A model of tobacco smoke-induced airflow obstruction in the guinea pig

Chest

Volumn 121, Issue 5 SUPPL., 2002, Pages 188S-191S

  Wright, Joanne L ^a   Churg, Andrew ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Animal models; Cigarette smoke; COPD; Emphysema; Guinea pig; Pulmonary hypertension; Species differences

Indexed keywords

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; COMPARATIVE STUDY; CONFERENCE PAPER; GUINEA PIG; HYPOTHESIS; MODEL; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOKING; SPECIES DIFFERENCE; TOBACCO;

EID: 0036257662     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.121.5_suppl.188S     Document Type: Conference Paper

References (45)

1. The definition of emphysema: Report of a National Heart, Lung, and Blood Institute; Division of Lung Diseases workshop
2. Penetration of respiratory epithelium of guinea pigs following exposure to cigarette smoke
3. The site of leukocyte migration through the tracheal mucosa in the guinea pig
4. The effect of acute airway inflammation on bronchial reactivity in guinea pigs
5. Histamine dose-response curves in guinea pigs
6. Airway permeability to horseradish peroxidase in guinea pigs: The repair phase after injury by cigarette smoke
7. Respiratory epithelial permeability after cigarette smoke exposure in guinea pigs
8. Airway responsiveness to intravenous and inhaled acetylcholine in the guinea pig after cigarette smoke exposure
9. Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke
10. Role of peroxynitrite in airway microvascular hyperpermeability during late allergic phase in guinea pigs
11. Peroxyni-trite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo
12. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-κB activation and IL-8 mRNA expression in guinea pigs in vivo
13. Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig
14. Cardiopulmonary effects of a brief exposure to cigarette smoke in the guinea pig
15. Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig
16. The effect of smoking cessation on pulmonary and cardiovascular function and structure
17. Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase
18. Smoke-induced emphysema in the guinea pig is associated with morphometric evidence of collagen breakdown and repair
19. Collagen and elastin in human pulmonary emphysema
20. The importance of ultramicroscopic emphysema in cigarette smoke induced lung disease
21. A morphologic grading scheme for membranous and respiratory bronchioles
22. Effect of long-term exposure to cigarette smoke on the small airways of the guinea pig
23. Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
24. Cigarette smoke-induced emphysema in guinea pigs is associated with diffusely decreased capillary density and capillary narrowing
25. Guinea pig pulmonary hypertension caused by cigarette smoke cannot be explained by capillary bed destruction
26. Dissociation of chronic vascular cell proliferation and vascular contractility after chronic cigarette smoke exposure
27. The relationship of increased pulmonary artery pressure and airflow obstruction to emphysema
28. A morphologic and physiologic bioassay for quantifying alterations in the lung following experimental chronic inhalation of tobacco smoke
29. Pathogenesis of lesions induced in rat lung by chronic tobacco smoke inhalation
30. Time course of neutrophil and macrophage elastinolytic activities in cigarette smoke-induced emphysema
31. N-acetylcysteine prevents cigarette smoke induced small airways alterations in rats
32. A longitudinal analysis of pulmonary function in rats during a 12 month cigarette smoke exposure
33. Morphometric analysis of tracheal gland secretion and hypertrophy in male and female rats after experimental exposure to tobacco smoke
34. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: The effect of tobacco smoke with and without the antiinflammatory agent phenylmethyloxadiozole
35. Animal models for chronic obstructive pulmonary disease
36. Macrophage elastase is required for cigarette smoke-induced emphysema in mice
37. A simple gag for the intragastric dosing of guinea pigs (Cavia porcellus)
38. Surface area and metabolism of growing guinea pigs
39. A method for endotracheal intubation of guinea pigs
40. Endotracheal intubation in guinea pigs by direct laryngoscopy
41. Sequential bronchoalveolar lavages by endotracheal intubation in guinea pigs
42. An improved method for direct laryngeal intubation in the guinea pig
43. Oral endotracheal intubation of guinea pigs