Behavioral changes in dogs associated with the development of idiopathic epilepsy

Epilepsy and Behavior

Volumn 21, Issue 2, 2011, Pages 160-167

  Shihab, Nadia ^a   Bowen, Jon ^a,b   Volk, Holger A ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Behavior; Canine; Comorbidity; Epilepsy; Seizure

Indexed keywords

ETIRACETAM; GABAPENTIN; PHENOBARBITAL; PHENYTOIN; POTASSIUM BROMIDE; TOPIRAMATE; ZONISAMIDE;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTICONVULSANT THERAPY; ANXIETY; APATHY; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DOG DISEASE; EPILEPSY; FEAR; FEMALE; FOCAL EPILEPSY; GRAND MAL SEIZURE; HUMAN; IDIOPATHIC DISEASE; IDIOPATHIC EPILEPSY; INTERVIEW; MALE; MONOTHERAPY; NONHUMAN; ONSET AGE; PERCEPTION DISORDER;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; DOGS; EPILEPSY; FACTOR ANALYSIS, STATISTICAL; FEMALE; HUMANS; MALE; QUESTIONNAIRES; SEX FACTORS; SPECIES SPECIFICITY;

EID: 79958745431     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.03.018     Document Type: Article

References (68)

1. Banerjee P.N., Filippi D., Allen Hauser W. The descriptive epidemiology of epilepsy: a review. Epilepsy Res 2009, 85:31-45.
2. Berendt M., Gredal H., Alving J. Characteristics and phenomenology of epileptic partial seizures in dogs: similarities with human seizure semiology. Epilepsy Res 2004, 61:167-173.
3. Chandler K. Canine epilepsy: what can we learn from human seizure disorders?. Vet J 2006, 172:207-217.
4. Zarrelli M.M., Beghi E., Rocca W.A., Hauser W.A. Incidence of epileptic syndromes in Rochester, Minnesota: 1980-1984. Epilepsia 1999, 40:1708-1714.
5. Austin J.K., Caplan R. Behavioral and psychiatric comorbidities in pediatric epilepsy: toward an integrative model. Epilepsia 2007, 48:1639-1651.
6. Gaitatzis A., Carroll K., Majeed A., Sander J.W. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 2004, 45:1613-1622.
7. Jalava M., Sillanpaa M. Concurrent illnesses in adults with childhood-onset epilepsy: a population-based 35-year follow-up study. Epilepsia 1996, 37:1155-1163.
8. LaFrance W.C., Kanner A.M., Hermann B. Psychiatric comorbidities in epilepsy. Int Rev Neurobiol 2008, 83:347-383.
9. Nuyen J., Schellevis F.G., Satariano W.A., et al. Comorbidity was associated with neurologic and psychiatric diseases: a general practice-based controlled study. J Clin Epidemiol 2006, 59:1274-1284.
10. Tellez-Zenteno J.F., Matijevic S., Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia 2005, 46:1955-1962.
11. Kanner A.M. Depression and epilepsy: a new perspective on two closely related disorders. Epilepsy Curr 2006, 6:141-146.
12. Heinrichs S.C., Seyfried T.N. Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms. Epilepsy Behav 2006, 8:5-38.
13. Gastens A.M., Brandt C., Bankstahl J.P., Löscher W. Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy. Epilepsia 2008, 49:1759-1776.
14. Löscher W. Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs: a review. Methods Find Exp Clin Pharmacol 1984, 6:531-547.
15. Licht B.G., Licht M.H., Harper K.M., et al. Clinical presentations of naturally occurring canine seizures: similarities to human seizures. Epilepsy Behav 2002, 3:460-470.
16. Löscher W., Schwartz-Porsche D., Frey H.H., Schmidt D. Evaluation of epileptic dogs as an animal model of human epilepsy. Arzneimittelforschung 1985, 35:82-87.
17. Beleza P. Refractory epilepsy: a clinically oriented review. Eur Neurol 2009, 62:65-71.
18. Podell M. Antiepileptic drug therapy. Clin Tech Small Anim Pract 1998, 13:185-192.
19. Volk H.A., Matiasek L.A., Feliu-Pascual A.L., Platt S.R., Chandler K.E. The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. Vet J 2008, 176:310-319.
