Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: Activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway

Arthritis Research and Therapy

Volumn 13, Issue 3, 2011, Pages

  Ulivi, Valentina ^a   Lenti, Manuela ^b   Gentili, Chiara ^a   Marcolongo, Gabriele ^c   Cancedda, Ranieri ^a,b   Descalzi Cancedda, Fiorella ^a,d  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; GALACTOSYLDIACYLGLYCEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; ANTIINFLAMMATORY AGENT; COLLAGEN TYPE 2; DRUG DERIVATIVE; GALACTOLIPID; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; ISOMERASE; PROSTAGLANDIN D2; PTGS2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTICULAR CARTILAGE; BACTERIAL COLONIZATION; CARTILAGE CELL; CELL CULTURE; COMPUTER PROGRAM; CONTROLLED STUDY; CULTURE MEDIUM; CYANOBACTERIUM; CYTOKINE PRODUCTION; CYTOTOXICITY; DENSITOMETRY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; ITALY; OSTEOARTHRITIS; PHENOTYPE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PRIMARY CELL CULTURE;

ANTI-INFLAMMATORY AGENTS; CARTILAGE, ARTICULAR; CELL SURVIVAL; CHONDROCYTES; COLLAGEN TYPE II; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME ACTIVATION; GALACTOLIPIDS; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; INTERLEUKIN-8; INTRAMOLECULAR OXIDOREDUCTASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PRIMARY CELL CULTURE; PROSTAGLANDIN D2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958789947     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3367     Document Type: Article

References (35)

