Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects

British Journal of Nutrition

Volumn 105, Issue 12, 2011, Pages 1783-1790

  Soriguer, Federico ^a,b   Gutiérrez Repiso, Carolina ^c   Rubio Martin, Elehazara ^b   Linares, Francisca ^c   Cardona, Isabel ^c   López Ojeda, Jaime ^a   Pacheco, Marta ^a   González Romero, Stella ^a   Garriga, Maria J ^a   Velasco, Ines ^d   Santiago, Piedad ^e   Garcí A Fuentes, Eduardo ^a,c,f  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Hospital University Carlos Haya de Málaga   (Spain)

^d Hospital Comarcal de Riotinto   (Spain)

^e Hospital General   (Spain)

^f Instituto de Salud Carlos III   (Spain)

Author keywords

Antioxidants; Iodine; Thyroid function; Urinary iodine

Indexed keywords

ALPHA 1 ANTITRYPSIN; C REACTIVE PROTEIN; CERULOPLASMIN; GLUTATHIONE PEROXIDASE; INTERLEUKIN 6; LIOTHYRONINE; POTASSIUM IODIDE; THYROTROPIN; THYROXINE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HORMONE ACTION; HUMAN; INFLAMMATION; IODINE DEFICIENCY; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; SALT INTAKE; SODIUM URINE LEVEL; THYROID FUNCTION; THYROXINE BLOOD LEVEL; TREATMENT DURATION; URINE LEVEL;

EID: 79958767082     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510005568     Document Type: Article

References (41)

