Biochemistry of smooth muscle myosin light chain kinase

Archives of Biochemistry and Biophysics

Volumn 510, Issue 2, 2011, Pages 135-146

  Hong, Feng ^a   Haldeman, Brian D ^a   Jackson, Del ^a   Carter, Mike ^a   Baker, Jonathan E ^a   Cremo, Christine R ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Actin; Actomyosin; Contraction; Kinases; Motility; Myosin; Myosin light chain kinase; Smooth muscle

Indexed keywords

CALCIUM ION; CALMODULIN; F ACTIN; MYOSIN; MYOSIN II; MYOSIN IIA; MYOSIN IIB; MYOSIN IIC; MYOSIN LIGHT CHAIN KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ASTHMA; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL ASSAY; CELL MOTILITY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; MUSCLE CONTRACTION; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REVIEW; SEPSIS; SMOOTH MUSCLE; THIN FILAMENT;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN KINASE; PROTEIN STRUCTURE, TERTIARY;

EID: 79958762330     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2011.04.018     Document Type: Review

References (124)

1. B.P. Herring, O. El-Mounayri, P.J. Gallagher, F. Yin, J. Zhou, Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues, Am. J. Physiol. Cell Physiol. 291 (2006) C817-27.
2. J.Y. Chan, M. Takeda, L.E. Briggs, M.L. Graham, J.T. Lu, N. Horikoshi, E.O. Weinberg, H. Aoki, N. Sato, K.R. Chien, H. Kasahara, Identification of cardiac-specific myosin light chain kinase, Circ. Res. 102 (2008) 571-580.
3. V. Lazar, J.G. Garcia, A single human myosin light chain kinase gene (MLCK; MYLK), Genomics 57 (1999) 256-267.
4. R.S. Adelstein, C.B. Klee, Purification and characterization of smooth muscle myosin light chain kinase, J. Biol. Chem. 256 (1981) 7501-7509.
5. R.S. Adelstein, C.B. Klee, Purification of smooth muscle myosin light-chain kinase, Methods Enzymol. 85 (Pt B) (1982) 298-308.
6. P.K. Ngai, C.A. Carruthers, M.P. Walsh, Isolation of the native form of chicken gizzard myosin light-chain kinase, Biochem. J. 218 (1984) 863-870. (Pubitemid 14165185)
7. M.A. Conti, R.S. Adelstein, Purification and properties of myosin light chain kinases, Methods Enzymol. 196 (1991) 34-47.
8. M.D. Pato, E. Kerc, Purification of smooth muscle myosin phosphatase from turkey gizzard, Methods Enzymol. 159 (1988) 446-453.
9. M.P. Walsh, S. Hinkins, I.L. Flink, D.J. Hartshorne, Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme, Biochemistry 21 (1982) 6890-6896.
10. N.J. Olson, R.B. Pearson, D.S. Needleman, M.Y. Hurwitz, B.E. Kemp, A.R. Means, Regulatory and structural motifs of chicken gizzard myosin light chain kinase, Proc. Natl. Acad. Sci. USA 87 (1990) 2284-2288.
11. S. Kanoh, M. Ito, E. Niwa, Y. Kawano, D.J. Hartshorne, Actin-binding peptide from smooth muscle myosin light chain kinase, Biochemistry 32 (1993) 8902-8907. (Pubitemid 23268815)
12. L. Smith, X. Su, P. Lin, G. Zhi, J.T. Stull, Identification of a novel actin binding motif in smooth muscle myosin light chain kinase, J. Biol. Chem. 274 (1999) 29433-29438.
13. P.J. Gallagher, J.T. Stull, Localization of an actin binding domain in smooth muscle myosin light chain kinase, Mol. Cell Biochem. 173 (1997) 51-57.
14. L.H. Ye, K. Hayakawa, H. Kishi, M. Imamura, A. Nakamura, T. Okagaki, T. Takagi, A. Iwata, T. Tanaka, K. Kohama, The structure and function of the actin-binding domain of myosin light chain kinase of smooth muscle, J. Biol. Chem. 272 (1997) 32182-32189.
15. J.R. Sellers, M.D. Pato, The binding of smooth muscle myosin light chain kinase and phosphatases to actin and myosin, J. Biol. Chem. 259 (1984) 7740-7746.