20. Caplan R., Siddarth P., Gurbani S., Ott D., Sankar R., Shields W.D. Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variables. Epilepsia 2004, 45:1273-1281.
21. Oostrom K.J., Schouten A., Kruitwagen C.L., Peters A.C., Jennekens-Schinkel A. Behavioral problems in children with newly diagnosed idiopathic or cryptogenic epilepsy attending normal schools are in majority not present. Epilepsia 2003, 44:97-106. for the Dutch Study Group of Epilepsy in Childhood.
22. Hsu Y., Serpell J.A. Development and validation of a questionnaire for measuring behavior and temperament traits in pet dogs. J Am Vet Med Assoc 2003, 223:1293-1300.
23. Segurson S.A., Serpell J.A., Hart B.L. Evaluation of a behavioral assessment questionnaire for use in the characterization of behavioral problems of dogs relinquished to animal shelters. J Am Vet Med Assoc 2005, 227:1755-1761.
24. Holt G., Volk H.A., Chandler K. The use of a questionnaire to compare clinical characteristics and type of seizure occurring in 3 dog breeds with idiopathic epilepsy. Research Abstracts, 18th Annual ECVN & ESVN Symposium, Munich, Germany, 23-24 September 2005. J Vet Intern Med 2006, 20:1279.
25. Commission on Classification and Terminology of the ILAE Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981, 22:489-501.
26. Berendt M., Gram L. Epilepsy and seizure classification in 63 dogs: a reappraisal of veterinary epilepsy terminology. J Vet Intern Med 1999, 13:14-20.
27. Trepanier L.A., Van Schoick A., Schwark W.S., Carrillo J. Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996). J Am Vet Med Assoc 1998, 213:1449-1453.
28. Cramer J.A., Blum D., Reed M., Fanning K. The influence of comorbid depression on quality of life for people with epilepsy. Epilepsy Behav 2003, 4:515-521.
29. Devinsky O. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy Behav 2003, 4(Suppl. 4):S2-S10.
30. Johnson E.K., Jones J.E., Seidenberg M., Hermann B.P. The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia 2004, 45:544-550.
31. Seminario N.A., Farias S.T., Jorgensen J., Bourgeois J.A., Seyal M. Determination of prevalence of depression in an epilepsy clinic using a brief DSM-IV-based self-report questionnaire. Epilepsy Behav 2009, 15:362-366.
32. Boro A., Haut S. Medical comorbidities in the treatment of epilepsy. Epilepsy Behav 2003, 4(Suppl. 2):S2-S12.
33. Kobau R., Gilliam F., Thurman D.J. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 HealthStyles Survey. Epilepsia 2006, 47:1915-1921.
34. Prueter C., Norra C. Mood disorders and their treatment in patients with epilepsy. J Neuropsychiatry Clin Neurosci 2005, 17:20-28.
35. Dunn D.W., Austin J.K. Differential diagnosis and treatment of psychiatric disorders in children and adolescents with epilepsy. Epilepsy Behav 2004, 5(Suppl. 3):S10-S17.
36. Nadkarni S., Arnedo V., Devinsky O. Psychosis in epilepsy patients. Epilepsia 2007, 48(Suppl. 9):17-19.
37. Jobe P.C. Common pathogenic mechanisms between depression and epilepsy: an experimental perspective. Epilepsy Behav 2003, 4(Suppl. 3):S14-S24.
38. Richerson G.B., Buchanan G.F. The serotonin axis: shared mechanisms in seizures, depression, and SUDEP. Epilepsia 2011, 52(Suppl. 1):28-38.
39. Kanner A.M. Depression and epilepsy: a bidirectional relation?. Epilepsia 2011, 52(Suppl. 1):21-27.
40. Frye C.A. Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology 2009, 34(Suppl. 1):S143-S161.
41. Umathe S.N., Vaghasiya J.M., Jain N.S., Dixit P.V. Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:1161-1166.
42. Biagini G., Panuccio G., Avoli M. Neurosteroids and epilepsy. Curr Opin Neurol 2010, 23:170-176.
43. Hesdorffer D.C., Hauser W.A., Olafsson E., Ludvigsson P., Kjartansson O. Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol 2006, 59:35-41.
