메뉴 건너뛰기




Volumn , Issue , 2007, Pages 269-294

Hepatocellular carcinoma: Molecular aspects in hepatitis B

Author keywords

Diabetes mellitus; HBV genome; Hepadnaviruses; Hepatitis B virus (HBV); Hepatocellular carcinoma (HCC)

Indexed keywords


EID: 79958793216     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470987131.ch17     Document Type: Chapter
Times cited : (2)

References (334)
  • 1
    • 84919580033 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22, 707 men in Taiwan
    • Beasley RP, Lin CC, Hwang LY, Chien CS. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22, 707 men in Taiwan. Lancet 1981;2:1129-33.
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Lin, C.C.2    Hwang, L.Y.3    Chien, C.S.4
  • 2
    • 0017796073 scopus 로고
    • Hepatocellular carcinoma and the hepatitis B virus: Evidence for a causal association
    • Szmuness W. Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol 1978;24:40-69.
    • (1978) Prog Med Virol , vol.24 , pp. 40-69
    • Szmuness, W.1
  • 4
    • 0026701093 scopus 로고
    • Hepatitis B viruses and hepatocellular carcinoma
    • Buendia MA. Hepatitis B viruses and hepatocellular carcinoma. Adv Cancer Res 1992;59:167-226.
    • (1992) Adv Cancer Res , vol.59 , pp. 167-226
    • Buendia, M.A.1
  • 6
    • 0024818649 scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
    • Chisari FV, Klopchin K, Moriyama T et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 1989;59:1145-56.
    • (1989) Cell , vol.59 , pp. 1145-1156
    • Chisari, F.V.1    Klopchin, K.2    Moriyama, T.3
  • 7
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim CM, Koike K, Saito I, Miyamura T, Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991;351:317-20.
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 8
    • 0022547592 scopus 로고
    • Hepatitis B virus DNA integration in a sequence homologous to v-erbA and steroid receptor genes in a hepatocellular carcinoma
    • Dejean A, Bougueleret L, Grzeschik KH, Tiollais P. Hepatitis B virus DNA integration in a sequence homologous to v-erbA and steroid receptor genes in a hepatocellular carcinoma. Nature 1986;322:70-2.
    • (1986) Nature , vol.322 , pp. 70-72
    • Dejean, A.1    Bougueleret, L.2    Grzeschik, K.H.3    Tiollais, P.4
  • 9
    • 0028096101 scopus 로고
    • Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line
    • Graef E, Caselmann WH, Wells J, Koshy R. Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line. Oncogene 1994;9:81-7.
    • (1994) Oncogene , vol.9 , pp. 81-87
    • Graef, E.1    Caselmann, W.H.2    Wells, J.3    Koshy, R.4
  • 10
    • 0025022001 scopus 로고
    • Hepatitis B virus integration in a cyclin A gene in a human hepatocellular carcinoma
    • Wang J, Chenivesse X, Henglein B, Bréchot C. Hepatitis B virus integration in a cyclin A gene in a human hepatocellular carcinoma. Nature 1990;343:555-7.
    • (1990) Nature , vol.343 , pp. 555-557
    • Wang, J.1    Chenivesse, X.2    Henglein, B.3    Bréchot, C.4
  • 11
    • 0035959742 scopus 로고    scopus 로고
    • Identification of human cancer-related genes by naturally occurring hepatitis B virus DNA tagging
    • Gozuacik D, Murakami Y, Saigo K et al. Identification of human cancer-related genes by naturally occurring hepatitis B virus DNA tagging. Oncogene 2001;20:6233-40.
    • (2001) Oncogene , vol.20 , pp. 6233-6240
    • Gozuacik, D.1    Murakami, Y.2    Saigo, K.3
  • 12
    • 0037663314 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    • Paterlini-Brechot P, Saigo K, Murakami Y et al. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 2003;22:3911-16.
    • (2003) Oncogene , vol.22 , pp. 3911-3916
    • Paterlini-Brechot, P.1    Saigo, K.2    Murakami, Y.3
  • 13
    • 0024160809 scopus 로고
    • Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma
    • Hsu TY, Möröy T, Etiemble J et al. Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell 1988;55:627-35.
    • (1988) Cell , vol.55 , pp. 627-635
    • Hsu, T.Y.1    Möröy, T.2    Etiemble, J.3
  • 15
    • 0036278326 scopus 로고    scopus 로고
    • Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex
    • Bergametti F, Sitterlin D, Transy C. Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex. J Virol 2002;76:6495-501.
    • (2002) J Virol , vol.76 , pp. 6495-6501
    • Bergametti, F.1    Sitterlin, D.2    Transy, C.3
  • 16
    • 0026793219 scopus 로고
    • Hepadnavirus integration: Mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors
    • Wei Y, Fourel G, Ponzetto A, Silvestro M, Tiollais P, Buendia MA. Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol 1992;66:5265-76.
    • (1992) J Virol , vol.66 , pp. 5265-5276
    • Wei, Y.1    Fourel, G.2    Ponzetto, A.3    Silvestro, M.4    Tiollais, P.5    Buendia, M.A.6
  • 17
    • 0025167175 scopus 로고
    • Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours
    • Fourel G, Trépo C, Bougueleret L et al. Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature 1990;347:294-8.
    • (1990) Nature , vol.347 , pp. 294-298
    • Fourel, G.1    Trépo, C.2    Bougueleret, L.3
  • 18
    • 0026517303 scopus 로고
    • Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus
    • Transy C, Fourel G, Robinson WS, Tiollais P, Marion PL, Buendia MA. Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus. Proc Natl Acad Sci USA 1992;89:3874-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3874-3878
    • Transy, C.1    Fourel, G.2    Robinson, W.S.3    Tiollais, P.4    Marion, P.L.5    Buendia, M.A.6
  • 19
    • 0030007645 scopus 로고    scopus 로고
    • A new hepadnavirus endemic in arctic ground squirrels in Alaska
    • Testut P, Renard CA, Terradillos O et al. A new hepadnavirus endemic in arctic ground squirrels in Alaska. J Virol 1996;70:4210-19.
    • (1996) J Virol , vol.70 , pp. 4210-4219
    • Testut, P.1    Renard, C.A.2    Terradillos, O.3
  • 20
    • 0025886914 scopus 로고
    • Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population
    • Tanaka K, Hirohata S, Koga S et al. Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population. Cancer Res 1991;51:2842-7.
    • (1991) Cancer Res , vol.51 , pp. 2842-2847
    • Tanaka, K.1    Hirohata, S.2    Koga, S.3
  • 21
    • 0037446291 scopus 로고    scopus 로고
    • Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: A prospective study of 12, 008 men in Taiwan
    • Sun CA, Wu DM, Lin CC et al. Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12, 008 men in Taiwan. Am J Epidemiol 2003;157:674-82
    • (2003) Am J Epidemiol , vol.157 , pp. 674-682
    • Sun, C.A.1    Wu, D.M.2    Lin, C.C.3
  • 22
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999;340:745-50.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 23
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001;37(Suppl. 8)):S4-S66.
    • (2001) Eur J Cancer , vol.37 , pp. S4-S66
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 24
    • 0347885319 scopus 로고    scopus 로고
    • Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000
    • Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ. Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer 2002;2:37.
    • (2002) BMC Cancer , vol.2 , pp. 37
    • Shibuya, K.1    Mathers, C.D.2    Boschi-Pinto, C.3    Lopez, A.D.4    Murray, C.J.5
  • 25
    • 0001889861 scopus 로고    scopus 로고
    • Hepatitis B virus
    • Fields BN, Knipe DM, Howley PM, eds., Philadelphia: Lippincott-Raven
    • Hollinger FB. Hepatitis B virus. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott-Raven, 1996:2738-808.
    • (1996) Fields Virology , pp. 2738-2808
    • Hollinger, F.B.1
  • 26
    • 0010326278 scopus 로고
    • Strongly supported features of the association between hepatitis B virus and hepatocellular carcinoma
    • Tabor E. Strongly supported features of the association between hepatitis B virus and hepatocellular carcinoma. Adv Appl Biotechnol Ser 1991;13:107-18.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 107-118
    • Tabor, E.1
  • 27
    • 0002247314 scopus 로고
    • Hepatocellular carcinoma in the world:Epidemiologic questions
    • Bosch FX, Munòz N. Hepatocellular carcinoma in the world:epidemiologic questions. Adv Appl Biotechnol Ser 1991;13:35-56.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 35-56
    • Bosch, F.X.1    Munòz, N.2
  • 28
    • 0032145740 scopus 로고    scopus 로고
    • Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: Results of a European concerted action
    • Bréchot C, Jaffredo F, Lagorce D et al. Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action. J Hepatol 1998;29:173-83.
    • (1998) J Hepatol , vol.29 , pp. 173-183
    • Bréchot, C.1    Jaffredo, F.2    Lagorce, D.3
  • 29
    • 0036829556 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus
    • Hassan MM, Hwang LY, Hatten CJ et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology 2002;36:1206-13.
    • (2002) Hepatology , vol.36 , pp. 1206-1213
    • Hassan, M.M.1    Hwang, L.Y.2    Hatten, C.J.3
  • 30
    • 0023933449 scopus 로고
    • Hepatitis B virus- the major etiology of hepatocellular carcinoma
    • Beasley RP. Hepatitis B virus- the major etiology of hepatocellular carcinoma. Cancer 1988;61:1942-56.
    • (1988) Cancer , vol.61 , pp. 1942-1956
    • Beasley, R.P.1
  • 31
    • 0002336833 scopus 로고
    • Role of cirrhosis and the development of HCC: Evidence from histologic studies and large population studies
    • Craig JR, Klatt EC, Yu M. Role of cirrhosis and the development of HCC: evidence from histologic studies and large population studies. Adv Appl Biotechnol Ser 1991;13:177-90.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 177-190
    • Craig, J.R.1    Klatt, E.C.2    Yu, M.3
  • 32
    • 0002694077 scopus 로고
    • Role of cirrhosis in hepatocarcinogenesis
    • Bannasch P, Keppler D, Weber G, eds., Dordrecht, The Netherlands: Kluwer Academic Publishers
    • Kew MC. Role of cirrhosis in hepatocarcinogenesis. In: Bannasch P, Keppler D, Weber G, eds. Liver Cell Carcinoma. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1989:37-45.
    • (1989) Liver Cell Carcinoma , pp. 37-45
    • Kew, M.C.1
  • 33
    • 0037446291 scopus 로고    scopus 로고
    • Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: A prospective study of 12, 008 men in Taiwan
    • Sun CA, Wu DM, Lin CC et al. Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12, 008 men in Taiwan. Am J Epidemiol 2003;157:674-82.
    • (2003) Am J Epidemiol , vol.157 , pp. 674-682
    • Sun, C.A.1    Wu, D.M.2    Lin, C.C.3
  • 34
    • 0021210486 scopus 로고
    • A prospective cohort study of hepatitis B surface antigen carriers in a working population
    • Iijima T, Saitoh N, Nobutomo K, Nambu M, Sakuma K. A prospective cohort study of hepatitis B surface antigen carriers in a working population. Gann 1984;75:571-3.
    • (1984) Gann , vol.75 , pp. 571-573
    • Iijima, T.1    Saitoh, N.2    Nobutomo, K.3    Nambu, M.4    Sakuma, K.5
  • 35
    • 84991176704 scopus 로고
    • Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma
    • Chen CJ, Liang KY, Chang AS et al. Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma. Hepatology 1991;13:398-406.
    • (1991) Hepatology , vol.13 , pp. 398-406
    • Chen, C.J.1    Liang, K.Y.2    Chang, A.S.3
  • 36
    • 0025881161 scopus 로고
    • Morbidity and mortality from chronic hepatitis B virus infection in family members of patients with malignant and non-malignant hepatitis B virus-related chronic liver diseases
    • Lok ASF, Lai CL, Chung H, Lau JYN, Leung EKY, Wong LSK. Morbidity and mortality from chronic hepatitis B virus infection in family members of patients with malignant and non-malignant hepatitis B virus-related chronic liver diseases. Hepatology 1991;13:834-7.
    • (1991) Hepatology , vol.13 , pp. 834-837
    • Lok, A.S.F.1    Lai, C.L.2    Chung, H.3    Lau, J.Y.N.4    Leung, E.K.Y.5    Wong, L.S.K.6
  • 37
    • 84984555343 scopus 로고    scopus 로고
    • Hepatitis B e antigen and the risk of hepatocellular carcinoma
    • Yang HI, Lu SN, Liaw YF et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002;347:168-74.
    • (2002) N Engl J Med , vol.347 , pp. 168-174
    • Yang, H.I.1    Lu, S.N.2    Liaw, Y.F.3
  • 38
    • 0021136243 scopus 로고
    • Fraternal hepatocellular carcinoma in young children in two families
    • Chang MH, Hsu C, Lee CY, Chen DS, Lee CH, Lin KS. Fraternal hepatocellular carcinoma in young children in two families. Cancer 1984;53:1807-10.
    • (1984) Cancer , vol.53 , pp. 1807-1810
    • Chang, M.H.1    Hsu, C.2    Lee, C.Y.3    Chen, D.S.4    Lee, C.H.5    Lin, K.S.6
  • 39
    • 0024550770 scopus 로고
    • Hepatitis B virus, aflatoxins and hepatocellular carcinoma in southern Guangxi, China
    • Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE. Hepatitis B virus, aflatoxins and hepatocellular carcinoma in southern Guangxi, China. Cancer Res 1989;49:2506-9.
    • (1989) Cancer Res , vol.49 , pp. 2506-2509
    • Yeh, F.S.1    Yu, M.C.2    Mo, C.C.3    Luo, S.4    Tong, M.J.5    Henderson, B.E.6
  • 40
    • 0036828782 scopus 로고    scopus 로고
    • Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China
    • Ming L, Thorgeirsson SS, Gail MH et al. Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology 2002;36:1214-20.
    • (2002) Hepatology , vol.36 , pp. 1214-1220
    • Ming, L.1    Thorgeirsson, S.S.2    Gail, M.H.3
  • 41
    • 0002107570 scopus 로고
    • The role of tobacco use and alcohol consumption in the etiology of hepatocellular carcinoma
    • Austin H. The role of tobacco use and alcohol consumption in the etiology of hepatocellular carcinoma. Adv Appl Biotechnol Ser 1991;13:57-76.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 57-76
    • Austin, H.1
  • 42
    • 0021997214 scopus 로고
    • Hepatitis B virus DNA in patients with chronic liver disease and negative test for hepatitis B surface antigen
    • Bréchot C, Degos F, Lugassy C et al. Hepatitis B virus DNA in patients with chronic liver disease and negative test for hepatitis B surface antigen. N Engl J Med 1985;312:270-6.
    • (1985) N Engl J Med , vol.312 , pp. 270-276
    • Bréchot, C.1    Degos, F.2    Lugassy, C.3
  • 43
    • 0025744345 scopus 로고
    • Different types of chronic hepatitis in alcoholic patients:Does chronic hepatitis induced by alcohol exist?