16. C. Xie, Y. Zhang, H.H. Wang, A. Matsumoto, A. Nakamura, R. Ishikawa, S. Yoshiyama, K. Hayakawa, K. Kohama, Y. Gao, Calcium regulation of nonkinase and kinase activities of recombinant myosin light-chain kinase and its mutants, IUBMB Life 61 (2009) 1092-1098.
17. D.L. Silver, A.V. Vorotnikov, D.M. Watterson, V.P. Shirinsky, J.R. Sellers, Sites of interaction between kinase-related protein and smooth muscle myosin, J. Biol. Chem. 272 (1997) 25353-25359.
18. V.P. Shirinsky, A.V. Vorotnikov, K.G. Birukov, A.K. Nanaev, M. Collinge, T.J. Lukas, J.R. Sellers, D.M. Watterson, A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP, J. Biol. Chem. 268 (1993) 16578-16583.
19. T. Numata, T. Katoh, M. Yazawa, Functional role of the C-terminal domain of smooth muscle myosin light chain kinase on the phosphorylation of smooth muscle myosin, J. Biochem. (Tokyo) 129 (2001) 437-444.
20. A. Sobieszek, Phosphorylation reaction of vertebrate smooth muscle myosin: an enzyme kinetic analysis, Biochemistry 24 (1985) 1266-1274. (Pubitemid 15096777)
21. F. Hong, B.D. Haldeman, O.A. John, P.D. Brewer, Y.Y. Wu, S. Ni, D.P. Wilson, M.P. Walsh, J.E. Baker, C.R. Cremo, Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes, J. Mol. Biol. 390 (2009) 879-892.
22. R.A. Cross, A. Sobieszek, Influence of smooth muscle myosin conformation on myosin light chain kinase binding and on phosphorylation, FEBS Lett. 188 (1985) 367-374. (Pubitemid 16249761)
23. B. Kobe, J. Heierhorst, S.C. Feil, M.W. Parker, G.M. Benian, K.R. Weiss, B.E. Kemp, Giant protein kinases: domain interactions and structural basis of autoregulation, Embo J. 15 (1996) 6810-6821. (Pubitemid 27023251)
24. J.K. Krueger, G.A. Olah, S.E. Rokop, G. Zhi, J.T. Stull, J. Trewhella, Structures of calmodulin and a functional myosin light chain kinase in the activated complex: a neutron scattering study, Biochemistry 36 (1997) 6017-6023. (Pubitemid 27257868)
25. Y. Mabuchi, K. Mabuchi, W.F. Stafford, Z. Grabarek, Modular structure of smooth muscle Myosin light chain kinase: hydrodynamic modeling and functional implications, Biochemistry 49 (2010) 2903-2917.
26. C.R. Bagshaw, Muscle Contraction, Chapman and Hall, London, 1993.
27. P.J. Gallagher, B.P. Herring, J.T. Stull, Myosin light chain kinases, J. Muscle Res. Cell Motil. 18 (1997) 1-16.
28. S.L. Yuen, O. Ogut, F.V. Brozovich, Nonmuscle myosin is regulated during smooth muscle contraction, Am. J. Physiol. Heart Circ. Physiol. 297 (2009) H191-9.
29. W.C. Zhang, Y.J. Peng, G.S. Zhang, W.Q. He, Y.N. Qiao, Y.Y. Dong, Y.Q. Gao, C. Chen, C.H. Zhang, W. Li, H.H. Shen, W. Ning, K.E. Kamm, J.T. Stull, X. Gao, M.S. Zhu, Myosin light chain kinase is necessary for tonic airway smooth muscle contraction, J. Biol. Chem. 285 (2010) 5522-5531.
30. W.Q. He, Y.J. Peng, W.C. Zhang, N. Lv, J. Tang, C. Chen, C.H. Zhang, S. Gao, H.Q. Chen, G. Zhi, R. Feil, K.E. Kamm, J.T. Stull, X. Gao, M.S. Zhu, Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice, Gastroenterology 135 (2008) 610-620.
31. M. Kovacs, K. Thirumurugan, P.J. Knight, J.R. Sellers, Load-dependent mechanism of nonmuscle myosin 2, Proc. Natl. Acad. Sci USA 104 (2007) 9994-9999. (Pubitemid 47175251)
32. F. Wang, M. Kovacs, A. Hu, J. Limouze, E.V. Harvey, J.R. Sellers, Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance, J. Biol. Chem. 278 (2003) 27439-27448.
