Down regulation of aortic nitric oxide and antioxidant systems in chronic alcohol-induced hypertension in rats

Human and Experimental Toxicology

Volumn 26, Issue 5, 2007, Pages 427-434

  Husain, Kazim ^a   Vazquez Ortiz, Manuel ^a   Lalla, Jainarine ^a  

^a PONCE SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

Alcohol; Antioxidant; Aorta; Blood pressure; Nitric oxide; VEGF

Indexed keywords

ALCOHOL; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ASSAY; GENE EXPRESSION; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; AORTA; BLOOD PRESSURE; CATALASE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; ETHANOL; GENE EXPRESSION; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYPERTENSION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, INBRED F344; RNA, MESSENGER; SUPEROXIDE DISMUTASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; RATTUS;

EID: 34447310288     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106072993     Document Type: Article

References (42)

1. Kannel WB, Ellison RC. Alcohol and coronary heart disease: the evidence for protective effect. Clin Chim Acta 1996; 246: 59-76.
2. Seiler C. Alcohol, the heart and cardiovascular system. Ther Umsch 2000; 57: 200-204.
3. Reynolds K, Lewis B, Nolen JD, Kinney GL et al. Alcohol consumption and risk of stroke: a metaanalysis. JAMA 2003; 289: 579-88.
4. Kaplan NM. Alcohol and hypertension. Lancet 1995; 345: 1588-89.
5. Rosenkranz S. Alcohol consumption and arterial hypertension. Dtsch Med Wochenschr 2003; 128: 24497-502.
6. Iso H, Baba S, Mannami T, Sasaki S et al. Alcohol consumption and risk of stroke among middle-aged men: the JPHC study cohort I. Stroke 2004; 35: 1124-29.
7. Scott RB, Reddy KS, Husain K, Somani SM. Time course response to ethanol of hepatic antioxidant system and cytochrome P450 II E1 in rat. Environ Nutr Interac 1999; 3: 217-31.
8. Mira L, Maia L, Barreira L, Manso CF. Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Arch Biochem Biophys 1995; 318: 53-58.
9. Anandatheerthavarada HK, Shanker SK, Bhamre S, Boyd MR et al. Induction of brain cytochrome P450IIE1 by chronic ethanol treatment. Brain Res 1993; 601: 279-85.
10. Mutlu-Teurkoglu U, Dogru-Abbasoglu S, Aykac-Toker G, Mirsal H et al. Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism. J Lab Clin Med 2000; 136: 287-91.
11. Somani SM, Husain K. Influence of exercise induced oxidative stress on the central nervous system. In Sen CK, Packer L, Hanninen O eds. Hand book of oxidants and antioxidants in exercise. Elsevier Science, 2000: 713-754.
12. Van Der Zee R, Murohara T, Luio Z, Zollmann F et al. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 1997; 95: 1030-37.
13. Husain K, Mejia J, Lalla J, Kazim S. Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma. Pharmacol Res 2005; 51: 337-43.
14. Husain K, Mejia J, Lalla J, Kazim S. Time response of alcohol-induced alterations in BP, nitric oxide and oxidant to antioxidants balance in the plasma of rats. Exp Clin Cardiol 2004; 9: 227-34.
15. Husain K, Somani SM. Response of exercise training and chronic ethanol ingestion on cardiac antioxidant system of rat. Alcohol 1997; 14: 301-307.
16. Husain K. Physical conditioning modulates rat cardiac VEGF gene expression in nitric oxide-deficient hypertension. Biochem Biophys Res Commun 2004; 320: 1169-74.
17. Husain K. Exercise conditioning attenuates the hypertensive effects of nitric oxide synthase inhibitor in rat. Mol Cell Biochem 2002; 231: 129-37.
18. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide-dismutase. J Biol Chem 1972; 247: 3170-75.