    • Takase S, Takada N, Enomoto N, Yasuhara M, Takada A. Different types of chronic hepatitis in alcoholic patients:does chronic hepatitis induced by alcohol exist? Hepatology 1991;13:876-81.
    • (1991) Hepatology , vol.13 , pp. 876-881
    • Takase, S.1    Takada, N.2    Enomoto, N.3    Yasuhara, M.4    Takada, A.5
  • 44
    • 0029947938 scopus 로고    scopus 로고
    • The role of previous hepatitis B virus infection and heavy smoking in hepatitis C virus-related hepatocellular carcinoma
    • Chiba T, Matsuzaki Y, Abei M et al. The role of previous hepatitis B virus infection and heavy smoking in hepatitis C virus-related hepatocellular carcinoma. Am J Gastroenterol 1996;91:1195-203.
    • (1996) Am J Gastroenterol , vol.91 , pp. 1195-1203
    • Chiba, T.1    Matsuzaki, Y.2    Abei, M.3
  • 45
    • 0034881446 scopus 로고    scopus 로고
    • The role of diabetes in hepatocellular carcinoma: A case-control study among United States Veterans
    • El-Serag HB, Richardson PA, Everhart JE. The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans. Am J Gastroenterol 2001;96:2462-7.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2462-2467
    • El-Serag, H.B.1    Richardson, P.A.2    Everhart, J.E.3
  • 46
    • 0025928752 scopus 로고
    • Hepatitis delta virus (HDV) infection and hepatocellular carcinoma
    • Gerin JL, Purcell RH, Rizetto M, eds., New York:Wiley-Liss
    • Oliveri F, Brunetto MR, Baldi M et al. Hepatitis delta virus (HDV) infection and hepatocellular carcinoma. In: Gerin JL, Purcell RH, Rizetto M, eds. The Hepatitis Delta Virus. New York:Wiley-Liss, 1991:217-22.
    • (1991) The Hepatitis Delta Virus , pp. 217-222
    • Oliveri, F.1    Brunetto, M.R.2    Baldi, M.3
  • 47
    • 0001604729 scopus 로고
    • Hepatitis C virus and hepatocellular carcinoma
    • Okuda K. Hepatitis C virus and hepatocellular carcinoma. Adv Appl Biotechnol Ser 1991;13:119-26.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 119-126
    • Okuda, K.1
  • 48
    • 0028961434 scopus 로고
    • Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients
    • Takano S, Yokosuda O, Imazeki F. Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology 1995;21:650-5.
    • (1995) Hepatology , vol.21 , pp. 650-655
    • Takano, S.1    Yokosuda, O.2    Imazeki, F.3
  • 49
    • 0036829856 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis C in the United States
    • El-Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 2002;36(5 Suppl. 1)):S74-S83.
    • (2002) Hepatology , vol.36 , pp. S74-S83
    • El-Serag, H.B.1
  • 51
    • 0018728052 scopus 로고
    • Nucleotide sequence of hepatitis B virus genome (subtype ayw) cloned in E. coli
    • Galibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P. Nucleotide sequence of hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 1979;281:646-50.
    • (1979) Nature , vol.281 , pp. 646-650
    • Galibert, F.1    Mandart, E.2    Fitoussi, F.3    Tiollais, P.4    Charnay, P.5
  • 52
    • 0018694215 scopus 로고
    • Hepatitis B virus genes and their expression in Escherichia coli
    • Pasek M, Goto T, Gilbert W et al. Hepatitis B virus genes and their expression in Escherichia coli. Nature 1979;282:575-9.
    • (1979) Nature , vol.282 , pp. 575-579
    • Pasek, M.1    Goto, T.2    Gilbert, W.3
  • 53
    • 0002086618 scopus 로고
    • The nucleotide sequence of the hepatitis B virus genome and the identification of the major viral genes
    • Fields B, Jaenisch R, Fox CF, eds., New York: Academic Press
    • Valenzuela P, Quiroga M, Zaldivar J, Gray J, Rutter WJ. The nucleotide sequence of the hepatitis B virus genome and the identification of the major viral genes. In: Fields B, Jaenisch R, Fox CF, eds. Animal Virus Genetics. New York: Academic Press, 1980:57-70.
    • (1980) Animal Virus Genetics , pp. 57-70
    • Valenzuela, P.1    Quiroga, M.2    Zaldivar, J.3    Gray, J.4    Rutter, W.J.5
  • 54
    • 0020557417 scopus 로고
    • Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus
    • Toh H, Hyashida H, Miyata T. Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus. Nature 1983;305:827-9.
    • (1983) Nature , vol.305 , pp. 827-829
    • Toh, H.1    Hyashida, H.2    Miyata, T.3
  • 55
    • 0013667470 scopus 로고
    • Genetic variability of hepatitis B virus:Potential clinical implications
    • Bréchot C, ed., Boca Raton:CRC Press
    • Kremsdorf D, Bréchot C. Genetic variability of hepatitis B virus:potential clinical implications. In: Bréchot C, ed. Primary Liver Cancer: Etiological and Progression Factors. Boca Raton:CRC Press, 1994:149-65.
    • (1994) Primary Liver Cancer: Etiological and Progression Factors , pp. 149-165
    • Kremsdorf, D.1    Bréchot, C.2
  • 56
    • 0029100703 scopus 로고
    • Naturally occuring hepatitis B virus mutants
    • Akarka US, Lok ASF. Naturally occuring hepatitis B virus mutants. Hepatology 1995;22:50-60.
    • (1995) Hepatology , vol.22 , pp. 50-60
    • Akarka, U.S.1    Lok, A.S.F.2
  • 57
    • 0025779319 scopus 로고
    • Persistence of hepatitis B virus DNA after serological recovery from hepatitis B virus infection
    • Blum HE, Liang TJ, Galun E, Wands JR. Persistence of hepatitis B virus DNA after serological recovery from hepatitis B virus infection. Hepatology 1991;14:56-63.
    • (1991) Hepatology , vol.14 , pp. 56-63
    • Blum, H.E.1    Liang, T.J.2    Galun, E.3    Wands, J.R.4
  • 58
    • 0023775832 scopus 로고
    • Transmission of hepatitis B from hepatitis B seronegative subjects
    • Thiers V, Nakajima E, Kremsdorf D et al. Transmission of hepatitis B from hepatitis B seronegative subjects. Lancet 1988:1273-6.
    • (1988) Lancet , pp. 1273-1276
    • Thiers, V.1    Nakajima, E.2    Kremsdorf, D.3
  • 59
    • 0025826748 scopus 로고
    • Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection
    • Tran A, Kremsdorf D, Capel F et al. Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection. J Virol 1991;65:3566-74.
    • (1991) J Virol , vol.65 , pp. 3566-3574
    • Tran, A.1    Kremsdorf, D.2    Capel, F.3
  • 60
    • 0010501704 scopus 로고
    • Identification and transmission of hepatitis B virus-related variants
    • Wands JR, Fujita YK, Isselbacher KJ et al. Identification and transmission of hepatitis B virus-related variants. Proc Natl Acad Sci USA 1986;83:6608-12.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6608-6612
    • Wands, J.R.1    Fujita, Y.K.2    Isselbacher, K.J.3
  • 61
    • 0027979134 scopus 로고
    • Enhanced replication of hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
    • Hasegawa K, Huang J, Rogers SA, Blum HE, Liang TJ. Enhanced replication of hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol 1994;68:1651-9.
    • (1994) J Virol , vol.68 , pp. 1651-1659
    • Hasegawa, K.1    Huang, J.2    Rogers, S.A.3    Blum, H.E.4    Liang, T.J.5
  • 62
    • 0025738478 scopus 로고
    • A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
    • Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben-Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991;324:1705-9.
    • (1991) N Engl J Med , vol.324 , pp. 1705-1709
    • Liang, T.J.1    Hasegawa, K.2    Rimon, N.3    Wands, J.R.4    Ben-Porath, E.5
  • 63
    • 0025739721 scopus 로고
    • Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis
    • Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-1704.
    • (1991) N Engl J Med , vol.324 , pp. 1699-1704
    • Omata, M.1    Ehata, T.2    Yokosuka, O.3    Hosoda, K.4    Ohto, M.5
  • 64
    • 0025767919 scopus 로고
    • Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection
    • Gerken G, Kremsdorf D, Capel F et al. Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 1991;183:555-65.
    • (1991) Virology , vol.183 , pp. 555-565
    • Gerken, G.1    Kremsdorf, D.2    Capel, F.3
  • 65
    • 0023388549 scopus 로고
    • Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission
    • Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn J Exp Med 1987;57:231-6.
    • (1987) Jpn J Exp Med , vol.57 , pp. 231-236
    • Okamoto, H.1    Imai, M.2    Kametani, M.3    Nakamura, T.4    Mayumi, M.5
  • 66
    • 0029094726 scopus 로고
    • In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA
    • Rosmorduc O, Petit MA, Pol S. In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA. Hepatology 1995;21:10-19.
    • (1995) Hepatology , vol.21 , pp. 10-19
    • Rosmorduc, O.1    Petit, M.A.2    Pol, S.3
  • 67
    • 0025950292 scopus 로고
    • Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo
    • Terré S, Petit MA, Bréchot C. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo. J Virol 1991;65:5539-43.
    • (1991) J Virol , vol.65 , pp. 5539-5543
    • Terré, S.1    Petit, M.A.2    Bréchot, C.3
  • 68
    • 0022538381 scopus 로고
    • Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus
    • Neurath AR, Kent SBH, Strick N, Parker K. Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell 1986;46:429-36.
    • (1986) Cell , vol.46 , pp. 429-436
    • Neurath, A.R.1    Kent, S.B.H.2    Strick, N.3    Parker, K.4
  • 69
    • 0026549687 scopus 로고
    • Identification of three essential regions of hepatitis B virus X protein for trans-activation function
    • Arii M, Takada S, Koike K. Identification of three essential regions of hepatitis B virus X protein for trans-activation function. Oncogene 1992;7:397-403.
    • (1992) Oncogene , vol.7 , pp. 397-403
    • Arii, M.1    Takada, S.2    Koike, K.3
  • 70
    • 0025061039 scopus 로고
    • Mutational analysis of the hepatitis B virus P gene product: Domain structure and RNase H activity
    • Radziwill G, Tucker W, Schaller H. Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity. J Virol 1990;64:613-60.
    • (1990) J Virol , vol.64 , pp. 613-660
    • Radziwill, G.1    Tucker, W.2    Schaller, H.3
  • 71
    • 0025311110 scopus 로고
    • Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues
    • Takada S, Koike K. Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues. Proc Natl Acad Sci USA 1990;87:5628-32.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5628-5632
    • Takada, S.1    Koike, K.2
  • 72
    • 0016818908 scopus 로고
    • Genome of hepatitis B virus: Restriction enzyme cleavage and structure of DNA extracted from Dane particles
    • Summers JA, O’Connell A, Millman I. Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles. Proc Natl Acad Sci USA 1975;72:4597-601.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 4597-4601
    • Summers, J.A.1    O’Connell, A.2    Millman, I.3
  • 73
    • 0022502287 scopus 로고
    • Biochemical and genetic evidence for the hepatitis B virus replication strategy
    • Seeger C, Ganem D, Varmus HE. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science 1986;232:477-84.
    • (1986) Science , vol.232 , pp. 477-484
    • Seeger, C.1    Ganem, D.2    Varmus, H.E.3
  • 74
    • 0023127729 scopus 로고
    • Replication strategy of human hepatitis B virus
    • Will H, Reiser W, Weimer T et al. Replication strategy of human hepatitis B virus. J Virol 1987;61:904-11.
    • (1987) J Virol , vol.61 , pp. 904-911
    • Will, H.1    Reiser, W.2    Weimer, T.3
  • 75
    • 0021488492 scopus 로고
    • Hepatitis B virus transcription in the infected liver
    • Cattaneo R, Will H, Schaller H. Hepatitis B virus transcription in the infected liver. EMBO J 1984;3:2191-6.
    • (1984) EMBO J , vol.3 , pp. 2191-2196
    • Cattaneo, R.1    Will, H.2    Schaller, H.3
  • 76
    • 0020545838 scopus 로고
    • Core and E antigen synthesis in rodent cells transformed with hepatitis B virus DNA is associated with greater than genome length viral messenger RNAs
    • Gough NM. Core and E antigen synthesis in rodent cells transformed with hepatitis B virus DNA is associated with greater than genome length viral messenger RNAs. J Mol Biol 1983;165:683-99.
    • (1983) J Mol Biol , vol.165 , pp. 683-699
    • Gough, N.M.1
  • 77
    • 0021210486 scopus 로고
    • A prospective cohort study of hepatitis B surface antigen carriers in a working population
    • Iijima T, Saitoh N, Nobutomo K, Nambu M, Sakuma K. A prospective cohort study of hepatitis B surface antigen carriers in a working population. Gann 1984;75:571-3.
    • (1984) Gann , vol.75 , pp. 571-573
    • Iijima, T.1    Saitoh, N.2    Nobutomo, K.3    Nambu, M.4    Sakuma, K.5
  • 78
    • 0022549015 scopus 로고
    • Transcriptional control elements of hepatitis B surface antigen gene
    • Siddiqui A, Jameel S, Mapoles JE. Transcriptional control elements of hepatitis B surface antigen gene. Proc Natl Acad Sci USA 1986;83:566-70.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 566-570
    • Siddiqui, A.1    Jameel, S.2    Mapoles, J.E.3
  • 79
    • 0023085012 scopus 로고
    • Identification of a promoter element located upstream from the hepatitis B virus X gene
    • Treinin M, Laub O. Identification of a promoter element located upstream from the hepatitis B virus X gene. Mol Cell Biol 1987;7:545-8.
    • (1987) Mol Cell Biol , vol.7 , pp. 545-548
    • Treinin, M.1    Laub, O.2
  • 80
    • 0037565188 scopus 로고    scopus 로고
    • A long HBV transcript encoding pX is inefficiently exported from the nucleus
    • Doitsh G, Shaul Y. A long HBV transcript encoding pX is inefficiently exported from the nucleus. Virology 2003;309:339-49.
    • (2003) Virology , vol.309 , pp. 339-349
    • Doitsh, G.1    Shaul, Y.2
  • 81
    • 0022032391 scopus 로고
    • Transcripts and the putative RNA pregenome of duck hepatitis B virus:Implications for reverse transcription
    • Buscher M, Reiser W, Will H, Schaller H. Transcripts and the putative RNA pregenome of duck hepatitis B virus:implications for reverse transcription. Cell 1985;40:717-24.
    • (1985) Cell , vol.40 , pp. 717-724
    • Buscher, M.1    Reiser, W.2    Will, H.3    Schaller, H.4
  • 82
    • 0022357385 scopus 로고
    • Mapping the major transcripts of ground squirrel hepatitis virus: The presumptive template for reverse transcriptase is terminally redundant
    • Enders GH, Ganem D, Varmus H. Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell 1985;42:297-308.
