Disease-modifying effect of ASP3258, a novel phosphodiesterase type 4 inhibitor, on subchronic cigarette smoke exposure-induced lung injury in guinea pigs

European Journal of Pharmacology

Volumn 659, Issue 1, 2011, Pages 79-84

  Kubo, Satoshi ^a   Kobayashi, Miki ^a   Iwata, Masahiro ^a   Takahashi, Koichiro ^a   Miyata, Keiji ^a   Shimizu, Yasuaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

ASP3258; Chronic obstructive pulmonary disease; Cigarette smoke; Guinea pig; Phosphodiesterase 4; Roflumilast

Indexed keywords

3 [4 (3 CHLOROPHENYL) 1 ETHYL 7 METHYL 2 OXO 1,2 DIHYDRO 1,8 NAPHTHYRIDIN 3 YL]PROPIONIC ACID; ASP 3258; CIGARETTE SMOKE; GELATINASE B; PHOSPHODIESTERASE IV INHIBITOR; PREDNISOLONE; ROFLUMILAST; UNCLASSIFIED DRUG; 3-(4-(3-CHLOROPHENYL)-1-ETHYL-7-METHYL-2-OXO-1,2-DIHYDRO-1,8-NAPHTHYRIDIN-3-YL)PROPANOIC ACID; NAPHTHYRIDINE DERIVATIVE; SMOKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; EPITHELIUM HYPERPLASIA; EXPERIMENTAL GUINEA PIG; HISTOPATHOLOGY; LONG TERM EXPOSURE; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS WALL; LUNG INJURY; LUNG LAVAGE; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL METAPLASIA; ADVERSE EFFECTS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GUINEA PIG; IMMUNOLOGY; LEUKOCYTE; LUNG; PATHOLOGY; SMOKE; TIME FACTOR; TOBACCO;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; GUINEA PIGS; LEUKOCYTES; LUNG; LUNG INJURY; MALE; NAPHTHYRIDINES; PHOSPHODIESTERASE 4 INHIBITORS; SMOKE; TIME FACTORS; TOBACCO;

EID: 79958777092     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.02.042     Document Type: Article

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