33. M. Lofgren, E. Ekblad, I. Morano, A. Arner, Nonmuscle Myosin motor of smooth muscle, J. Gen. Physiol. 121 (2003) 301-310.
34. I. Morano, G.X. Chai, L.G. Baltas, V. Lamounier-Zepter, G. Lutsch, M. Kott, H. Haase, M. Bader, in Nat Cell Biol, Vol. 2, (2000) 371-5.
35. A.Y. Rhee, O. Ogut, F.V. Brozovich, Nonmuscle myosin, force maintenance, and the tonic contractile phenotype in smooth muscle, Pflugers Arch. 452 (2006) 766-774.
36. J.M.F. Sherry, A.A. Górecka, M.O. Aksoy, R. Dabrowska, D.J. Hartshorne, Roles of Calcium and Phosphorylation in the Regulation of the Activity of Gizzard Myosin, Biochemistry 17 (1978) 4411-4418.
37. R.B. Pearson, M. Ito, N.A. Morrice, A.J. Smith, R. Condron, R.E. Wettenhall, B.E. Kemp, D.J. Hartshorne, Proteolytic cleavage sites in smooth muscle myosinlight- chain kinase and their relation to structural and regulatory domains, Eur. J. Biochem. 200 (1991) 723-730.
38. P. Lin, K. Luby-Phelps, J.T. Stull, Properties of filament-bound myosin light chain kinase, J. Biol. Chem. 274 (1999) 5987-5994.
39. P.-j. Lin, K. Luby-Phelps, J.T. Stull, Binding fo Myosin Light Chain Kinase to Cellular Actin-Myosin Filaments, J. Biol. Chem. 272 (1997) 7412-7420.
40. H.L. Foyt, V. Guerriero Jr., A.R. Means, Functional domains of chicken gizzard myosin light chain kinase, J. Biol. Chem. 260 (1985) 7765-7774.
41. M.P. Walsh, R. Dabrowska, S. Hinkins, D.J. Hartshorne, Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification, and characterization, Biochemistry 21 (1982) 1919-1925.
42. M. Ikebe, M. Stepinska, B.E. Kemp, A.R. Means, D.J. Hartshorne, Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments, J. Biol. Chem. 262 (1987) 13828-13834.
43. 2+-independent smooth muscle contraction. a novel function for integrin-linked kinase, J. Biol. Chem. 276 (2001) 16365-16373.
44. N. Niiro, M. Ikebe, Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation, J. Biol. Chem. 276 (2001) 29567-29574.
45. M. Ikebe, M. Inagaki, M. Naka, H. Hidaka, Correlation of conformation and phosphorylation and dephosphorylation of smooth muscle myosin, J. Biol. Chem. 263 (1988) 10698-10704.
46. K.E. Kamm, L.C. Hsu, Y. Kubota, J.T. Stull, Phosphorylation of smooth muscle myosin heavy and light chains. Effects of phorbol dibutyrate and agonists, J. Biol. Chem. 264 (1989) 21223-21229. (Pubitemid 20017942)
47. U. Geuss, G.W. Mayr, L.M. Heilmeyer Jr., Steady-state kinetics of skeletal muscle myosin light chain kinase indicate a strong down regulation by products, Eur. J. Biochem. 153 (1985) 327-334.
48. J.M. Krisanda, R.J. Paul, Phosphagen and metabolite content during contraction in porcine carotid artery, Am. J. Physiol. 244 (1983) C385-90.
49. A. Wirth, M. Schroeter, C. Kock-Hauser, E. Manser, J.M. Chalovich, P. de Lanerolle, G. Pfitzer, Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1, J. Physiol. (Paris) 549 (2003) 489-500.
50. P.J. Gallagher, B.P. Herring, A. Trafny, J. Sowadski, J.T. Stull, A molecular mechanism for autoinhibition of myosin light chain kinases, J. Biol. Chem. 268 (1993) 26578-26582.
51. K.E. Kamm, J.T. Stull, Dedicated myosin light chain kinases with diverse cellular functions, J. Biol. Chem. 276 (2001) 4527-4530.
52. J.T. Stull, M.G. Tansey, D.C. Tang, R.A. Word, K.E. Kamm, Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization, Mol. Cell Biochem. 127-128 (1993) 229-237.