    • (1985) Cell , vol.42 , pp. 297-308
    • Enders, G.H.1    Ganem, D.2    Varmus, H.3
  • 83
    • 0022083293 scopus 로고
    • Transcription of woodchuck hepatitis virus in the chronically infected liver
    • Möröy T, Etiemble J, Trépo C, Tiollais P, Buendia MA. Transcription of woodchuck hepatitis virus in the chronically infected liver. EMBO J 1985;4:1507-14.
    • (1985) EMBO J , vol.4 , pp. 1507-1514
    • Möröy, T.1    Etiemble, J.2    Trépo, C.3    Tiollais, P.4    Buendia, M.A.5
  • 84
    • 0022021926 scopus 로고
    • A human hepatitis B viral enhancer element
    • Shaul Y, Rutter WJ, Laub O. A human hepatitis B viral enhancer element. EMBO J. 1985;4:427-30.
    • (1985) EMBO J , vol.4 , pp. 427-430
    • Shaul, Y.1    Rutter, W.J.2    Laub, O.3
  • 85
    • 0024468844 scopus 로고
    • A liver-specific enhancer in the core promoter region of human hepatitis B virus
    • Yee JK. A liver-specific enhancer in the core promoter region of human hepatitis B virus. Science 1989;246:658-61.
    • (1989) Science , vol.246 , pp. 658-661
    • Yee, J.K.1
  • 86
    • 0010577045 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in the woodchuck
    • Rizzetto M, Purcell RH, Gerin JL, Verme G, eds., Turin: Edizioni Minerva Medica
    • Flajolet M, Fourel G, Wei Y et al. Hepatocellular carcinoma in the woodchuck. In: Rizzetto M, Purcell RH, Gerin JL, Verme G, eds. Viral Hepatitis and Liver Diseases. Turin: Edizioni Minerva Medica, 1997:509-14.
    • (1997) Viral Hepatitis and Liver Diseases , pp. 509-514
    • Flajolet, M.1    Fourel, G.2    Wei, Y.3
  • 87
    • 0029914172 scopus 로고    scopus 로고
    • The HNF-1/HNF-4- dependent WE2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter
    • Fourel G, Ringeisen F, Flajolet M et al. The HNF-1/HNF-4- dependent WE2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter. J Virol 1996;70:8571-83.
    • (1996) J Virol , vol.70 , pp. 8571-8583
    • Fourel, G.1    Ringeisen, F.2    Flajolet, M.3
  • 88
    • 0027280169 scopus 로고
    • Binding of nuclear factors to functional domains of the duck hepatitis B virus enhancer
    • Lilienbaum A, Crescenzo-Chaigne B, Sall AA, Pillot J, Elfassi E. Binding of nuclear factors to functional domains of the duck hepatitis B virus enhancer. J Virol 1993;67:6192-200.
    • (1993) J Virol , vol.67 , pp. 6192-6200
    • Lilienbaum, A.1    Crescenzo-Chaigne, B.2    Sall, A.A.3    Pillot, J.4    Elfassi, E.5
  • 89
    • 0028210967 scopus 로고
    • Idenfication of factor-binding sites in the duck hepatitis B virus enhancer and in vivo effects of enhancer mutations
    • Liu C, Mason WS, Burch JBE. Idenfication of factor-binding sites in the duck hepatitis B virus enhancer and in vivo effects of enhancer mutations. J Virol 1994;68:2286-96.
    • (1994) J Virol , vol.68 , pp. 2286-2296
    • Liu, C.1    Mason, W.S.2    Burch, J.B.E.3
  • 90
    • 0029976343 scopus 로고    scopus 로고
    • Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnavirus genomes: Key role of enhancer II
    • Ueda K, Wei Y, Ganem D. Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnavirus genomes: key role of enhancer II. Virology 1996;217:413-17.
    • (1996) Virology , vol.217 , pp. 413-417
    • Ueda, K.1    Wei, Y.2    Ganem, D.3
  • 91
    • 0029888986 scopus 로고    scopus 로고
    • Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II
    • Ueda K, Wei Y, Ganem D. Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. J Virol 1996;70:4714-23.
    • (1996) J Virol , vol.70 , pp. 4714-4723
    • Ueda, K.1    Wei, Y.2    Ganem, D.3
  • 92
    • 0343789889 scopus 로고
    • Common evolutionary origin of hepatitis B virus and retroviruses
    • Miller RH, Robinson WS. Common evolutionary origin of hepatitis B virus and retroviruses. Proc Natl Acad Sci USA 1986;83:2531-5.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2531-2535
    • Miller, R.H.1    Robinson, W.S.2
  • 93
    • 0021917921 scopus 로고
    • Antibodies to peptides detect new hepatitis B antigen: Serological correlation with hepatocellular carcinoma
    • Moriarty AM, Alexander H, Lerner RA. Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science 1985;227:429-33.
    • (1985) Science , vol.227 , pp. 429-433
    • Moriarty, A.M.1    Alexander, H.2    Lerner, R.A.3
  • 94
    • 0022069746 scopus 로고
    • The HBV HBx gene expressed in E. coli is recognized by sera from hepatitis patients
    • Kay A, Mandart E, Trepo C, Galibert F. The HBV HBx gene expressed in E. coli is recognized by sera from hepatitis patients. EMBO J. 1985;4:1287-92.
    • (1985) EMBO J , vol.4 , pp. 1287-1292
    • Kay, A.1    Mandart, E.2    Trepo, C.3    Galibert, F.4
  • 96
    • 0022652839 scopus 로고
    • Hepatitis B virus polypeptide X: Expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans
    • Meyers ML, Vitvitski Trépo L, Nath N, Sninsky JJ. Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans. J Virol 1986;57:101-9.
    • (1986) J Virol , vol.57 , pp. 101-109
    • Meyers, M.L.1    Vitvitski Trépo, L.2    Nath, N.3    Sninsky, J.J.4
  • 97
    • 0023262668 scopus 로고
    • Synthesis of the X protein of hepatitis B virus in vitro and detection of anti-X antibodies in human sera
    • Pfaff E, Salfeld J, Gmelin K, Schaller H, Theilmann L. Synthesis of the X protein of hepatitis B virus in vitro and detection of anti-X antibodies in human sera. Virology 1987;158:456-60.
    • (1987) Virology , vol.158 , pp. 456-460
    • Pfaff, E.1    Salfeld, J.2    Gmelin, K.3    Schaller, H.4    Theilmann, L.5
  • 98
    • 0025648443 scopus 로고
    • Early and frequent detection of HBxAg and/or anti-HBxAg in hepatitis B virus infection
    • Vitvitski-Trepo L, Kay A, Pichoud C et al. Early and frequent detection of HBxAg and/or anti-HBxAg in hepatitis B virus infection. Hepatology 1990;12:1278-83.
    • (1990) Hepatology , vol.12 , pp. 1278-1283
    • Vitvitski-Trepo, L.1    Kay, A.2    Pichoud, C.3
  • 99
    • 0025830064 scopus 로고
    • Expression of X protein and hepatitis B virus replication in chronic hepatitis
    • Haruna Y, Hayashi N, Katamaya K et al. Expression of X protein and hepatitis B virus replication in chronic hepatitis. Hepatology 1991;13:417-21.
    • (1991) Hepatology , vol.13 , pp. 417-421
    • Haruna, Y.1    Hayashi, N.2    Katamaya, K.3
  • 100
    • 0025971806 scopus 로고
    • Significance of anti-HBx antibodies in hepatitis B virus infection
    • Levrero M, Stemler M, Pasquinelli C et al. Significance of anti-HBx antibodies in hepatitis B virus infection. Hepatology 1991;13:143-9.
    • (1991) Hepatology , vol.13 , pp. 143-149
    • Levrero, M.1    Stemler, M.2    Pasquinelli, C.3
  • 101
    • 0025858179 scopus 로고
    • HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis
    • Wang W, London WT, Lega L, Feitelson MA. HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology 1991;14:29-37.
    • (1991) Hepatology , vol.14 , pp. 29-37
    • Wang, W.1    London, W.T.2    Lega, L.3    Feitelson, M.A.4
  • 102
    • 0029955711 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and in woodchuck hepatocellular carcinomas which are permissive for viral replication
    • Dandri M, Schirmacher P, Rogler CE. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and in woodchuck hepatocellular carcinomas which are permissive for viral replication. J Virol 1996;70:5246-54.
    • (1996) J Virol , vol.70 , pp. 5246-5254
    • Dandri, M.1    Schirmacher, P.2    Rogler, C.E.3
  • 103
    • 0031898616 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinoma
    • Su Q, Schröder CH, Hofman WJ, Otto G, Pichlmayr R, Bannasch P. Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinoma. Hepatology 1998;27:1109-20.
    • (1998) Hepatology , vol.27 , pp. 1109-1120
    • Su, Q.1    Schröder, C.H.2    Hofman, W.J.3    Otto, G.4    Pichlmayr, R.5    Bannasch, P.6
  • 104
    • 0025873579 scopus 로고
    • Topoisomerase I-mediated integration of hepadnavirus DNA in vitro
    • Wang HP, Rogler CE. Topoisomerase I-mediated integration of hepadnavirus DNA in vitro. J Virol 1991;65:2381-92.
    • (1991) J Virol , vol.65 , pp. 2381-2392
    • Wang, H.P.1    Rogler, C.E.2
  • 105
    • 0033604446 scopus 로고    scopus 로고
    • Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
    • Takada S, Shirakata Y, Kaneniwa N, Koike K. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene 1999;18:6965-73.
    • (1999) Oncogene , vol.18 , pp. 6965-6973
    • Takada, S.1    Shirakata, Y.2    Kaneniwa, N.3    Koike, K.4
  • 106
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 2001;21:7721-30.
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 107
    • 0029147911 scopus 로고
    • The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
    • Doria M, Klein N, Lucito R, Schneider RJ. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J 1995;14:4747-57.
    • (1995) EMBO J , vol.14 , pp. 4747-4757
    • Doria, M.1    Klein, N.2    Lucito, R.3    Schneider, R.J.4
  • 108
    • 0025319078 scopus 로고
    • Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA
    • Höhne M, Schaefer S, Seifer M, Feitelson MA, Paul D, Gerlich WH. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J 1990;9:1137-45.
    • (1990) EMBO J , vol.9 , pp. 1137-1145
    • Höhne, M.1    Schaefer, S.2    Seifer, M.3    Feitelson, M.A.4    Paul, D.5    Gerlich, W.H.6
  • 109
    • 0042416572 scopus 로고    scopus 로고
    • Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
    • Hafner A, Brandenburg B, Hildt E. Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein. EMBO Rep 2003;4:767-73.
    • (2003) EMBO Rep , vol.4 , pp. 767-773
    • Hafner, A.1    Brandenburg, B.2    Hildt, E.3
  • 110
    • 0033046316 scopus 로고    scopus 로고
    • Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation
    • Nomura T, Lin Y, Dorjsuren D, Ohno S, Yamashita T, Murakami S. Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation. Biochim Biophys Acta 1999;1453:330-40.
    • (1999) Biochim Biophys Acta , vol.1453 , pp. 330-340
    • Nomura, T.1    Lin, Y.2    Dorjsuren, D.3    Ohno, S.4    Yamashita, T.5    Murakami, S.6
  • 111
    • 0032772369 scopus 로고    scopus 로고
    • Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
    • Weil R, Sirma H, Giannini C et al. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Mol Cell Biol 1999;19:6345-54.
    • (1999) Mol Cell Biol , vol.19 , pp. 6345-6354
    • Weil, R.1    Sirma, H.2    Giannini, C.3
  • 112
    • 0042091978 scopus 로고    scopus 로고
    • Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles
    • Forgues M, Difilippantonio MJ, Linke SP et al. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol 2003;23:5282-92.
    • (2003) Mol Cell Biol , vol.23 , pp. 5282-5292
    • Forgues, M.1    Difilippantonio, M.J.2    Linke, S.P.3
  • 113
    • 0027478980 scopus 로고
    • The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks
    • Chen HS, Kanado S, Girones R et al. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol 1993;67:1218-26.
    • (1993) J Virol , vol.67 , pp. 1218-1226
    • Chen, H.S.1    Kanado, S.2    Girones, R.3
  • 114
    • 0028013064 scopus 로고
    • Woodchuck hepatitis virus X protein is required for viral infection in vivo
    • Zoulim F, Saputelli J, Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 1994;68:2026-30.
    • (1994) J Virol , vol.68 , pp. 2026-2030
    • Zoulim, F.1    Saputelli, J.2    Seeger, C.3
  • 115
    • 0026514186 scopus 로고
    • Hepatitis B virus X-gene product: A promiscuous transcriptional transactivator
    • Rossner MT. Hepatitis B virus X-gene product: a promiscuous transcriptional transactivator. J Med Virol 1992;36:101-17.
    • (1992) J Med Virol , vol.36 , pp. 101-117
    • Rossner, M.T.1
  • 116
    • 0033176296 scopus 로고    scopus 로고
    • The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis
    • Andrisani OM, Barnabas S. The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis. Int J Oncol 1999;15:373-9.
    • (1999) Int J Oncol , vol.15 , pp. 373-379
    • Andrisani, O.M.1    Barnabas, S.2
  • 117
    • 0032847032 scopus 로고    scopus 로고
    • Hepatitis B virus X protein: Structure, function and biology
    • Murakami S. Hepatitis B virus X protein: structure, function and biology. Intervirology 1999;42:81-99.
    • (1999) Intervirology , vol.42 , pp. 81-99
    • Murakami, S.1
  • 118
    • 0042416572 scopus 로고    scopus 로고
    • Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
    • Hafner A, Brandenburg B, Hildt E. Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein. EMBO Rep 2003;4:767-73.
    • (2003) EMBO Rep , vol.4 , pp. 767-773
    • Hafner, A.1    Brandenburg, B.2    Hildt, E.3
  • 119
    • 0023201790 scopus 로고
    • Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children
    • Yaginuma K, Kobayashi H, Kobayashi M, Morishima T, Matsuyama K, Koike K. Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children. J Virol 1987;61:1808-13.
    • (1987) J Virol , vol.61 , pp. 1808-1813
    • Yaginuma, K.1    Kobayashi, H.2    Kobayashi, M.3    Morishima, T.4    Matsuyama, K.5    Koike, K.6
  • 121
    • 0024391379 scopus 로고
    • Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication
    • Colgrove R, Simon G, Ganem D. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol 1989;63:4019-26.
    • (1989) J Virol , vol.63 , pp. 4019-4026
    • Colgrove, R.1    Simon, G.2    Ganem, D.3
  • 122
    • 0023833938 scopus 로고
    • Trans-activation of viral enhancers by the hepatitis B virus X protein
    • Spandau DF, Lee CH. Trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol 1988;62:427-34.
    • (1988) J Virol , vol.62 , pp. 427-434
    • Spandau, D.F.1    Lee, C.H.2
  • 123
    • 0023627343 scopus 로고
    • Transcriptional trans-activating function of hepatitis B virus
    • Twu JS, Schloemer RH. Transcriptional trans-activating function of hepatitis B virus. J Virol 1987;61:3448-53.
