., Yong V. W., Ransohoff R. M., and, MacVicar B. A., (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J. Neurosci. 21, 7135-7142. (Pubitemid 32846961)
45. Phillips B. W., Sharma R., Leco P. A., and, Edwards D. R., (1999) A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene. J. Biol. Chem. 274, 22197-22207.
46. Rivera S., Tremblay E., Timsit S., Canals O., Ben-Ari Y., and, Khrestchatisky M., (1997) Tissue inhibitor of metalloproteinases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: evidence for developmental, immediate early gene, and lesion response. J. Neurosci. 17, 4223-4235. (Pubitemid 27220613)
47. Sandhir R., and, Berman N. E., (2010) Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Neurochem. Int. 56, 188-193.
48. Sears R. C., and, Sealy L., (1994) Multiple forms of C/EBP beta bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol. Cell. Biol. 14, 4855-4871. (Pubitemid 24196835)
49. Sofroniew M. V., (2005) Reactive astrocytes in neural repair and protection. Neuroscientist 11, 400-407. (Pubitemid 41339226)
50. Sofroniew M. V., and, Vinters H. V., (2010) Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35.
51. Sterneck E., and, Johnson P. F., (1998) CCAAT/enhancer binding protein beta is a neuronal transcriptional regulator activated by nerve growth factor receptor signaling. J. Neurochem. 70, 2424-2433. (Pubitemid 28252368)
52. Suryadevara R., Holter S., Borgmann K., Persidsky R., Labenz-Zink C., Persidsky Y., Gendelman H. E., Wu L., and, Ghorpade A., (2003) Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Glia 44, 47-56. (Pubitemid 37176319)
53. Yadav A., and, Collman R. G., (2009) CNS inflammation and macrophage/microglial biology associated with HIV-1 infection. J. Neuroimmune Pharmacol. 4, 430-447.
54. Yong V. W., Krekoski C. A., Forsyth P. A., Bell R., and, Edwards D. R., (1998) Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 21, 75-80.
55. +/calmodulin kinases activation in hippocampal neurons. J. Biol. Chem. 273, 31345-31351. (Pubitemid 28533151)