53. M.G. Tansey, K. Luby-Phelps, K.E. Kamm, J.T. Stull, Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells, J. Biol. Chem. 269 (1994) 9912-9920.
54. E. Isotani, G. Zhi, K.S. Lau, J. Huang, Y. Mizuno, A. Persechini, R. Geguchadze, K.E. Kamm, J.T. Stull, Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse, Proc. Natl. Acad. Sci. USA 101 (2004) 6279-6284. (Pubitemid 38520565)
55. R. Geguchadze, G. Zhi, K.S. Lau, E. Isotani, A. Persechini, K.E. Kamm, J.T. Stull, Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells, FEBS Lett. 557 (2004) 121-124.
56. A. Fajmut, M. Jagodic, M. Brumen, Mathematical modeling of the myosin light chain kinase activation, J. Chem. Inf. Model 45 (2005) 1605-1609.
57. E.R. Injeti, R.J. Sandoval, J.M. Williams, A.V. Smolensky, L.E. Ford, W.J. Pearce, Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries, Am. J. Physiol. Heart Circ. Physiol. 295 (2008) H2289-98.
58. M.P. Walsh, S. Hinkins, R. Dabrowska, D.J. Hartshorne, Smooth muscle myosin light chain kinase, Methods Enzymol. 99 (1983) 279-288. (Pubitemid 13009539)
59. R. Dabrowska, S. Hinkins, M.P. Walsh, D.J. Hartshorne, The binding of smooth muscle myosin light chain kinase to actin, Biochem. Biophys. Res. Commun. 107 (1982) 1524-1531.
60. D.J. Hartshorn, Physiology of the Gastrointestinal Tract, Raven Press, New York, 1987.
61. R.A. Murphy, S.P. Driska, D.M. Cohen, Excitation-Contraction Coupling in Smooth Muscles, Elsevier-North Holland Biomedical Press, Amsterdam, 1977.
62. R.A. Murphy, J.T. Herlihy, J. Megerman, Force-generating capacity and contractile protein content of arterial smooth muscle, J. Gen. Physiol. 64 (1974) 691-705.
63. S. Walcott, P.M. Fagnant, K.M. Trybus, D.M. Warshaw, Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion, J. Biol. Chem. 284 (2009) 18244-18251.
64. C.R. Cremo, D.J. Hartshorne, in: L.M. Coluccio (Ed.), Myosins: A Superfamily of Molecular Motors, vol. 7, Springer, Dordrecht, The Netherlands, 2008, pp. 171-222.
65. R.E. Kenney, P.E. Hoar, G.L. Kerrick, The Relationship between ATPase Activity, Isometric Force, and Myosin Light-chain Phosphorylation and Thiophosphorylation in Skinned Smooth Muscle Fiber Bundles from Chicken Gizzard, J. Biol. Chem. 265 (1990) 8642-8649.
66. C.R. Bagshaw, J.F. Eccleston, D.R. Trentham, D.W. Yates, Transient kinetic studies of the Mg++-dependent ATPase of myosin and its proteolytic subfragments, Cold Spring Harbor Symp. Quant. Biol 37 (1972) 127-135.
67. J. Barrington-Leigh, K.C. Holmes, H.G. Mannherz, G. Rosenbaum, F. Eckstein, R.S. Goody, Effects of ATP analogs on the lowangle x-ray diffraction pattern of insect flight muscle, Cold SpringHarbor Symp. Quant. Biol. 37 (1972) 443-448.
68. T. Kossmann, D. Furst, J.V. Small, Structural and biochemical analysis of skinned smooth muscle preparations, J. Muscle Res. Cell Motil. 8 (1987) 135-144.
69. A. Sobieszek, Vectorial activation of smooth muscle myosin filaments and its modulation by telokin, Can. J. Physiol. Pharmacol. 83 (2005) 899-912. (Pubitemid 43235415)
70. A. Sobieszek, O.Y. Andruchov, Z. Grabarek, N. Kulikova, C. Liebetrau, O.S. Matusovsky, Modulation of myosin filament activation by telokin in smooth muscle liberation of myosin kinase and phosphatase from supramolecular complexes, Biophys. Chem. 113 (2005) 25-40.