    • (1987) J Virol , vol.61 , pp. 3448-3453
    • Twu, J.S.1    Schloemer, R.H.2
  • 124
    • 0026526978 scopus 로고
    • Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C
    • Lucito R, Schneider RJ. Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C. J Virol 1992;66:983-91.
    • (1992) J Virol , vol.66 , pp. 983-991
    • Lucito, R.1    Schneider, R.J.2
  • 125
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by proteinprotein interactions
    • Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by proteinprotein interactions. Science 1991;252:842-4.
    • (1991) Science , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 126
    • 0029008054 scopus 로고
    • The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB
    • Williams JS, Andrisam OM. The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc Natl Acad Sci USA 1995;92:3819-23.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3819-3823
    • Williams, J.S.1    Andrisam, O.M.2
  • 127
    • 0032493107 scopus 로고    scopus 로고
    • The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4
    • Lee YI, Lee S, Lee Y et al. The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4. Oncogene 1998;16:2367-80.
    • (1998) Oncogene , vol.16 , pp. 2367-2380
    • Lee, Y.I.1    Lee, S.2    Lee, Y.3
  • 128
    • 0028878098 scopus 로고
    • Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
    • Cheong J, Yi M, Lin Y, Murakami S. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J 1995;14:143-50.
    • (1995) EMBO J , vol.14 , pp. 143-150
    • Cheong, J.1    Yi, M.2    Lin, Y.3    Murakami, S.4
  • 129
    • 0028878710 scopus 로고
    • The X protein of hepatitis B virus coactivates potent activation domains
    • Haviv I, Vaizel D, Shaul Y. The X protein of hepatitis B virus coactivates potent activation domains. Mol Cell Biol 1995;15:1079-85.
    • (1995) Mol Cell Biol , vol.15 , pp. 1079-1085
    • Haviv, I.1    Vaizel, D.2    Shaul, Y.3
  • 130
    • 0028890351 scopus 로고
    • Hepatitis B virus transactivator protein X interacts with the TATA-binding protein
    • Qadri I, Maguire HF, Siddiqui A. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci USA 1995;92:1003-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1003-1007
    • Qadri, I.1    Maguire, H.F.2    Siddiqui, A.3
  • 131
    • 0031932893 scopus 로고    scopus 로고
    • Hepatitis B virus pX targets TFIIB in transcription coactivation
    • Haviv I, Shamay M, Doitsh O, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol 1998;18:1562-9.
    • (1998) Mol Cell Biol , vol.18 , pp. 1562-1569
    • Haviv, I.1    Shamay, M.2    Doitsh, O.3    Shaul, Y.4
  • 132
    • 0029743407 scopus 로고    scopus 로고
    • Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH
    • Qadri I, Conaway JW, Conaway RC, Schaack J, Siddiqui A. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc Natl Acad Sci USA 1996;93:10578-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10578-10583
    • Qadri, I.1    Conaway, J.W.2    Conaway, R.C.3    Schaack, J.4    Siddiqui, A.5
  • 133
    • 0037155818 scopus 로고    scopus 로고
    • Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription
    • Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem 2002;277:9982-8.
    • (2002) J Biol Chem , vol.277 , pp. 9982-9988
    • Shamay, M.1    Barak, O.2    Doitsh, G.3    Ben-Dor, I.4    Shaul, Y.5
  • 134
    • 0025176474 scopus 로고
    • Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors
    • Seto E, Mitchell PJ, Yen TSB. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 1990;344:72-4.
    • (1990) Nature , vol.344 , pp. 72-74
    • Seto, E.1    Mitchell, P.J.2    Yen, T.S.B.3
  • 135
    • 0029895723 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-jun N-terminal mitogenactivated protein kinases
    • Benn J, Su F, Doria M, Schneider RJ. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-jun N-terminal mitogenactivated protein kinases. J Virol 1996;70:4978-85.
    • (1996) J Virol , vol.70 , pp. 4978-4985
    • Benn, J.1    Su, F.2    Doria, M.3    Schneider, R.J.4
  • 136
    • 0028059895 scopus 로고
    • Ras and Rafdependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX
    • Natoli G, Avantaggiati ML, Chirillo P et al. Ras and Rafdependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX. Oncogene 1994;9:2837-43.
    • (1994) Oncogene , vol.9 , pp. 2837-2843
    • Natoli, G.1    Avantaggiati, M.L.2    Chirillo, P.3
  • 137
    • 0035860752 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
    • Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 2001;276:34671-80.
    • (2001) J Biol Chem , vol.276 , pp. 34671-34680
    • Tarn, C.1    Lee, S.2    Hu, Y.3    Ashendel, C.4    Andrisani, O.M.5
  • 138
    • 0029147911 scopus 로고
    • The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
    • Doria M, Klein N, Lucito R, Schneider RJ. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J 1995;14:4747-57.
    • (1995) EMBO J , vol.14 , pp. 4747-4757
    • Doria, M.1    Klein, N.2    Lucito, R.3    Schneider, R.J.4
  • 139
    • 0029656133 scopus 로고    scopus 로고
    • Hepatitis B virus pX activates NF-κB-dependent transcription through a Raf-independent pathway
    • Chirillo P, Falco M, Puri PL et al. Hepatitis B virus pX activates NF-κB-dependent transcription through a Raf-independent pathway. J Virol 1996;70:641-6.
    • (1996) J Virol , vol.70 , pp. 641-646
    • Chirillo, P.1    Falco, M.2    Puri, P.L.3
  • 140
    • 0032403765 scopus 로고    scopus 로고
    • The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway
    • Lara-Pezzi E, Armesilla AL, Majano PL, Redondo JM, Lopez-Cabrera M. The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. EMBO J 1998;17:7066-77.
    • (1998) EMBO J , vol.17 , pp. 7066-7077
    • Lara-Pezzi, E.1    Armesilla, A.L.2    Majano, P.L.3    Redondo, J.M.4    Lopez-Cabrera, M.5
  • 141
    • 0029982621 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activates transcription factor NF-KB by acting on multiple cytoplasmic inhibitors of rel-related proteins
    • Su P, Schneider RJ. Hepatitis B virus HBx protein activates transcription factor NF-KB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J Virol 1996;70:4558-66.
    • (1996) J Virol , vol.70 , pp. 4558-4566
    • Su, P.1    Schneider, R.J.2
  • 142
    • 0028855276 scopus 로고
    • Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition of p53 response element-directed transactivation
    • Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish JA. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition of p53 response element-directed transactivation. J Virol 1995;69:1851-9.
    • (1995) J Virol , vol.69 , pp. 1851-1859
    • Truant, R.1    Antunovic, J.2    Greenblatt, J.3    Prives, C.4    Cromlish, J.A.5
  • 143
    • 0032509549 scopus 로고    scopus 로고
    • Hepatitis Bx protein inhibits p53-dependent DNA repair in primary mouse hepatocytes
    • Prost S, Ford JM, Taylor C, Doig J, Harrison DJ. Hepatitis Bx protein inhibits p53-dependent DNA repair in primary mouse hepatocytes. J Biol Chem 1998;273:33327-32.
    • (1998) J Biol Chem , vol.273 , pp. 33327-33332
    • Prost, S.1    Ford, J.M.2    Taylor, C.3    Doig, J.4    Harrison, D.J.5
  • 144
    • 0030696170 scopus 로고    scopus 로고
    • Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells
    • Takada S, Kaneniwa N, Tsuchida N, Koike K. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells. Oncogene 1997;15:1895-901.
    • (1997) Oncogene , vol.15 , pp. 1895-1901
    • Takada, S.1    Kaneniwa, N.2    Tsuchida, N.3    Koike, K.4
  • 145
    • 0028853994 scopus 로고
    • Hepatitis B virus X protein interacts with a probable DNA repair protein
    • Lee TH, Elledge SJ, Butel JS. Hepatitis B virus X protein interacts with a probable DNA repair protein. J Virol 1995;69:1107-14.
    • (1995) J Virol , vol.69 , pp. 1107-1114
    • Lee, T.H.1    Elledge, S.J.2    Butel, J.S.3
  • 146
    • 0031985778 scopus 로고    scopus 로고
    • Hepatitis B virus X protein interferes with cellular DNA repair
    • Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol 1998;72:266-72.
    • (1998) J Virol , vol.72 , pp. 266-272
    • Becker, S.A.1    Lee, T.H.2    Butel, J.S.3    Slagle, B.L.4
  • 147
    • 0037064038 scopus 로고    scopus 로고
    • Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2
    • Bontron S, Lin-Marq N, Strubin M. Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2. J Biol Chem 2002;277:38847-54.
    • (2002) J Biol Chem , vol.277 , pp. 38847-38854
    • Bontron, S.1    Lin-Marq, N.2    Strubin, M.3
  • 148
    • 0038365225 scopus 로고    scopus 로고
    • Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities
    • Leupin O, Bontron S, Strubin M. Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities. J Virol 2003;77:6274-83.
    • (2003) J Virol , vol.77 , pp. 6274-6283
    • Leupin, O.1    Bontron, S.2    Strubin, M.3
  • 149
    • 0035659925 scopus 로고    scopus 로고
    • Stimulation of cellular proliferation by hepatitis B virus X protein
    • Madden CR, Slagle BL. Stimulation of cellular proliferation by hepatitis B virus X protein. Dis Markers 2001;17:153-7.
    • (2001) Dis Markers , vol.17 , pp. 153-157
    • Madden, C.R.1    Slagle, B.L.2
  • 150
    • 0032559971 scopus 로고    scopus 로고
    • Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome
    • Sirma H, Weil R, Rosmorduc O et al. Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome. Oncogene 1998;16:2051-63.
    • (1998) Oncogene , vol.16 , pp. 2051-2063
    • Sirma, H.1    Weil, R.2    Rosmorduc, O.3
  • 151
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard MJ, Wang LH, Schneider RJ. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 2001;294:2376-8.
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 153
    • 0041355327 scopus 로고    scopus 로고
    • Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein
    • Chami M, Ferrari D, Nicotera P, Paterlini-Bréchot P, Rizzuto R. Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein. J Biol Chem 2003;278:31745-55.
    • (2003) J Biol Chem , vol.278 , pp. 31745-31755
    • Chami, M.1    Ferrari, D.2    Nicotera, P.3    Paterlini-Bréchot, P.4    Rizzuto, R.5
  • 154
    • 0031972604 scopus 로고    scopus 로고
    • X-gene product of hepatitis B virus induces apoptosis in liver cells
    • Kim H, Lee H, Yun Y. X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 1998;273:381-5.
    • (1998) J Biol Chem , vol.273 , pp. 381-385
    • Kim, H.1    Lee, H.2    Yun, Y.3
  • 155
    • 0038558163 scopus 로고    scopus 로고
    • Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
    • Kim KH, Seong BL. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 2003;22:2104-16.
    • (2003) EMBO J , vol.22 , pp. 2104-2116
    • Kim, K.H.1    Seong, B.L.2
  • 156
    • 0032748493 scopus 로고    scopus 로고
    • Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system
    • Shintani Y, Yotsuyanagi H, Moriya K et al. Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system. J Gen Virol 1999;80(Pt 12)):3257-65.
    • (1999) J Gen Virol , vol.80 , pp. 3257-3265
    • Shintani, Y.1    Yotsuyanagi, H.2    Moriya, K.3
  • 157
    • 0038158319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential
    • Shirakata Y, Koike K. Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J Biol Chem 2003;278:22071-8.
    • (2003) J Biol Chem , vol.278 , pp. 22071-22078
    • Shirakata, Y.1    Koike, K.2
  • 158
    • 0030787584 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis alpha
    • Su F, Schneider RJ. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis alpha. Proc Natl Acad Sci USA 1997;94:8744-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.J.2
  • 159
    • 0034739918 scopus 로고    scopus 로고
    • Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein
    • Su F, Theodosis CN, Schneider RJ. Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J Virol 2001;75:215-25.
    • (2001) J Virol , vol.75 , pp. 215-225
    • Su, F.1    Theodosis, C.N.2    Schneider, R.J.3
  • 160
    • 0037179902 scopus 로고    scopus 로고
    • Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses
    • Schuster R, Hildt E, Chang SF et al. Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses. Oncogene 2002;21:6606-13.
    • (2002) Oncogene , vol.21 , pp. 6606-6613
    • Schuster, R.1    Hildt, E.2    Chang, S.F.3
  • 161
    • 0031460372 scopus 로고    scopus 로고
    • Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
    • Elmore LW, Hancock AR, Chang S-F et al. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci USA 1997;94:14707-12.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14707-14712
    • Elmore, L.W.1    Hancock, A.R.2    Chang, S.-F.3
  • 162
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappaB
    • Pan J, Duan LX, Sun BS, Feitelson MA. Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappaB. J Gen Virol 2001;82(Pt 1)):171-82.
    • (2001) J Gen Virol , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3    Feitelson, M.A.4
  • 163
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3- kinase pathway
    • Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL. Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3- kinase pathway. J Biol Chem 2000;275:25858-64.
    • (2000) J Biol Chem , vol.275 , pp. 25858-25864
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3    Cheng, A.L.4    Doong, S.L.5
  • 164
    • 0028834376 scopus 로고
    • Abrogation of p53- induced apoptosis by the hepatitis B virus X gene
    • Wang XW, Gibson MK, Vermeulen W et al. Abrogation of p53- induced apoptosis by the hepatitis B virus X gene. Cancer Res 1995;55:6012-16.
    • (1995) Cancer Res , vol.55 , pp. 6012-6016
    • Wang, X.W.1    Gibson, M.K.2    Vermeulen, W.3
  • 165
    • 0024797064 scopus 로고
    • The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells
    • Shirakata Y, Kawada M, Fujiki Y et al. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res 1989;80:617-21.
    • (1989) Jpn J Cancer Res , vol.80 , pp. 617-621
    • Shirakata, Y.1    Kawada, M.2    Fujiki, Y.3
  • 166
    • 0032529463 scopus 로고    scopus 로고
    • Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation
    • Gottlob K, Pagano S, Levrero M, Graessmann A. Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation. Cancer Res 1998;58:3566-70.
    • (1998) Cancer Res , vol.58 , pp. 3566-3570
    • Gottlob, K.1    Pagano, S.2    Levrero, M.3    Graessmann, A.4
  • 167
    • 0035804226 scopus 로고    scopus 로고
    • Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis
    • Kim YC, Song KS, Yoon G, Nam MJ, Ryu WS. Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene 2001;20:16-23.
    • (2001) Oncogene , vol.20 , pp. 16-23
    • Kim, Y.C.1    Song, K.S.2    Yoon, G.3    Nam, M.J.4    Ryu, W.S.5
  • 168
    • 0034708234 scopus 로고    scopus 로고
    • Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts
    • Schuster R, Gerlich WH, Schaefer S. Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene 2000;19:1173-80.
    • (2000) Oncogene , vol.19 , pp. 1173-1180
    • Schuster, R.1    Gerlich, W.H.2    Schaefer, S.3
  • 169
    • 0028230728 scopus 로고
    • High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
    • Koike K, Moriya K, Lino S et al. High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology 1994;19:810-19.
