The bone architecture is enhanced with combined PTH and alendronate treatment compared to monotherapy while maintaining the state of surface mineralization in the OVX rat

Bone

Volumn 49, Issue 2, 2011, Pages 225-232

  Campbell, Graeme M ^a   Bernhardt, R ^b   Scharnweber, D ^b   Boyd, Steven K ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Finite element modeling; Micro architecture; Mineralization; Ovariectomized rat; Synchrotron radiation

Indexed keywords

ALENDRONIC ACID; PARATHYROID HORMONE[1-34]; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERALIZATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORTICAL BONE; DRUG MECHANISM; DRUG POTENTIATION; EX VIVO STUDY; FEMALE; FINITE ELEMENT ANALYSIS; IMAGE ANALYSIS; IN VIVO STUDY; LUMBAR VERTEBRA; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NONHUMAN; OVARIECTOMY; RAT; SYNCHROTRON; TIBIA; TRABECULAR BONE; TREATMENT DURATION;

ALENDRONATE; ANIMALS; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; CALCIFICATION, PHYSIOLOGIC; FEMALE; FINITE ELEMENT ANALYSIS; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, WISTAR; X-RAY MICROTOMOGRAPHY;

EID: 79958770989     PISSN: 87563282     EISSN: 87563282     Source Type: Journal    
DOI: 10.1016/j.bone.2011.04.008     Document Type: Article

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