71. R. Leguillette, M. Laviolette, C. Bergeron, N. Zitouni, P. Kogut, J. Solway, L. Kachmar, Q. Hamid, A.-M. Lauzon, Myosin, Transgelin, and Myosin Light Chain Kinase: Expression and Function in Asthma, J. Respir. Crit. Care Med. 179 (2009) 194-204.
72. H. Jiang, K. Rao, A.J. Halayko, X. Liu, N.L. Stephens, Ragweed sensitization-induced increase of myosin light chain kinase content in canine airway smooth muscle, Am. J. Respir. Cell Mol. Biol. 7 (1992) 567-573.
73. C. Flores, S.F. Ma, K. Maresso, C. Ober, J.G. Garcia, A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans, Genet. Epidemiol. 31 (2007) 296-305.
74. L. Gao, A.V. Grant, N. Rafaels, M. Stockton-Porter, T. Watkins, P. Gao, P. Chi, M. Munoz, H. Watson, G. Dunston, A. Togias, N. Hansel, J. Sevransky, J.P. Maloney, M. Moss, C. Shanholtz, R. Brower, J.G. Garcia, D.N. Grigoryev, C. Cheadle, T.H. Beaty, R.A. Mathias, K.C. Barnes, Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma, J. Allergy Clin. Immunol. 119 (2007) 1111-1118.
75. J. Moitra, C. Evenoski, S. Sammani, R. Wadgaonkar, J.R. Turner, S.F. Ma, J.G. Garcia, A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age, Transl. Res. 151 (2008) 141-153.
76. G. Liu, X. Liu, K. Rao, H. Jiang, N.L. Stephens, Increased myosin light chain kinase content in sensitized canine saphenous vein, J. Appl. Physiol. 80 (1996) 665-669.
77. J.R. Turner, Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application, Am. J. Pathol. 169 (2006) 1901-1909.
78. L. Shen, E.D. Black, E.D. Witkowski, W.I. Lencer, V. Guerriero, E.E. Schneeberger, J.R. Turner, Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure, J. Cell Sci. 119 (2006) 2095-2106. (Pubitemid 43904964)
79. L. Shen, L. Su, J.R. Turner, Mechanisms and functional implications of intestinal barrier defects, Dig. Dis. 27 (2009) 443-449.
80. J.G. Garcia, A.D. Verin, K. Schaphorst, R. Siddiqui, C.E. Patterson, C. Csortos, V. Natarajan, Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src), Am. J. Physiol. 276 (1999) L989-98.
81. L. Su, L. Shen, D.R. Clayburgh, S.C. Nalle, E.A. Sullivan, J.B. Meddings, C. Abraham, J.R. Turner, Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis, Gastroenterology 136 (2009) 551-563.
82. C.R. Weber, J.R. Turner, Inflammatory bowel disease: is it really just another break in the wall?, Gut 56 (2007) 6-8. (Pubitemid 46044880)
83. S.A. Blair, S.V. Kane, D.R. Clayburgh, J.R. Turner, Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease, Lab Invest. 86 (2006) 191-201. (Pubitemid 43117598)
84. D.R. Clayburgh, T.A. Barrett, Y. Tang, J.B. Meddings, L.J. Van Eldik, D.M. Watterson, L.L. Clarke, R.J. Mrsny, J.R. Turner, Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo, J. Clin. Invest. 115 (2005) 2702-2715.
85. R. Reynoso, R.M. Perrin, J.W. Breslin, D.A. Daines, K.D. Watson, D.M. Watterson, M.H. Wu, S. Yuan, A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns, Shock 28 (2007) 589-595. (Pubitemid 350287445)
86. Y. Zolotarevsky, G. Hecht, A. Koutsouris, D.E. Gonzalez, C. Quan, J. Tom, R.J. Mrsny, J.R. Turner, A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease,, Gastroenterology 123 (2002) 163-172. (Pubitemid 34747537)
87. M. Ito, R. Dabrowska, V. Guerriero, D.J. Hartshorne, Identification in Turkey Gizzard of an Acidic Protein Related to the C-terminal Portion of Smooth Muscle Myosin Light Chain Kinase, J. Biol. Chem. 264 (1989) 13971-13974.
88. O.V. Shcherbakova, D.V. Serebryanaya, A.B. Postnikov, M.M. Schroeter, S. Zittrich, A.A. Noegel, V.P. Shirinsky, A.V. Vorotnikov, G. Pfitzer, Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli, Biochem J 429 (2010) 291-302.