    • (1994) Hepatology , vol.19 , pp. 810-819
    • Koike, K.1    Moriya, K.2    Lino, S.3
  • 170
    • 0029129018 scopus 로고
    • In vivo activity of the hepatitis B virus core promoter tissue specificity and temporal regulation
    • Billet O, Grimber G, Levrero M, Seye KA, Briand P, Joulin V. In vivo activity of the hepatitis B virus core promoter tissue specificity and temporal regulation. J Virol 1995;69:5912-16.
    • (1995) J Virol , vol.69 , pp. 5912-5916
    • Billet, O.1    Grimber, G.2    Levrero, M.3    Seye, K.A.4    Briand, P.5    Joulin, V.6
  • 171
  • 172
    • 0030041821 scopus 로고    scopus 로고
    • Hepadnaviral X protein: Review of recent progress
    • Yen BTS. Hepadnaviral X protein: review of recent progress. J Biomed Sci 1996;3:20-30.
    • (1996) J Biomed Sci , vol.3 , pp. 20-30
    • Yen, B.T.S.1
  • 173
    • 0029870749 scopus 로고    scopus 로고
    • Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
    • Slagel BL, Lee TH, Medina D, Finegold MJ, Butel JS. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog 1996;15:261-9.
    • (1996) Mol Carcinog , vol.15 , pp. 261-269
    • Slagel, B.L.1    Lee, T.H.2    Medina, D.3    Finegold, M.J.4    Butel, J.S.5
  • 174
    • 0031035764 scopus 로고    scopus 로고
    • The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice
    • Terradillos O, Billet O, Renard CA et al. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene 1997;14:395-404.
    • (1997) Oncogene , vol.14 , pp. 395-404
    • Terradillos, O.1    Billet, O.2    Renard, C.A.3
  • 175
    • 0036828029 scopus 로고    scopus 로고
    • Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein
    • Madden CR, Finegold MJ, Slagle BL. Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J Virol 2002;76:11770-4.
    • (2002) J Virol , vol.76 , pp. 11770-11774
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 176
    • 0141532010 scopus 로고    scopus 로고
    • Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
    • Yoo YG, Oh SH, Park ES et al. Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. J Biol Chem 2003;278:39076-84.
    • (2003) J Biol Chem , vol.278 , pp. 39076-39084
    • Yoo, Y.G.1    Oh, S.H.2    Park, E.S.3
  • 177
    • 0032558845 scopus 로고    scopus 로고
    • p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro
    • Terradillos O, Pollicino T, Lecoeur H et al. p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro. Oncogene 1998;17:2115-23.
    • (1998) Oncogene , vol.17 , pp. 2115-2123
    • Terradillos, O.1    Pollicino, T.2    Lecoeur, H.3
  • 178
    • 0037076396 scopus 로고    scopus 로고
    • Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis
    • Tralhao JG, Roudier J, Morosan S et al. Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis. Proc Natl Acad Sci USA 2002;99:6991-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6991-6996
    • Tralhao, J.G.1    Roudier, J.2    Morosan, S.3
  • 179
    • 0021997009 scopus 로고
    • Hybrid hepatitis B virus-host transcripts in a human hepatoma cell
    • Ou JH, Rutter WJ. Hybrid hepatitis B virus-host transcripts in a human hepatoma cell. Proc Natl Acad Sci USA 1985;82:83-7.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 83-87
    • Ou, J.H.1    Rutter, W.J.2
  • 180
    • 0023429677 scopus 로고
    • The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma
    • Nagaya T, Nakamura T, Tokino T. The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes Dev 1983;1:773-82.
    • (1983) Genes Dev , vol.1 , pp. 773-782
    • Nagaya, T.1    Nakamura, T.2    Tokino, T.3
  • 181
    • 0023617758 scopus 로고
    • Tight clustering of human hepatitis B virus integration sites in hepatomas near a triplestranded region
    • Shih C, Burke K, Chou MJ et al. Tight clustering of human hepatitis B virus integration sites in hepatomas near a triplestranded region. J Virol 1987;61:3491-8.
    • (1987) J Virol , vol.61 , pp. 3491-3498
    • Shih, C.1    Burke, K.2    Chou, M.J.3
  • 182
    • 0035502957 scopus 로고    scopus 로고
    • Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues
    • Tu H, Bonura C, Giannini C, Mouly H et al. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 2001;61:7803-10.
    • (2001) Cancer Res , vol.61 , pp. 7803-7810
    • Tu, H.1    Bonura, C.2    Giannini, C.3    Mouly, H.4
  • 183
    • 0942289920 scopus 로고    scopus 로고
    • Characterization of HBV integrants in 14 hepatocellular carcinomas:Association of truncated X gene and hepatocellular carcinogenesis
    • Wang Y, Lau SH, Sham JS, Wu MC, Wang T, Guan XY. Characterization of HBV integrants in 14 hepatocellular carcinomas:association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004;23:142-8.
    • (2004) Oncogene , vol.23 , pp. 142-148
    • Wang, Y.1    Lau, S.H.2    Sham, J.S.3    Wu, M.C.4    Wang, T.5    Guan, X.Y.6
  • 184
    • 0024240296 scopus 로고
    • A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state
    • Wollersheim M, Debelka U, Hofschneider PH. A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 1988;3:545-52.
    • (1988) Oncogene , vol.3 , pp. 545-552
    • Wollersheim, M.1    Debelka, U.2    Hofschneider, P.H.3
  • 185
    • 8044256175 scopus 로고
    • Deregulation of cellular gene expression by HBV transactivators in hepatocarcinogenesis
    • Koshy R, Wells J. Deregulation of cellular gene expression by HBV transactivators in hepatocarcinogenesis. Adv Appl Biotechnol Ser 1991;13:159-70.
    • (1991) Adv Appl Biotechnol Ser , vol.13 , pp. 159-170
    • Koshy, R.1    Wells, J.2
  • 186
    • 0033607041 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
    • Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999;18:4848-59.
    • (1999) Oncogene , vol.18 , pp. 4848-4859
    • Sirma, H.1    Giannini, C.2    Poussin, K.3    Paterlini, P.4    Kremsdorf, D.5    Brechot, C.6
  • 187
    • 0033521846 scopus 로고    scopus 로고
    • Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas
    • Poussin K, Dienes H, Sirma H et al. Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas. Int J Cancer 1999;80:497-505.
    • (1999) Int J Cancer , vol.80 , pp. 497-505
    • Poussin, K.1    Dienes, H.2    Sirma, H.3
  • 188
    • 0034597514 scopus 로고    scopus 로고
    • Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma
    • Yeh CT, Shen CH, Tai DI, Chu CM, Liaw YF. Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma. Oncogene 2000;19:5213-20.
    • (2000) Oncogene , vol.19 , pp. 5213-5220
    • Yeh, C.T.1    Shen, C.H.2    Tai, D.I.3    Chu, C.M.4    Liaw, Y.F.5
  • 189
    • 0035927496 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis
    • Huo TI, Wang XW, Forgues M et al. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 2001;20:3620-8.
    • (2001) Oncogene , vol.20 , pp. 3620-3628
    • Huo, T.I.1    Wang, X.W.2    Forgues, M.3
  • 190
    • 0022366887 scopus 로고
    • Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice
    • Babinet C, Farza H, Morello D, Hadchouel M, Pourcel C. Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice. Science 1985;230:1160-3.
    • (1985) Science , vol.230 , pp. 1160-1163
    • Babinet, C.1    Farza, H.2    Morello, D.3    Hadchouel, M.4    Pourcel, C.5
  • 191
    • 0022397571 scopus 로고
    • A transgenic mouse model of the chronic hepatitis B surface antigen carrier state
    • Chisari FV, Pinckert CA, Milich DR et al. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 1985;230:1157-9.
    • (1985) Science , vol.230 , pp. 1157-1159
    • Chisari, F.V.1    Pinckert, C.A.2    Milich, D.R.3
  • 192
    • 0023687224 scopus 로고
    • Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome
    • Farza H, Hadchouel M, Scotto J, Tiollais P, Babinet C, Pourcel C. Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J Virol 1988;62:4144-52.
    • (1988) J Virol , vol.62 , pp. 4144-4152
    • Farza, H.1    Hadchouel, M.2    Scotto, J.3    Tiollais, P.4    Babinet, C.5    Pourcel, C.6
  • 193
    • 0029130068 scopus 로고
    • High-level hepatitis B virus replication in transgenic mice
    • Guidotti LG, Matzke B, Schaller H, Chisari FV. High-level hepatitis B virus replication in transgenic mice. J Virol 1995;69:6158-9.
    • (1995) J Virol , vol.69 , pp. 6158-6159
    • Guidotti, L.G.1    Matzke, B.2    Schaller, H.3    Chisari, F.V.4
  • 194
    • 0023037176 scopus 로고
    • Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice
    • Chisari FV, Filippi P, McLachlan A et al. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol 1986;60:880-7.
    • (1986) J Virol , vol.60 , pp. 880-887
    • Chisari, F.V.1    Filippi, P.2    McLachlan, A.3
  • 195
    • 0028567172 scopus 로고
    • Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
    • Hagen TM, Huang SM, Curnutte J et al. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci USA 1994;91:12808-12.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12808-12812
    • Hagen, T.M.1    Huang, S.M.2    Curnutte, J.3
  • 196
    • 0028966041 scopus 로고
    • Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice
    • Huang S, Chisari FV. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 1995;21:620-6.
    • (1995) Hepatology , vol.21 , pp. 620-626
    • Huang, S.1    Chisari, F.V.2
  • 197
    • 0025166025 scopus 로고
    • Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas
    • Teeter LD, Becker FF, Chisari FV, Li D, Kuo MT. Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol Cell Biol 1990;10:5728-35.
    • (1990) Mol Cell Biol , vol.10 , pp. 5728-5735
    • Teeter, L.D.1    Becker, F.F.2    Chisari, F.V.3    Li, D.4    Kuo, M.T.5
  • 198
    • 0025098651 scopus 로고
    • The pre-S2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
    • Kekulé AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R. The pre-S2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 1990;343:457-61.
    • (1990) Nature , vol.343 , pp. 457-461
    • Kekulé, A.S.1    Lauer, U.2    Meyer, M.3    Caselmann, W.H.4    Hofschneider, P.H.5    Koshy, R.6
  • 199
    • 0026808738 scopus 로고
    • The hepatitis B virus pre-S/St transactivator is generated by 3' truncations within a defined region of the S gene
    • Lauer U, Weiss L, Hofschneider PH, Kekulé AS. The hepatitis B virus pre-S/St transactivator is generated by 3' truncations within a defined region of the S gene. J Virol 1992;66:5284-9.
    • (1992) J Virol , vol.66 , pp. 5284-5289
    • Lauer, U.1    Weiss, L.2    Hofschneider, P.H.3    Kekulé, A.S.4
  • 200
    • 0037084160 scopus 로고    scopus 로고
    • The PreS2 activator MHBs(t) of hepatitis B virus activates craf-1/Erk2 signaling in transgenic mice
    • Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH. The PreS2 activator MHBs(t) of hepatitis B virus activates craf-1/Erk2 signaling in transgenic mice. EMBO J 2002;21:525-35.
    • (2002) EMBO J , vol.21 , pp. 525-535
    • Hildt, E.1    Munz, B.2    Saher, G.3    Reifenberg, K.4    Hofschneider, P.H.5
  • 201
    • 0019313239 scopus 로고
    • Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma
    • Bréchot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980;286:533-5.
    • (1980) Nature , vol.286 , pp. 533-535
    • Bréchot, C.1    Pourcel, C.2    Louise, A.3    Rain, B.4    Tiollais, P.5
  • 202
    • 0019307425 scopus 로고
    • Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line
    • Chakraborty PR, Ruiz Opazo H, Shouval D, Shafritz DA. Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line. Nature 1980;286:531-3.
    • (1980) Nature , vol.286 , pp. 531-533
    • Chakraborty, P.R.1    Ruiz Opazo, H.2    Shouval, D.3    Shafritz, D.A.4
  • 203
    • 0019311009 scopus 로고
    • Integration of hepatitis B virus sequences and their expression in a human hepatoma cell
    • Edman JC, Gray P, Valenzuela P, Rall LB, Rutter WJ. Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature 1980;286:535-7.
    • (1980) Nature , vol.286 , pp. 535-537
    • Edman, J.C.1    Gray, P.2    Valenzuela, P.3    Rall, L.B.4    Rutter, W.J.5
  • 204
    • 0023146129 scopus 로고
    • Sequences of hepatitis B virus DNA in the serum and liver of patients with acute benign and fulminant hepatitis
    • Lugassy C, Bernuau J, Thiers V et al. Sequences of hepatitis B virus DNA in the serum and liver of patients with acute benign and fulminant hepatitis. J Infect Dis 1987;155:64-71.
    • (1987) J Infect Dis , vol.155 , pp. 64-71
    • Lugassy, C.1    Bernuau, J.2    Thiers, V.3
  • 205
    • 0024535985 scopus 로고
    • An in-vitro system for infection with hepatitis B virus that uses primary human fetal hepatocytes
    • Ochiya T, Tsurimoto T, Ueda K, Okubo K, Shiozawa M, Matsubara K. An in-vitro system for infection with hepatitis B virus that uses primary human fetal hepatocytes. Proc Natl Acad Sci USA 1989;86:1875-9.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1875-1879
    • Ochiya, T.1    Tsurimoto, T.2    Ueda, K.3    Okubo, K.4    Shiozawa, M.5    Matsubara, K.6
  • 206
    • 0021951140 scopus 로고
    • Detection of integration during active replication of hepatitis B virus in the liver
    • Boender PJ, Schalm SW, Heijtink RA. Detection of integration during active replication of hepatitis B virus in the liver. J Med Virol 1985;16:47-54.
    • (1985) J Med Virol , vol.16 , pp. 47-54
    • Boender, P.J.1    Schalm, S.W.2    Heijtink, R.A.3
  • 207
    • 0023687635 scopus 로고
    • Frequent integration of hepatitis B virus DNA in noncancerous liver tissue from hepatocellular carcinoma patients
    • Tanaka Y, Esumi M, Shikata T. Frequent integration of hepatitis B virus DNA in noncancerous liver tissue from hepatocellular carcinoma patients. J Med Virol 1988;26:7-14.
    • (1988) J Med Virol , vol.26 , pp. 7-14
    • Tanaka, Y.1    Esumi, M.2    Shikata, T.3
  • 208
    • 0025007987 scopus 로고
    • Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis
    • Matsubara K, Tokino T. Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis. Mol Biol Med 1990;7:243-260.
    • (1990) Mol Biol Med , vol.7 , pp. 243-260
    • Matsubara, K.1    Tokino, T.2
  • 209
    • 84991172307 scopus 로고
    • Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood
    • Chang MH, Chen PJ, Chen JY et al. Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood. Hepatology 1991;13:316-20.
    • (1991) Hepatology , vol.13 , pp. 316-320
    • Chang, M.H.1    Chen, P.J.2    Chen, J.Y.3
  • 211
    • 84984537206 scopus 로고    scopus 로고
    • Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas
    • Tsuei DJ, Chang MH, Chen PJ, Hsu TY, Ni YH. Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas. J Med Virol 2002;68:513-21.