19. Aebi H. Catalase in vitro. Meth Enzymol 1984; 105: 121-26.
20. Flohe L, Gunzler W. Assays of glutathione peroxidase. Meth Enzymol 1984; 105: 114-21.
21. Read SM, Northcole DH. Minimization of variation in the response to different protein of the Coomassie blue G-dye-binding assay for protein. Anal Biochem 1981; 116: 53-64.
22. Williams SP, Adams RD, Mustafa SJ. The effects of chronic ethanol treatment on endothelium-dependent responses in rat thoracic aorta. Alcohol 1990; 7: 121-27.
23. Utkan T, Yildiz F, Ilbay G, Ozdemirci S et al. Blood pressure and vascular reactivity to endothelin-1, phenylephrine, serotonin, KCl, and acetylcholine following chronic alcohol consumption in vitro. Funct Clin Pharmacol 2001; 15: 157-65.
24. Pinardi G, Brieva R, Vinet R, Penna M. Effects of chronic ethanol consumption on α-adrenergic induced contractions in rat thoracic aorta. Gen Pharmacol 1992; 23: 245-48.
25. Puddey I, Zilkens R, Croft K, Beilin LJ. Alcohol and endothelial function: a brief review. Clin Exp Pharmacol Physiol 2001; 28: 1020-24.
26. Slomiany BL, Piotrowski J, Slomiany A. Alterations in buccal mucosal endothelin-1 and nitric oxide synthase with chronic alcohol ingestion. Biochem Mol Biol Int 1998; 45: 681-88.
27. Broeders MAW, Doevendans PA, Maessen JG, Gorsel EV et al. The human internal thoracic artery releases more nitric oxide in response to vascular endothelial growth factor than the human saphenous vein. J Thorac Cardiovasc Surg 2001; 122: 305-309.
28. Seipelt RG, Backer CL, Mavroudis C, Stellmach V et al. Topical VEGF enhances healing of thoracic aortic anastomosis for coarctation in a rabbit model. Circulation 2003; 108: 150-54.
29. Isner, JM. Myocardial gene therapy. Nature 2002; 415: 234-39.
30. Liu MH, Jin H, Floten HS, Ren Z et al. Vascular endothelial growth factor - mediated, endotheliumdependent relaxation in human internal mammary artery. Ann Thorac Surg 2002; 73: 819-24.
31. Gavin TP, Wagner PD. Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle. J Appl Physiol 2002; 92: 1176-82.
32. Gu JW, Elam J, Sartin A, Li W et al. Moderate levels of ethanol induces expression of vascular endothelial growth factor and stimulates angiogenesis. Am J Physiol 2001; 281: R365-72.
33. Kimura H, Esumi H. Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochim Pol 2003; 50: 49-59.
34. Werner P, Cohen G. Glutathione disulfide (GSSG) as a marker of oxidative injury to brain mitochondria. Ann NY Acad Sci 1993; 679: 364-69.
35. Vaziri ND, Wang XQ, Oveisi F, Rad B. Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension 2000; 36: 142-46.
36. Marklund SL. Regulation of cytokines of extracellular superoxide dismutase and other superoxide dismutase isozyme in fibroblasts. J Biol Chem 1992; 267: 6696-701.
37. Beckman JS, Beckman TW, Chen J, Marshall PA et al. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-24.
38. Yang ZW, Zheng T, Zhang A, Altura BT et al. Mechanism of hydrogen peroxide-induced contraction of rat aorta. Eur J Pharmacol 1998; 344: 169-81.
39. Lounsbury KM, Hu Q, Ziegelstein RC. Calcium signaling and oxidant stress in the vasculature. Free Rad Biol Med 2000; 28: 1362-69.
40. Doelman CJ, de Vlieger JF, Sprong RC, Bast A. Oxidative stress and receptor responses in guineapig tracheal tissue. Agents Actions Suppl 1990; 31: 143-45.
41. Doelman CJ, Bast A. Oxygen radicals in lung pathology. Free Radic Biol Med 1990; 9: 381-400.
42. Husain K. Vazquez-Ortiz M. and Lalla, J. Physical training ameliorates chronic alcohol-induced hypertension and aortic reactivity in rats. Alcohol & Alcoholism 2006; 41: 247-53.