89. A. Houmeida, J. Holt, L. Tskhovrebova, J. Trinick, Studies of the interaction between titin and myosin, J. Cell Biol. 131 (1995) 1471-1481. (Pubitemid 26001751)
90. R.J. Levine, P.D. Chantler, R.W. Kensler, J.L. Woodhead, Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments, J. Cell Biol. 113 (1991) 563-572. (Pubitemid 21926013)
91. R.J. Levine, R.W. Kensler, Z. Yang, J.T. Stull, H.L. Sweeney, Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments, Biophys. J. 71 (1996) 898-907. (Pubitemid 26289174)
92. R.J. Levine, Z. Yang, N.D. Epstein, L. Fananapazir, J.T. Stull, H.L. Sweeney, Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains, J. Struct. Biol. 122 (1998) 149-161.
93. T. Masato, T. Numata, T. Katoh, F. Morita, M. Yazawa, Crosslinking of telokin to chicken gizzard smooth muscle myosin, J. Biochem. (Tokyo) 121 (1997) 225-230.
94. H.M. Holden, M. Ito, D.J. Hartshorne, I. Rayment, Structure Determination of Telokin, the C-terminal Domain of Myosin Light Chain Kinase at 2.8 A Resolution, J. Mol. Biol. 227 (1992) 840-851.
95. K. Rogowski, J. van Dijk, M.M. Magiera, C. Bosc, J.C. Deloulme, A. Bosson, L. Peris, N.D. Gold, B. Lacroix, M.B. Grau, N. Bec, C. Larroque, S. Desagher, M. Holzer, A. Andrieux, M.J. Moutin, C. Janke, A family of protein-deglutamylating enzymes associated with neurodegeneration, Cell 143 (2010) 564-578.
96. F. Rusconi, M.C. Potier, J.P. Le Caer, J.M. Schmitter, J. Rossier, Characterization of the chicken telokin heterogeneity by time-of-flight mass spectrometry, Biochemistry 36 (1997) 11021-11026. (Pubitemid 27396259)
97. D.L. Milton, A.N. Schneck, D.A. Ziech, M. Ba, K.C. Facemyer, A.J. Halayko, J.E. Baker, W.T. Gerthoffer, C.R. Cremo, Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells, Proc. Natl. Acad. Sci. USA 108 (2011) 1421-1426.
98. P.K. Ngai, M.P. Walsh, Purification of smooth-muscle myosin free of calmodulin and myosin light-chain kinase. Susceptibility to oxidation, Biochem. J. 246 (1987) 205-211.
99. V. Hatch, G. Zhi, L. Smith, J.T. Stull, R. Craig, W. Lehman, Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction, J. Cell Biol. 154 (2001) 611-617. (Pubitemid 34286165)
100. A. McGough, F-actin-binding proteins, Curr. Opin. Struct. Biol. 8 (1998) 166-176. (Pubitemid 28221047)
101. R. Dominguez, Actin-binding proteins-a unifying hypothesis, Trends. Biochem. Sci. 29 (2004) 572-578.
102. L. Smith, J.T. Stull, Myosin light chain kinase binding to actin filaments, FEBS Lett 480 (2000) 298-300.
103. C.A. Otey, R. Dixon, C. Stack, S.M. Goicoechea, Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease, Cell Motil. Cytoskeleton 66 (2009) 618-634.
104. S. Galler, Molecular basis of the catch state in molluscan smooth muscles: a catchy challenge, J. Muscle Res. Cell Motil. 29 (2008) 73-99.
105. S.B. Marston, W. Lehman, Caldesmon is a Ca2+-regulatory component of native smooth-muscle thin filaments, Biochem. J. 231 (1985) 517-522. (Pubitemid 16194543)
106. S.B. Marston, C.W. Smith, Purification and properties of Ca2+-regulated thin filaments and F-actin from sheep aorta smooth muscle, J. Muscle Res. Cell Motil. 5 (1984) 559-575.
107. S. Driska, D.J. Hartshorne, The contractile proteins of smooth muscle. Properties and components of a Ca2+-sensitive actomyosin from chicken gizzard, Arch Biochem. Biophys. 167 (1975) 203-212.
108. M. Walters, S.B. Marston, Phosphorylation of the calcium ion-regulated thin filaments from vascular smooth muscle. A new regulatory mechanism?, Biochem J. 197 (1981) 127-139.
