Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 12, 1997, Pages 4049-4053

  Kahaly, George ^a   Dienes, Hans Peter ^a   Beyer, Jürgen ^a   Hommel, Gerhard ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IODIDE; MICROSOME ANTIBODY; THYROGLOBULIN ANTIBODY; THYROID ANTIBODY;

ADULT; AGED; ANTIBODY TITER; ARTICLE; ASPIRATION BIOPSY; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ENDEMIC GOITER; FEMALE; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; LYMPHOCYTIC INFILTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

EID: 0030867097     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.12.4416     Document Type: Article

References (37)

1. Dunn JT. 1992 Iodine deficiency: the next target for elimination? N Engl J Med. 326:267-268.
2. Dunn JT. 1996 Seven deadly sins in confronting endemic iodine deficiency, and how to avoid them. J Clin Endocrinol Metab. 81:1332-1335.
3. Delange FM, Ermans AM. 1996 Iodine deficiency. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid, 7th ed. Philadelphia: Lippincott-Raven; 296-316.
4. Pennington JA. 1990 A review of iodine toxicity reports. J Am Diet Assoc. 90:1571-1581.
5. Delange F, Benker G, Caron Ph, et al. 1997 Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency. Eur J Endocrinol. 136:180-187.
6. Roti E, Vagenakis AG. 1996 Effect of excess iodine; clinical aspects. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid, 7th ed. Philadelphia: Lippincott-Raven; 316-327.
7. Konno N, Makita H, Yuri K, Iuzuka N, Kawasaki K. 1994 Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab. 78:393-397.
8. Weetman AP, McGregor AM. 1994 Autoimmune thyroid disease: further developments in our understanding. Endocr Rev. 15:788-830.
9. Dayan CM, Daniels GH. 1996 Chronic autoimmune thyroiditis. N Engl J Med. 335:99-107.
10. Weaver DK, Batsakis JG, Nishiyama RH. 1969 Relationship of iodine to lymphocytic goiters. Arch Surg. 98:183-186.
11. McConahey WM, Keating FR, Beahrs OH, Woolner LB. 1962 On the increasing occurence of Hashimoto's thyroiditis. J Clin Endocrinol Metab. 22:542-544.
12. Boukis MA, Koutras DA, Souvatzoglou A, et al. 1983 Thyroid hormone and immunological studies in endemic goiter. J Clin Endocrinol Metab. 57:859-862.
13. Martino E, Safran M, Aghini-Lombardi F, et al. 1984 Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med. 154:2722-2726.
14. Elnagar B, Eltom M, Karlsson FA, et al. 1995 The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones. J Clin Endocrinol Metab. 80:891-897.
15. Todd CH, Allain T, Gomo ZAR, et al. 1995 Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe. Lancet. 346:1563-1564.
16. Bourdoux PP, Ermans AM, Mukalay wa Mukalay A, Filetti S, Vigneri R. 1996 Iodine-induced thyrotoxicosis in Kivu, Zaire. Lancet. 347:552-553.
17. Tonglet R, Bourdoux P, Tshilembi M, Ermans AM. 1992 Effect of low oral doses of iodized oil in the control of iodine deficiency in Zaire. N Engl J Med. 326:236-241.
18. Benmiloud M, Chauki ML, Gutekunst R, Teichert HM, Graham W, Dunn JT. 1994 Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection. J Clin Endocrinol Metab. 79:20-24.
19. Gutekunst R, Smolarek H, Hasenpusch U, et al. 1986 Goiter epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinol (Copenh). 112:494-501.
20. Dunn JT, Crutchfield HE, Gutekunst R, Dunn AD. 1993 Two simple methods for measuring iodine in urine. Thyroid. 3:119-123.
21. Okamura K, Inoue K, Omae T. 1978 A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol (Copenh). 88:703-712.
22. Adams DD, Kennedy TH, Stewart JC, et al. 1975 Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid stimulating antibodies and thyrotropin. J Clin Endocrinol Metab. 41:221-228.
23. Harach HR, Williams ED. 1995 Thyroid cancer and thyroiditis in the goitrous region of Salta, Argentina, before and after iodine prophylaxis. Clin Endocrinol (Oxf). 43:701-706.
24. 3 and Kl. Thyroidology. 2:81-88.
25. Kahaly G, Dienes HP, Hommel G. Iodide induces thyroid autoimmunity in patients with endemic goiter. A randomised, double-blind, placebo-controlled trial. Clin Exp Immunol, In press.
26. Yoshida H, Amino N, Yagawa K, et al. 1978 Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J Clin Endocrinol Metab. 46:859-862.
27. Mizukami Y, Michigishi T, Nonomura A, et al. 1993 Iodine-induced hypothyroidism: a clinical and histological study of 28 patients. J Clin Endocrinol Metab. 76:466-471.
28. Sundick RS, Herdegen DM, Brown TR, Bagchi N. 1987 The incorporation of dietary iodine into thyroglobulin increases its immunogenecity. Endocrinology. 120:2078-2084.
29. Sundick RS, Bagchi N, Brown TR. 1992 The role of iodine in thyroid auto-immunity: from chickens to humans: a review. Autoimmunity. 13:61-68.
30. Champion B, Rayner DC, Byfield PGH, et al. 1987 Critical role of iodination for T cell recognition of thyroglobulin in experimental murine thyroid autoimmunity. J Immunol. 139:3665-3670.
31. Weetman AP, McGregor AM, Campbell H, et al. 1983 Iodide enhances IgG synthesis by human peripheral blood lymphocytes in vitro. Acta Endocrinol (Copenh). 103:210-215.
32. Rabinowe SL, Larsen PR, Antman EM, et al. 1986 Amiodarone therapy and autoimmune thyroid disease. Increase in a new monoclonal antibody-defined T cell subset. Am J Med. 81:53-57.
33. Davies TF, Young C, Platzer M. 1989 The influence of antithyroid drugs and iodine on thyroid cell MHC class II antigen expression. Clin Endocrinol (Oxf). 31:125-135.
34. Sztankay A, Trieb K, Lucciarini P, et al. 1994 Interferon gamma and iodide increase the inducibility of the 72kD heat shock protein in cultured human thyroid epithelial cells. J Autoimmun. 7:219-230.
35. Paul T, Meyers B, Witorsch RJ, et al. 1988 The effects of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism. 37:14-19.
36. Gardner DF, Centor RM, Utiger RD. 1988 Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol (Oxf). 28:283-288.
37. Chow CC, Phillips DIW, Lazarus JH, Parker AB. 1991 Effect of low iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable? Clin Endocrinol (Oxf). 34:413-416.