Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 7, 2006, Pages 1487-1493

  Bovenschen, N ^a,c   Van Stempvoort, G ^a   Voorberg, J ^a   Mertens, K ^a,b   Meijer, Alexander B ^a,b  

^a SANQUIN RESEARCH   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Clearance; Factor VIII; Heavy chain; Ligand binding; Lipoprotein receptor related protein; Thrombin

Indexed keywords

ARGININE; BLOOD CLOTTING FACTOR 8; GLUTAMIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LYSINE; PHENYLALANINE; RECOMBINANT ANTIBODY; THROMBIN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CIRCULATION; CONTROLLED STUDY; ENDOCYTOSIS; HEAVY CHAIN; LIGHT CHAIN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; SURFACE PLASMON RESONANCE;

BINDING SITES; FACTOR VIII; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SURFACE PLASMON RESONANCE;

EID: 33745281224     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01965.x     Document Type: Article

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