109. S.B. Marston, C.W. Smith, The thin filaments of smooth muscles,, J. Muscle Res. Cell Motil. 6 (1985) 669-708.
110. J.L. Hodgkinson, M. el-Mezgueldi, R. Craig, P. Vibert, S.B. Marston, W. Lehman, 3-D image reconstruction of reconstituted smooth muscle thin filaments containing calponin: visualization of interactions between F-actin and calponin, J. Mol. Biol. 273 (1997) 150-159.
111. E.B. Babiychuk, V.S. Babiychuk, A. Sobieszek, Modulation of smooth muscle myosin light chain kinase activity by Ca2+/calmodulin-dependent, oligomeric-type modifications, Biochemistry 34 (1995) 6366-6372.
112. K. Nieznanski, A. Sobieszek, Telokin (kinase-related protein) modulates the oligomeric state of smooth-muscle myosin light-chain kinase and its interaction with myosin filaments, Biochem. J. 322 (Pt 1) (1997) 65-71.
113. T. Okagaki, K. Hayakawa, K. Samizo, K. Kohama, Inhibition of the ATP-dependent interaction of actin and myosin by the catalytic domain of the myosin light chain kinase of smooth muscle: possible involvement in smooth muscle relaxation, J. Biochem. (Tokyo) 125 (1999) 619-626.
114. L.H. Ye, H. Kishi, A. Nakamura, T. Okagaki, T. Tanaka, K. Oiwa, K. Kohama, Myosin light-chain kinase of smooth muscle stimulates myosin ATPase activity without phosphorylating myosin light chain,, Proc. Natl. Acad. Sci. USA 96 (1999) 6666-6671. (Pubitemid 29274940)
115. A. Nakamura, C. Xie, Y. Zhang, Y. Gao, H.H. Wang, L.H. Ye, H. Kishi, T. Okagaki, S. Yoshiyama, K. Hayakawa, R. Ishikawa, K. Kohama, Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi, Biochem. Biophys. Res. Commun. 369 (2008) 135-143.
116. Y. Gao, K. Kawano, S. Yoshiyama, H. Kawamichi, X. Wang, A. Nakamura, K. Kohama, Myosin light chain kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain, Biochem. Biophys. Res. Commun. 305 (2003) 16-21. (Pubitemid 36535403)
117. H.H. Wang, A. Nakamura, A. Matsumoto, S. Yoshiyama, X. Qin, L.H. Ye, C. Xie, Y. Zhang, Y. Gao, R. Ishikawa, K. Kohama, Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine, Am. J. Physiol. Heart Circ. Physiol. 296 (2009) H1683-93.
118. H. Shimizu, M. Ito, M. Miyahara, K. Ichikawa, S. Okubo, T. Konishi, M. Naka, T. Tanaka, K. Hirano, D.J. Hartshorne, et al., Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase, J. Biol. Chem. 269 (1994) 30407-30411.
119. J. Kolega, Fluorescent analogues of myosin II for tracking the behavior of different myosin isoforms in living cells, J. Cell Biochem. 68 (1998) 389-401. (Pubitemid 28080130)
120. E.K. Blue, Z.M. Goeckeler, Y. Jin, L. Hou, S.A. Dixon, B.P. Herring, R.B. Wysolmerski, P.J. Gallagher, 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns, Am. J. Physiol. Cell Physiol. 282 (2002) C451-60.
121. K. Kohama, T. Okagaki, K. Hayakawa, Y. Lin, R. Ishikawa, T. Shimmen, A. Inoue, ) A novel regulatory effect of myosin light chain kinase from smooth muscle on the ATP-dependent interaction between actin and myosin, Biochem. Biophys. Res. Commun. 184 (1992) 1204-1211.
122. M.J. Greenberg, J.R. Moore, The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors, Cytoskeleton (Hoboken) 67 (2010) 273-285.
123. J.J. Olney, J.R. Sellers, C.R. Cremo, Structure and Function of the 10 S Conformation of Smooth Muscle Myosin, J. Biol. Chem. 271 (1996) 20375-20384.
124. S.A. Burgess, S. Yu, M.L. Walker, R.J. Hawkins, J.M. Chalovich, P.J. Knight, Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state, J. Mol. Biol. 372 (2007) 1165-1178. (Pubitemid 47374715)