    • (2002) J Med Virol , vol.68 , pp. 513-521
    • Tsuei, D.J.1    Chang, M.H.2    Chen, P.J.3    Hsu, T.Y.4    Ni, Y.H.5
  • 212
    • 0024334177 scopus 로고
    • Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration
    • Hino O, Ohtake K, Rogler CE. Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration. J Virol 1989;63:2638-43.
    • (1989) J Virol , vol.63 , pp. 2638-2643
    • Hino, O.1    Ohtake, K.2    Rogler, C.E.3
  • 213
    • 2442676945 scopus 로고
    • Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11 base pair direct repeat
    • Dejean A, Sonigo P, Wain-Hobson S, Tiollais P. Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11 base pair direct repeat. Proc Natl Acad Sci USA 1984;81:5350-4.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5350-5354
    • Dejean, A.1    Sonigo, P.2    Wain-Hobson, S.3    Tiollais, P.4
  • 214
    • 0023236579 scopus 로고
    • Integrated state of subgenomic fragments of hepatitis B virus DNA in hepatocellular carcinoma from mainland China
    • Zhou YZ, Butel JS, Li PJ, Finegold MJ, Melnick JL. Integrated state of subgenomic fragments of hepatitis B virus DNA in hepatocellular carcinoma from mainland China. J Natl Cancer Inst 1987;79:223-231.
    • (1987) J Natl Cancer Inst , vol.79 , pp. 223-231
    • Zhou, Y.Z.1    Butel, J.S.2    Li, P.J.3    Finegold, M.J.4    Melnick, J.L.5
  • 215
    • 0033860678 scopus 로고    scopus 로고
    • Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    • Bréchot C, Gozuacik D, Murakami Y, Paterlini-Bréchot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin Cancer Biol 2000;10:211-31.
    • (2000) Semin Cancer Biol , vol.10 , pp. 211-231
    • Bréchot, C.1    Gozuacik, D.2    Murakami, Y.3    Paterlini-Bréchot, P.4
  • 216
    • 0142227237 scopus 로고    scopus 로고
    • Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons
    • Bushman FD. Targeting survival: integration site selection by retroviruses and LTR-retrotransposons. Cell 2003;115:135-8.
    • (2003) Cell , vol.115 , pp. 135-138
    • Bushman, F.D.1
  • 217
    • 0025167175 scopus 로고
    • Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours
    • Fourel G, Trépo C, Bougueleret L et al. Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature 1990;347:294-8.
    • (1990) Nature , vol.347 , pp. 294-298
    • Fourel, G.1    Trépo, C.2    Bougueleret, L.3
  • 218
    • 0026636121 scopus 로고
    • Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma
    • Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Bréchot C. Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma. Oncogene 1992;7:1653-6.
    • (1992) Oncogene , vol.7 , pp. 1653-1656
    • Wang, J.1    Zindy, F.2    Chenivesse, X.3    Lamas, E.4    Henglein, B.5    Bréchot, C.6
  • 220
    • 0032510412 scopus 로고    scopus 로고
    • Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon hepatitis B virus genome insertion
    • Berasain C, Patil D, Perara E, Huang SM, Mouly H, Bréchot C. Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon hepatitis B virus genome insertion. Oncogene 1998;16:1277-88.
    • (1998) Oncogene , vol.16 , pp. 1277-1288
    • Berasain, C.1    Patil, D.2    Perara, E.3    Huang, S.M.4    Mouly, H.5    Bréchot, C.6
  • 221
    • 0001215032 scopus 로고
    • Hepatitis B virus and primary liver cancer in hepatitis B surface antigen-positive and -negative patients
    • Bréchot C, ed., Boca Raton: CRC Press
    • Paterlini P, Bréchot C. Hepatitis B virus and primary liver cancer in hepatitis B surface antigen-positive and -negative patients. In: Bréchot C, ed. Primary Liver Cancer: Etiological and Progression Factors. Boca Raton: CRC Press, 1994:167-90.
    • (1994) Primary Liver Cancer: Etiological and Progression Factors , pp. 167-190
    • Paterlini, P.1    Bréchot, C.2
  • 222
    • 0027531408 scopus 로고
    • Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: A study of a low-endemic area
    • Paterlini P, Driss F, Nalpas B et al. Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: a study of a low-endemic area. Hepatology 1993;17:20-9.
    • (1993) Hepatology , vol.17 , pp. 20-29
    • Paterlini, P.1    Driss, F.2    Nalpas, B.3
  • 223
    • 0034622018 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis
    • Chami M, Gozuacik D, Saigo K et al. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene 2000;19:2877-86.
    • (2000) Oncogene , vol.19 , pp. 2877-2886
    • Chami, M.1    Gozuacik, D.2    Saigo, K.3
  • 224
    • 0037871858 scopus 로고    scopus 로고
    • Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers
    • Ferber MJ, Montoya DP, Yu C et al. Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers. Oncogene 2003;22:3813-20.
    • (2003) Oncogene , vol.22 , pp. 3813-3820
    • Ferber, M.J.1    Montoya, D.P.2    Yu, C.3
  • 225
    • 0035423134 scopus 로고    scopus 로고
    • cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome
    • Horikawa I, Barrett JC. cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. J Natl Cancer Inst 2001;93:1171-3.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1171-1173
    • Horikawa, I.1    Barrett, J.C.2
  • 226
    • 0022809150 scopus 로고
    • Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation
    • Hino O, Shows TB, Rogler CE. Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci USA 1986;83:8338-42.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8338-8342
    • Hino, O.1    Shows, T.B.2    Rogler, C.E.3
  • 227
    • 0023520212 scopus 로고
    • Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas
    • Tokino T, Fukushige S, Nakamura T et al. Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas. J Virol 1987;61:3848-54.
    • (1987) J Virol , vol.61 , pp. 3848-3854
    • Tokino, T.1    Fukushige, S.2    Nakamura, T.3
  • 228
    • 0022006880 scopus 로고
    • Hepatitis B virus integration in hepatocellular carcinoma DNA: Duplication of cellular flanking sequences at the integration site
    • Yaginuma K, Kobayashi M, Yoshida E, Koike K. Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site. Proc Natl Acad Sci USA 1985;82:4458-62.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4458-4462
    • Yaginuma, K.1    Kobayashi, M.2    Yoshida, E.3    Koike, K.4
  • 229
    • 0025990943 scopus 로고
    • Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA
    • Hino O, Tabata S, Hotta Y. Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci USA 1991;88:9248-52.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9248-9252
    • Hino, O.1    Tabata, S.2    Hotta, Y.3
  • 230
    • 0026089373 scopus 로고
    • Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in viruspositive hepatocellular carcinomas
    • Slagle BL, Zhou YZ, Butel JS. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in viruspositive hepatocellular carcinomas. Cancer Res 1991;51:49-54.
    • (1991) Cancer Res , vol.51 , pp. 49-54
    • Slagle, B.L.1    Zhou, Y.Z.2    Butel, J.S.3
  • 231
    • 0025966721 scopus 로고
    • Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host
    • Seeger C, Baldwin B, Hornbuckle WE et al. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. J Virol 1991;65:1673-9.
    • (1991) J Virol , vol.65 , pp. 1673-1679
    • Seeger, C.1    Baldwin, B.2    Hornbuckle, W.E.3
  • 232
    • 0038043101 scopus 로고
    • Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus
    • Marion PL, Van Davelaar MJ, Knight SS et al. Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus. Proc Natl Acad Sci USA 1986;83:4543-6.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4543-4546
    • Marion, P.L.1    Van Davelaar, M.J.2    Knight, S.S.3
  • 233
    • 0026470728 scopus 로고
    • Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter
    • Fourel G, Transy C, Tennant BC, Buendia MA. Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter. Mol Cell Biol 1992;12:5336-44.
    • (1992) Mol Cell Biol , vol.12 , pp. 5336-5344
    • Fourel, G.1    Transy, C.2    Tennant, B.C.3    Buendia, M.A.4
  • 235
    • 0033541954 scopus 로고    scopus 로고
    • Activation of the N-myc2 oncogene by woodchuck hepatitis virus integration in the linked downstream b3n locus in woodchuck hepatocellular carcinoma
    • Bruni R, D’Ugo E, Giuseppetti R, Argentini C, Rapicetta M. Activation of the N-myc2 oncogene by woodchuck hepatitis virus integration in the linked downstream b3n locus in woodchuck hepatocellular carcinoma. Virology 1999;257:483-90.
    • (1999) Virology , vol.257 , pp. 483-490
    • Bruni, R.1    D’Ugo, E.2    Giuseppetti, R.3    Argentini, C.4    Rapicetta, M.5
  • 236
    • 0031818149 scopus 로고    scopus 로고
    • Identification of scaffold/matrix attachment region in recurrent site of woodchuck hepatitis virus integration
    • D’Ugo E, Bruni R, Argentini C, Giuseppetti R, Rapicetta M. Identification of scaffold/matrix attachment region in recurrent site of woodchuck hepatitis virus integration. DNA Cell Biol 1998;17:519-27.
    • (1998) DNA Cell Biol , vol.17 , pp. 519-527
    • D’Ugo, E.1    Bruni, R.2    Argentini, C.3    Giuseppetti, R.4    Rapicetta, M.5
  • 237
    • 0028144710 scopus 로고
    • Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion
    • Etiemble J, Degott C, Renard CA et al. Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion. Oncogene 1994;9:727-37.
    • (1994) Oncogene , vol.9 , pp. 727-737
    • Etiemble, J.1    Degott, C.2    Renard, C.A.3
  • 238
    • 0034682340 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in WHV/N-myc 2 transgenic mice: Oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles
    • Renard CA, Fourel G, Bralet MP et al. Hepatocellular carcinoma in WHV/N-myc 2 transgenic mice: Oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles. Oncogene 2000;19:2678-86.
    • (2000) Oncogene , vol.19 , pp. 2678-2686
    • Renard, C.A.1    Fourel, G.2    Bralet, M.P.3
  • 239
    • 0024556087 scopus 로고
    • Fused transcripts of c-myc and a new cellular locus, hcr, in a primary liver tumor
    • Etiemble J, Möröy T, Jacquemin E, Tiollais P, Buendia MA. Fused transcripts of c-myc and a new cellular locus, hcr, in a primary liver tumor. Oncogene 1989;4:51-7.
    • (1989) Oncogene , vol.4 , pp. 51-57
    • Etiemble, J.1    Möröy, T.2    Jacquemin, E.3    Tiollais, P.4    Buendia, M.A.5
  • 240
    • 0023005611 scopus 로고
    • Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks
    • Möröy T, Marchio A, Etiemble J, Trépo C, Tiollais P, Buendia MA. Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks. Nature 1986;324:276-9.
    • (1986) Nature , vol.324 , pp. 276-279
    • Möröy, T.1    Marchio, A.2    Etiemble, J.3    Trépo, C.4    Tiollais, P.5    Buendia, M.A.6
  • 241
    • 0020580576 scopus 로고
    • Importance of markers of hepatitis B virus in alcoholic liver disease
    • Saunders JB, Wodak AD, Morgan-Capner P et al. Importance of markers of hepatitis B virus in alcoholic liver disease. BMJ 1983;286:1851-4.
    • (1983) BMJ , vol.286 , pp. 1851-1854
    • Saunders, J.B.1    Wodak, A.D.2    Morgan-Capner, P.3
  • 242
    • 0023094230 scopus 로고
    • Hepatitis B virus (HBV) and hepatocellular carcinoma, HBV status and its implication
    • Bréchot C. Hepatitis B virus (HBV) and hepatocellular carcinoma, HBV status and its implication. J Hepatol 1987;4:269-79.
    • (1987) J Hepatol , vol.4 , pp. 269-279
    • Bréchot, C.1
  • 243
    • 0021435966 scopus 로고
    • Relationship between hepatocellular carcinoma and cirrhosis
    • Kew M, Popper H. Relationship between hepatocellular carcinoma and cirrhosis. Semin Liver Dis 1984;4:136-45.
    • (1984) Semin Liver Dis , vol.4 , pp. 136-145
    • Kew, M.1    Popper, H.2
  • 244
    • 0024541949 scopus 로고
    • Hepatocellular carcinoma: Possible etiologies in patients without serologic evidence of hepatitis B virus infection
    • Tabor E. Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection. J Med Virol 1989;27:1-6.
    • (1989) J Med Virol , vol.27 , pp. 1-6
    • Tabor, E.1
  • 245
    • 0344405675 scopus 로고    scopus 로고
    • Molecular and serological aspects of HBsAg-negative hepatitis B virus infections in North America
    • Hsia CC, Scudamore CH, Di Bisceglie AM, Tabor E. Molecular and serological aspects of HBsAg-negative hepatitis B virus infections in North America. J Med Virol 2003;70:20-6.
    • (2003) J Med Virol , vol.70 , pp. 20-26
    • Hsia, C.C.1    Scudamore, C.H.2    Di Bisceglie, A.M.3    Tabor, E.4
  • 246
    • 0026735844 scopus 로고
    • Hepatocellular carcinoma
    • Colombo M. Hepatocellular carcinoma. J Hepatol 1992;15:225-36.
    • (1992) J Hepatol , vol.15 , pp. 225-236
    • Colombo, M.1
  • 247
    • 0026085984 scopus 로고
    • Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease
    • Nalpas B, Driss F, Pol S et al. Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease. J Hepatol 1991;12:70-4.
    • (1991) J Hepatol , vol.12 , pp. 70-74
    • Nalpas, B.1    Driss, F.2    Pol, S.3
  • 248
    • 0023595068 scopus 로고
    • Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: Relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors
    • Pol S, Thiers V, Nalpas B et al. Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors. Eur J Clin Invest 1987;17:515-21.
    • (1987) Eur J Clin Invest , vol.17 , pp. 515-521
    • Pol, S.1    Thiers, V.2    Nalpas, B.3
  • 249
    • 0024555632 scopus 로고
    • Hepatocellular carcinoma with normal adjacent liver hepatitis B virus DNA status
    • Marcellin P, Thiers V, Degott C et al. Hepatocellular carcinoma with normal adjacent liver hepatitis B virus DNA status. J Hepatol 1989;8:249-253.
    • (1989) J Hepatol , vol.8 , pp. 249-253
    • Marcellin, P.1    Thiers, V.2    Degott, C.3
  • 250
    • 0023247248 scopus 로고
    • HBV DNA sequences are rarely detected in the liver of patients with HBsAg negative chronic active liver disease and with hepatocellular carcinoma in Italy
    • Pontisso P, Stanico D, Diodati G et al. HBV DNA sequences are rarely detected in the liver of patients with HBsAg negative chronic active liver disease and with hepatocellular carcinoma in Italy. Liver 1987;7:211-15.
    • (1987) Liver , vol.7 , pp. 211-215
    • Pontisso, P.1    Stanico, D.2    Diodati, G.3
  • 251
    • 0026289326 scopus 로고
    • Does hepatitis B virus play a role in primary liver cancer in children of western countries?
