Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction

Biochemistry

Volumn 50, Issue 23, 2011, Pages 5322-5332

  Hubmacher, Dirk ^a   Sabatier, Laetitia ^a   Annis, Douglas S ^b   Mosher, Deane F ^b   Reinhardt, Dieter P ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ELEVATED LEVEL; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PROTEIN; EXTRACELLULAR PROTEINS; FIBRILLIN-1; FUNCTIONAL PROPERTIES; GENETIC DISORDERS; HOMOCYSTEINES; LONG BONE; MARFAN SYNDROME; MATRIX; OCULAR SYMPTOMS; PROTEOLYTIC FRAGMENTS; STRUCTURAL CHANGE; WESTERN BLOTTING;

DIMERS; MONOCLONAL ANTIBODIES; POLYSACCHARIDES; TISSUE;

CELL CULTURE;

CELL PROTEIN; FIBRILLIN 1; FIBRONECTIN; HEPARIN; HEPARIN BINDING PROTEIN; HOMOCYSTEINE; MONOCLONAL ANTIBODY;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYSTEINYLATION; DIMERIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMOCYSTEINYLATION; HOMOCYSTINURIA; HUMAN; HUMAN CELL; MARFAN SYNDROME; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; WESTERN BLOTTING;

FIBROBLASTS; FIBRONECTINS; HOMOCYSTEINE; HUMANS; MICROFILAMENT PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958819483     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200183z     Document Type: Article

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