1. WHO (1996) Recommended Iodine Levels in Salt and Guidelines for Monitoring their Adequacy and Effectiveness. Geneva: WHO.
2. WHO, UNICEF, ICCIDD (2007) Assessment of Iodine Deficiency Disorders and Monitoring their Elimination. A Guide for Programme Managers, 3rd ed. Geneva: WHO.
3. Santiago-Fernandez P, Torres-Barahona R, Muela-Mart́nez JA, et al. (2004) Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab 89, 3851-3857. (Pubitemid 39071484)
4. Vermiglio F, Lo Presti VP, Moleti M, et al. (2004) Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab 89, 6054-6060. (Pubitemid 39628414)
5. Dominguez I, Reviriego S, Rojo-Mart́nez G, et al. (2004) Iodine deficiency and thyroid function in healthy pregnant women. Med Clin (Barc) 122, 449-453. (Pubitemid 38667669)
6. Consejeŕa de Salud (2005) Pregnancy, Childbirth and Postpartum: Integrated Care Process, 2nd rev. ed. Sevilla: Consejeŕa de Salud.
7. Velasco I, Carreira M, Santiago P, et al. (2009) Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab 94, 3234-3241.
8. Garća-Fuentes E, Gallo M, Garća L, et al. (2008) Amniotic fluid iodine concentrations do not vary in pregnant women with varying iodine intake. Br J Nutr 99, 1178-1181.
9. Soriguer F, Santiago P, Vila L, et al. (2009) Clinical dilemmas arising from the increased intake of iodine in the Spanish population and the recommendation for systematic prescription of potassium iodide in pregnant and lactating women (Consensus of the TDY Working Group of SEEN). J Endocrinol Invest 32, 184-191.
10. Wolff J & Chaikoff IL (1948) Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 174, 555-564.
11. Chow CC, Phillips DI, Lazarus JH, et al. (1991) Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable? Clin Endocrinol (Oxf) 34, 413-416.
12. Vagenakis AG, Downs P, Braverman LE, et al. (1973) Control of thyroid hormone secretion in normal subjects receiving iodides. J Clin Invest 52, 528-532.
13. Saberi M & Utiger RD (1975) Augmentation of thyrotropin responses to thyrotropin-releasing hormone following small decreases in serum thyroid hormone concentrations. J Clin Endocrinol Metab 40, 435-441.
14. Ikeda H & Nagataki S (1976) Augmentation of thyrotropin responses to thyrotropin-releasing hormone following inorganic iodide. Endocrinol Jpn 23, 431-433. (Pubitemid 8068647)
15. Jubiz W, Carlile S & Lagerquist LD (1977) Serum thyrotropin and thyroid hormone levels in humans receiving chronic potassium iodide. J Clin Endocrinol Metab 44, 379-382. (Pubitemid 8044867)
16. Kahaly G, Dienes HP, Beyer J, et al. (1997) Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. J Clin Endocrinol Metab 82, 4049-4053. (Pubitemid 27525510)
17. Poncin S, Gérard AC, Boucquey M, et al. (2008) Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. Endocrinology 149, 424-433.
18. Joanta AE, Filip A, Clichici S, et al. (2006) Iodide excess exerts oxidative stress in some target tissues of the thyroid hormones. Acta Physiol Hung 93, 347-359. (Pubitemid 46002335)
19. Vitale M, Di Matola T, D'Ascoli F, et al. (2000) Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress. Endocrinology 141, 598-605. (Pubitemid 32250483)
20. Küpper FC, Carpenter LJ, McFiggans GB, et al. (2008) Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry. Proc Natl Acad Sci USA 105, 6954-6958. (Pubitemid 351754511)
21. Smyth PP (2003) Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors 19, 121-130. (Pubitemid 38175115)
22. Cocchi M & Venturi S (2000) Iodide, antioxidant function and omega-6 and omega-3 fatty acids: a new hypothesis of biochemical cooperation? Prog Nutr 2, 15-19.
23. Giray B & Hincal F (2002) Oxidative DNA base damage, antioxidant enzyme activities and selenium status in highly iodine-deficient goitrous children. Free Radic Res 36, 55-62. (Pubitemid 34498549)
24. Moser M, Buchberger W, Mayer H, et al. (1991) Influence of an iodine-drinking cure on the antioxidative status of diabetic patients. Wien Klin Wochenschr 103, 183-186.
25. Maier J, van Steeg H, van Oostrom C, et al. (2007) Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice. Biochim Biophys Acta 1773, 990-999. (Pubitemid 46829440)
26. Weetman AP, McGregor AM, Campbell H, et al. (1983) Iodide enhances IgG synthesis by human peripheral blood lymphocytes in vitro. Acta Endocrinol (Copenh) 103, 210-215. (Pubitemid 13093822)
27. Lialikau SA, Haurylik LL, Sobieska M, et al. (2005) Acute phase proteins serum concentrations in children are related to urinary iodine excretion. Rocz Akad Med Bialymst 50, 279-283.
28. SCF (2002) Opinion of the scientific committee on food on the tolerable upper intake level of iodine (expressed on 26 September 2002). http://europa.eu.int/comm/food/fs/sc/ scf/out146-en.pdf
29. Benotti J & Benotti N (1963) Protein bound iodine, total iodine and protein and butanol extractable iodine by partial automation. Clin Chem 9, 408-416.
30. Delange F, Benker G, Caron P, et al. (1997) Thyroid volume and urinary iodine in European schoolchildren: standarization of values for assesment of iodine deficiency. Eur J Endocrinol 136, 180-187. (Pubitemid 27096347)
31. Vitti P, Martino E, Aghini-Lombardi F, et al. (1994) Thyroid volume measurement by ultrasound in children as a tool for the assessment of mild iodine deficiency. J Clin Endocrinol Metab 79, 600-603. (Pubitemid 24256560)
32. Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, et al. (2009) Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity (Silver Spring) 17, 240-246.
33. Soriguer F, Valdes S, Morcillo S, et al. (2008) Thyroid hormone levels predict the change in body weight: a prospective study. Obes Rev 11, 350.
34. Paul T, Meyers B, Witorsch RJ, et al. (1988) The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism 37, 121-124. (Pubitemid 18055225)
35. Gardner DF, Centor RM & Utiger RD (1988) Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol (Oxf) 28, 283-288. (Pubitemid 18079397)
36. Konno N, Makita H, Yuri K, et al. (1994) Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 78, 393-397. (Pubitemid 24061759)
37. Weetman AP & McGregor AM (1994) Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 15, 788-830.
38. Dayan CM & Daniels GH (1996) Chronic autoimmune thyroiditis. N Engl J Med 335, 99-107. (Pubitemid 26240112)
39. Li Y, Teng D, Shan Z, et al. (2008) Antithyroperoxidase and antithyroglobulin antibodies in a five-year follow-up survey of populations with different iodine intakes. J Clin Endocrinol Metab 93, 1751-1757. (Pubitemid 351656514)
40. Morreale de Escobar G, Obregón MJ & Escobar del Rey F (2000) Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 85, 3975-3987. (Pubitemid 32055337)
41. Beukelman CJ, van den Berg AJ, Hoekstra MJ, et al. (2008) Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel) for wound healing in vitro. Burns 34, 845-855.