    • Pontisso P, Basso G, Perilongo G et al. Does hepatitis B virus play a role in primary liver cancer in children of western countries? Cancer Detect Prev 1991;15:363-8.
    • (1991) Cancer Detect Prev , vol.15 , pp. 363-368
    • Pontisso, P.1    Basso, G.2    Perilongo, G.3
  • 252
    • 0023778097 scopus 로고
    • Hepatocellular carcinoma in alcoholic liver disease: No evidence for a pathogenetic role of hepatitis B virus infection
    • Walter E, Blum H, Meier P et al. Hepatocellular carcinoma in alcoholic liver disease: no evidence for a pathogenetic role of hepatitis B virus infection. Hepatology 1988;8:745-8.
    • (1988) Hepatology , vol.8 , pp. 745-748
    • Walter, E.1    Blum, H.2    Meier, P.3
  • 253
    • 0023022320 scopus 로고
    • Hepatocellular carcinoma in North-East England: Importance of hepatitis B infection and ex-tropical military service
    • Cobden I, Bassendine M, James O. Hepatocellular carcinoma in North-East England: importance of hepatitis B infection and ex-tropical military service. Q J Med 1986;60:855-63.
    • (1986) Q J Med , vol.60 , pp. 855-863
    • Cobden, I.1    Bassendine, M.2    James, O.3
  • 254
    • 0023835029 scopus 로고
    • Hepatocellular carcinoma:Clinical, aetiological and pathological features in British patients
    • Dunk A, Spiliadis H, Sherlock S et al. Hepatocellular carcinoma:clinical, aetiological and pathological features in British patients. Int J Cancer 1988;41:17-23.
    • (1988) Int J Cancer , vol.41 , pp. 17-23
    • Dunk, A.1    Spiliadis, H.2    Sherlock, S.3
  • 255
    • 0025288533 scopus 로고
    • Frequency of hepatic HBV-DNA in patients with cirrhosis and hepatocellular carcinoma: Relation to serum HBV markers
    • White YS, Johnson PJ, Davison F, Williams R. Frequency of hepatic HBV-DNA in patients with cirrhosis and hepatocellular carcinoma: relation to serum HBV markers. Br J Cancer 1990;61:909-12.
    • (1990) Br J Cancer , vol.61 , pp. 909-912
    • White, Y.S.1    Johnson, P.J.2    Davison, F.3    Williams, R.4
  • 256
    • 0024213491 scopus 로고
    • Status of hepatitis B virus DNA in alcoholic liver disease: A study of a large urban population in the united states
    • Fong T, Govindarajan S, Valinluck B, Redeker A. Status of hepatitis B virus DNA in alcoholic liver disease: a study of a large urban population in the united states. Hepatology 1988;8:1602-4.
    • (1988) Hepatology , vol.8 , pp. 1602-1604
    • Fong, T.1    Govindarajan, S.2    Valinluck, B.3    Redeker, A.4
  • 257
    • 0021832510 scopus 로고
    • Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinomas in Japan
    • Hino O, Kitagawa T, Sugano H. Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinomas in Japan. Int J Cancer 1985;35:5-10.
    • (1985) Int J Cancer , vol.35 , pp. 5-10
    • Hino, O.1    Kitagawa, T.2    Sugano, H.3
  • 258
    • 0021333320 scopus 로고
    • Detection of hepatitis B virus DNA in hepatocellular carcinomas in Japan
    • Hino O, Kitagawa T, Koike K et al. Detection of hepatitis B virus DNA in hepatocellular carcinomas in Japan. Hepatology 1984;4:90-5.
    • (1984) Hepatology , vol.4 , pp. 90-95
    • Hino, O.1    Kitagawa, T.2    Koike, K.3
  • 260
    • 0024401107 scopus 로고
    • HBV DNA hybridization in hepatocellular carcinoma associated with alcohol in Japan
    • Horiike N, Michitaka K, Onji M, Murota T, Ohta Y. HBV DNA hybridization in hepatocellular carcinoma associated with alcohol in Japan. J Med Virol 1989;28:189-92.
    • (1989) J Med Virol , vol.28 , pp. 189-192
    • Horiike, N.1    Michitaka, K.2    Onji, M.3    Murota, T.4    Ohta, Y.5
  • 261
    • 15844417036 scopus 로고
    • Hepatocellular detection of hepatitis B virus DNA in hepatocellular carcinoma
    • Chen C, Diani A, Brown P, Kaluzny M, Epps D. Hepatocellular detection of hepatitis B virus DNA in hepatocellular carcinoma. Br J Exp Pathol 1986;67:1868.
    • (1986) Br J Exp Pathol , vol.67 , pp. 1868
    • Chen, C.1    Diani, A.2    Brown, P.3    Kaluzny, M.4    Epps, D.5
  • 262
    • 0025887693 scopus 로고
    • Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules
    • Hsu HC, Chiou TJ, Chen JY, Lee CS, Lee PH, Peng SY. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 1991;13:923-8.
    • (1991) Hepatology , vol.13 , pp. 923-928
    • Hsu, H.C.1    Chiou, T.J.2    Chen, J.Y.3    Lee, C.S.4    Lee, P.H.5    Peng, S.Y.6
  • 263
    • 0025485004 scopus 로고
    • Hepatitis B virus replication in Chinese patients with hepatocellular carcinoma
    • Lok A, Ma O. Hepatitis B virus replication in Chinese patients with hepatocellular carcinoma. Hepatology 1990;12:582-8.
    • (1990) Hepatology , vol.12 , pp. 582-588
    • Lok, A.1    Ma, O.2
  • 264
    • 84984535714 scopus 로고
    • Identification and characterization of intrahepatic hepatitis B virus DNA in HBsAg-seronegative patients with chronic liver disease and hepatocellular carcinoma in Taïwan
    • Lai M, Chen P, Yang P, Sheu J, Sung J, Chen D. Identification and characterization of intrahepatic hepatitis B virus DNA in HBsAg-seronegative patients with chronic liver disease and hepatocellular carcinoma in Taïwan. Hepatology 1990;3:575-81.
    • (1990) Hepatology , vol.3 , pp. 575-581
    • Lai, M.1    Chen, P.2    Yang, P.3    Sheu, J.4    Sung, J.5    Chen, D.6
  • 265
    • 0019797004 scopus 로고
    • Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas
    • Shafritz D, Kew M. Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas. Hepatology 1981;1:1-8.
    • (1981) Hepatology , vol.1 , pp. 1-8
    • Shafritz, D.1    Kew, M.2
  • 266
    • 0026347064 scopus 로고
    • Hepatitis B virus DNA in HBsAg-negative patients. Molecular characterization and clinical implications
    • Bréchot C, Kremsdorf D, Paterlini P, Thiers V. Hepatitis B virus DNA in HBsAg-negative patients. Molecular characterization and clinical implications. J Hepatol 1991;13:S49-S55.
    • (1991) J Hepatol , vol.13 , pp. S49-S55
    • Bréchot, C.1    Kremsdorf, D.2    Paterlini, P.3    Thiers, V.4
  • 267
    • 0001959179 scopus 로고
    • Ground squirrel hepatitis virus
    • McLachlan A, ed., Boca Raton: CRC Press
    • Marion PL. Ground squirrel hepatitis virus. In: McLachlan A, ed. Molecular Biology of the Hepatitis B Virus. Boca Raton: CRC Press, 1991:39-51.
    • (1991) Molecular Biology of the Hepatitis B Virus , pp. 39-51
    • Marion, P.L.1
  • 268
    • 0038174751 scopus 로고    scopus 로고
    • Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg)
    • Shimada S, Aizawa R, Abe H, Suto S, Miyakawa Y, Aizawa Y. Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg). Intern Med 2003;42:389-93.
    • (2003) Intern Med , vol.42 , pp. 389-393
    • Shimada, S.1    Aizawa, R.2    Abe, H.3    Suto, S.4    Miyakawa, Y.5    Aizawa, Y.6
  • 269
    • 84991186978 scopus 로고
    • Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance
    • Mendenhall CL, Seeff L, Diehl AM et al. Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. Hepatology 1991;14:581-9.
    • (1991) Hepatology , vol.14 , pp. 581-589
    • Mendenhall, C.L.1    Seeff, L.2    Diehl, A.M.3
  • 270
    • 0025690422 scopus 로고
    • Hepatitis C virus antibodies in chronic alcoholic patients association with severity of liver injury
    • Pares A, Barrera JM, Caballeria J et al. Hepatitis C virus antibodies in chronic alcoholic patients association with severity of liver injury. Hepatology 1990;12:1295-9.
    • (1990) Hepatology , vol.12 , pp. 1295-1299
    • Pares, A.1    Barrera, J.M.2    Caballeria, J.3
  • 271
    • 0019775608 scopus 로고
    • Les marqueurs du virus B chez les alcooliques chroniques
    • (in French)
    • Attali P, Thibault N, Buffett C et al. Les marqueurs du virus B chez les alcooliques chroniques. Clin Biol 1981;5:1095-102 (in French).
    • (1981) Clin Biol , vol.5 , pp. 1095-1102
    • Attali, P.1    Thibault, N.2    Buffett, C.3
  • 272
    • 0021812955 scopus 로고
    • Hepatitis B virus multiplication in the absence of usual serological markers. A study of 146 alcoholics
    • Nalpas B, Berthelot P, Thiers V et al. Hepatitis B virus multiplication in the absence of usual serological markers. A study of 146 alcoholics. J Hepatol 1985;1:89-97.
    • (1985) J Hepatol , vol.1 , pp. 89-97
    • Nalpas, B.1    Berthelot, P.2    Thiers, V.3
  • 273
    • 0025820028 scopus 로고
    • Independent risk factors for hepatocellular carcinoma in French drinkers
    • Poynard T, Aubert A, Lazizi Y et al. Independent risk factors for hepatocellular carcinoma in French drinkers. Hepatology 1991;13:896-901.
    • (1991) Hepatology , vol.13 , pp. 896-901
    • Poynard, T.1    Aubert, A.2    Lazizi, Y.3
  • 274
    • 0025369361 scopus 로고
    • Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen
    • Paterlini P, Gerken G, Nakajima E et al. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N Engl J Med 1990;323:80-5.
    • (1990) N Engl J Med , vol.323 , pp. 80-85
    • Paterlini, P.1    Gerken, G.2    Nakajima, E.3
  • 275
    • 0026579271 scopus 로고
    • Latent hepatitis B virus infection in childhood hepatocellular carcinoma
    • Pontisso P, Morsica G, Ruvoletto MG et al. Latent hepatitis B virus infection in childhood hepatocellular carcinoma. Cancer 1992;69:2731-5.
    • (1992) Cancer , vol.69 , pp. 2731-2735
    • Pontisso, P.1    Morsica, G.2    Ruvoletto, M.G.3
  • 276
    • 0026775254 scopus 로고
    • Hepatitis B and C viral infections in patients with hepatocellular carcinoma
    • Ruiz J, Sangro B, Guende JI et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992;3:637-40.
    • (1992) Hepatology , vol.3 , pp. 637-640
    • Ruiz, J.1    Sangro, B.2    Guende, J.I.3
  • 277
    • 0025152890 scopus 로고
    • Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction
    • Ohkoshi S, Kato N, Kinoshita T et al. Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction. Jpn J Cancer Res 1990;81:862-5.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 862-865
    • Ohkoshi, S.1    Kato, N.2    Kinoshita, T.3
  • 278
    • 0026425526 scopus 로고
    • Detection of hepatitis B virus DNA by polymerase chain reaction in HBsAg negative Senegalese patients suffering from cirrhosis or primary liver cancer
    • Coursaget P, Le Cann P, Leboulleux D, Diop MT, Bao O, Coll AM. Detection of hepatitis B virus DNA by polymerase chain reaction in HBsAg negative Senegalese patients suffering from cirrhosis or primary liver cancer. FEMS Microbiol Lett 1991;67:35-8.
    • (1991) FEMS Microbiol Lett , vol.67 , pp. 35-38
    • Coursaget, P.1    Le Cann, P.2    Leboulleux, D.3    Diop, M.T.4    Bao, O.5    Coll, A.M.6
  • 279
    • 0025868337 scopus 로고
    • Polymerase chain reaction for detection of hepatitis B virus DNA in HBsAg seronegative patients with hepatocellular carcinoma from Mozambique
    • Dazza MC, Meneses LV, Girard PM et al. Polymerase chain reaction for detection of hepatitis B virus DNA in HBsAg seronegative patients with hepatocellular carcinoma from Mozambique. Ann Trop Med Paraitol 1991;85:277-9.
    • (1991) Ann Trop Med Paraitol , vol.85 , pp. 277-279
    • Dazza, M.C.1    Meneses, L.V.2    Girard, P.M.3
  • 280
    • 15844369216 scopus 로고
    • Viral etiology of hepatocellular carcinoma in United States
    • Liang TJ, Jeffers L, Cheinquer H et al. Viral etiology of hepatocellular carcinoma in United States. Hepatology 1992;16:128A.
    • (1992) Hepatology , vol.16 , pp. 128
    • Liang, T.J.1    Jeffers, L.2    Cheinquer, H.3
  • 281
    • 0034950571 scopus 로고    scopus 로고
    • Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: Clinically significant or purely ‘occult’?
    • Bréchot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Bréchot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely ‘occult’? Hepatology 2001;34:194-203.
    • (2001) Hepatology , vol.34 , pp. 194-203
    • Bréchot, C.1    Thiers, V.2    Kremsdorf, D.3    Nalpas, B.4    Pol, S.5    Paterlini-Bréchot, P.6
  • 282
    • 0024571542 scopus 로고
    • Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections
    • Korba BE, Wells FV, Baldwin B et al. Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections. Hepatology 1989;9:461-70.
    • (1989) Hepatology , vol.9 , pp. 461-470
    • Korba, B.E.1    Wells, F.V.2    Baldwin, B.3
  • 283
  • 284
    • 15844362107 scopus 로고
    • Primary liver cancer in HBsAg-negative patients: A study of HBV genome using the polymerase chain reaction
    • Hollinger FB, Lemon SM, Margolis H, eds., USA: Williams & Wilkins
    • Paterlini P, Gerken G, Khemeny F et al. Primary liver cancer in HBsAg-negative patients: a study of HBV genome using the polymerase chain reaction. In: Hollinger FB, Lemon SM, Margolis H, eds. Viral Hepatitis and Liver Disease. USA: Williams & Wilkins, 1991:605-10.
    • (1991) Viral Hepatitis and Liver Disease , pp. 605-610
    • Paterlini, P.1    Gerken, G.2    Khemeny, F.3
  • 285
    • 0020659255 scopus 로고
    • The oncogenic potential of herpes simplex viruses evidence for a ‘hit and run’ mechanism
    • Galloway DA, Mc Dougall JK. The oncogenic potential of herpes simplex viruses evidence for a ‘hit and run’ mechanism. Nature 1983;302:21-4.