1. Dormann P, Benning C. Galactolipids rule in seed plants. Trends Plant Sci 2002, 7:112-118. 10.1016/S1360-1385(01)02216-6, 11906834.
2. Schmidt-Schultz T, Althaus HH. Monogalactosyl diglyceride, a marker for myelination, activates oligodendroglial protein kinase C. J Neurochem 1994, 62:1578-1585.
3. Loya S, Reshef V, Mizrachi E, Silberstein C, Rachamim Y, Carmeli S, Hizi A. The inhibition of the reverse transcriptase of HIV-1 by the natural sulfoglycolipids from cyanobacteria: contribution of different moieties to their high potency. J Nat Prod 1998, 61:891-895. 10.1021/np970585j, 9677270.
4. Maeda N, Hada T, Yoshida H, Mizushina Y. Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach. Curr Med Chem 2007, 14:955-967. 10.2174/092986707780362952, 17439396.
5. Berge JP, Debiton E, Dumay J, Durand P, Barthomeuf C. In vitro anti-inflammatory and anti-proliferative activity of sulfolipids from the red alga Porphyridium cruentum. J Agric Food Chem 2002, 50:6227-6232. 10.1021/jf020290y, 12358507.
6. Larsen E, Kharazmi A, Christensen LP, Christensen SB. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 2003, 66:994-995. 10.1021/np0300636, 12880322.
7. Manez S, Recio MC, Gil I, Gomez C, Giner RM, Waterman PG, Rios JL. A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa. J Nat Prod 1999, 62:601-604. 10.1021/np980132u, 10217718.
8. Marcolongo G, de Appolonia F, Venzo A, Berrie CP, Carofiglio T, Ceschi Berrini C. Diacylglycerolipids isolated from a thermophile cyanobacterium from the Euganean hot springs. Nat Prod Res 2006, 20:766-774. 10.1080/14786410500176393, 16753911.
9. Bruno A, Rossi C, Marcolongo G, Di Lena A, Venzo A, Berrie CP, Corda D. Selective in vivo anti-inflammatory action of the galactolipid monogalactosyldiacylglycerol. Eur J Pharmacol 2005, 524:159-168. 10.1016/j.ejphar.2005.09.023, 16253232.
10. Bellometti S, Cecchettin M, Galzigna L. Mud pack therapy in osteoarthrosis. Changes in serum levels of chondrocyte markers. Clin Chim Acta 1997, 268:101-106. 10.1016/S0009-8981(97)00171-X, 9495574.
11. Lenti M, Gentili C, Pianezzi A, Marcolongo G, Lalli A, Cancedda R, Descalzi Cancedda F. Monogalactosyldiacylglycerol anti-inflammatory activity on adult articular cartilage. Nat Prod Res 2009, 23:754-762. 10.1080/14786410802456956, 19418358.
12. Dozin B, Malpeli M, Camardella L, Cancedda R, Pietrangelo A. Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects. Matrix Biol 2002, 21:449-459. 10.1016/S0945-053X(02)00028-8, 12225810.
13. Ulivi V, Cancedda R, Descalzi Cancedda F. 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. J Cell Physiol 2008, 217:433-441. 10.1002/jcp.21516, 18615580.
14. Ulivi V, Tutolo G, Mallein-Gerin F, Daga A, Cancedda R, Descalzi Cancedda F. A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes. J Cell Physiol 2006, 206:728-737. 10.1002/jcp.20511, 16222708.
15. Ulivi V, Giannoni P, Gentili C, Cancedda R, Descalzi F. p38/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes. J Cell Biochem 2008, 104:1393-1406. 10.1002/jcb.21717, 18286508.
16. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979, 76:4350-4354. 10.1073/pnas.76.9.4350, 411572, 388439.
17. Fahmi H. mPGES-1 as a novel target for arthritis. Curr Opin Rheumatol 2004, 16:623-627. 10.1097/01.bor.0000129664.81052.8e, 15314505.
18. Gilroy DW, Colville-Nash PR, McMaster S, Sawatzky DA, Willoughby DA, Lawrence T. Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. FASEB J 2003, 17:2269-2271.
19. Kapoor M, Shaw O, Appleton I. Possible anti-inflammatory role of COX-2-derived prostaglandins: implications for inflammation research. Curr Opin Investig Drugs 2005, 6:461-466.
20. Andreas K, Lubke C, Haupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M. Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther 2008, 10:R9. 10.1186/ar2358, 2374452, 18205922.
21. Kaneko S, Satoh T, Chiba J, Ju C, Inoue K, Kagawa J. Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther 2000, 6:71-79. 10.1080/13684730050515796, 11108572.
22. Takami M, Terry V, Petruzzelli L. Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. J Immunol 2002, 168:4559-4566.
23. Lotz M, Terkeltaub R, Villiger PM. Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes. J Immunol 1992, 148:466-473.
24. Matsukawa A, Yoshimura T, Maeda T, Ohkawara S, Takagi K, Yoshinaga M. Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo. J Immunol 1995, 154:5418-5425.
25. Merz D, Liu R, Johnson K, Terkeltaub R. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003, 171:4406-4415.
26. Desgeorges A, Gabay C, Silacci P, Novick D, Roux-Lombard P, Grau G, Dayer JM, Vischer T, Guerne PA. Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid. J Rheumatol 1997, 24:1510-1516.
27. Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, De Benedetti F, Poli V, Ciliberto G. Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 1998, 187:461-468. 10.1084/jem.187.4.461, 2212160, 9463396.
28. Poree B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann DJ, Mallein-Gerin F, Pujol JP, Boumediene K, Galera P. Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. J Biol Chem 2008, 283:4850-4865.
29. Herschman HR. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2. Cancer Metastasis Rev 1994, 13:241-256. 10.1007/BF00666095, 7712587.
30. Willoughby DA, Moore AR, Colville-Nash PR. Cyclopentenone prostaglandins-new allies in the war on inflammation. Nat Med 2000, 6:137-138. 10.1038/72224, 10655096.
31. Rajakariar R, Yaqoob MM, Gilroy DW. COX-2 in inflammation and resolution. Mol Interv 2006, 6:199-207. 10.1124/mi.6.4.6, 16960142.
32. Bianchi A, Moulin D, Sebillaud S, Koufany M, Galteau MM, Netter P, Terlain B, Jouzeau JY. Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. Arthritis Res Ther 2005, 7:R1325-R1337. 10.1186/ar1830, 1297580, 16277686.
33. Reyes-Martin P, Ramirez-Rubio S, Parra-Cid T, Bienes-Martinez R, Lucio-Cazana J. 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. Pharmacol Res 2008, 57:344-350. 10.1016/j.phrs.2008.03.007, 18456507.
34. Fahmi H, Pelletier JP, Mineau F, Martel-Pelletier J. 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2002, 10:845-848. 10.1053/joca.2002.0835, 12435328.
35. Guerrero MD, Aquino M, Bruno I, Riccio R, Terencio MC, Paya M. Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression. Eur J Pharmacol 2009, 620:112-119. 10.1016/j.ejphar.2009.08.007, 19686718.