44. Stafstrom C.E. Behavioral and cognitive testing procedures in animal models of epilepsy. Models of seizures and epilepsy 2006, 613-628. Elsevier Academic Press, Amsterdam. A. Pitkänen, P.A. Schwartzkroin, S.L. Moshé (Eds.).
45. Müller C.J., Groticke I., Bankstahl M., Löscher W. Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. Exp Neurol 2009, 219:284-297.
46. Drane D.L., Meador K.J. Cognitive and behavioral effects of antiepileptic drugs. Epilepsy Behav 2002, 3:49-53.
47. Levisohn P.M., Mintz M., Hunter S.J., Yang H.C., Jones J. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial. Epilepsia 2009, 50:2377-2389. for the N01103 Levetiracetam Study Group.
48. Dewey C.W. A practical guide to canine and feline neurology 2008, 237-260. Wiley-Blackwell, London. 2nd ed.
49. Podell M. Seizures. BSAVA manual of canine and feline neurology 2004, 97-112. British Small Animal Veterinary Assoc., Gloucester. 3rd ed. S.R. Platt, N. Olby (Eds.).
50. Chang Y., Mellor D.J., Anderson T.J. Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. J Small Anim Pract 2006, 47:574-581.
51. Kaindl A.M., Asimiadou S., Manthey D., Hagen M.V., Turski L., Ikonomidou C. Antiepileptic drugs and the developing brain. Cell Mol Life Sci 2006, 63:399-413.
52. Kanner A.M. Epilepsy and mood disorders. Epilepsia 2007, 48(Suppl. 9):20-22.
53. Oguz A., Kurul S., Dirik E. Relationship of epilepsy-related factors to anxiety and depression scores in epileptic children. J Child Neurol 2002, 17:37-40.
54. Thome-Souza S., Kuczynski E., Assumpção F., et al. Which factors may play a pivotal role in determining the type of psychiatric disorder in children and adolescents with epilepsy?. Epilepsy Behav 2004, 5:988-994.
55. Hitiris N., Mohanraj R., Norrie J., Sills G.J., Brodie M.J. Predictors of pharmacoresistant epilepsy. Epilepsy Res 2007, 75:192-196.
56. Arroyo S., Brodie M.J., Avanzini G., et al. Is refractory epilepsy preventable?. Epilepsia 2002, 43:437-444.
57. Kwan P., Brodie M.J. Refractory epilepsy: a progressive, intractable but preventable condition?. Seizure 2002, 1:77-84.
58. Volk H.A., Löscher W. Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures. Brain 2005, 128(Pt. 6):1358-1368.
59. Volk H.A., Arabadzisz D., Fritschy J.M., Brandt C., Bethmann K., Löscher W. Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy. Neurobiol Dis 2006, 21:633-646.
60. Potschka H. Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?. Epilepsia 2010, 518:1333-1347.
61. Luscher B., Shen Q., Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry 2011, 16:383-406.
62. Shalev H., Serlin Y., Friedman A. Breaching the blood-brain barrier as a gate to psychiatric disorder. Cardiovasc Psychiatry Neurol 2009, 278531.
63. Patrikelis P., Angelakis E., Gatzonis S. Neurocognitive and behavioral functioning in frontal lobe epilepsy: a review. Epilepsy Behav 2009, 14:19-26.
64. Quiske A., Helmstaedter C., Lux S., Elger C.E. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy Res 2000, 39:121-125.
65. Patterson E.E., Mickelson J.R., Da Y., et al. Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas. J Vet Intern Med 2003, 17:319-325.
66. Buckmaster P.S., Smith M.O., Buckmaster C.L., LeCouteur R.A., Dudek F.E. Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy. J Vet Intern Med 2002, 16:95-99.
67. Hermann B.P., Whitman S. Neurological, psychosocial and pharmacological factors underlying interictal psychopathology in epilepsy. Neurobehavioral problems in epilepsy 1991, 439-452. Raven Press, New York. D.B. Smith, D.M. Treiman, M.R. Trimble (Eds.).
68. Dudra-Jastrzebska M., Andres-Mach M.M., Luszczki J.J., Czuczwar S.J. Mood disorders in patients with epilepsy. Pharmacol Rep 2007, 59:369-378.