    • (1983) Nature , vol.302 , pp. 21-24
    • Galloway, D.A.1    Mc Dougall, J.K.2
  • 286
    • 0023941830 scopus 로고
    • ‘Hit and run’ transformation of mouse C127 cells by bovine papillomavirus type 4: The viral DNA is required for the initiation but not for maintenance of the transformed phenotype
    • Smith KT, Campo MS. ‘Hit and run’ transformation of mouse C127 cells by bovine papillomavirus type 4: the viral DNA is required for the initiation but not for maintenance of the transformed phenotype. Virology 1988;64:39-47.
    • (1988) Virology , vol.64 , pp. 39-47
    • Smith, K.T.1    Campo, M.S.2
  • 287
    • 0030058333 scopus 로고    scopus 로고
    • Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells
    • Gong SS, Jensen AD, Rogler CE. Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells. J Virol 1996;70:2000-7.
    • (1996) J Virol , vol.70 , pp. 2000-2007
    • Gong, S.S.1    Jensen, A.D.2    Rogler, C.E.3
  • 288
    • 17344381535 scopus 로고    scopus 로고
    • Hepatitis C virus biology
    • Giannini C, Brechot C. Hepatitis C virus biology. Cell Death Differ 2003;10(Suppl. 1)):S27-S38.
    • (2003) Cell Death Differ , vol.10 , pp. S27-S38
    • Giannini, C.1    Brechot, C.2
  • 289
    • 0028097986 scopus 로고
    • Conservation of hepatitis C virus 5' untranslated sequence in hepatocellular carcinoma and the surrounding liver
    • Sullivan DE, Gerber MA. Conservation of hepatitis C virus 5' untranslated sequence in hepatocellular carcinoma and the surrounding liver. Hepatology 1994;19:551-3.
    • (1994) Hepatology , vol.19 , pp. 551-553
    • Sullivan, D.E.1    Gerber, M.A.2
  • 290
    • 0028818269 scopus 로고
    • Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR
    • Landford R, Chavez D, Vonchisari F, Sureau C. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol 1995;69:8079-83.
    • (1995) J Virol , vol.69 , pp. 8079-8083
    • Landford, R.1    Chavez, D.2    Vonchisari, F.3    Sureau, C.4
  • 291
    • 0141626825 scopus 로고    scopus 로고
    • Mechanisms of viral hepatitis induced liver injury
    • Nakamoto Y, Kaneko S. Mechanisms of viral hepatitis induced liver injury. Curr Mol Med 2003;3:537-44.
    • (2003) Curr Mol Med , vol.3 , pp. 537-544
    • Nakamoto, Y.1    Kaneko, S.2
  • 292
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block TM, Mehta AS, Fimmel CJ, Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003;22:5093-107.
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 293
    • 0028950183 scopus 로고
    • HCV-associated liver cancer without cirrhosis
    • De Mitri S, Poussin K, Baccarini P. HCV-associated liver cancer without cirrhosis. Lancet 1995;345:413-15.
    • (1995) Lancet , vol.345 , pp. 413-415
    • De Mitri, S.1    Poussin, K.2    Baccarini, P.3
  • 294
    • 0029114785 scopus 로고
    • Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
    • Ray R, Lagging L, Meyer K, Steele R, Ray R. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res 1995;37:209-20.
    • (1995) Virus Res , vol.37 , pp. 209-220
    • Ray, R.1    Lagging, L.2    Meyer, K.3    Steele, R.4    Ray, R.5
  • 295
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K, Fujie H, Shintani Y et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998;4:1065-7.
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3
  • 296
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H, Honda M, Beard MR et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002;122:352-65.
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.R.3
  • 297
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virusassociated hepatocarcinogenesis
    • Moriya K, Nakagawa K, Santa T et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virusassociated hepatocarcinogenesis. Cancer Res 2001;61:4365-70.
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 298
    • 0028564739 scopus 로고
    • Trans-suppression of gene expression by hepatitis C viral core protein
    • Kim DW, Suzuki R, Harada T. Trans-suppression of gene expression by hepatitis C viral core protein. Jpn J Med Sci Biol 1994;47:211-20.
    • (1994) Jpn J Med Sci Biol , vol.47 , pp. 211-220
    • Kim, D.W.1    Suzuki, R.2    Harada, T.3
  • 299
    • 0028794910 scopus 로고
    • Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
    • Shih CM, Chen CM, Chen SY, Lee YH. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J Virol 1995;69:1160-70.
    • (1995) J Virol , vol.69 , pp. 1160-1170
    • Shih, C.M.1    Chen, C.M.2    Chen, S.Y.3    Lee, Y.H.4
  • 300
    • 11144357274 scopus 로고    scopus 로고
    • Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
    • Barba G, Harper F, Harada T et al. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci USA 1997;94:1200-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1200-1205
    • Barba, G.1    Harper, F.2    Harada, T.3
  • 301
    • 0028840840 scopus 로고
    • Differential subcellular localization of hepatitis C virus core gene products
    • Lo SY, Masiarz F, Hwang SB, Lai MMC, Ou JH. Differential subcellular localization of hepatitis C virus core gene products. Virology 1995;213:455-61.
    • (1995) Virology , vol.213 , pp. 455-461
    • Lo, S.Y.1    Masiarz, F.2    Hwang, S.B.3    Lai, M.M.C.4    Ou, J.H.5
  • 302
    • 0035855632 scopus 로고    scopus 로고
    • Activation of the interferoninducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein
    • Delhem N, Sabile A, Gajardo R et al. Activation of the interferoninducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein. Oncogene 2001;20:5836-45.
    • (2001) Oncogene , vol.20 , pp. 5836-5845
    • Delhem, N.1    Sabile, A.2    Gajardo, R.3
  • 303
    • 0030051841 scopus 로고    scopus 로고
    • Detection of different quasispecies of hepatitis C virus core region in cancerous and noncancerous lesions
    • Horie C, Iwahana H, Horie T et al. Detection of different quasispecies of hepatitis C virus core region in cancerous and noncancerous lesions. Biochem Biophys Res Commun 1996;218:674-81.
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 674-681
    • Horie, C.1    Iwahana, H.2    Horie, T.3
  • 304
    • 0343930741 scopus 로고    scopus 로고
    • Hepatitis C virus sequences encoding truncated core proteins detected in a hepatocellular carcinoma
    • Ruster B, Zeuzem S, Roth WK. Hepatitis C virus sequences encoding truncated core proteins detected in a hepatocellular carcinoma. Biochem Biophys Res Commun 1996;219:911-15.
    • (1996) Biochem Biophys Res Commun , vol.219 , pp. 911-915
    • Ruster, B.1    Zeuzem, S.2    Roth, W.K.3
  • 305
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G, Waris G, Tanveer R, Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci USA 2001;98:9599-604.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 306
    • 0141588518 scopus 로고    scopus 로고
    • Hepatitis C virus: Molecular biology and genetic variability
    • Schmid R, ed., Basel, Switzerland: Kluwer Academic
    • Bréchot C. Hepatitis C virus: molecular biology and genetic variability. In: Schmid R, ed. Acute and Chronic liver Diseases. Basel, Switzerland: Kluwer Academic, 1996:35-57.
    • (1996) Acute and Chronic liver Diseases , pp. 35-57
    • Bréchot, C.1
  • 307
    • 0028812140 scopus 로고
    • Hepatitis C virus types 1b (II) infection in France and Italy
    • Nousbaum JB, Pol S, Nalpas B. Hepatitis C virus types 1b (II) infection in France and Italy. Ann Intern Med 1995;122:161-8.
    • (1995) Ann Intern Med , vol.122 , pp. 161-168
    • Nousbaum, J.B.1    Pol, S.2    Nalpas, B.3
  • 308
    • 0030006391 scopus 로고    scopus 로고
    • Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A case-control study
    • Silini E, Bottelli R, Asti M et al. Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: a case-control study. Gastroenterology 1996;111:199-205.
    • (1996) Gastroenterology , vol.111 , pp. 199-205
    • Silini, E.1    Bottelli, R.2    Asti, M.3
  • 309
    • 0026080914 scopus 로고
    • Point-mutation, allelic loss and increased methylation of c-Ha-Ras gene in human hepatocellular carcinoma
    • Ogata N, Kamimura T, Asakura H. Point-mutation, allelic loss and increased methylation of c-Ha-Ras gene in human hepatocellular carcinoma. Hepatology 1991;13:31-7.
    • (1991) Hepatology , vol.13 , pp. 31-37
    • Ogata, N.1    Kamimura, T.2    Asakura, H.3
  • 310
    • 0025169651 scopus 로고
    • Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing
    • Tada M, Omata M, Ohto M. Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res 1990;50:1121-4.
    • (1990) Cancer Res , vol.50 , pp. 1121-1124
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 311
    • 15144361323 scopus 로고    scopus 로고
    • Concerted nonsyntenic allelic losses in hyperploid hepatocellular carcinoma as determined by a high-resolution allelotype
    • Boige V, Laurent-Puig P, Fouchet P et al. Concerted nonsyntenic allelic losses in hyperploid hepatocellular carcinoma as determined by a high-resolution allelotype. Cancer Res 1997;57:1986-90.
    • (1997) Cancer Res , vol.57 , pp. 1986-1990
    • Boige, V.1    Laurent-Puig, P.2    Fouchet, P.3
  • 312
    • 0030849123 scopus 로고    scopus 로고
    • Comprehensive allelotyping of human hepatocellular carcinoma
    • Nagai H, Pineau P, Tiollais P, Buendia MA, Dejean A. Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene 1997;14:2927-33.
    • (1997) Oncogene , vol.14 , pp. 2927-2933
    • Nagai, H.1    Pineau, P.2    Tiollais, P.3    Buendia, M.A.4    Dejean, A.5
  • 313
    • 0031022784 scopus 로고    scopus 로고
    • Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
    • Marchio A, Meddeb M, Pineau P et al. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 1997;18:59-65.
    • (1997) Genes Chromosomes Cancer , vol.18 , pp. 59-65
    • Marchio, A.1    Meddeb, M.2    Pineau, P.3
  • 314
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000;10:185-200.
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 316
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001;120:1763-73.
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3
  • 317
    • 0034601378 scopus 로고    scopus 로고
    • Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
    • Marchio A, Pineau P, Meddeb M et al. Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene 2000;19:3733-8.
    • (2000) Oncogene , vol.19 , pp. 3733-3738
    • Marchio, A.1    Pineau, P.2    Meddeb, M.3
  • 318
    • 0032847563 scopus 로고    scopus 로고
    • Genetic aspects of hepatocellular carcinogenesis
    • Ozturk M. Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 1999;19:235-42.
    • (1999) Semin Liver Dis , vol.19 , pp. 235-242
    • Ozturk, M.1
  • 320
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350:429-31.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 321
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 1991;350:427-8.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5
  • 322
    • 0027337609 scopus 로고
    • Aflatoxin B induces the transversion of G-T in codon 249 of the p53 tumor suppressor gene in human hepatocytes
    • Aguilar F, Hussain SP, Cerutti P. Aflatoxin B induces the transversion of G-T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci USA 1993;90:8586-90.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8586-8590
    • Aguilar, F.1    Hussain, S.P.2    Cerutti, P.3
  • 323
    • 0028343058 scopus 로고
    • Geographic variation of p53 mutational profile in nonmalignant human liver
    • Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science 1994;264:1317-19.
    • (1994) Science , vol.264 , pp. 1317-1319
    • Aguilar, F.1    Harris, C.C.2    Sun, T.3    Hollstein, M.4    Cerutti, P.5
  • 324
    • 0026041836 scopus 로고
    • Aberrations of the tumor suppressor p53 and retinoblastoma benes in human hepatocellular carcinoma
    • Murakami Y, Hayashi K, Hirohashi S, Sekiya T. Aberrations of the tumor suppressor p53 and retinoblastoma benes in human hepatocellular carcinoma. Cancer Res 1991;51:5520-5.
    • (1991) Cancer Res , vol.51 , pp. 5520-5525
    • Murakami, Y.1    Hayashi, K.2    Hirohashi, S.3    Sekiya, T.4
  • 325
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 1995;11:447-9.
    • (1995) Nat Genet , vol.11 , pp. 447-449
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 326
    • 0032936050 scopus 로고    scopus 로고
    • Frequent allelic loss on chromosome 9 in hepatocellular carcinoma
    • Liew CT, Li HM, Lo KW et al. Frequent allelic loss on chromosome 9 in hepatocellular carcinoma. Int J Cancer 1999;81:319-24.
    • (1999) Int J Cancer , vol.81 , pp. 319-324
    • Liew, C.T.1    Li, H.M.2    Lo, K.W.3
  • 327
    • 0036725378 scopus 로고    scopus 로고
    • Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, β-catenin expression and clinical features
    • Wei Y, Tran Van Nhieu J, Prigent S, Srivatanakul P, Tiollais P, Buendia MA. Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, β-catenin expression and clinical features. Hepatology 2002;36:692-701.
    • (2002) Hepatology , vol.36 , pp. 692-701
    • Wei, Y.1    Tran Van Nhieu, J.2    Prigent, S.3    Srivatanakul, P.4    Tiollais, P.5    Buendia, M.A.6
  • 328
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003;163:1371-8.
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3    Lee, H.S.4    Jang, J.J.5    Kang, G.H.6
  • 329
    • 0036725378 scopus 로고    scopus 로고
    • Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, β-catenin expression and clinical features
    • Wei Y, Tran Van Nhieu J, Prigent S, Srivatanakul P, Tiollais P, Buendia MA. Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, β-catenin expression and clinical features. Hepatology 2002;36:692-701.
    • (2002) Hepatology , vol.36 , pp. 692-701
    • Wei, Y.1    Tran Van Nhieu, J.2    Prigent, S.3    Srivatanakul, P.4    Tiollais, P.5    Buendia, M.A.6
  • 330
    • 0033054464 scopus 로고    scopus 로고
    • The oncogenic activation of beta-catenin
    • Polakis P. The oncogenic activation of beta-catenin. Curr Opin Genet Dev 1999;9:15-21.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 15-21
    • Polakis, P.1
  • 332
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • de La Coste A, Romagnolo B, Billuart P et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998;95:8847-51.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8847-8851
    • De La Coste, A.1    Romagnolo, B.2    Billuart, P.3
  • 333
    • 0032885751 scopus 로고    scopus 로고
    • Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
    • Tran van Nhieu J, Renard CA, Wei Y, Cherqui D, Zafrani ES, Buendia MA. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol 1999;155:703-10.
    • (1999) Am J Pathol , vol.155 , pp. 703-710
    • Tran Van Nhieu, J.1    Renard, C.A.2    Wei, Y.3    Cherqui, D.4    Zafrani, E.S.5    Buendia, M.A.6
  • 334
    • 0037079250 scopus 로고    scopus 로고
    • P53 mutation as a source of aberrant betacatenin accumulation in cancer cells
    • Cagatay T, Ozturk M. P53 mutation as a source of aberrant betacatenin accumulation in cancer cells. Oncogene 2002;21:7971-80.
    • (2002) Oncogene , vol.21 , pp. 7971-7980
    • Cagatay, T.1    Ozturk, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.