Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients

Journal of Chemical Technology and Biotechnology

Volumn 86, Issue 7, 2011, Pages 942-948

  Falconer, Robert J ^a   Chan, Cherrine ^b   Hughes, Karen ^b   Munro, Trent P ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Arginine; Differential scanning calorimetry; Histidine; Immunoglobulin G; Lysine

Indexed keywords

ACID ADDITION; ACIDIC AMINO ACIDS; HISTIDINE; IMMUNOGLOBULIN-G; LIQUID FORMULATIONS; LYSINE; MANUFACTURING PROCESS; POSITIVE CHARGES; PROTEIN A; PROTEIN STABILITY; SIDE-CHAINS; SOLVATION SHELL; THERAPEUTIC MONOCLONAL ANTIBODIES;

ARGININE; DIFFERENTIAL SCANNING CALORIMETRY; MONOCLONAL ANTIBODIES; PROTEINS; PURIFICATION; SURFACE PLASMON RESONANCE;

STABILIZATION;

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; BUFFER; EXCIPIENT; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; IMMUNOGLOBULIN G; LYSINE; MONOCLONAL ANTIBODY; PROLINE; PROTEIN A; SERINE;

ADDITION REACTION; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PURIFICATION; DRUG STABILITY; DRUG STORAGE; TRANSITION TEMPERATURE;

EID: 79958742888     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.2657     Document Type: Article

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